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Volumn 31, Issue 6, 2007, Pages 1465-1472

The combination of glycyrrhizin and lamivudine can reverse the cisplatin resistance in hepatocellular carcinoma cells through inhibition of multidrug resistance-associated proteins

Author keywords

Cisplatin; Glycyrrhizin; Hepatocellular carcinoma; Lamivudine; Multidrug resistance associated proteins

Indexed keywords

ABCB1 PROTEIN, HUMAN; ABCC5 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; CARRIER PROTEIN; CISPLATIN; GLYCOPROTEIN P; GLYCYRRHIZIC ACID; LAMIVUDINE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2; UNCLASSIFIED DRUG;

EID: 38449088390     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.31.6.1465     Document Type: Article
Times cited : (77)

References (57)
  • 1
    • 0141491273 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • Llovet JM: Hepatocellular carcinoma. Lancet 362: 1907-1917, 2003.
    • (2003) Lancet , vol.362 , pp. 1907-1917
    • Llovet, J.M.1
  • 2
    • 0033541491 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • Schafer DF and Sorrell MF: Hepatocellular carcinoma. Lancet 353: 1253-1257, 1999.
    • (1999) Lancet , vol.353 , pp. 1253-1257
    • Schafer, D.F.1    Sorrell, M.F.2
  • 4
    • 0028069259 scopus 로고
    • Immunohistochemical study of expression and cellular localization of the multidrug resistance gene product P-glycoprotein in primary liver carcinoma
    • Itsubo M, Ishikawa T, Toda G and Tanaka M: Immunohistochemical study of expression and cellular localization of the multidrug resistance gene product P-glycoprotein in primary liver carcinoma. Cancer 73: 298-303, 1994.
    • (1994) Cancer , vol.73 , pp. 298-303
    • Itsubo, M.1    Ishikawa, T.2    Toda, G.3    Tanaka, M.4
  • 5
    • 0025013836 scopus 로고
    • Doxorubicin for unresectable hepatocellular carcinoma. A prospective study on the addition of verapamil
    • Lai EC, Choi TK, Cheng CH, Mok FP, Fan ST, Tan ES and Wong J: Doxorubicin for unresectable hepatocellular carcinoma. A prospective study on the addition of verapamil. Cancer 66: 1685-1687, 1990.
    • (1990) Cancer , vol.66 , pp. 1685-1687
    • Lai, E.C.1    Choi, T.K.2    Cheng, C.H.3    Mok, F.P.4    Fan, S.T.5    Tan, E.S.6    Wong, J.7
  • 6
    • 0026071402 scopus 로고
    • Human hepatocellular carcinoma cell lines exhibit multidrug resistance unrelated to MRD1 gene expression
    • Shen DW, Lu YG, Chin KV, Pastan I and Gottesman MM: Human hepatocellular carcinoma cell lines exhibit multidrug resistance unrelated to MRD1 gene expression. J Cell Sci 98: 317-322, 1991.
    • (1991) J Cell Sci , vol.98 , pp. 317-322
    • Shen, D.W.1    Lu, Y.G.2    Chin, K.V.3    Pastan, I.4    Gottesman, M.M.5
  • 7
    • 0034674901 scopus 로고    scopus 로고
    • A family of drug transporters, the multidrug resistance-associated proteins
    • Borst P, Evers R, Kool M and Wijnholds J: A family of drug transporters, the multidrug resistance-associated proteins. J Natl Cancer Inst 92: 1295-1302, 2000.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1295-1302
    • Borst, P.1    Evers, R.2    Kool, M.3    Wijnholds, J.4
  • 8
    • 0028054888 scopus 로고
    • Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs
    • Grant CE, Valdimarsson G, Hipfner DR, Almquist KC, Cole SP and Deeley RG: Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs. Cancer Res 54: 357-361, 1994.
    • (1994) Cancer Res , vol.54 , pp. 357-361
    • Grant, C.E.1    Valdimarsson, G.2    Hipfner, D.R.3    Almquist, K.C.4    Cole, S.P.5    Deeley, R.G.6
  • 9
    • 0345724724 scopus 로고    scopus 로고
    • The MRP family of drug efflux pumps
    • Kruh GD and Belinsky MG: The MRP family of drug efflux pumps. Oncogene 22: 7537-7552, 2003.
