-
1
-
-
2642549867
-
The obesity epidemic
-
DOI 10.1126/science.304.5676.1413
-
Abelson P & Kennedy D (2004) The obesity epidemic. Science 304, 1413. (Pubitemid 38720893)
-
(2004)
Science
, vol.304
, Issue.5676
, pp. 1413
-
-
Abelson, P.1
Kennedy, D.2
-
2
-
-
79251520008
-
The obesity epidemic: Challenges, health initiatives, and implications for gastroenterologists
-
Hurt RT, Kulisek C, Buchanan LA, et al. (2010) The obesity epidemic: challenges, health initiatives, and implications for gastroenterologists. Gastroenterol Hepatol (N Y) 6, 780-792.
-
(2010)
Gastroenterol Hepatol (N Y)
, vol.6
, pp. 780-792
-
-
Hurt, R.T.1
Kulisek, C.2
Buchanan, L.A.3
-
3
-
-
0034917709
-
Impact of overweight on the risk of developing common chronic diseases during a 10-year period
-
Field AE, Coakley EH, Must A, et al. (2001) Impact of overweight on the risk of developing common chronic diseases during a 10-year period. Arch Intern Med 161, 1581-1586. (Pubitemid 32681139)
-
(2001)
Archives of Internal Medicine
, vol.161
, Issue.13
, pp. 1581-1586
-
-
Field, A.E.1
Coakley, E.H.2
Must, A.3
Spadano, J.L.4
Laird, N.5
Dietz, W.H.6
Rimm, E.7
Colditz, G.A.8
-
4
-
-
79957482239
-
Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: Comparison to highfat diet
-
Sampey BP, Vanhoose AM, Winfield HM, et al. (2011) Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to highfat diet. Obesity 19, 1109-1117.
-
(2011)
Obesity
, vol.19
, pp. 1109-1117
-
-
Sampey, B.P.1
Vanhoose, A.M.2
Winfield, H.M.3
-
5
-
-
79952538203
-
Modulatory effect of grape-seed procyanidins on local and systemic inflammation in diet-induced obesity rats
-
Terra X, Pallares V, Ardevol A, et al. (2011) Modulatory effect of grape-seed procyanidins on local and systemic inflammation in diet-induced obesity rats. J Nutr Biochem 22, 380-387.
-
(2011)
J Nutr Biochem
, vol.22
, pp. 380-387
-
-
Terra, X.1
Pallares, V.2
Ardevol, A.3
-
6
-
-
33845520528
-
Diferential gene expression and adiposity reduction induced by ascorbic acid supplementation in a cafeteria model of obesity
-
Campion J, Milagro FI, Fernandez D, et al. (2006) Diferential gene expression and adiposity reduction induced by ascorbic acid supplementation in a cafeteria model of obesity. J Physiol Biochem 62, 71-80. (Pubitemid 44920834)
-
(2006)
Journal of Physiology and Biochemistry
, vol.62
, Issue.2
, pp. 71-80
-
-
Campion, J.1
Milargo, F.I.2
Fernandez, D.3
Martinez, J.A.4
-
7
-
-
0018908253
-
Persistent obesity in rats following a period of consumption of a mixed, high energy diet
-
Rolls BJ, Rowe EA & Turner RC (1980) Persistent obesity in rats following a period of consumption of a mixed, high energy diet. J Physiol 298, 415-427. (Pubitemid 10111744)
-
(1980)
Journal of Physiology
, vol.298
, pp. 415-427
-
-
Rolls, B.J.1
Rowe, E.A.2
Turner, R.C.3
-
8
-
-
78751535748
-
Diet-induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model
-
Sishi B, Loos B, Ellis B, et al. (2011) Diet-induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model. Exp Physiol 96, 179-193.
