메뉴 건너뛰기




Volumn 231, Issue 1, 2014, Pages 269-281

Co-administration of 5-HT6 receptor antagonists with clozapine, risperidone, and a 5-HT2A receptor antagonist: Effects on prepulse inhibition in rats

Author keywords

5 HT2A receptor; 5 HT6 receptor; Antipsychotics; Clozapine; Prepulse inhibition; Risperidone; Schizophrenia; Startle response

Indexed keywords

5 CHLORO N [4 METHOXY 3 (1 PIPERAZINYL)PHENYL] 3 METHYL 2 BENZOTHIOPHENESULFONAMIDE; CLOZAPINE; DIZOCILPINE; HALOPERIDOL; N (3,5 DICHLORO 2 METHOXYPHENYL) 4 METHOXY 3 (1 PIPERAZINYL)BENZENESULFONAMIDE; RISPERIDONE; SEROTONIN 2A RECEPTOR; SEROTONIN 6 RECEPTOR; VOLINANSERIN;

EID: 84891834187     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-013-3234-2     Document Type: Article
Times cited : (24)

References (54)
  • 2
    • 0032030496 scopus 로고    scopus 로고
    • M100907, a selective 5-HT2A receptor antagonist and a potential antipsychotic drug, facilitates N-methyl-D-aspartate-receptor mediated neurotransmission in the rat medial prefrontal cortical neurons in vitro
    • 1:CAS:528:DyaK1cXptlGgsA%3D%3D 9471117 10.1016/S0893-133X(97)00126-7
    • Arvanov VL, Wang RY (1998) M100907, a selective 5-HT2A receptor antagonist and a potential antipsychotic drug, facilitates N-methyl-D-aspartate- receptor mediated neurotransmission in the rat medial prefrontal cortical neurons in vitro. Neuropsychopharmacology 18:197-209
    • (1998) Neuropsychopharmacology , vol.18 , pp. 197-209
    • Arvanov, V.L.1    Wang, R.Y.2
  • 3
    • 33747361259 scopus 로고    scopus 로고
    • Actions of novel antipsychotic agents on apomorphine-induced PPI disruption: Influence of combined serotonin 5-HT1A receptor activation and dopamine D2 receptor blockade
    • 1:CAS:528:DC%2BD28XotFKlurY%3D 16421514 10.1038/sj.npp.1301015
    • Auclair AL, Kleven MS, Besnard J, Depoortere R, Newman-Tancredi A (2006) Actions of novel antipsychotic agents on apomorphine-induced PPI disruption: influence of combined serotonin 5-HT1A receptor activation and dopamine D2 receptor blockade. Neuropsychopharmacology 31:1900-1909
    • (2006) Neuropsychopharmacology , vol.31 , pp. 1900-1909
    • Auclair, A.L.1    Kleven, M.S.2    Besnard, J.3    Depoortere, R.4    Newman-Tancredi, A.5
  • 4
    • 0028143103 scopus 로고
    • Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response
    • 1:CAS:528:DyaK2MXisVOqu7o%3D 7965797
    • Bakshi VP, Swerdlow NR, Geyer MA (1994) Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response. J Pharmacol Exp Ther 271:787-794
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 787-794
    • Bakshi, V.P.1    Swerdlow, N.R.2    Geyer, M.A.3
  • 5
    • 0034493029 scopus 로고    scopus 로고
    • Effects of MK801 and neuroleptics on prepulse inhibition: Re-examination in two strains of rats
    • 1:CAS:528:DC%2BD3MXnslSmsA%3D%3D 11164097 10.1016/S0091-3057(00)00409-3
    • Bast T, Zhang W, Feldon J, White IM (2000) Effects of MK801 and neuroleptics on prepulse inhibition: re-examination in two strains of rats. Pharmacol Biochem Behav 67:647-658
    • (2000) Pharmacol Biochem Behav , vol.67 , pp. 647-658
    • Bast, T.1    Zhang, W.2    Feldon, J.3    White, I.M.4
  • 6
    • 0030995586 scopus 로고    scopus 로고
    • Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells
