Gallic acid is an active component for the anticarcinogenic action of grape seed procyanidins in pancreatic cancer cells

Nutrition and Cancer

Volumn 66, Issue 1, 2014, Pages 88-96

  Cedó, Lídia ^a   Castell Auví, Anna ^a   Pallarès, Victor ^a   Macià, Alba ^b   Blay, Mayte ^a   Ardévol, Anna ^a   Motilva, Maria José ^b   Pinent, Montserrat ^a  

^a UNIVERSITAT ROVIRA I VIRGILI   (Spain)

^b UNIVERSITY OF LLEIDA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GALLIC ACID; GRAPE SEED EXTRACT; PROCYANIDIN; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL PROLIFERATION; CONTROLLED STUDY; DEPOLARIZATION; MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; PANCREAS ADENOCARCINOMA;

AGOUTI PACA; VITACEAE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BIFLAVONOIDS; CATECHIN; CELL LINE, TUMOR; CELL PROLIFERATION; GALLIC ACID; GRAPE SEED EXTRACT; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; PROANTHOCYANIDINS; REACTIVE OXYGEN SPECIES; SEEDS; VITIS;

EID: 84891829363     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635581.2014.851714     Document Type: Article

References (51)

1. Gu L, Kelm MA, Hammerstone JF, Beecher G, Holden J, et al.: Concentrations of Proanthocyanidins in Common Foods and Estimations of Normal Consumption. J Nutr 134, 613-617, 2004.
2. Rasmussen SE, Frederiksen H, Struntze Krogholm K, and Poulsen L: Dietary proanthocyanidins: Occurrence, dietary intake, bioavailability, and protection against cardiovascular disease. Mol Nutr Food Res 49, 159-174, 2005.
3. Pinent M, Ced́o L, Montagut G, Blay M, and Ard́evol A: Procyanidins improve some disrupted glucose homoeostatic situations: An analysis of doses and treatments according to different animal models. Crit Rev Food Sci Nutr 52, 569-584, 2012.
4. Castell-Auv́i A, Ced́o L, Pallares V, Blay MT, PinentM, et al.: Procyanidins modify insulinemia by affecting insulin production and degradation. J Nutr Biochem 23, 1565-1572, 2012.
5. Ced́o L, Castell-Auv́i A, Pallares V, Blay M, Ard́evol A, et al.: Grape seed procyanidin extract modulates proliferation and apoptosis of pancreatic beta-cells. Food Chem 138, 524-530, 2013.
6. Ced́o L, Castell-Auv́i A, Pallares V, Ubaida Mohien C, Baiges I, et al.: Pancreatic islet proteome profile in Zucker fatty rats chronically treated with a grape seed procyanidin extract. Food Chem 135, 1948-1956, 2012.
7. Nandakumar V, Singh T, and Katiyar SK: Multi-targeted prevention and therapy of cancer by proanthocyanidins. Cancer Lett 269, 378-387, 2008.
8. Rossi M, Rosato V, Bosetti C, Lagiou P, Parpinel M, et al.: Flavonoids, proanthocyanidins, and the risk of stomach cancer. Cancer Causes Control 21, 1597-1604, 2010.
9. Theodoratou E, Kyle J, Cetnarskyj R, Farrington SM, Tenesa A, et al.: Dietary Flavonoids and the Risk of Colorectal Cancer. Cancer Epidem Biomar 16, 684-693, 2007.
10. Cutler GJ, Nettleton JA, Ross JA, Harnack LJ, Jacobs DR, et al.: Dietary flavonoid intake and risk of cancer in postmenopausal women: The Iowa Women's Health Study. Int J Cancer 123, 664-671, 2008.
11. Borska S, Drag-Zalesinska M, Wysocka T, Sopel M, Dumanska M, et al.: Antiproliferative and pro-apoptotic effects of quercetin on human pancreatic carcinoma cell lines EPP85-181P and EPP85-181RDB. Folia Histochem Cyto 48, 222-229, 2010.
12. Bardeesy N and DePinho RA: Pancreatic cancer biology and genetics. Nat Rev Cancer 2, 897-909, 2002.
13. Chu D, Kohlmann W, and Adler DG: Identification and screening of individuals at increased risk for pancreatic cancer with emphasis on known environmental and genetic factors and hereditary syndromes. JOP 11, 203-212, 2010.