-
(2011)
Exp Physiol
, vol.96
, pp. 179-193
-
-
Sishi, B.1
Loos, B.2
Ellis, B.3
-
9
-
-
77954933682
-
Cafeteria dietinduced insulin resistance is not associated with decreased insulin signaling or AMPK activity and is alleviated by physical training in rats
-
Brandt N, De Bock K, Richter EA, et al. (2010) Cafeteria dietinduced insulin resistance is not associated with decreased insulin signaling or AMPK activity and is alleviated by physical training in rats. Am J Physiol Endocrinol Metab 299, E215-E224.
-
(2010)
Am J Physiol Endocrinol Metab
, vol.299
-
-
Brandt, N.1
De Bock, K.2
Richter, E.A.3
-
10
-
-
48349089690
-
Retinolbinding protein 4 and nicotinamide phosphoribosyltransferase/ visfatin in rat obesity models
-
Mercader J, Granados N, Caimari A, et al. (2008) Retinolbinding protein 4 and nicotinamide phosphoribosyltransferase/visfatin in rat obesity models. Horm Metab Res 40, 467-472.
-
(2008)
Horm Metab Res
, vol.40
, pp. 467-472
-
-
Mercader, J.1
Granados, N.2
Caimari, A.3
-
11
-
-
75449119458
-
Pregnancy restores insulin secretion from pancreatic islets in cafeteria diet-induced obese rats
-
Vanzela EC, Ribeiro RA, de Oliveira CA, et al. (2010) Pregnancy restores insulin secretion from pancreatic islets in cafeteria diet-induced obese rats. Am J Physiol Regul Integr Comp Physiol 298, R320-R328.
-
(2010)
Am J Physiol Regul Integr Comp Physiol
, vol.298
-
-
Vanzela, E.C.1
Ribeiro, R.A.2
De Oliveira, C.A.3
-
12
-
-
4143151942
-
Pathogenesis of type 2 diabetes mellitus
-
DeFronzo RA (2004) Pathogenesis of type 2 diabetes mellitus. Med Clin North Am 88, 787-835, ix.
-
(2004)
Med Clin North Am
, vol.88
, Issue.787-835
-
-
Defronzo, R.A.1
-
13
-
-
0036217052
-
Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
-
DOI 10.1210/er.23.2.201
-
Lewis GF, Carpentier A, Adeli K, et al. (2002) Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev 23, 201-229. (Pubitemid 34299024)
-
(2002)
Endocrine Reviews
, vol.23
, Issue.2
, pp. 201-229
-
-
Lewis, G.F.1
Carpentier, A.2
Adeli, K.3
Giacca, A.4
-
14
-
-
0029036835
-
Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans
-
Zhou YP & Grill V (1995) Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans. J Clin Endocrinol Metab 80, 1584-1590.
-
(1995)
J Clin Endocrinol Metab
, vol.80
, pp. 1584-1590
-
-
Zhou, Y.P.1
Grill, V.2
-
15
-
-
0031690490
-
Insulin degradation: Progress and potential
-
DOI 10.1210/er.19.5.608
-
Duckworth WC, Bennett RG & Hamel FG (1998) Insulin degradation: progress and potential. Endocr Rev 19, 608-624. (Pubitemid 28467714)
-
(1998)
Endocrine Reviews
, vol.19
, Issue.5
, pp. 608-624
-
-
Duckworth, W.C.1
Bennett, R.G.2
Hamel, F.G.3
-
16
-
-
0034284938
-
Insulindegrading enzyme identified as a candidate diabetes susceptibility gene in GK rats
-
Fakhrai-Rad H, Nikoshkov A, Kamel A, et al. (2000) Insulindegrading enzyme identified as a candidate diabetes susceptibility gene in GK rats. Hum Mol Genet 9, 2149-2158.
