메뉴 건너뛰기




Volumn 41, Issue 4, 2012, Pages 322-331

The chemoadjuvant potential of grape seed procyanidins on p53-related cell death in oral cancer cells

Author keywords

Apoptosis; Cell cycle; Grape seed procyanidins; Oral squamous cell carcinoma; P53

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; GELATINASE A; GELATINASE B; GRAPE SEED PROCYANIDIN; ONCOPROTEIN; PROCYANIDIN; PROTEIN BCL 2; PROTEIN P53; UNCLASSIFIED DRUG;

EID: 84858701242     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/j.1600-0714.2011.01103.x     Document Type: Article
Times cited : (28)

References (54)
  • 1
    • 49749121765 scopus 로고    scopus 로고
    • Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis
    • Chen YJ, Chang JT, Liao CT, et al. Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis. Cancer Sci 2008; 99: 1507-14.
    • (2008) Cancer Sci , vol.99 , pp. 1507-1514
    • Chen, Y.J.1    Chang, J.T.2    Liao, C.T.3
  • 2
    • 0023713975 scopus 로고
    • A combined treatment for advanced oral cavity cancers
    • Olasz L, Szabó I, Horváth A. A combined treatment for advanced oral cavity cancers. Cancer 1988; 62: 1267-74.
    • (1988) Cancer , vol.62 , pp. 1267-1274
    • Olasz, L.1    Szabó, I.2    Horváth, A.3
  • 3
    • 33846593409 scopus 로고    scopus 로고
    • Recent advances in oral oncology
    • Scully C, Bagan JV. Recent advances in oral oncology. Oral Oncol 2007; 43: 107-15.
    • (2007) Oral Oncol , vol.43 , pp. 107-115
    • Scully, C.1    Bagan, J.V.2
  • 4
    • 0030804415 scopus 로고    scopus 로고
    • Results of surgical salvage of locoregional recurrence of carcinoma of the tongue after radiotherapy failure
    • Yuen AP, Wei WI, Lam LK, Ho WK, Kwong D. Results of surgical salvage of locoregional recurrence of carcinoma of the tongue after radiotherapy failure. Ann Otol Rhinol Laryngol 1997; 106: 779-82.
    • (1997) Ann Otol Rhinol Laryngol , vol.106 , pp. 779-782
    • Yuen, A.P.1    Wei, W.I.2    Lam, L.K.3    Ho, W.K.4    Kwong, D.5
  • 5
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene, clues to cancer etiology and molecular pathogenesis
    • Greenblatt MS, Bennett WP, Hollstein M, Harris CC. Mutations in the p53 tumor suppressor gene, clues to cancer etiology and molecular pathogenesis. Cancer Res 1994; 54: 4855-78.
    • (1994) Cancer Res , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 6
    • 30744454806 scopus 로고    scopus 로고
    • p53 apoptotic response to dna damage dependent on bcl2 but not bax in head and neck squamous cell carcinoma lines
    • Crowe DL, Sinha UK. p53 apoptotic response to dna damage dependent on bcl2 but not bax in head and neck squamous cell carcinoma lines. Head Neck 2006; 28: 15-23.
    • (2006) Head Neck , vol.28 , pp. 15-23
    • Crowe, D.L.1    Sinha, U.K.2
  • 9
    • 0027283604 scopus 로고
    • Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents
    • Lotem J, Sachs L. Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents. Blood 1993; 82: 1092-6.
    • (1993) Blood , vol.82 , pp. 1092-1096
    • Lotem, J.1    Sachs, L.2
  • 10
    • 0028820663 scopus 로고
    • Overexpression of p53 predicts organ preservation using induction chemotherapy and radiation in patients with advanced laryngeal cancer
    • Department of Veterans Affairs Laryngeal Cancer Study Group
    • Bradford CR, Zhu S, Wolf GT, et al. Overexpression of p53 predicts organ preservation using induction chemotherapy and radiation in patients with advanced laryngeal cancer. Department of Veterans Affairs Laryngeal Cancer Study Group. Otolaryngol Head Neck Surg 1995; 113: 408-12.