14. World Cancer Research Fund/American Institute for Cancer Research: Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective. American Institute for Cancer Research, Washington, DC, 2007.
15. Polesel J, Talamini R, Negri E, Bosetti C, Boz G, et al.: Dietary habits and risk of pancreatic cancer: An Italian case-control study. Cancer Causes Control 21, 493-500, 2010.
16. Rossi M, Lugo A, Lagiou P, Zucchetto A, Polesel J, et al.: Proanthocyanidins and other flavonoids in relation to pancreatic cancer: A case-control study in Italy. Ann Oncol 23, 1488-1493, 2012.
17. Bobe G, Weinstein SJ, Albanes D, Hirvonen T, Ashby J, et al.: Flavonoid intake and risk of pancreatic cancer in male smokers (Finland). Cancer Epidem Biomak 17, 553-562, 2008.
18. Chung Y-C, Huang C-C, Chen C-H, Chiang H-C, Chen K-B, et al.: Grapeseed procyanidins inhibit the in vitro growth and invasion of pancreatic carcinoma cells. Pancreas 41, 447-454, 2012.
19. Serra A, Macia A, Romero M-P, Valls J, Blad́e C, et al.: Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models. Br J Nutr 103, 944-952, 2010.
20. Quinones M, Guerrero L, Suarez M, Pons Z, Aleixandre A, et al.: Lowmolecular procyanidin rich grape seed extract exerts antihypertensive effect in males spontaneously hypertensive rats. Food Res Int 51, 587-595, 2013.
21. Montagut G, Baiges I, Valls J, Terra X, del Bas JM, et al.: A trimer plus a dimer-gallate reproduce the bioactivity described for an extract of grape seed procyanidins. Food Chem 116, 265-270, 2009.
22. Castell-Auv́i A, Ced́o L, Pallaŕes V, Blay MT, Pinent M, et al.: Development of a coculture system to evaluate the bioactivity of plant extracts on pancreatic β-cells. Planta Med 76, 1576-1581, 2010.
23. Serra A, Macia A, RomeroM-P, Salvad́oM-J, BustosM, et al.: Determination of procyanidins and their metabolites in plasma samples by improved liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 877, 1169-1176, 2009.
24. Baselga-Escudero L, Blad́e C, Ribas-Latre A, Casanova E, Salvad́o MJ, et al.: Grape seed proanthocyanidins repress the hepatic lipid regulators miR-33 and miR-122 in rats. Mol Nutr Food Res 56, 1636-1646, 2012.
25. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72, 248-254, 1976.
26. Castell-Auv́i A, Ced́o L, Pallares V, Blay M, Ard́evol A, et al.: The effects of a cafeteria diet on insulin production and clearance in rats. Br J Nutr 108, 1155-1162, 2012.
27. Orrenius S, Gogvadze V, and Zhivotovsky B: Mitochondrial oxidative stress: Implications for cell death. Annu Rev Pharmacol 47, 143-183, 2007.
28. Crozier A, Jaganath IB, and Clifford MN: Dietary phenolics: Chemistry, bioavailability and effects on health. Nat Prod Rep 26, 1001-1043, 2009.
29. Eguchi A, Murakami A, and Ohigashi H: Novel bioassay system for evaluating anti-oxidative activities of food items: Use of basolateral media from differentiated Caco-2 cells. Free Radic Res 39, 1367-1375, 2005.
30. Wicker CA, Sahu RP, Kulkarni-Datar K, Srivastava SK, and Brown TL: BITC sensitizes pancreatic adenocarcinomas to TRAIL-induced apoptosis. Cancer Growth Metastasis 2009, 45-55, 2010.
31. Li Y, Zhang T, Jiang Y, Lee H-F, Schwartz SJ, et al.: (-)-Epigallocatechin- 3-gallate inhibits Hsp90 function by impairing Hsp90 association with cochaperones in pancreatic cancer cell line Mia Paca-2. Mol Pharm 6, 1152-1159, 2009.
32. Kuete V,Wabo HK, Eyong KO, Feussi MT,Wiench B, et al.:Anticancer activities of six selected natural compounds of some Cameroonian medicinal plants. PLoS ONE 6, e21762, 2011.