-
(2000)
Hum Mol Genet
, vol.9
, pp. 2149-2158
-
-
Fakhrai-Rad, H.1
Nikoshkov, A.2
Kamel, A.3
-
17
-
-
1642290835
-
Partial Loss-of-Function Mutations in Insulin-Degrading Enzyme that Induce Diabetes also Impair Degradation of Amyloid β-Protein
-
Farris W, Mansourian S, Leissring MA, et al. (2004) Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid betaprotein. Am J Pathol 164, 1425-1434. (Pubitemid 38387808)
-
(2004)
American Journal of Pathology
, vol.164
, Issue.4
, pp. 1425-1434
-
-
Farris, W.1
Mansourian, S.2
Leissring, M.A.3
Eckman, E.A.4
Bertram, L.5
Eckman, C.B.6
Tanzi, R.E.7
Selkoe, D.J.8
-
18
-
-
67651209216
-
Loci of TCF7L2 HHEX and IDE on chromosome 10q and the susceptibility of their genetic polymorphisms to type 2 diabetes
-
Nordman S, Ostenson CG, Efendic S, et al. (2009) Loci of TCF7L2, HHEX and IDE on chromosome 10q and the susceptibility of their genetic polymorphisms to type 2 diabetes. Exp Clin Endocrinol Diabetes 117, 186-190.
-
(2009)
Exp Clin Endocrinol Diabetes
, vol.117
, pp. 186-190
-
-
Nordman, S.1
Ostenson, C.G.2
Efendic, S.3
-
19
-
-
38149040036
-
Polymorphisms in the IDE-KIF11-HHEX gene locus are reproducibly associated with type 2 diabetes in a Japanese population
-
Furukawa Y, Shimada T, Furuta H, et al. (2008) Polymorphisms in the IDE-KIF11-HHEX gene locus are reproducibly associated with type 2 diabetes in a Japanese population. J Clin Endocrinol Metab 93, 310-314.
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 310-314
-
-
Furukawa, Y.1
Shimada, T.2
Furuta, H.3
-
20
-
-
0038659900
-
Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study
-
DOI 10.2337/diabetes.52.6.1562
-
Karamohamed S, Demissie S, Volcjak J, et al. (2003) Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study. Diabetes 52, 1562-1567. (Pubitemid 36666215)
-
(2003)
Diabetes
, vol.52
, Issue.6
, pp. 1562-1567
-
-
Karamohamed, S.1
Demissie, S.2
Volcjak, J.3
Liu, C.4
Heard-Costa, N.5
Liu, J.6
Shoemaker, C.M.7
Panhuysen, C.I.8
Meigs, J.B.9
Wilson, P.10
Atwood, L.D.11
Cupples, L.A.12
Herbert, A.13
-
21
-
-
76249098866
-
Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX SOX4, and IRX3
-
Ragvin A, Moro E, Fredman D, et al. (2010) Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3. Proc Natl Acad Sci USA 107, 775-780.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 775-780
-
-
Ragvin, A.1
Moro, E.2
Fredman, D.3
-
22
-
-
0037390039
-
Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo
-
DOI 10.1073/pnas.0230450100
-
Farris W, Mansourian S, Chang Y, et al. (2003) Insulindegrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci USA 100, 4162-4167. (Pubitemid 36418174)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.7
, pp. 4162-4167
-
-
Farris, W.1
Mansourian, S.2
Chang, Y.3
Lindsley, L.4
Eckman, E.A.5
Frosch, M.P.6
Eckman, C.B.7
Tanzi, R.E.8
Selkoe, D.J.9
Guenette, S.10
-
23
-
-
77954747643
-
Effects of a grapeseed procyanidin extract (GSPE) on insulin resistance
-
Montagut G, Blade C, Blay M, et al. (2010) Effects of a grapeseed procyanidin extract (GSPE) on insulin resistance. J Nutr Biochem 21, 961-967.
-
(2010)
J Nutr Biochem
, vol.21
, pp. 961-967
-
-
Montagut, G.1
Blade, C.2
Blay, M.3
-
24
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72, 248-254.
-
(1976)
Anal Biochem
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
25
-
-
0028557012
-
The animal fatty acid synthase: One gene, one polypeptide, seven enzymes
-
Smith S (1994) The animal fatty acid synthase: one gene, one polypeptide, seven enzymes. FASEB J 8, 1248-1259.