    • (1995) Otolaryngol Head Neck Surg , vol.113 , pp. 408-412
    • Bradford, C.R.1    Zhu, S.2    Wolf, G.T.3
  • 11
    • 0030021748 scopus 로고    scopus 로고
    • Specific loss of apoptotic but not cell cycle arrest function in a human tumor derived p53 mutant
    • Rowan S, Ludwig RL, Haupt Y, et al. Specific loss of apoptotic but not cell cycle arrest function in a human tumor derived p53 mutant. EMBO J 1996; 15: 827-38.
    • (1996) EMBO J , vol.15 , pp. 827-838
    • Rowan, S.1    Ludwig, R.L.2    Haupt, Y.3
  • 12
    • 0031806708 scopus 로고    scopus 로고
    • Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest
    • Ryan KM, Vousden KH. Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest. Mol Cell Biol 1998; 18: 3692-8.
    • (1998) Mol Cell Biol , vol.18 , pp. 3692-3698
    • Ryan, K.M.1    Vousden, K.H.2
  • 13
    • 0141639855 scopus 로고    scopus 로고
    • Antioxidant activity of tea polyphenols in vivo: evidence from animal studies
    • Frei B, Higdon JV. Antioxidant activity of tea polyphenols in vivo: evidence from animal studies. J Nutr 2003; 133: 3275S-84S.
    • (2003) J Nutr , vol.133
    • Frei, B.1    Higdon, J.V.2
  • 14
    • 37349094340 scopus 로고    scopus 로고
    • Green tea and coffee intake and risk of pancreatic cancer in a large-scale, population-based cohort study in Japan (JPHC study)
    • Luo J, Inoue M, Iwasaki M, et al. Green tea and coffee intake and risk of pancreatic cancer in a large-scale, population-based cohort study in Japan (JPHC study). Eur J Cancer Prev 2007; 16: 542-8.
    • (2007) Eur J Cancer Prev , vol.16 , pp. 542-548
    • Luo, J.1    Inoue, M.2    Iwasaki, M.3
  • 17
    • 34447511565 scopus 로고    scopus 로고
    • Effects of red grape skin and seed extract supplementation on atherosclerosis in Watanabe heritable hyperlipidemic rabbits
    • Frederiksen H, Mortensen A, Schrøder M, et al. Effects of red grape skin and seed extract supplementation on atherosclerosis in Watanabe heritable hyperlipidemic rabbits. Mol Nutr Food Res 2007; 51: 564-71.
    • (2007) Mol Nutr Food Res , vol.51 , pp. 564-571
    • Frederiksen, H.1    Mortensen, A.2    Schrøder, M.3
  • 18
    • 3843092956 scopus 로고    scopus 로고
    • Phenolics from commercialized grape extracts prevent early atherosclerotic lesions in hamsters by mechanisms other than antioxidant effect
    • Auger C, Gérain P, Laurent-Bichon F, et al. Phenolics from commercialized grape extracts prevent early atherosclerotic lesions in hamsters by mechanisms other than antioxidant effect. J Agric Food Chem 2004; 52: 5297-302.
    • (2004) J Agric Food Chem , vol.52 , pp. 5297-5302
    • Auger, C.1    Gérain, P.2    Laurent-Bichon, F.3
  • 19
    • 0036299088 scopus 로고    scopus 로고
    • Cellular protection with proanthocyanidins derived from grape seeds
    • Bagchi D, Bagchi M, Stohs S, et al. Cellular protection with proanthocyanidins derived from grape seeds. Ann N Y Acad Sci 2002; 957: 260-70.
    • (2002) Ann N Y Acad Sci , vol.957 , pp. 260-270
    • Bagchi, D.1    Bagchi, M.2    Stohs, S.3
  • 20
    • 14644446143 scopus 로고    scopus 로고
    • Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract
    • Bagchi D, Sen CK, Ray SD, et al. Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract. Mutat Res 2003; 523-524: 87-89.