33. Roy AM, Baliga MS, Elmets CA, and Katiyar SK: Grape Seed proanthocyanidins induce apoptosis through p53, Bax, and Caspase 3 pathways. Neoplasia 7, 24-36, 2005.
34. Lin Y-S, Chen S-F, Liu C-L, and Nieh S: The chemoadjuvant potential of grape seed procyanidins on p53-related cell death in oral cancer cells. J Oral Pathol Med 41, 322-331, 2012.
35. Maldonado-Celisa ME, Roussia S, Foltzer-Jourdainne C, Gosśe F, Lobstein A, et al.: Modulation by polyamines of apoptotic pathways triggered by procyanidins in human metastatic SW620 cells. Cell Mol Life Sci 65, 1425-1434, 2008.
36. Chung W-G, Miranda CL, Stevens JF, and Maier CS: Hop proanthocyanidins induce apoptosis, protein carbonylation, and cytoskeleton disorganization in human colorectal adenocarcinoma cells via reactive oxygen species. Food Chem Toxicol 47, 827-836, 2009.
37. Zambonin L, Caliceti C, Vieceli Dalla Sega F, Fiorentini D, Hrelia S, et al.: Dietary phenolic acids act as effective antioxidants in membrane models and in cultured cells, exhibiting proapoptotic effects in leukaemia cells. Oxid Med Cell Longev 2012, 839298, 2012.
38. Lizarraga D, LozanoC,Bried́e JJ, vanDelft JH, Tourino S, et al.: The importance of polymerization and galloylation for the antiproliferative properties of procyanidin-rich natural extracts. FEBS J 274, 4802-4811, 2007.
39. Ferruzzi MG, Lobo JK, Janle EM, Cooper B, Simon JE, et al.: Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: Implications for treatment in Alzheimer's disease. J Alzheimers Dis 18, 113-124, 2009.
40. Gonthier M-P, Donovan JL, Texier O, Felgines C, Remesy C, et al.: Metabolism of dietary procyanidins in rats. Free Radical Bio Med 35, 837-844, 2003.
41. Basu A and Haldar S: Combinatorial effect of epigallocatechin-3-gallate and TRAIL on pancreatic cancer cell death. Int J Oncol 34, 281-286, 2009.
42. Kostin SF, McDonald DE, and McFadden DW: Inhibitory effects of (-)- epigallocatechin-3-gallate and pterostilbene on pancreatic cancer growth in vitro. J Surg Res 177, 255-262, 2012.
43. Qanungo S, Das M, Haldar S, and Basu A: Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells. Carcinogenesis 26, 958-967, 2005.
44. Liu Z, Li D, Yu L, and Niu F: Gallic acid as a cancer-selective agent induces apoptosis in pancreatic cancer cells. Chemotherapy 58, 185-194, 2012.
45. You BR, Kim SZ, Kim SH, and Park WH: Gallic acid-induced lung cancer cell death is accompanied by ROS increase and glutathione depletion. Mol Cell Biochem 357, 295-303, 2011.
46. Chen H-M, Wu Y-C, Chia Y-C, Chang F-R, Hsu H-K, et al.: Gallic acid, a major component of Toona sinensis leaf extracts, contains a ROSmediated anti-cancer activity in human prostate cancer cells. Cancer Lett 286, 161-171, 2009.
47. Veluri R, Singh RP, Liu Z, Thompson JA, Agarwal R, et al.: Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells. Carcinogenesis 27, 1445-1453, 2006.
48. Konishi Y, Kobayashi S, and Shimizu M: Transepithelial transport of pcoumaric acid and gallic acid in Caco-2 cell monolayers. Biosci Biotechnol Biochem 67, 2317-2324, 2003.
49. Konishi Y, Hitomi Y, and Yoshioka E: Intestinal absorption of p-coumaric and gallic acids in rats after oral administration. J Agric Food Chem 52, 2527-2532, 2004.
50. Konishi Y, Zhao Z, and Shimizu M: Phenolic acids are absorbed from the rat stomach with different absorption rates. J Agric Food Chem 54, 7539-7543, 2006.
51. Koga T, Moro K, Nakamori K, Yamakoshi J, Hosoyama H, et al.: Increase of antioxidative potential of rat plasma by oral administration of proanthocyanidin-rich extract from grape seeds. J Agric Food Chem 47, 1892-1897, 1999.