Mitogen-activated protein kinases and protein phosphatase 5 mediate glucocorticoid-induced cytotoxicity in pancreatic islets and β-cells

Molecular and Cellular Endocrinology

Volumn 383, Issue 1-2, 2014, Pages 126-136

  Fransson, Liselotte ^a   Rosengren, Victoria ^a   Saha, Titu Kumar ^a   Grankvist, Nina ^a,d   Islam, Tohidul ^a   Honkanen, Richard E ^a,b   Sjöholm, Åke ^b,c   Ortsäter, Henrik ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Södertälje University   (Sweden)

^c UNIVERSITY OF SOUTH ALABAMA   (United States)

^d BURNHAM INSTITUTE   (United States)

Author keywords

Apoptosis; Glucocorticoids; JNK; P38 MAPK; Pancreatic islet; Protein phosphatase 5

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; DEXAMETHASONE; MIFEPRISTONE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 5; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ISOLATION; CELL PROTECTION; CELLULAR DISTRIBUTION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; ENZYME ACTIVATION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

APOPTOSIS; GLUCOCORTICOIDS; JNK; P38 MAPK; PANCREATIC ISLET; PROTEIN PHOSPHATASE 5;

ANIMALS; APOPTOSIS; CASPASE 3; DEXAMETHASONE; DNA FRAGMENTATION; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; INSULIN-SECRETING CELLS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NUCLEAR PROTEINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL;

EID: 84891639991     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2013.12.010     Document Type: Article

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