Cisplatin-induced chemoresistance in colon cancer cells involves FXR-dependent and FXR-independent up-regulation of ABC proteins

Molecular Pharmaceutics

Volumn 9, Issue 9, 2012, Pages 2565-2576

  Herraez, Elisa ^a   Gonzalez Sanchez, Ester ^a   Vaquero, Javier ^a   Romero, Marta R ^a,b   Serrano, Maria A ^a,b   Marin, Jose J G ^a,b   Briz, Oscar ^a,b  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

ABC proteins; antitumor drugs; cancer; colon; promoter

Indexed keywords

3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; BREAST CANCER RESISTANCE PROTEIN; CCAAT ENHANCER BINDING PROTEIN BETA; CISPLATIN; FIBROBLAST GROWTH FACTOR 19; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HEPATOCYTE NUCLEAR FACTOR 3BETA; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MULTIDRUG RESISTANCE PROTEIN 2; PROTEIN TYROSINE PHOSPHATASE SHP; SCLEROSTIN;

ARTICLE; CANCER CELL; CANCER RESISTANCE; CELL STRAIN CACO 2; COLON CANCER; CONTROLLED STUDY; DRUG EXPOSURE; GENE DELETION; HUMAN; HUMAN CELL; MOLECULAR CLONING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; UPREGULATION;

ATP-BINDING CASSETTE TRANSPORTERS; CACO-2 CELLS; CELL LINE, TUMOR; CISPLATIN; COLONIC NEOPLASMS; DNA-BINDING PROTEINS; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION; GENES, REPORTER; HEP G2 CELLS; HUMANS; MICROFILAMENT PROTEINS; NEOPLASM PROTEINS; PROMOTER REGIONS, GENETIC; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION; UP-REGULATION;

EID: 84865979848     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300178a     Document Type: Article

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