M100907, a selective 5-HT(2A) receptor antagonist and a potential antipsychotic drug, facilitates N-methyl-D-aspartate-receptor mediated neurotransmission in the rat medial prefrontal cortical neurons in vitro

Neuropsychopharmacology

Volumn 18, Issue 3, 1998, Pages 197-209

  Arvanov, Viktor L ^a   Wang, Rex Y ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

5 HT(2A) receptor; Antipsychotic drugs; Medial prefrontal cortex; NMDA receptor; Pyramidal cells; Schizophrenia

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; AMPA RECEPTOR; BICUCULLINE; CLOZAPINE; GLYCINE; HALOPERIDOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROLEPTIC AGENT; RESERPINE; RILUZOLE; SEROTONIN 2A ANTAGONIST; THAPSIGARGIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; EXCITATORY POSTSYNAPTIC POTENTIAL; FORCEPS; INTRACELLULAR RECORDING; ION CURRENT; NERVE POTENTIAL; NEUROTRANSMISSION; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SCHIZOPHRENIA;

ANIMALS; ANTIPSYCHOTIC AGENTS; CLOZAPINE; FLUOROBENZENES; HALOPERIDOL; MALE; PATCH-CLAMP TECHNIQUES; PIPERIDINES; PREFRONTAL CORTEX; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS;

EID: 0032030496     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(97)00126-7     Document Type: Article

References (72)