    • 1:CAS:528:DyaK2sXktlSru7w%3D 9225298 10.1016/S0028-3908(97)00019-1
    • Boess FG, Monsma FJ Jr, Carolo C, Meyer V, Rudler A, Zwingelstein C, Sleight AJ (1997) Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells. Neuropharmacology 36:713-720
    • (1997) Neuropharmacology , vol.36 , pp. 713-720
    • Boess, F.G.1    Monsma, Jr.F.J.2    Carolo, C.3    Meyer, V.4    Rudler, A.5    Zwingelstein, C.6    Sleight, A.J.7
  • 8
    • 0025190458 scopus 로고
    • Sensorimotor gating and schizophrenia. Human and animal model studies
    • 1:STN:280:DyaK3c7ks1yksQ%3D%3D 2405807 10.1001/archpsyc.1990. 01810140081011
    • Braff DL, Geyer MA (1990) Sensorimotor gating and schizophrenia. Human and animal model studies. Arch Gen Psychiatry 47:181-188
    • (1990) Arch Gen Psychiatry , vol.47 , pp. 181-188
    • Braff, D.L.1    Geyer, M.A.2
  • 9
    • 22444441301 scopus 로고    scopus 로고
    • The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating
    • 1:CAS:528:DC%2BD2MXivFKmtrY%3D 15820528 10.1016/j.pbb.2005.01.012
    • Bubenikova V, Votava M, Horacek J, Palenicek T, Dockery C (2005) The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating. Pharmacol Biochem Behav 80:591-596
    • (2005) Pharmacol Biochem Behav , vol.80 , pp. 591-596
    • Bubenikova, V.1    Votava, M.2    Horacek, J.3    Palenicek, T.4    Dockery, C.5
  • 10
    • 78649282727 scopus 로고    scopus 로고
    • Emerging role of sertindole in the management of schizophrenia
    • 1:CAS:528:DC%2BC3cXptlGrsb4%3D 2938292 20856607
    • Cincotta SL, Rodefer JS (2010) Emerging role of sertindole in the management of schizophrenia. Neuropsychiatr Dis Treat 6:429-441
    • (2010) Neuropsychiatr Dis Treat , vol.6 , pp. 429-441
    • Cincotta, S.L.1    Rodefer, J.S.2
  • 11
    • 0027298969 scopus 로고
    • Actions of clozapine and haloperidol on the extracellular levels of excitatory amino acids in the prefrontal cortex and striatum of conscious rats
    • 1:CAS:528:DyaK3sXktVSku7Y%3D 8100055 10.1016/0304-3940(93)90483-2
    • Daly DA, Moghaddam B (1993) Actions of clozapine and haloperidol on the extracellular levels of excitatory amino acids in the prefrontal cortex and striatum of conscious rats. Neurosci Lett 152:61-64
    • (1993) Neurosci Lett , vol.152 , pp. 61-64
    • Daly, D.A.1    Moghaddam, B.2
  • 12
    • 0034782825 scopus 로고    scopus 로고
    • The 5-HT(6) receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus
    • 1:CAS:528:DC%2BD3MXnslCjsbw%3D 11682249 10.1016/S0893-133X(01)00265-2
    • Dawson LA, Nguyen HQ, Li P (2001) The 5-HT(6) receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus. Neuropsychopharmacology 25:662-668
    • (2001) Neuropsychopharmacology , vol.25 , pp. 662-668
    • Dawson, L.A.1    Nguyen, H.Q.2    Li, P.3
  • 13
    • 0037441579 scopus 로고    scopus 로고
    • Potentiation of amphetamine-induced changes in dopamine and 5-HT by a 5-HT(6) receptor antagonist
    • 1:CAS:528:DC%2BD3sXptFGisw%3D%3D 12576149 10.1016/S0361-9230(02)00967-X
    • Dawson LA, Nguyen HQ, Li P (2003) Potentiation of amphetamine-induced changes in dopamine and 5-HT by a 5-HT(6) receptor antagonist. Brain Res Bull 59:513-521
    • (2003) Brain Res Bull , vol.59 , pp. 513-521
    • Dawson, L.A.1    Nguyen, H.Q.2    Li, P.3
  • 14
    • 0033609543 scopus 로고    scopus 로고