    • (2003) Oncogene , vol.22 , pp. 7537-7552
    • Kruh, G.D.1    Belinsky, M.G.2
  • 10
    • 0030841332 scopus 로고    scopus 로고
    • Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines
    • Kool M, de Haas M, Scheffer GL, Scheper RJ, van Eijk MJ, Juijn JA, Baas F and Borst P: Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res 57: 3537-3547, 1997.
    • (1997) Cancer Res , vol.57 , pp. 3537-3547
    • Kool, M.1    De Haas, M.2    Scheffer, G.L.3    Scheper, R.J.4    Van Eijk, M.J.5    Juijn, J.A.6    Baas, F.7    Borst, P.8
  • 12
    • 0030668526 scopus 로고    scopus 로고
    • ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2
    • Jedlitschky G, Leier I, Buchholz U, Hummel-Eisenbeiss J, Burchell B and Keppler D: ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. Biochem J 327: 305-310, 1997.
    • (1997) Biochem J , vol.327 , pp. 305-310
    • Jedlitschky, G.1    Leier, I.2    Buchholz, U.3    Hummel-Eisenbeiss, J.4    Burchell, B.5    Keppler, D.6
  • 13
    • 0034282991 scopus 로고    scopus 로고
    • Transport of amphipathic anion by human multidrug resistance protein 3
    • Zeng H, Liu G, Rea PA and Kruh GD: Transport of amphipathic anion by human multidrug resistance protein 3. Cancer Res 60: 4779-4784, 2000.
    • (2000) Cancer Res , vol.60 , pp. 4779-4784
    • Zeng, H.1    Liu, G.2    Rea, P.A.3    Kruh, G.D.4
  • 16
    • 7044239399 scopus 로고    scopus 로고
    • Hepatocellular carcinoma, current management and future trends
    • Carr BI: Hepatocellular carcinoma, current management and future trends. Gastroenterology 127 (suppl 1): S218-S224, 2004.
    • (2004) Gastroenterology , vol.127 , Issue.SUPPL. 1
    • Carr, B.I.1
  • 18
    • 9544233652 scopus 로고    scopus 로고
    • A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation
    • Taniguchi K, Wada M, Kohno K, Nakamura T, Kawabe T, Kawakami M, Kagotani K, Okumura K, Akiyama S and Kuwano M: A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. Cancer Res 56: 4124-4129, 1996.
    • (1996) Cancer Res , vol.56 , pp. 4124-4129
    • Taniguchi, K.1    Wada, M.2    Kohno, K.3    Nakamura, T.4    Kawabe, T.5    Kawakami, M.6    Kagotani, K.7    Okumura, K.8    Akiyama, S.9    Kuwano, M.10
  • 19
    • 0031468814 scopus 로고    scopus 로고
    • A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells
    • Koike K, Kawabe T, Tanaka T, Toh S, Uchiumi T, Wada M, Akiyama S, Ono M and Kuwano M: A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells. Cancer Res 57: 5475-5479, 1997.
    • (1997) Cancer Res , vol.57 , pp. 5475-5479
    • Koike, K.1    Kawabe, T.2    Tanaka, T.3    Toh, S.4    Uchiumi, T.5    Wada, M.6    Akiyama, S.7    Ono, M.8    Kuwano, M.9
  • 20
    • 1542435945 scopus 로고    scopus 로고
    • Overexpression of mutated MRP4 in cisplatin resistant small cell lung cancer cell line: Collateral sensitivity to azidothymidine
    • Savaraj N, Wu C, Wangpaichitr M, Kuo MT, Lampidis T, Robles C, Furst AJ and Feun L: Overexpression of mutated MRP4 in cisplatin resistant small cell lung cancer cell line: Collateral sensitivity to azidothymidine. Int J Oncol 23: 173-179, 2003.
    • (2003) Int J Oncol , vol.23 , pp. 173-179
    • Savaraj, N.1    Wu, C.2    Wangpaichitr, M.3    Kuo, M.T.4    Lampidis, T.5    Robles, C.6    Furst, A.J.7    Feun, L.8
  • 21
    • 0034094338 scopus 로고    scopus 로고
    • Increased expression of the MRP5 gene is associated with exposure to platinum drugs in lung cancer
    • DOI 10.1002/(SICI)1097-0215(20000401)86:1<95::AID-IJC15>3.0.CO;2-G
    • Oguri T, Isobe T, Suzuki T, Nishio K, Fujiwara Y, Katoh O and Yamakido M: Increased expression of the MRP5 gene is associated with exposure to platinum drugs in lung cancer. Int J Cancer 86: 95-100, 2000. (Pubitemid 30133993)
    • (2000) International Journal of Cancer , vol.86 , Issue.1 , pp. 95-100
    • Oguri, T.1    Isobe, T.2    Suzuki, T.3    Nishio, K.4    Fujiwara, Y.5    Katoh, O.6    Yamakido, M.7
  • 22
    • 0026484655 scopus 로고
    • An antigranulomatous effect of glycyrrhizin
    • Matsushima Y and Baba T: An antigranulomatous effect of glycyrrhizin. J Exp Pathol 6: 25-30, 1992.