1. Akbarian S, Sucher NJ, Bradley D, Tafazzoli A, Trinh D, Hetrick WP, Potkin SG, Sandman CA, Bunney Jr, WE, Jone E (1996): Selective alterations in gene expression for NMDA receptor subunits in prefrontal cortex of schizophrenics. J Neurosci 16:19-30
2. Arvanov VL, Usherwood PNR (1991): Concentration jump studies of intracellularly dialyzed Xenopus oocytes show desensitization of kainate receptors. Neurosci Lett 129: 201-204
3. Arvanov VL, Holmes KH, Keele NB, Shinnick-Gallagher P (1995): The functional role of metabotropic glutamate receptors in epileptiform activity induced by 4-amino-peridine in the rat amygdala slice. Brain Res 669:140-144
4. Arvanov VL, Magro P, Wang RY (1996): Pre-and post-synaptic actions of hallucinogens on NMDA-neurotransmission in the rat medial prefrontal cortical (mPFC) slices. Neurosci Abstr 22:65
5. Arvanov VL, Wang RY (1997): NMDA-evoked response in pyramidal neurons of the rat medial prefrontal cortex slices consists of NMDA and non-NMDA components. Brain Res (in press)
6. Arvanov VL, Liang X, Schwartz J, Grossman S, Wang RY (1997a): Clozapine and haloperidol modulate NMDA and non-NMDA receptor mediated neurotransmission in rat prefrontal cortical neurons in vitro. J Pharmacol Exp Ther (in press)
7. 2A/2c receptor agonist DOB on NMDA-evoked responses in pyramidal cells of rat medial prefrontal cortex. J Neurosci (submitted)
8. Berretta N, Jones RSG (1996): Tonic facilitation of glutamate release by presynaptic N-methyl-D-aspartate autoreceptors in the entorhinal cortex. Neuroscience 75:339-344.
9. 2 receptors and serotonergic axons in rat neocortex. Brain Res 453: 315-328
10. Carlsson M, Carlsson A (1990): Interactions between glutamatergic and monoaminergic systems within the basal ganglia - Implications for schizophrenia and Parkinson's disease. Trends Pharmacol Sci 13:272-276
11. Cauli B, Audinat E, Lambolez B, Angulo MC, Ropert N, Tsuzuki K, Hestrin S, Rossier J (1997): Molecular and physiological diversity of cortical nonpyramidal cells. J Neurosci 17:3894-3906
12. Connors BW, Gutnick MJ (1990): Intrinsic firing patterns of diverse neocortical neurons. Trends Pharmacol Sci 13: 99-104
13. Davis KL, Kahn RS, Ko G, Davidson M (1991): Dopamine in schizophrenia: A review and reconstruction. Am J Psychiatry 148:1474-1486
14. Deakin JFW, Slater P, Simpson MDC, Gilchrist AC, Skan WJ, Royston MC, Reynolds GP, Cross AJ (1989): Frontal cortical and left temporal glutamatergic dysfunction in schizophrenia. J Neurochem 52:1781-1786
15. Deutsch SI, Mastrpaolo J, Schwartz BL, Rosse RB, Morihisa JM (1989): A "glutamatergic hypothesis" of schizophrenia: Rationale for pharmacology with glycine. Clin Neuropharmacol 12:1-13
16. Dure LSIV, Young AB (1995): The distribution of glutamate receptor subtypes in mammalian central nervous system using quantitative in vitro autoradiography. In Stone TW (ed), CNS Neurotransmitters and Neuromodulators: Glutamate. New York, CRC Press, pp 83-94
17. Finkel AS, Redman SJ (1985): Optimal voltage clamping with single microelectrodes. In Smith TG, Lecar A, Redman SJ, Gage PW (eds), Voltage and Patch Clamping with Microelectrodes. Baltimore, MD, Williams & Wilkins, pp 95-120
18. Grotta J (1994): Safety and tolerability of the glutamate antagonist CGS 19755 in acute stroke patients. Stroke 25: 255
19. Halliwell JV, Adams PR (1982): Voltage-clamp analysis of muscarinic excitation in hippocampal neurons. Brain Res 250:71-92
20. Harrison PJ, McLaughlin D, Kerwin RW (1991): Decreased hippocampal expression of a glutamate receptor gene in schizophrenia. Lancet 337:450-452
21. Herrling PL (1994): D-CPPene (SDZ EAA 494), a competitive NMDA antagonist: Results from animal models and first results in humans. Neuropsychopharmacology 10:591S
22. Hess G, Kuhnt U, Voronin LL (1987): Quantal analysis of paired-pulse facilitation in guinea pig hippocampal slices. Neurosci Lett 77:187-192
23. Holmes K, Keele B, Arvanov V, Shinnick-Gallagher P (1996): Metabotropic glutamate receptor agonist-induced hyperpolarization in rat basolateral amygdala neurons: Receptor characterization, second messengers and ion channels. J Neurophysiol 76:3059-3069
24. Ishimaru M, Kurumaji A, Toru M (1994): Increases in strychnine-insensitive glycine binding sites in cerebral cortex of chronic schizophrenics: Evidence for glutamate hypothesis. Biol Psychiatry 35:4-95
25. 2A receptor ligand. Naunyn-Schmideberg's Arch Pharmacol 354:205-209
26. Johnston D, Brown TH (1983): Interpretation of voltage-clamp measurements in hippocampal neurons. J Neurophysiol 50:464-486
27. Kawaguchi Y (1993): Groupings of nonpyramidal and pyramidal cells with specific physiological and morphological characteristics in rat frontal cortex. J Neurophysiol 69:416-431
28. Kawaguchi Y, Kubota Y (1996): Physiological and morphological identification of somatostatin-or vasoactive intestinal polypeptide-containing cells among GABAergic cell types in rat frontal cortex. J Neurosci 16:2701-2715
29. 2A antagonist with a favorable CNS safety profile. J Pharmacol Exp Ther 277:968-981
30. Kerwin R, Patel S, Meldrum B (1990): Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem. Neuroscience 39:25-32
31. Kim JS, Kornhuber J, Schmid-Burgk W, Holzmuller B (1980): Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia. Neurosci Lett 20:379-382
32. Kornhuber J, Kornhuber ME (1986): Presynaptic dopaminergic modulation of cortical input to the striatum. Life Sci 39:669-674
33. 3H-MK-801 binding studies in postmortem brain regions of schizophrenic patients. J Neural Transm 77:231-236
34. Kristensen JD, Svensson B, Gordh T (1992): The NMDA receptor antagonist CPP abolishes neurogenic "wind-up pain" after intrathecal administration in humans. Pain 51:249-253