    • Effects of clozapine and haloperidol on 5-HT6 receptor mRNA levels in rat brain
    • 1:STN:280:DyaK1Mzls1KisQ%3D%3D 10427606 10.1016/S0920-9964(99)00002-X
    • Frederick JA, Meador-Woodruff JH (1999) Effects of clozapine and haloperidol on 5-HT6 receptor mRNA levels in rat brain. Schizophr Res 38:7-12
    • (1999) Schizophr Res , vol.38 , pp. 7-12
    • Frederick, J.A.1    Meador-Woodruff, J.H.2
  • 15
  • 16
    • 0034917841 scopus 로고    scopus 로고
    • Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: A decade in review
    • 1:CAS:528:DC%2BD3MXmtlCqtLY%3D 10.1007/s002130100811
    • Geyer MA, Krebs-Thomson K, Braff DL, Swerdlow NR (2001) Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review. Psychopharmacology (Berl) 156:117-154
    • (2001) Psychopharmacology (Berl) , vol.156 , pp. 117-154
    • Geyer, M.A.1    Krebs-Thomson, K.2    Braff, D.L.3    Swerdlow, N.R.4
  • 17
    • 0029295914 scopus 로고
    • Clozapine: Selective labeling of sites resembling 5HT6 serotonin receptors may reflect psychoactive profile
    • 1:CAS:528:DyaK2MXmsVGgtbc%3D 2229994 8521297
    • Glatt CE, Snowman AM, Sibley DR, Snyder SH (1995) Clozapine: selective labeling of sites resembling 5HT6 serotonin receptors may reflect psychoactive profile. Mol Med 1:398-406
    • (1995) Mol Med , vol.1 , pp. 398-406
    • Glatt, C.E.1    Snowman, A.M.2    Sibley, D.R.3    Snyder, S.H.4
  • 18
    • 79952992514 scopus 로고    scopus 로고
    • Effects of 5-HT6 antagonists, Ro-4368554 and SB-258585, in tests used for the detection of cognitive enhancement and antipsychotic-like activity
    • 1:CAS:528:DC%2BC3MXivVCqs7s%3D 21301322 10.1097/FBP.0b013e328343d804
    • Gravius A, Laszy J, Pietraszek M, Saghy K, Nagel J, Chambon C, Wegener N, Valastro B, Danysz W, Gyertyan I (2011) Effects of 5-HT6 antagonists, Ro-4368554 and SB-258585, in tests used for the detection of cognitive enhancement and antipsychotic-like activity. Behav Pharmacol 22:122-135
    • (2011) Behav Pharmacol , vol.22 , pp. 122-135
    • Gravius, A.1    Laszy, J.2    Pietraszek, M.3    Saghy, K.4    Nagel, J.5    Chambon, C.6    Wegener, N.7    Valastro, B.8    Danysz, W.9    Gyertyan, I.10
  • 19
    • 79955964765 scopus 로고    scopus 로고
    • Effect of cannabidiol in a MK-801-rodent model of aspects of schizophrenia
    • 1:CAS:528:DC%2BC3MXmtFWqt7c%3D 21458498 10.1016/j.bbr.2011.03.053
    • Gururajan A, Taylor DA, Malone DT (2011) Effect of cannabidiol in a MK-801-rodent model of aspects of schizophrenia. Behav Brain Res 222:299-308
    • (2011) Behav Brain Res , vol.222 , pp. 299-308
    • Gururajan, A.1    Taylor, D.A.2    Malone, D.T.3
  • 20
  • 21
    • 0031783008 scopus 로고    scopus 로고
    • Localizing haloperidol effects on sensorimotor gating in a predictive model of antipsychotic potency
    • 1:CAS:528:DyaK1cXlsVaht78%3D 9715813 10.1016/S0091-3057(98)00079-3
    • Hart S, Zreik M, Carper R, Swerdlow NR (1998) Localizing haloperidol effects on sensorimotor gating in a predictive model of antipsychotic potency. Pharmacol Biochem Behav 61:113-119
    • (1998) Pharmacol Biochem Behav , vol.61 , pp. 113-119
    • Hart, S.1    Zreik, M.2    Carper, R.3    Swerdlow, N.R.4
  • 22
    • 26444461639 scopus 로고    scopus 로고
    • 5-HT6 receptor antagonists improve performance in an attentional set shifting task in rats
