M100907, a serotonin 5-HT(2A) receptor antagonist and putative antipsychotic, blocks dizocilpine-induced prepulse inhibition deficits in Sprague-Dawley and Wistar rats

Neuropsychopharmacology

Volumn 20, Issue 4, 1999, Pages 311-321

  Varty, Geoffrey B ^a   Bakshi, Vaishali P ^b,c   Geyer, Mark A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Dizocilpine; Glutamate; M100907, Schizophrenia; Prepulse inhibition; Rat; Serotonin; Startle; Strain

Indexed keywords

4,5,7A,8,9,10,11,11A OCTAHYDRO 10 METHYL 7H INDOLO[1,7 BC][2,6]NAPHTHYRIDINE; ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; CIRAZOLINE; DIZOCILPINE; RECEPTOR SUBTYPE; RISPERIDONE; SEROTONIN 2A ANTAGONIST; SEROTONIN RECEPTOR;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PREPULSE INHIBITION; PRIORITY JOURNAL; RAT; STRAIN DIFFERENCE; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; ANTIPSYCHOTIC AGENTS; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; FLUOROBENZENES; MALE; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; RISPERIDONE; SEROTONIN ANTAGONISTS; SPECIES SPECIFICITY; STARTLE REACTION;

EID: 0033017227     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(98)00072-4     Document Type: Article

References (37)