    • (2003) Mutat Res , vol.523-524 , pp. 87-89
    • Bagchi, D.1    Sen, C.K.2    Ray, S.D.3
  • 21
    • 0032890180 scopus 로고    scopus 로고
    • Vanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits
    • Yamakoshi J, Kataoka S, Koga T, Ariga T. Vanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 1999; 142: 139-49.
    • (1999) Atherosclerosis , vol.142 , pp. 139-149
    • Yamakoshi, J.1    Kataoka, S.2    Koga, T.3    Ariga, T.4
  • 22
    • 34247159678 scopus 로고    scopus 로고
    • Grape seed proanthocyanidins promote apoptosis in human epidermoid carcinoma A431 cells through alterations in Cdki-Cdk-cyclin cascade, and caspase-3 activation via loss of mitochondrial membrane potential
    • Meeran SM, Katiyar SK. Grape seed proanthocyanidins promote apoptosis in human epidermoid carcinoma A431 cells through alterations in Cdki-Cdk-cyclin cascade, and caspase-3 activation via loss of mitochondrial membrane potential. Exp Dermatol 2007; 16: 405-15.
    • (2007) Exp Dermatol , vol.16 , pp. 405-415
    • Meeran, S.M.1    Katiyar, S.K.2
  • 23
    • 61349174095 scopus 로고    scopus 로고
    • Grape seed proanthocyanidins inhibit the growth of human non-small cell lung cancer xenografts by targeting insulin-like growth factor binding protein-3, tumor cell proliferation, and angiogenic factors
    • Akhtar S, Meeran SM, Katiyar N, Katiyar SK. Grape seed proanthocyanidins inhibit the growth of human non-small cell lung cancer xenografts by targeting insulin-like growth factor binding protein-3, tumor cell proliferation, and angiogenic factors. Clin Cancer Res 2009; 15: 821-31.
    • (2009) Clin Cancer Res , vol.15 , pp. 821-831
    • Akhtar, S.1    Meeran, S.M.2    Katiyar, N.3    Katiyar, S.K.4
  • 24
    • 0346995279 scopus 로고    scopus 로고
    • Suppression of estrogen biosynthesis by procyanidin dimers in red wine and grape seeds
    • Eng ET, Ye J, Williams D, et al. Suppression of estrogen biosynthesis by procyanidin dimers in red wine and grape seeds. Cancer Res 2003; 63: 8516-22.
    • (2003) Cancer Res , vol.63 , pp. 8516-8522
    • Eng, E.T.1    Ye, J.2    Williams, D.3
  • 25
    • 33747879101 scopus 로고    scopus 로고
    • Grape seed proanthocyanidins induce apoptosis and inhibit metastasis of highly metastatic breast carcinoma cells
    • Mantena SK, Baliga MS, Katiyar SK. Grape seed proanthocyanidins induce apoptosis and inhibit metastasis of highly metastatic breast carcinoma cells. Carcinogenesis 2006; 27: 1682-91.
    • (2006) Carcinogenesis , vol.27 , pp. 1682-1691
    • Mantena, S.K.1    Baliga, M.S.2    Katiyar, S.K.3
  • 26
    • 16844372775 scopus 로고    scopus 로고
    • Inhibition of NF-kappa B pathway in grape seed extract-induced apoptotic death of human prostate carcinoma DU145 cells
    • Dhanalakshmi S, Agarwal R, Agarwal C. Inhibition of NF-kappa B pathway in grape seed extract-induced apoptotic death of human prostate carcinoma DU145 cells. Int J Oncol 2003; 23: 721-7.
    • (2003) Int J Oncol , vol.23 , pp. 721-727
    • Dhanalakshmi, S.1    Agarwal, R.2    Agarwal, C.3
  • 27
    • 0037422199 scopus 로고    scopus 로고
    • Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis
    • Tyagi A, Agarwal R, Agarwal C. Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis. Oncogene 2003; 22: 1302-16.