    • 1:CAS:528:DC%2BD2MXhtFCrtL3L 10.1007/s00213-005-2261-z
    • Hatcher PD, Brown VJ, Tait DS, Bate S, Overend P, Hagan JJ, Jones DN (2005) 5-HT6 receptor antagonists improve performance in an attentional set shifting task in rats. Psychopharmacology (Berl) 181:253-259
    • (2005) Psychopharmacology (Berl) , vol.181 , pp. 253-259
    • Hatcher, P.D.1    Brown, V.J.2    Tait, D.S.3    Bate, S.4    Overend, P.5    Hagan, J.J.6    Jones, D.N.7
  • 24
    • 0027286113 scopus 로고
    • The effects of haloperidol and clozapine on the disruption of sensorimotor gating induced by the noncompetitive glutamate antagonist MK-801
    • 1:CAS:528:DyaK3sXlsFWqur8%3D 10.1007/BF02244950
    • Hoffman DC, Donovan H, Cassella JV (1993) The effects of haloperidol and clozapine on the disruption of sensorimotor gating induced by the noncompetitive glutamate antagonist MK-801. Psychopharmacology (Berl) 111:339-344
    • (1993) Psychopharmacology (Berl) , vol.111 , pp. 339-344
    • Hoffman, D.C.1    Donovan, H.2    Cassella, J.V.3
  • 25
    • 0026040158 scopus 로고
    • Failure of haloperidol to block the effects of phencyclidine and dizocilpine on prepulse inhibition of startle
    • 1:CAS:528:DyaK3MXmsVOqtrg%3D 1834231 10.1016/0006-3223(91)90025-H
    • Keith VA, Mansbach RS, Geyer MA (1991) Failure of haloperidol to block the effects of phencyclidine and dizocilpine on prepulse inhibition of startle. Biol Psychiatry 30:557-566
    • (1991) Biol Psychiatry , vol.30 , pp. 557-566
    • Keith, V.A.1    Mansbach, R.S.2    Geyer, M.A.3
  • 26
    • 79251605205 scopus 로고    scopus 로고
    • Prefrontal NMDA receptor antagonism reduces impairments in pre-attentive information processing
    • 1:CAS:528:DC%2BC3MXhtlejtr4%3D 21111580 10.1016/j.euroneuro.2010.10.010
    • Klamer D, Svensson L, Fejgin K, Palsson E (2011) Prefrontal NMDA receptor antagonism reduces impairments in pre-attentive information processing. Eur Neuropsychopharmacol 21:248-253
    • (2011) Eur Neuropsychopharmacol , vol.21 , pp. 248-253
    • Klamer, D.1    Svensson, L.2    Fejgin, K.3    Palsson, E.4
  • 27
    • 0038107717 scopus 로고    scopus 로고
    • Effect of the 5-HT6 receptor antagonists Ro04-6790 and Ro65-7199 on latent inhibition and prepulse inhibition in the rat: Comparison to clozapine
    • 1:CAS:528:DC%2BD3sXlsVansbo%3D 12873617 10.1016/S0091-3057(03)00082-0
    • Leng A, Ouagazzal A, Feldon J, Higgins GA (2003) Effect of the 5-HT6 receptor antagonists Ro04-6790 and Ro65-7199 on latent inhibition and prepulse inhibition in the rat: comparison to clozapine. Pharmacol Biochem Behav 75:281-288
    • (2003) Pharmacol Biochem Behav , vol.75 , pp. 281-288
    • Leng, A.1    Ouagazzal, A.2    Feldon, J.3    Higgins, G.A.4
  • 28
    • 18044383794 scopus 로고    scopus 로고
    • Nicotine and clozapine actions on pre-pulse inhibition deficits caused by N-methyl-D-aspartate (NMDA) glutamatergic receptor blockade
    • 1:CAS:528:DC%2BD2MXjs1Giurc%3D 15866361 10.1016/j.pnpbp.2005.01.012
    • Levin ED, Petro A, Caldwell DP (2005) Nicotine and clozapine actions on pre-pulse inhibition deficits caused by N-methyl-D-aspartate (NMDA) glutamatergic receptor blockade. Prog Neuropsychopharmacol Biol Psychiatry 29:581-586
    • (2005) Prog Neuropsychopharmacol Biol Psychiatry , vol.29 , pp. 581-586