-
(1994)
FASEB J
, vol.8
, pp. 1248-1259
-
-
Smith, S.1
-
26
-
-
55449133428
-
Dietary procyanidins lower triglyceride levels signaling through the nuclear receptor small heterodimer partner
-
Del Bas JM, Ricketts ML, Baiges I, et al. (2008) Dietary procyanidins lower triglyceride levels signaling through the nuclear receptor small heterodimer partner. Mol Nutr Food Res 52, 1172-1181.
-
(2008)
Mol Nutr Food Res
, vol.52
, pp. 1172-1181
-
-
Del Bas, J.M.1
Ricketts, M.L.2
Baiges, I.3
-
27
-
-
0034891713
-
Uncoupling proteins: Their roles in adaptive thermogenesis and substrate metabolism reconsidered
-
Dulloo AG & Samec S (2001) Uncoupling proteins: their roles in adaptive thermogenesis and substrate metabolism reconsidered. Br J Nutr 86, 123-139. (Pubitemid 32780616)
-
(2001)
British Journal of Nutrition
, vol.86
, Issue.2
, pp. 123-139
-
-
Dulloo, A.G.1
Samec, S.2
-
28
-
-
0036724133
-
Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-γ inhibition
-
Patane G, Anello M, Piro S, et al. (2002) Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferatoractivated receptor-gamma inhibition. Diabetes 51, 2749-2756. (Pubitemid 34970928)
-
(2002)
Diabetes
, vol.51
, Issue.9
, pp. 2749-2756
-
-
Patane, G.1
Anello, M.2
Piro, S.3
Vigneri, R.4
Purrello, F.5
Rabuazzo, A.M.6
-
29
-
-
54049119217
-
Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues
-
Yfanti C, Mengele K, Gkazepis A, et al. (2008) Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues. Int J Mol Med 22, 421-431.
-
(2008)
Int J Mol Med
, vol.22
, pp. 421-431
-
-
Yfanti, C.1
Mengele, K.2
Gkazepis, A.3
-
30
-
-
0027452730
-
Insulin-degrading enzyme is differentially expressed and developmentally regulated in various rat tissues
-
DOI 10.1210/en.132.2.604
-
Kuo WL, Montag AG & Rosner MR (1993) Insulin-degrading enzyme is differentially expressed and developmentally regulated in various rat tissues. Endocrinology 132, 604-611. (Pubitemid 23056115)
-
(1993)
Endocrinology
, vol.132
, Issue.2
, pp. 604-611
-
-
Kuo, W.-L.1
Montag, A.G.2
Rosner, M.R.3
-
31
-
-
0027410472
-
The rat insulin-degrading enzyme. Molecular cloning and characterization of tissue-specific transcripts
-
DOI 10.1016/0014-5793(93)81286-9
-
Baumeister H, Muller D, Rehbein M, et al. (1993) The rat insulin-degrading enzyme. Molecular cloning and characterization of tissue-specific transcripts. FEBS Lett 317, 250-254. (Pubitemid 23045799)
-
(1993)
FEBS Letters
, vol.317
, Issue.3
, pp. 250-254
-
-
Baumeister, H.1
Muller, D.2
Rehbein, M.3
Richter, D.4
-
32
-
-
77955657267
-
Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: The missing links. The Claude Bernard Lecture 2009
-
DeFronzo RA (2010) Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009. Diabetologia 53, 1270-1287.
