The role of reduced intracellular concentrations of active drugs in the lack of response to anticancer chemotherapy

Acta Pharmacologica Sinica

Volumn 35, Issue 1, 2014, Pages 1-10

  Marin, Jose J G ^a   Monte, Maria J ^a   Blazquez, Alba G ^a   MacIas, Rocio I ^a   Serrano, Maria A ^a   Briz, Oscar ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

anticancer drug; ATP binding cassette protein; cancer; chemoresistance; cytochrome P450 related enzyme; drug metabolism; drug refractoriness; plasma membrane transporter; prodrug

Indexed keywords

ANTINEOPLASTIC AGENT; PRODRUG; PROTEIN VARIANT;

CANCER CHEMOTHERAPY; CELLS; DRUG CONCENTRATION; DRUG INACTIVATION; DRUG TREATMENT FAILURE; DRUG UPTAKE; GENE EXPRESSION; GENETIC VARIABILITY; HUMAN; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE; TUMOR CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG RESISTANCE, NEOPLASM; HUMANS; INTRACELLULAR FLUID; NEOPLASMS;

EID: 84891759536     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2013.131     Document Type: Review

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