    • Levin, E.D.1    Petro, A.2    Caldwell, D.P.3
  • 29
    • 33846348402 scopus 로고    scopus 로고
    • 5-HT(6) receptor antagonist SB-399885 potentiates haloperidol and risperidone-induced dopamine efflux in the medial prefrontal cortex or hippocampus
    • 1:CAS:528:DC%2BD2sXpvFSjsg%3D%3D 17207474 10.1016/j.brainres.2006.11.060
    • Li Z, Huang M, Prus AJ, Dai J, Meltzer HY (2007) 5-HT(6) receptor antagonist SB-399885 potentiates haloperidol and risperidone-induced dopamine efflux in the medial prefrontal cortex or hippocampus. Brain Res 1134:70-78
    • (2007) Brain Res , vol.1134 , pp. 70-78
    • Li, Z.1    Huang, M.2    Prus, A.J.3    Dai, J.4    Meltzer, H.Y.5
  • 30
    • 33645029075 scopus 로고    scopus 로고
    • Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice
    • 1:CAS:528:DC%2BD28XitlKms7c%3D 16052245 10.1038/sj.npp.1300838
    • Long LE, Malone DT, Taylor DA (2006) Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice. Neuropsychopharmacology 31:795-803
    • (2006) Neuropsychopharmacology , vol.31 , pp. 795-803
    • Long, L.E.1    Malone, D.T.2    Taylor, D.A.3
  • 31
    • 84891836759 scopus 로고    scopus 로고
    • Study ID: 12450A. ClinicalTrials.gov Identifier: 00810667. Title: Efficacy study exploring the effect of Lu AE58054 as augmentation therapy in patients with Schizophrenia
    • Lundbeck (2008) Study ID: 12450A. ClinicalTrials.gov Identifier: 00810667. Title: Efficacy study exploring the effect of Lu AE58054 as augmentation therapy in patients with Schizophrenia
    • (2008) Lundbeck
  • 32
    • 50349086807 scopus 로고    scopus 로고
    • Antipsychotic property of a muscarinic receptor agonist in animal models for schizophrenia
    • 1:CAS:528:DC%2BD1cXhtVylu7%2FN 18651995 10.1016/j.pbb.2008.06.023
    • Maehara S, Hikichi H, Satow A, Okuda S, Ohta H (2008) Antipsychotic property of a muscarinic receptor agonist in animal models for schizophrenia. Pharmacol Biochem Behav 91:140-149
    • (2008) Pharmacol Biochem Behav , vol.91 , pp. 140-149
    • Maehara, S.1    Hikichi, H.2    Satow, A.3    Okuda, S.4    Ohta, H.5
  • 33
    • 80052024632 scopus 로고    scopus 로고
    • Antipsychotic effects of N-desmethylclozapine on sensorimotor gating function in rats-possible involvement of activation of M(1) muscarinic receptors
    • 1:CAS:528:DC%2BC3MXhtVGlt7zM 21658379 10.1016/j.ejphar.2011.05.063
    • Maehara S, Satow A, Hikichi H, Ohta H (2011) Antipsychotic effects of N-desmethylclozapine on sensorimotor gating function in rats-possible involvement of activation of M(1) muscarinic receptors. Eur J Pharmacol 667:242-249
    • (2011) Eur J Pharmacol , vol.667 , pp. 242-249
    • Maehara, S.1    Satow, A.2    Hikichi, H.3    Ohta, H.4
  • 34
    • 84879206282 scopus 로고    scopus 로고
    • The atypical antipsychotic risperidone reverses the recognition memory deficits induced by post-weaning social isolation in rats
    • McIntosh AL, Ballard TM, Steward LJ, Moran PM, Fone KC (2013) The atypical antipsychotic risperidone reverses the recognition memory deficits induced by post-weaning social isolation in rats. Psychopharmacology (Berl) 228: 31-42
    • (2013) Psychopharmacology (Berl) , vol.228 , pp. 31-42
    • McIntosh, A.L.1    Ballard, T.M.2    Steward, L.J.3    Moran, P.M.4    Fone, K.C.5
  • 35
    • 0024333202 scopus 로고