    • (1992) J Exp Pathol , vol.6 , pp. 25-30
    • Matsushima, Y.1    Baba, T.2
  • 23
    • 1542316127 scopus 로고    scopus 로고
    • Hepatitis B virus infection - Natural history and clinical consequences
    • Ganem D and Prince AM: Hepatitis B virus infection - natural history and clinical consequences. N Engl J Med 350: 1118-1129, 2004.
    • (2004) N Engl J Med , vol.350 , pp. 1118-1129
    • Ganem, D.1    Prince, A.M.2
  • 24
    • 0021347915 scopus 로고
    • Phenotypical stability of a human hepatoma cell line, Huh-7, in long-term culture with chemically defined medium
    • Nakabayashi H, Taketa K, Yamane T, Miyazaki M, Miyano K and Sato J: Phenotypical stability of a human hepatoma cell line, Huh-7, in long-term culture with chemically defined medium. Gann 75: 151-158, 1984.
    • (1984) Gann , vol.75 , pp. 151-158
    • Nakabayashi, H.1    Taketa, K.2    Yamane, T.3    Miyazaki, M.4    Miyano, K.5    Sato, J.6
  • 25
    • 0032838498 scopus 로고    scopus 로고
    • Apoptosis-promoting gene (bax) transfer potentiates sensitivity of squamous cell carcinoma to cisplatin in vitro and in vivo
    • Sugimoto C, Fujieda S, Seki M, Sunaga H, Fan GK, Tsuzuki H, Borner C, Saito H and Matsukawa S: Apoptosis-promoting gene (bax) transfer potentiates sensitivity of squamous cell carcinoma to cisplatin in vitro and in vivo. Int J Cancer 82: 860-867, 1999.
    • (1999) Int J Cancer , vol.82 , pp. 860-867
    • Sugimoto, C.1    Fujieda, S.2    Seki, M.3    Sunaga, H.4    Fan, G.K.5    Tsuzuki, H.6    Borner, C.7    Saito, H.8    Matsukawa, S.9
  • 26
    • 0027569924 scopus 로고
    • Dual-attribute continuous monitoring of cell proliferation/cytotoxicity
    • Fields RD and Lancaster MV: Dual-attribute continuous monitoring of cell proliferation/cytotoxicity. Am Biotechnol Lab 11: 48-50, 1993.
    • (1993) Am Biotechnol Lab , vol.11 , pp. 48-50
    • Fields, R.D.1    Lancaster, M.V.2
  • 27
    • 0036827601 scopus 로고    scopus 로고
    • Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction
    • Alcorn J, Lu X, Moscow JA and McNamara PJ: Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction. J Pharmacol Exp Ther 303: 487-496, 2002.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 487-496
    • Alcorn, J.1    Lu, X.2    Moscow, J.A.3    McNamara, P.J.4
  • 29
    • 0017692635 scopus 로고
    • Analysis for platinum in biological material by flameless atomic absorption spectrometry
    • Pera MF Jr and Harder HC: Analysis for platinum in biological material by flameless atomic absorption spectrometry. Clin Chem 23: 1245-1249, 1977.
    • (1977) Clin Chem , vol.23 , pp. 1245-1249
    • Pera Jr., M.F.1    Harder, H.C.2
  • 30
    • 0032169105 scopus 로고    scopus 로고
    • Cellular and molecular determinants of cisplatin resistance
    • Perez RP: Cellular and molecular determinants of cisplatin resistance. Eur J Cancer 34: 1535-1542, 1998.
    • (1998) Eur J Cancer , vol.34 , pp. 1535-1542
    • Perez, R.P.1
  • 32
    • 0027233829 scopus 로고
    • Cellular accumulation of the anticancer agent cisplatin: A review
    • Gately DP and Howell SB: Cellular accumulation of the anticancer agent cisplatin: a review. Br J Cancer 67: 1171-1176, 1993.