35. Lahti AC, Holcomb HH, Medoff DR, Taminga CA (1995): Ketamine activates psychosis and alters limbic blood flow in schizophrenia. Neuroreport 6:869-872
36. Lancaster B, Nicoll RA (1987): Properties of two calcium-activated hyperpolarizations in rat hippocampal neurons. J Physiol (Lond) 389:187-203
37. Lidsky TI, Yablonsky-Alter E, Zuck L, Banerjee SP (1993): Anti-glutamatergic effects of clozapine. Neurosci Lett 163:155-158
38. Lupica CR, Proctor WR, Dunwiddie TV (1992): Presynaptic inhibition of excitatory transmission by adenosine in rat hippocampus: analyses of unitary EPSP variance measured by whole-cell recording. J Neurosci 12:3753-3764
39. Madison DV, Lancaster B, Nicoll RA (1987): Voltage clamp analysis of cholinergic action in the hippocampus. J Neurosci 7:733-741
40. Malhotra AK, Pinals DA, Weingartner H, Sirocco K, Missar CD, Pickar D, Breier A (1996): NMDA receptor function and human cognition: the effects of ketamine in healthy volunteers. Neuropsychopharmacology 14:301-307
41. Malinow R, Tsien RW (1990): Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices. Nature 346:177-180
42. Manabe T, Wyllie DJA, Perkel DJ, Nicoll RA (1993): Modulation of synaptic transmission and long-term potentiation: Effects on paired-pulse facilitation and EPSC variance in CA1 region of the hippocampus. J Neurophysiol 70:1451-1459
43. 2A receptor antagonist. Eur J Pharmacol 259:137-141
44. Martin D, Thompson MA, Nadler JV (1993): The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1. Eur J Pharmacol 250:473-476
45. 2 dopamine receptors are located on striatal glutamatergic nerve terminals. J Pharmacol Exp Ther 247:680-684
46. 2 receptors. Eur J Pharmacol 145:31-38
47. McCormick DA, Connors BW, Lighthall JW, Prince DA (1985): Comparative electrophysiology of pyramidal and sparsely spiny neurons of the neocortex. J Neurophysiol 54:782-806
48. McDonald J, Mody I, Salter MW (1989): Regulation of N-methyl-D-aspartate receptors revealed by intracellular dialysis of murine neurons in culture. J Physiol 414:17-34
49. Meltzer HY (1991): Clozapine: Pattern of efficacy in treatment-resistant schizophrenia. In Meltzer HY (ed), Novel Antipsychotic Drugs. New York, Raven Press, pp 33-46
50. i values. J Pharmacol Exp Ther 251:238-246
51. 2 receptor by in situ hybridization histochemistry. Correlation with the distribution of receptor sites. Brain Res 524:139-143
52. Moghaddam B (1994): Recent basic findings in support of excitatory amino acid hypotheses of schizophrenia. Prog Neuro-Psychopharmacol Biol Psychiatry 18:859-870
53. Nathan T, Jensen MS, Lambert JDC (1990): The slow inhibitory postsynaptic potentials in rat hippocampal CA1 neurons is blocked by intracellular injection of QX-314. Neurosci Lett 110:309-313
54. 3H-kainic acid binding in the prefrontal cortex in schizophrenia. Neurosci Lett 40:245-250
55. Nowicky AV, Bindman LJ (1993): The nitric oxide synthase inhibitor, N-monomethyl-L-arginine blocks induction of a long-term potentiation-like phenomenon in rat medial frontal cortical neurons in vitro. J Neurophysiol 70:1255-1259
56. Olney JW, Farber NB (1995): Glutamate receptor disfunction and schizophrenia. Arch Gen Psychiatry 52:998-1007
57. 2 dopamine receptors in rat striatal slices. Synapse 2:450-456
58. 2A receptor antagonist, MDL 100907, increases dopamine efflux in the prefrontal cortex of the rat. Eur J Pharmacol 273: 273-279
59. Schweitzer P, Madamba S, Champagnat J, Siggins GR (1993): Somatostatin inhibition of hippocampal CA1 pyramidal neurons: mediation by arachidonic acid and its metabolites. J Neurosci 13:2033-2049
60. Simpson MD, Slater P, Royston MC, Deakin JF (1991): Alterations in phencyclidine and sigma binding sites in schizophrenic brains. Effects of disease process and neuroleptic medication. Schizophr Res 6:41-48
61. 2A antagonist MDL 100907 as a putative atypical antipsychotic: Behavioral, electrophysiological, and neurochemical studies. J Pharmacol Exp Ther 266:1-8
62. Tanaka E, North A (1993): Actions of 5-HT on neurons of rat cingulate cortex. J Neurophysiol 69:174:9-1757
63. Tarazi FI, Floriji J, Creese I (1996): Regulation of ionotropic glutamate receptors following subchronic and chronic treatment with typical and atypical antipsychotics. Psychopharmacology 128:371-379
64. Ulas J, Cottman CW (1993): Excitatory amino acid receptors in schizophrenia. Schizophr Bull 19:105-117
65. Wachtel H, Turski L (1990): Glutamate: A new target in schizophrenia. Trends Pharmacol Sci 11:219-220
66. Wang RY, Arvanov VL (1996): The potentiation of NMDA-induced inward current by antipsychotics in cortical cells. Neurosci Abstr 22:65
67. Weinberger DR, Lipska BK (1995): Cortical maldevelopment, antipsychotic drugs, and schizophrenia: A search for common ground. Schizophr Res 16:87-110
68. Witkin JM (1995): Role of NMDA receptors in behavior and behavioral effects of drugs. In Stone TW (ed), CNS Neurotransmitters and Neuromodulators: Glutamate. New York, CRC Press, pp 323-350
69. Wuarin JP, Peacock WJ, Dubek FE (1992): Single-electrode voltage clamp analysis of the N-methyl-D-aspartate component of synaptic responses in neocortical slices from children with intractable epilepsy. J Neurophysiol 67:84-93
70. Yang CR, Seamans JK, Gorelova N (1996): Electrophysiological and morphological properties of layers V-VI principal pyramidal cells in rat prefrontal cortex in vitro. J Neurosci 16:1904-1921
71. Zilles K (1985): The Cortex of the Rat. Berlin, Heidelberg, Springer-Verlag
72. Zucker RS (1989): Short-term synaptic plasticity. Annu Rev Neurosci 12:13-31