    • Clozapine: New research on efficacy and mechanism of action
    • 1:STN:280:DyaL1Mzls1Omtw%3D%3D 2569975 10.1007/BF00449814
    • Meltzer HY, Bastani B, Ramirez L, Matsubara S (1989) Clozapine: new research on efficacy and mechanism of action. Eur Arch Psychiatry Neurol Sci 238:332-339
    • (1989) Eur Arch Psychiatry Neurol Sci , vol.238 , pp. 332-339
    • Meltzer, H.Y.1    Bastani, B.2    Ramirez, L.3    Matsubara, S.4
  • 36
    • 79951531704 scopus 로고    scopus 로고
    • 5-HT6 receptor memory and amnesia: Behavioral pharmacology - Learning and memory processes
    • 1:CAS:528:DC%2BC3MXpsFGks74%3D 21329783
    • Meneses A, Perez-Garcia G, Ponce-Lopez T, Castillo C (2011) 5-HT6 receptor memory and amnesia: behavioral pharmacology - learning and memory processes. Int Rev Neurobiol 96:27-47
    • (2011) Int Rev Neurobiol , vol.96 , pp. 27-47
    • Meneses, A.1    Perez-Garcia, G.2    Ponce-Lopez, T.3    Castillo, C.4
  • 37
    • 28044437798 scopus 로고    scopus 로고
    • 5-HT6 receptors: A novel target for cognitive enhancement
    • 1:CAS:528:DC%2BD2MXht1Olsr%2FO 16005519 10.1016/j.pharmthera.2005.05.001
    • Mitchell ES, Neumaier JF (2005) 5-HT6 receptors: a novel target for cognitive enhancement. Pharmacol Ther 108:320-333
    • (2005) Pharmacol Ther , vol.108 , pp. 320-333
    • Mitchell, E.S.1    Neumaier, J.F.2
  • 38
    • 36148938722 scopus 로고    scopus 로고
    • 5-HT6 receptor antagonist reversal of emotional learning and prepulse inhibition deficits induced by apomorphine or scopolamine
    • 1:CAS:528:DC%2BD2sXhtlCru7rL 2322863 17920665 10.1016/j.pbb.2007.08.015
    • Mitchell ES, Neumaier JF (2008) 5-HT6 receptor antagonist reversal of emotional learning and prepulse inhibition deficits induced by apomorphine or scopolamine. Pharmacol Biochem Behav 88:291-298
    • (2008) Pharmacol Biochem Behav , vol.88 , pp. 291-298
    • Mitchell, E.S.1    Neumaier, J.F.2
  • 39
    • 69049088714 scopus 로고    scopus 로고
    • Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: A comparison with risperidone and exploration of mechanisms involved
    • 10.1007/s00213-009-1578-4
    • Mork A, Witten LM, Arnt J (2009) Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: a comparison with risperidone and exploration of mechanisms involved. Psychopharmacology (Berl) 206:39-49
    • (2009) Psychopharmacology (Berl) , vol.206 , pp. 39-49
    • Mork, A.1    Witten, L.M.2    Arnt, J.3
  • 40
    • 84864881933 scopus 로고    scopus 로고
    • Double-blind placebo-controlled randomized efficacy and safety trial of add-on treatment of dimebon plus risperidone in schizophrenic patients during transition from acute psychotic episode to remission
    • 22706414
    • Morozova MA, Beniashvili AG, Lepilkina TA, Rupchev GE (2012) Double-blind placebo-controlled randomized efficacy and safety trial of add-on treatment of dimebon plus risperidone in schizophrenic patients during transition from acute psychotic episode to remission. Psychiatr Danub 24:159-166
    • (2012) Psychiatr Danub , vol.24 , pp. 159-166
    • Morozova, M.A.1    Beniashvili, A.G.2    Lepilkina, T.A.3    Rupchev, G.E.4
  • 41
    • 79961166634 scopus 로고    scopus 로고
    • Comparative pharmacology of antipsychotics possessing combined dopamine D(2) and serotonin 5-HT (1A) receptor properties