-
(2010)
Diabetologia
, vol.53
, pp. 1270-1287
-
-
Defronzo, R.A.1
-
33
-
-
9444242665
-
Five of stages of evolving β-cell dysfunction during progression to diabetes
-
DOI 10.2337/diabetes.53.suppl-3.S16
-
Weir GC & Bonner-Weir S (2004) Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes 53, Suppl. 3, S16-S21. (Pubitemid 39564517)
-
(2004)
Diabetes
, vol.53
, Issue.SUPPL. 3
-
-
Weir, G.C.1
Bonner-Weir, S.2
-
34
-
-
70349119490
-
Grape seed proanthocyanidins correct dyslipidemia associated with a high-fat diet in rats and repress genes controlling lipogenesis and VLDL assembling in liver
-
Quesada H, del Bas JM, Pajuelo D, et al. (2009) Grape seed proanthocyanidins correct dyslipidemia associated with a high-fat diet in rats and repress genes controlling lipogenesis and VLDL assembling in liver. Int J Obes (Lond) 33, 1007-1012.
-
(2009)
Int J Obes (Lond)
, vol.33
, pp. 1007-1012
-
-
Quesada, H.1
Del Bas, J.M.2
Pajuelo, D.3
-
35
-
-
84870832658
-
Antiobesogenic and antiatherosclerotic properties of Caralluma fimbriata extract
-
Kamalakkannan S, Rajendran R, Venkatesh RV, et al. (2010) Antiobesogenic and antiatherosclerotic properties of Caralluma fimbriata extract. J Nutr Metab 2010, 285301.
-
(2010)
J Nutr Metab
, vol.2010
, pp. 285301
-
-
Kamalakkannan, S.1
Rajendran, R.2
Venkatesh, R.V.3
-
36
-
-
77749340965
-
Reversibility of metabolic and morphological changes associated with chronic exposure of pancreatic islet beta-cells to fatty acids
-
Pinnick K, Neville M, Clark A, et al. (2010) Reversibility of metabolic and morphological changes associated with chronic exposure of pancreatic islet beta-cells to fatty acids. J Cell Biochem 109, 683-692.
-
(2010)
J Cell Biochem
, vol.109
, pp. 683-692
-
-
Pinnick, K.1
Neville, M.2
Clark, A.3
-
37
-
-
0037093532
-
Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: Effects on cell metabolism and insulin secretion
-
Rubi B, Antinozzi PA, Herrero L, et al. (2002) Adenovirusmediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretion. Biochem J 364, Pt 1, 219-226. (Pubitemid 34538965)
-
(2002)
Biochemical Journal
, vol.364
, Issue.1
, pp. 219-226
-
-
Rubi, B.1
Antinozzi, P.A.2
Herrero, L.3
Ishihara, H.4
Asins, G.5
Serra, D.6
Wollheim, C.B.7
Maechler, P.8
Hegardt, F.G.9
-
38
-
-
0028268936
-
Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
-
Zhou YP & Grill VE (1994) Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 93, 870-876. (Pubitemid 24072831)
-
(1994)
Journal of Clinical Investigation
, vol.93
, Issue.2
, pp. 870-876
-
-
Zhou, Y.-P.1
Grill, V.E.2
-
39
-
-
0035078830
-
Uncoupling protein 2: A possible link between fatty acid excess and impaired glucose-induced insulin secretion?
-
Lameloise N, Muzzin P, Prentki M, et al. (2001) Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion? Diabetes 50, 803-809. (Pubitemid 32242637)
-
(2001)
Diabetes
, vol.50
, Issue.4
, pp. 803-809
-
-
Lameloise, N.1
Muzzin, P.2
Prentki, M.3
Assimacopoulos-Jeannet, F.4
-
40
-
-
0036214365
-
Induction of uncoupling protein 2 mRNA in β-cells is stimulated by oxidation of fatty acids but not by nutrient oversupply
-
DOI 10.1210/en.143.4.1371
-
Li LX, Skorpen F, Egeberg K, et al. (2002) Induction of uncoupling protein 2 mRNA in beta-cells is stimulated by oxidation of fatty acids but not by nutrient oversupply. Endocrinology 143, 1371-1377. (Pubitemid 34274367)
-
(2002)
Endocrinology
, vol.143
, Issue.4
, pp. 1371-1377
-
-
Li-Xin, L.I.1
Skorpen, F.2
Egeberg, K.3
Jorgensen, I.H.4
Grill, V.5
-
41
-
-
33847065108
-
Peroxisome proliferator-activated receptor-gamma regulates expression of PDX-1 and NKX6.1 in INS-1 cells
-
Moibi JA, Gupta D, Jetton TL, et al. (2007) Peroxisome proliferator-activated receptor-gamma regulates expression of PDX-1 and NKX6.1 in INS-1 cells. Diabetes 56, 88-95.