1. 2A receptor antagonist and a potential antipsychotic drug, facilitates N-methyl-D-aspartate-receptor-mediated neurotransmission in the rat medial prefrontal cortical neurons in vitro. Neuropsychopharmacology. 18:1998;197-209.
2. Bakshi V.P., Swerdlow N.R., Geyer M.A. Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response. J Pharmacol Exp Ther. 271:1994;787-794.
3. Bakshi V.P., Geyer M.A. Antagonism of phencyclidine-induced deficits in prepulse inhibition by the putative atypical antipsychotic olanzapine. Psychopharmacology. 122:1995;198-201.
4. Bakshi V.P., Geyer M.A. Phencyclidine-induced deficits in prepulse inhibition of startle are blocked by prazosin, an alpha-1 noradrenergic antagonist. J Pharmacol Exp Ther. 283:1997;666-674.
5. Bolino F., DiMichele V., DiCocco L., Manna V., Daneluzzo E., Casacchia M. Sensorimotor gating and habituation evoked by electrocutaneous stimulation in schizophrenics. Biol. Psychiatr. 36:1994;670-679.
6. Braff D.L., Stone C., Callaway E., Geyer M.A., Glick I., Bali L. Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology. 15:1978;339-343.
7. Braff D.L., Grillon C., Geyer M.A. Gating and habituation of the startle reflex in schizophrenic patients. Arch Gen Psychiatr. 49:1992;206-215.
8. Brooks EW, Mansbach RS (1997): Effects of the novel antipsychotic ziprasidone on drug-disrupted prepulse inhibition in the rat. Abs Soc Neurosci 23:759.9.
9. Carasso B.S., Bakshi V.P., Geyer M.A. Disruption in prepulse inhibition after alpha-1 adrenoceptor stimulation in rats. Neuropharmacology. 37:1998;401-404.
10. Geyer M.A., Swerdlow N.R., Mansbach R.S., Braff D.L. Startle response models of sensorimotor gating and habituation deficits in schizophrenia. Brain Res Bull. 25:1990;485-498.
11. Gleason S.D., Shannon H.E. Blockade of phencyclidine-induced hyperlocomotion by olanzapine, clozapine and serotonin receptor subtype selective antagonists in mice. Psychopharmacol. 129:1997;79-84.
12. Grillon C., Ameli R., Charney D.S., Krystal J., Braff D. Startle gating deficits occur across prepulse intensities in schizophrenic patients. Biol Psychiatr. 32:1992;939-943.
13. Halberstadt A.L. The phencyclidine-glutamate model of schizophrenia. Clin Neuropharmacol. 18:1995;237-249.
14. Hoffman D.C., Donovan H., Cassella J.V. The effects of haloperidol and clozapine on the disruption of sensorimotor gating induced by the noncompetitive glutamate antagonist MK-801. Psychopharmacology. 111:1993;339-344.
15. Hoffman H.S., Ison J.R. Reflex modification in the domain of startle. I. Some empirical findings and their implication for how the nervous system processes sensory input Psychol Rev. 87:1980;175-189.
16. Iqbal N., van Praag H.M. The role of serotonin in schizophrenia. Eur Neuropsychopharmacol. 5:1995;11-23.
17. 2A antagonist with a favorable CNS safety profile. J Pharmacol Exp Ther. 277:1996;968-981.
18. Keith V.A., Mansbach R.S., Geyer M.A. Failure of haloperidol to block the effects of PCP and dizocilpine on prepulse inhibition of startle. Biol Psychiatr. 30:1991;557-566.
19. Kitaichi K., Yamada K., Hasegawa T., Furukawa H., Nabeshima T. Effects of risperidone on phencyclidine-induced behaviors. Comparison with haloperidol and ritanserin Japan J Pharmacol. 66:1994;181-189.
20. Krebs-Thomson K., Lehmann-Masten V., Naiem S., Paulus M.P., Geyer M.A. Modulation of phencyclidine-induced changes in locomotor activity and patterns in rats by serotonin. Eur J Pharmacol. 343:1998;135-143.
21. Mansbach R.S., Geyer M.A., Braff D.L. Dopaminergic stimulation disrupts sensorimotor gating in the rat. Psychopharmacology. 94:1988;507-514.
22. Martin P., Waters N., Waters S., Carlsson A., Carlsson M.L. MK-801-induced hyperlocomotion. Differential effects of M100907, SDZ PSD 958 and raclopride Eur J Pharmacol. 335:1997;107-116.
23. 2A receptors. Eur J Pharmacol. 280:1995;R9-R11.
24. Nozulak J, Kalkman HO, Florersheim P, Hoyer D, Buerki HR (1993): SDZ SER 082, a centrally acting and selective 5-HT-2C antagonist. Abs Soc Neurosci 19:126.11.
25. 2A receptor affinity J Med Chem. 38:1995;28-32.
26. Rigdon G.C. Differential effects of apomorphine on prepulse inhibition of acoustic startle reflex in two rat strains. Psychopharmacology. 102:1990;419-421.
27. Schotte A., Janssen P.F.M., Gommeren W., Luyten W.H.M.L., Van Gompel P., Lesage A.S., De Loore K., Leysen J.E. Risperidone compared with new and reference antipsychotic drugs. In vitro and in vivo receptor binding Psychopharmacology. 124:1996;57-73.
28. Sipes T.E., Geyer M.A. Multiple serotonin receptor subtypes modulate prepulse inhibition of the startle response in rats. Neuropharmacology. 33:1994;441-448.
29. Sipes T.E., Geyer M.A. DOI disruption of prepulse inhibition of startle in the rat is mediated by 5-HT2A and not by 5-HT2C receptors. Behav Pharmacol. 6:1995;839-842.
30. Swerdlow N.R., Geyer M.A. Clozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia. Pharmacol Biochem Behav. 44:1993;741-744.
31. Swerdlow N.R., Braff D.L., Taaid N., Geyer M.A. Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients. Arch Gen Psychiatr. 51:1994;139-154.
32. Swerdlow N.R., Bakshi V.P., Geyer M.A. Seroquel restores sensorimotor gating in phencyclidine-treated rats. J Pharmacol Exp Ther. 279:1996;1290-1299.
33. Swerdlow N.R., Varty G.B., Geyer M.A. Discrepant findings of clozapine effects on prepulse inhibition of startle. Is it the route or the rat? Neuropsychopharmacology. 18:1998;50-56.
34. Tamminga C.A., Holcomb H.H., Gao X.M., Lahti A.C. Glutamate pharmacology and the treatment of schizophrenia. Current status and future directions Intern Clin Psychopharmacol. 10:1995;29-37.
35. Varty G.B., Higgins G.A. Differences between three rat strains in sensitivity to prepulse inhibition of an acoustic startle response. Influence of apomorphine and phencyclidine pretreatment J Psychopharmacol. 8:1994;148-156.
36. Varty G.B., Higgins G.A. Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs. Psychopharmacology. 122:1995;15-26. a.
37. 2 antagonist ketanserin. Eur J Pharmacol. 287:1995;201-205. b.