    • 1:CAS:528:DC%2BC3MXivFyqtr0%3D 10.1007/s00213-011-2247-y
    • Newman-Tancredi A, Kleven MS (2011) Comparative pharmacology of antipsychotics possessing combined dopamine D(2) and serotonin 5-HT (1A) receptor properties. Psychopharmacology (Berl) 216:451-473
    • (2011) Psychopharmacology (Berl) , vol.216 , pp. 451-473
    • Newman-Tancredi, A.1    Kleven, M.S.2
  • 42
    • 0036119234 scopus 로고    scopus 로고
    • Effects of the 5-HT(6) receptor antagonist, SB-271046, in animal models for schizophrenia
    • 1:CAS:528:DC%2BD38XhvVChur4%3D 11888555 10.1016/S0091-3057(01)00743-2
    • Pouzet B, Didriksen M, Arnt J (2002) Effects of the 5-HT(6) receptor antagonist, SB-271046, in animal models for schizophrenia. Pharmacol Biochem Behav 71:635-643
    • (2002) Pharmacol Biochem Behav , vol.71 , pp. 635-643
    • Pouzet, B.1    Didriksen, M.2    Arnt, J.3
  • 43
    • 0037468873 scopus 로고    scopus 로고
    • Influence of the 5-HT6 receptor on acetylcholine release in the cortex: Pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4- sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist
    • 1:CAS:528:DC%2BD3sXhsVygu7s%3D 12646038 10.1021/jm021085c
    • Riemer C, Borroni E, Levet-Trafit B, Martin JR, Poli S, Porter RH, Bos M (2003) Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4- sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. J Med Chem 46:1273-1276
    • (2003) J Med Chem , vol.46 , pp. 1273-1276
    • Riemer, C.1    Borroni, E.2    Levet-Trafit, B.3    Martin, J.R.4    Poli, S.5    Porter, R.H.6    Bos, M.7
  • 44
    • 51749091526 scopus 로고    scopus 로고
    • Reversal of subchronic PCP-induced deficits in attentional set shifting in rats by sertindole and a 5-HT(6) receptor antagonist: Comparison among antipsychotics
    • 1:CAS:528:DC%2BD1cXhtFWhs7zO 18094666 10.1038/sj.npp.1301654
    • Rodefer JS, Nguyen TN, Karlsson JJ, Arnt J (2008) Reversal of subchronic PCP-induced deficits in attentional set shifting in rats by sertindole and a 5-HT(6) receptor antagonist: comparison among antipsychotics. Neuropsychopharmacology 33:2657-2666
    • (2008) Neuropsychopharmacology , vol.33 , pp. 2657-2666
    • Rodefer, J.S.1    Nguyen, T.N.2    Karlsson, J.J.3    Arnt, J.4
  • 45
    • 33645358358 scopus 로고    scopus 로고
    • A pharmacological model for psychosis based on N-methyl-D-aspartate receptor hypofunction: Molecular, cellular, functional and behavioral abnormalities
    • 1:CAS:528:DC%2BD28XjtFaju7c%3D 16427029 10.1016/j.biopsych.2005.08.029
    • Rujescu D, Bender A, Keck M, Hartmann AM, Ohl F, Raeder H, Giegling I, Genius J, McCarley RW, Moller HJ, Grunze H (2006) A pharmacological model for psychosis based on N-methyl-D-aspartate receptor hypofunction: molecular, cellular, functional and behavioral abnormalities. Biol Psychiat 59:721-729
    • (2006) Biol Psychiat , vol.59 , pp. 721-729
    • Rujescu, D.1    Bender, A.2    Keck, M.3    Hartmann, A.M.4    Ohl, F.5    Raeder, H.6    Giegling, I.7    Genius, J.8    McCarley, R.W.9    Moller, H.J.10    Grunze, H.11
  • 48
    • 0346023029 scopus 로고    scopus 로고
    • Role of the medial prefrontal cortex in N-methyl-D-aspartate receptor antagonist induced sensorimotor gating deficit in rats
    • 1:CAS:528:DC%2BD2cXjsFSgsA%3D%3D 14729221 10.1016/j.neulet.2003.10.028