-
(2007)
Diabetes
, vol.56
, pp. 88-95
-
-
Moibi, J.A.1
Gupta, D.2
Jetton, T.L.3
-
42
-
-
77449139439
-
Overexpression of kinase-negative protein kinase Cdelta in pancreatic beta-cells protects mice from diet-induced glucose intolerance and beta-cell dysfunction
-
Hennige AM, Ranta F, Heinzelmann I, et al. (2010) Overexpression of kinase-negative protein kinase Cdelta in pancreatic beta-cells protects mice from diet-induced glucose intolerance and beta-cell dysfunction. Diabetes 59, 119-127.
-
(2010)
Diabetes
, vol.59
, pp. 119-127
-
-
Hennige, A.M.1
Ranta, F.2
Heinzelmann, I.3
-
43
-
-
77954495751
-
XOMA 052, an anti-IL-1{beta} monoclonal antibody, improves glucose control and {beta}-cell function in the diet-induced obesity mouse model
-
Owyang AM, Maedler K, Gross L, et al. (2010) XOMA 052, an anti-IL-1{beta} monoclonal antibody, improves glucose control and {beta}-cell function in the diet-induced obesity mouse model. Endocrinology 151, 2515-2527.
-
(2010)
Endocrinology
, vol.151
, pp. 2515-2527
-
-
Owyang, A.M.1
Maedler, K.2
Gross, L.3
-
44
-
-
34948813565
-
Leptin decreases apoptosis and alters BCL-2: Bax ratio in clonal rodent pancreatic beta-cells
-
DOI 10.1002/dmrr.726
-
Brown JE & Dunmore SJ (2007) Leptin decreases apoptosis and alters BCL-2: Bax ratio in clonal rodent pancreatic beta-cells. Diabetes Metab Res Rev 23, 497-502. (Pubitemid 47520908)
-
(2007)
Diabetes/Metabolism Research and Reviews
, vol.23
, Issue.6
, pp. 497-502
-
-
Brown, J.E.P.1
Dunmore, S.J.2
-
45
-
-
0042922453
-
Saturated fatty acids synergize with elevated glucose to cause pancreatic β-cell death
-
DOI 10.1210/en.2003-0410
-
El-Assaad W, Buteau J, Peyot ML, et al. (2003) Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death. Endocrinology 144, 4154-4163. (Pubitemid 37088771)
-
(2003)
Endocrinology
, vol.144
, Issue.9
, pp. 4154-4163
-
-
El-Assaad, W.1
Buteau, J.2
Peyot, M.-L.3
Nolan, C.4
Roduit, R.5
Hardy, S.6
Joly, E.7
Dbaibo, G.8
Rosenberg, L.9
Prentki, M.10
-
46
-
-
0036797785
-
Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: Possible role of oxidative stress
-
DOI 10.1053/meta.2002.35200
-
Piro S, Anello M, Di Pietro C, et al. (2002) Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress. Metabolism 51, 1340-1347. (Pubitemid 35174157)
-
(2002)
Metabolism: Clinical and Experimental
, vol.51
, Issue.10
, pp. 1340-1347
-
-
Piro, S.1
Anello, M.2
Di Pietro, C.3
Lizzio, M.N.4
Patane, G.5
Rabuazzo, A.M.6
Vigneri, R.7
Purrello, M.8
Purrello, F.9
-
47
-
-
0032478314
-
Fatty acid-induced β cell apoptosis: A link between obesity and diabetes
-
DOI 10.1073/pnas.95.5.2498
-
Shimabukuro M, Zhou YT, Levi M, et al. (1998) Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci USA 95, 2498-2502. (Pubitemid 28145970)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.5
, pp. 2498-2502
-
-
Shimabukuro, M.1
Zhou, Y.-T.2
Levi, M.3
Unger, R.H.4
-
48
-
-
0035042679
-
β-Cell mass dynamics in Zucker diabetic fatty rats: Rosiglitazone prevents the rise in net cell death
-
Finegood DT, McArthur MD, Kojwang D, et al. (2001) Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death. Diabetes 50, 1021-1029. (Pubitemid 32374532)
-
(2001)
Diabetes
, vol.50
, Issue.5
, pp. 1021-1029
-
-
Finegood, D.T.1
McArthur, M.D.2
Kojwang, D.3
Thomas, M.J.4
Topp, B.G.5
Leonard, T.6
Buckingham, R.E.7
-
49
-
-
77954825385
-
The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction
-
Zmuda EJ, Qi L, Zhu MX, et al. (2010) The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction. Mol Endocrinol 24, 1423-1433.