    • (1993) Br J Cancer , vol.67 , pp. 1171-1176
    • Gately, D.P.1    Howell, S.B.2
  • 34
    • 0027172153 scopus 로고
    • Modulatory effects of tamoxifen and recombinant human alpha-interferon on doxorubicin resistance
    • Kang Y and Perry RR: Modulatory effects of tamoxifen and recombinant human alpha-interferon on doxorubicin resistance. Cancer Res 53: 3040-3045, 1993.
    • (1993) Cancer Res , vol.53 , pp. 3040-3045
    • Kang, Y.1    Perry, R.R.2
  • 35
    • 0027506202 scopus 로고
    • Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs
    • Chaudhary PM and Roninson IB: Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs. J Natl Cancer Inst 85: 632-639, 1993.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 632-639
    • Chaudhary, P.M.1    Roninson, I.B.2
  • 36
    • 0034097234 scopus 로고    scopus 로고
    • Metabolisn of chemical carcinogens
    • Guengerich FP: Metabolisn of chemical carcinogens. Carcinogenesis 21: 345-351, 2000.
    • (2000) Carcinogenesis , vol.21 , pp. 345-351
    • Guengerich, F.P.1
  • 37
    • 0032955185 scopus 로고    scopus 로고
    • Glutathione S-transferases - A review
    • Salinas AE and Wong MG: Glutathione S-transferases - a review. Curr Med Chem 6: 279-309, 1999.
    • (1999) Curr Med Chem , vol.6 , pp. 279-309
    • Salinas, A.E.1    Wong, M.G.2
  • 38
    • 0028862385 scopus 로고
    • Glutathione-S-transferases pi, alpha, mu and mdr1 mRNA expression in normal lymphocytes and chronic lymphocytic leukemia
    • Marie JP, Simonin G, Legrand O, Delmer A, Faussat AM, Lewis AD, Sikic BI and Zittoun R: Glutathione-S-transferases pi, alpha, mu and mdr1 mRNA expression in normal lymphocytes and chronic lymphocytic leukemia. Leukemia 9: 1742-1747, 1995.
    • (1995) Leukemia , vol.9 , pp. 1742-1747
    • Marie, J.P.1    Simonin, G.2    Legrand, O.3    Delmer, A.4    Faussat, A.M.5    Lewis, A.D.6    Sikic, B.I.7    Zittoun, R.8
  • 39
    • 0035080458 scopus 로고    scopus 로고
    • Involvement of the multidrug resistance protein 3 in drug sensitivity and its expression in human glioma
    • Haga S, Hinoshita E, Ikezaki K, Fukui M, Scheffer GL, Uchiumi T and Kuwano M: Involvement of the multidrug resistance protein 3 in drug sensitivity and its expression in human glioma. Jpn J Cancer Res 92: 211-219, 2001.
    • (2001) Jpn J Cancer Res , vol.92 , pp. 211-219
    • Haga, S.1    Hinoshita, E.2    Ikezaki, K.3    Fukui, M.4    Scheffer, G.L.5    Uchiumi, T.6    Kuwano, M.7
  • 40
    • 0033591235 scopus 로고    scopus 로고
    • Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3)
    • Hirohashi T, Suzuki H and Sugiyama Y: Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3). J Biol Chem 274: 15181-15185, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 15181-15185
    • Hirohashi, T.1    Suzuki, H.2    Sugiyama, Y.3
  • 42
    • 6444228081 scopus 로고    scopus 로고
    • Multidrug resistance associated genes MRP1, MRP2 and MRP3 in primary and anthracycline exposed breast cancer
    • Faneyte IF, Kristel PM and van de Vijver MJ: Multidrug resistance associated genes MRP1, MRP2 and MRP3 in primary and anthracycline exposed breast cancer. Anticancer Res 24: 2931-2939, 2004.
    • (2004) Anticancer Res , vol.24 , pp. 2931-2939
    • Faneyte, I.F.1    Kristel, P.M.2    Van De Vijver, M.J.3
  • 44
    • 0042766881 scopus 로고    scopus 로고
    • Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane
    • Rius M, Nies AT, Hummel-Eisenbeiss J, Jedlitschky G and Keppler D: Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Hepatology 38: 374-384, 2003.
    • (2003) Hepatology , vol.38 , pp. 374-384
    • Rius, M.1    Nies, A.T.2    Hummel-Eisenbeiss, J.3    Jedlitschky, G.4    Keppler, D.5
  • 45
    • 0032127347 scopus 로고    scopus 로고
    • Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter
    • Lee K, Belinsky MG, Bell DW, Testa JR and Kruh GD: Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter. Cancer Res 58: 2741-2747, 1998.