    • (2003) Oncogene , vol.22 , pp. 1302-1316
    • Tyagi, A.1    Agarwal, R.2    Agarwal, C.3
  • 28
    • 55949101361 scopus 로고    scopus 로고
    • Grape seed extract induces cell cycle arrest and apoptosis in human colon carcinoma cells
    • Kaur M, Mandair R, Agarwa R, Agarwal C. Grape seed extract induces cell cycle arrest and apoptosis in human colon carcinoma cells. Nutr Cancer 2008; 60: 2-11.
    • (2008) Nutr Cancer , vol.60 , pp. 2-11
    • Kaur, M.1    Mandair, R.2    Agarwa, R.3    Agarwal, C.4
  • 29
    • 33750719426 scopus 로고    scopus 로고
    • Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells
    • Kaur M, Singh RP, Gu M, Agarwal R, Agarwal C. Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells. Clin Cancer Res 2006; 12: 6194-202.
    • (2006) Clin Cancer Res , vol.12 , pp. 6194-6202
    • Kaur, M.1    Singh, R.P.2    Gu, M.3    Agarwal, R.4    Agarwal, C.5
  • 30
    • 35348992576 scopus 로고    scopus 로고
    • Proanthocyanidin from grape seeds inactivates the PI3-kinase/PKB pathway and induces apoptosis in a colon cancer cell line
    • Engelbrecht AM, Mattheyse M, Ellis B, et al. Proanthocyanidin from grape seeds inactivates the PI3-kinase/PKB pathway and induces apoptosis in a colon cancer cell line. Cancer Lett 2007; 258: 144-53.
    • (2007) Cancer Lett , vol.258 , pp. 144-153
    • Engelbrecht, A.M.1    Mattheyse, M.2    Ellis, B.3
  • 31
    • 61449136095 scopus 로고    scopus 로고
    • Mechanisms of grape seed procyanidin-induced apoptosis in colorectal carcinoma cells
    • Hsu CP, Lin YH, Chou CC, et al. Mechanisms of grape seed procyanidin-induced apoptosis in colorectal carcinoma cells. Anticancer Res 2009; 29: 283-9.
    • (2009) Anticancer Res , vol.29 , pp. 283-289
    • Hsu, C.P.1    Lin, Y.H.2    Chou, C.C.3
  • 32
    • 0036230511 scopus 로고    scopus 로고
    • Safety evaluation of proanthocyanidin-rich extract from grape seeds
    • Yamakoshi J, Saito M, Kataoka S, Kikuchi M. Safety evaluation of proanthocyanidin-rich extract from grape seeds. Food Chem Toxicol 2002; 40: 599-607.
    • (2002) Food Chem Toxicol , vol.40 , pp. 599-607
    • Yamakoshi, J.1    Saito, M.2    Kataoka, S.3    Kikuchi, M.4
  • 33
    • 0032797136 scopus 로고    scopus 로고
    • The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells
    • Ye X, Krohn RL, Liu W, et al. The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells. Mol Cell Biochem 1999; 96: 99-108.
    • (1999) Mol Cell Biochem , vol.96 , pp. 99-108
    • Ye, X.1    Krohn, R.L.2    Liu, W.3
  • 34
    • 0042889220 scopus 로고    scopus 로고
    • Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: relationship to decreased fat and lipid peroxidation
    • Mittal A, Elmets CA, Katiyar SK. Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: relationship to decreased fat and lipid peroxidation. Carcinogenesis 2003; 24: 1379-88.
    • (2003) Carcinogenesis , vol.24 , pp. 1379-1388
    • Mittal, A.1    Elmets, C.A.2    Katiyar, S.K.3
  • 35
    • 33646038605 scopus 로고    scopus 로고
    • Matrix metalloproteinases in cancer metastasis: molecular targets for prostate cancer prevention by green tea polyphenols and grape seed proanthocyanidins
    • Katiyar SK. Matrix metalloproteinases in cancer metastasis: molecular targets for prostate cancer prevention by green tea polyphenols and grape seed proanthocyanidins. Endocr Metab Immune Disord Drug Targets 2006; 6: 17-24.