    • Schwabe K, Koch M (2004) Role of the medial prefrontal cortex in N-methyl-D-aspartate receptor antagonist induced sensorimotor gating deficit in rats. Neurosci Lett 355:5-8
    • (2004) Neurosci Lett , vol.355 , pp. 5-8
    • Schwabe, K.1    Koch, M.2
  • 49
    • 0030426257 scopus 로고    scopus 로고
    • Seroquel restores sensorimotor gating in phencyclidine-treated rats
    • 1:CAS:528:DyaK2sXmslKk 8968353
    • Swerdlow NR, Bakshi V, Geyer MA (1996) Seroquel restores sensorimotor gating in phencyclidine-treated rats. J Pharmacol Exp Ther 279:1290-1299
    • (1996) J Pharmacol Exp Ther , vol.279 , pp. 1290-1299
    • Swerdlow, N.R.1    Bakshi, V.2    Geyer, M.A.3
  • 50
    • 0033938877 scopus 로고    scopus 로고
    • Animal models of deficient sensorimotor gating: What we know, what we think we know, and what we hope to know soon
    • 1:STN:280:DC%2BD3M%2FltVKkug%3D%3D 11103873 10.1097/00008877-200006000- 00002
    • Swerdlow NR, Braff DL, Geyer MA (2000) Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon. Behav Pharmacol 11:185-204
    • (2000) Behav Pharmacol , vol.11 , pp. 185-204
    • Swerdlow, N.R.1    Braff, D.L.2    Geyer, M.A.3
  • 51
    • 0034927844 scopus 로고    scopus 로고
    • Neural circuit regulation of prepulse inhibition of startle in the rat: Current knowledge and future challenges
    • 1:CAS:528:DC%2BD3MXmtlCqtbs%3D 10.1007/s002130100799
    • Swerdlow NR, Geyer MA, Braff DL (2001) Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges. Psychopharmacology (Berl) 156:194-215
    • (2001) Psychopharmacology (Berl) , vol.156 , pp. 194-215
    • Swerdlow, N.R.1    Geyer, M.A.2    Braff, D.L.3
  • 52
    • 46749118971 scopus 로고    scopus 로고
    • 5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease
    • 1:CAS:528:DC%2BD1cXhtVOgtLrJ 18625457 10.1016/j.nurt.2008.05.008
    • Upton N, Chuang TT, Hunter AJ, Virley DJ (2008) 5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease. Neurotherapeutics 5:458-469
    • (2008) Neurotherapeutics , vol.5 , pp. 458-469
    • Upton, N.1    Chuang, T.T.2    Hunter, A.J.3    Virley, D.J.4
  • 53
    • 0028834467 scopus 로고
    • Reversal of dizocilpine-induced disruption of prepulse inhibition of an acoustic startle response by the 5-HT2 receptor antagonist ketanserin
    • 1:CAS:528:DyaK2MXpslKisrc%3D 8749037 10.1016/0014-2999(95)00660-5
    • Varty GB, Higgins GA (1995) Reversal of dizocilpine-induced disruption of prepulse inhibition of an acoustic startle response by the 5-HT2 receptor antagonist ketanserin. Eur J Pharmacol 287:201-205
    • (1995) Eur J Pharmacol , vol.287 , pp. 201-205
    • Varty, G.B.1    Higgins, G.A.2
  • 54
    • 0033017227 scopus 로고    scopus 로고
    • M100907, a serotonin 5-HT2a receptor antagonist and putative antipsychotic, blocks dizocilpine-induced prepulse inhibition deficits in Sprague-Dawley and wistar rats
    • 1:CAS:528:DyaK1MXitVSntbo%3D 10088132 10.1016/S0893-133X(98)00072-4
    • Varty GB, Bakshi VP, Geyer MA (1999) M100907, a serotonin 5-HT2a receptor antagonist and putative antipsychotic, blocks dizocilpine-induced prepulse inhibition deficits in Sprague-Dawley and wistar rats. Neuropsychopharmacology 20:311-321
    • (1999) Neuropsychopharmacology , vol.20 , pp. 311-321
    • Varty, G.B.1    Bakshi, V.P.2    Geyer, M.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.