    • (1998) Cancer Res , vol.58 , pp. 2741-2747
    • Lee, K.1    Belinsky, M.G.2    Bell, D.W.3    Testa, J.R.4    Kruh, G.D.5
  • 47
    • 33645222292 scopus 로고    scopus 로고
    • Tissue distribution and induction of the rat multidrug resistance-associated proteins 5 and 6
    • Maher JM, Cherrington NJ, Slitt AL and Klaassen CD: Tissue distribution and induction of the rat multidrug resistance-associated proteins 5 and 6. Life Sci 78: 2219-2225, 2006.
    • (2006) Life Sci , vol.78 , pp. 2219-2225
    • Maher, J.M.1    Cherrington, N.J.2    Slitt, A.L.3    Klaassen, C.D.4
  • 48
    • 20044383925 scopus 로고    scopus 로고
    • The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites
    • Pratt S, Shepard RL, Kandasamy RA, Johnston PA, Perry W III and Dantzig AH: The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites. Mol Cancer Ther 4: 855-863, 2005.
    • (2005) Mol Cancer Ther , vol.4 , pp. 855-863
    • Pratt, S.1    Shepard, R.L.2    Kandasamy, R.A.3    Johnston, P.A.4    Perry III, W.5    Dantzig, A.H.6
  • 49
    • 0033551671 scopus 로고    scopus 로고
    • pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells
    • McAleer MA, Breen MA, White NL and Matthews N: pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells. J Biol Chem 274: 23541-23548, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 23541-23548
    • McAleer, M.A.1    Breen, M.A.2    White, N.L.3    Matthews, N.4
  • 50
    • 0035210464 scopus 로고    scopus 로고
    • The MRP family and anticancer drug metabolism
    • Suzuki T, Nishio K and Tanabe S: The MRP family and anticancer drug metabolism. Curr Drug Metab 2: 367-377, 2001.
    • (2001) Curr Drug Metab , vol.2 , pp. 367-377
    • Suzuki, T.1    Nishio, K.2    Tanabe, S.3
  • 51
    • 0035889601 scopus 로고    scopus 로고
    • Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma
    • Nies AT, Konig J, Cui Y, Brom M, Spring H and Keppler D: Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma. Int J Cancer 94: 492-499, 2001.
    • (2001) Int J Cancer , vol.94 , pp. 492-499
    • Nies, A.T.1    Konig, J.2    Cui, Y.3    Brom, M.4    Spring, H.5    Keppler, D.6
  • 53
    • 26244435620 scopus 로고    scopus 로고
    • Herbal medicines for liver diseases
    • Dhiman RK and Chawla YK: Herbal medicines for liver diseases. Dig Dis Sci 50: 1807-1812, 2005.
    • (2005) Dig Dis Sci , vol.50 , pp. 1807-1812
    • Dhiman, R.K.1    Chawla, Y.K.2
  • 54
    • 0037613131 scopus 로고    scopus 로고
    • The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: Probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites
    • Horikawa M, Kato Y, Tyson CA and Sugiyama Y: The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites. Drug Metab Pharmacokinet 17: 23-33, 2002.
    • (2002) Drug Metab Pharmacokinet , vol.17 , pp. 23-33
    • Horikawa, M.1    Kato, Y.2    Tyson, C.A.3    Sugiyama, Y.4
  • 55
    • 0141860843 scopus 로고    scopus 로고
    • Mechanisms of action of interferon and nucleoside analogues
    • Thomas H, Foster G and Platis D: Mechanisms of action of interferon and nucleoside analogues. J Hepatol 39: S93-S98, 2003.
    • (2003) J Hepatol , vol.39
    • Thomas, H.1    Foster, G.2    Platis, D.3
  • 56
    • 0037223033 scopus 로고    scopus 로고
    • Management of chronic hepatitis B
    • Conjeevaram HS and Lok AS: Management of chronic hepatitis B. J Hepatol 38 (suppl 1): S90-S103, 2003.
    • (2003) J Hepatol , vol.38 , Issue.SUPPL. 1
    • Conjeevaram, H.S.1    Lok, A.S.2
  • 57
    • 0037308133 scopus 로고    scopus 로고
    • Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival
    • Llovet JM and Bruix J: Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Hepatology 37: 429-442, 2003.
    • (2003) Hepatology , vol.37 , pp. 429-442
    • Llovet, J.M.1    Bruix, J.2


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