    • (2006) Endocr Metab Immune Disord Drug Targets , vol.6 , pp. 17-24
    • Katiyar, S.K.1
  • 37
    • 0027331855 scopus 로고
    • State of p53, Rb and DCC tumor suppressor genes in human oral cancer cell lines
    • Kim MS, Li SL, Bertolami CN, Cherrick HM, Park NH. State of p53, Rb and DCC tumor suppressor genes in human oral cancer cell lines. Anticancer Res 1993; 13: 1405-13.
    • (1993) Anticancer Res , vol.13 , pp. 1405-1413
    • Kim, M.S.1    Li, S.L.2    Bertolami, C.N.3    Cherrick, H.M.4    Park, N.H.5
  • 38
    • 77954532077 scopus 로고    scopus 로고
    • The effect of Longan seed polyphenols on colorectal carcinoma cells
    • Chung YC, Lin CC, Chou CC, Hsu CP. The effect of Longan seed polyphenols on colorectal carcinoma cells. Eur J Clin Invest 2010; 40: 713-21.
    • (2010) Eur J Clin Invest , vol.40 , pp. 713-721
    • Chung, Y.C.1    Lin, C.C.2    Chou, C.C.3    Hsu, C.P.4
  • 40
    • 0031431501 scopus 로고    scopus 로고
    • Dietary flavonoid and cancer prevention: evidence and potential mechanism
    • Kuo SM. Dietary flavonoid and cancer prevention: evidence and potential mechanism. Crit Rev Oncog 1997; 8: 47-69.
    • (1997) Crit Rev Oncog , vol.8 , pp. 47-69
    • Kuo, S.M.1
  • 41
    • 44849135016 scopus 로고    scopus 로고
    • Bioactive food components and cancer risk reduction
    • Stan SD, Kar S, Stoner GD, Singh SV. Bioactive food components and cancer risk reduction. J Cell Biochem 2008; 104: 339-56.
    • (2008) J Cell Biochem , vol.104 , pp. 339-356
    • Stan, S.D.1    Kar, S.2    Stoner, G.D.3    Singh, S.V.4
  • 42
    • 39749114901 scopus 로고    scopus 로고
    • Prevention of colorectal cancer: diet, chemoprevention, and lifestyle
    • Marshall JR. Prevention of colorectal cancer: diet, chemoprevention, and lifestyle. Gastroenterol Clin North Am 2008; 37: 73-82.
    • (2008) Gastroenterol Clin North Am , vol.37 , pp. 73-82
    • Marshall, J.R.1
  • 43
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 2003; 3: 768-80.
    • (2003) Nat Rev Cancer , vol.3 , pp. 768-780
    • Surh, Y.J.1
  • 44
    • 16444383794 scopus 로고    scopus 로고
    • The antioxidative function, preventive action on disease and utilization of proanthocyanidins
    • Ariga T. The antioxidative function, preventive action on disease and utilization of proanthocyanidins. Biofactors 2004; 21: 197-201.
    • (2004) Biofactors , vol.21 , pp. 197-201
    • Ariga, T.1
  • 45
    • 0034617986 scopus 로고    scopus 로고
    • Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention
    • Bagchi D, Bagchi M, Stohs SJ, et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 2000; 148: 187-97.
    • (2000) Toxicology , vol.148 , pp. 187-197
    • Bagchi, D.1    Bagchi, M.2    Stohs, S.J.3
  • 46
    • 53449095485 scopus 로고    scopus 로고
    • Grape seed proanthocyanidines and skin cancer prevention: inhibition of oxidative stress and protection of immune system
    • Katiyar SK. Grape seed proanthocyanidines and skin cancer prevention: inhibition of oxidative stress and protection of immune system. Mol Nutr Food Res 2008; 52(Suppl 1): S71-6.