-
(2010)
Mol Endocrinol
, vol.24
, pp. 1423-1433
-
-
Zmuda, E.J.1
Qi, L.2
Zhu, M.X.3
-
50
-
-
78649448389
-
Insulin metabolism in human adipocytes from subcutaneous and visceral depots
-
Fawcett J, Sang H, Permana PA, et al. (2010) Insulin metabolism in human adipocytes from subcutaneous and visceral depots. Biochem Biophys Res Commun 402, 762-766.
-
(2010)
Biochem Biophys Res Commun
, vol.402
, pp. 762-766
-
-
Fawcett, J.1
Sang, H.2
Permana, P.A.3
-
51
-
-
37549035051
-
Intake of sucrosesweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease
-
Cao D, Lu H, Lewis TL, et al. (2007) Intake of sucrosesweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease. J Biol Chem 282, 36275-36282.
-
(2007)
J Biol Chem
, vol.282
, pp. 36275-36282
-
-
Cao, D.1
Lu, H.2
Lewis, T.L.3
-
52
-
-
4644286910
-
Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
-
Ho L, Qin W, Pompl PN, et al. (2004) Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease. FASEB J 18, 902-904.
-
(2004)
FASEB J
, vol.18
, pp. 902-904
-
-
Ho, L.1
Qin, W.2
Pompl, P.N.3
-
53
-
-
0029764427
-
Adipose tissue extraction of circulating insulin in anaesthetized Zucker obese rats
-
Ardevol A, Adan C, Canas X, et al. (1996) Adipose tissue extraction of circulating insulin in anaesthetized Zucker obese rats. Int J Obes Relat Metab Disord 20, 837-841. (Pubitemid 26313107)
-
(1996)
International Journal of Obesity
, vol.20
, Issue.9
, pp. 837-841
-
-
Ardevol, A.1
Adan, C.2
Canas, X.3
Rafecas, I.4
Esteve, M.5
Remesar, X.6
Fernandez-Lopez, J.A.7
Alemany, M.8
-
55
-
-
0033656589
-
Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response
-
Mittelman SD, Van Citters GW, Kim SP, et al. (2000) Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response. Diabetes 49, 2116-2125.
-
(2000)
Diabetes
, vol.49
, pp. 2116-2125
-
-
Mittelman, S.D.1
Van Citters, G.W.2
Kim, S.P.3
-
56
-
-
0008760969
-
Free fatty acids timedependently impair glucose metabolism by mechanisms unrelated to the Randle's cycle
-
Lam T, Yoshii H, Haber A, et al. (2000) Free fatty acids timedependently impair glucose metabolism by mechanisms unrelated to the Randle's cycle. Diabetes 49, A286-A286.
-
(2000)
Diabetes
, vol.49
-
-
Lam, T.1
Yoshii, H.2
Haber, A.3
|