    • (2008) Mol Nutr Food Res , vol.52 , Issue.SUPPL. 1
    • Katiyar, S.K.1
  • 47
    • 62349141473 scopus 로고    scopus 로고
    • Grape seed extract inhibits angiogenesis via suppression of the vascular endothelial growth factor receptor signaling pathway
    • Wen W, Lu J, Zhang K, Chen S. Grape seed extract inhibits angiogenesis via suppression of the vascular endothelial growth factor receptor signaling pathway. Cancer Prev Res (Phila) 2008; 1: 554-61.
    • (2008) Cancer Prev Res (Phila) , vol.1 , pp. 554-561
    • Wen, W.1    Lu, J.2    Zhang, K.3    Chen, S.4
  • 48
    • 0030162560 scopus 로고    scopus 로고
    • Balancing cell life and death: bax, apoptosis, and breast cancer
    • Reed JC. Balancing cell life and death: bax, apoptosis, and breast cancer. J Clin Invest 1996; 97: 2403-7.
    • (1996) J Clin Invest , vol.97 , pp. 2403-2407
    • Reed, J.C.1
  • 49
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Review.
    • Green DR, Reed JC. Mitochondria and apoptosis. Science 1998; 28: 1309-12. Review.
    • (1998) Science , vol.28 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 50
    • 9044225527 scopus 로고    scopus 로고
    • BCL-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy
    • Reed JC, Miyashita T, Takayama S, et al. BCL-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy. J Cell Biochem 1996; 60: 23-32.
    • (1996) J Cell Biochem , vol.60 , pp. 23-32
    • Reed, J.C.1    Miyashita, T.2    Takayama, S.3
  • 51
    • 0036334059 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their role in pancreatic cancer: a review of preclinical studies and clinical trials
    • Bloomston M, Zervos EE, Rosemurgy AS II. Matrix metalloproteinases and their role in pancreatic cancer: a review of preclinical studies and clinical trials. Ann Surg Oncol 2002; 9: 668-74.
    • (2002) Ann Surg Oncol , vol.9 , pp. 668-674
    • Bloomston, M.1    Zervos, E.E.2    Rosemurgy II, A.S.3
  • 52
    • 0029929672 scopus 로고    scopus 로고
    • Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax:Bcl-2 ratio
    • Chresta CM, Masters JR, Hickman JA. Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax:Bcl-2 ratio. Cancer Res 1996; 56: 1834-41.
    • (1996) Cancer Res , vol.56 , pp. 1834-1841
    • Chresta, C.M.1    Masters, J.R.2    Hickman, J.A.3
  • 53
    • 72349084411 scopus 로고    scopus 로고
    • Grape seed extract suppresses lipopolysaccharide-induced matrix metalloproteinase (MMP) secretion by macrophages and inhibits human MMP-1 and -9 activities
    • La VD, Bergeron C, Gafner S, Grenier D. Grape seed extract suppresses lipopolysaccharide-induced matrix metalloproteinase (MMP) secretion by macrophages and inhibits human MMP-1 and -9 activities. J Periodontol 2009; 80: 1875-82.
    • (2009) J Periodontol , vol.80 , pp. 1875-1882
    • La, V.D.1    Bergeron, C.2    Gafner, S.3    Grenier, D.4
  • 54
    • 33745714239 scopus 로고    scopus 로고
    • Ras stimulation of E2F activity and a consequent E2F regulation of integrin alpha6beta4 promote the invasion of breast carcinoma cells
    • Yoon SO, Shin S, Mercurio AM. Ras stimulation of E2F activity and a consequent E2F regulation of integrin alpha6beta4 promote the invasion of breast carcinoma cells. Cancer Res 2006; 66: 6288-95.
    • (2006) Cancer Res , vol.66 , pp. 6288-6295
    • Yoon, S.O.1    Shin, S.2    Mercurio, A.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.