Prednisolone-induced beta cell dysfunction is associated with impaired endoplasmic reticulum homeostasis in INS-1E cells

Cellular Signalling

Volumn 23, Issue 11, 2011, Pages 1708-1715

  Linssen, Margot M L ^a   van Raalte, Daniel H ^b   Toonen, Erik J M ^c   Alkema, Wynand ^c   van der Zon, Gerard C ^a   Dokter, Wim H ^c   Diamant, Michaela ^b   Guigas, Bruno ^a   Ouwens, D Margriet ^a,d  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c NV ORGANON   (Netherlands)

^d LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

Author keywords

Apoptosis; Beta cells; ER stress; Glucocorticoids; Insulin; Prednisolone

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; CALPAIN 10; CASPASE 3; GLUCOCORTICOID RECEPTOR; GLUCOSE; INITIATION FACTOR 2ALPHA; INSULIN; MIFEPRISTONE; PREDNISOLONE; PROTEIN IRE1; TRANSCRIPTION FACTOR PDX 1; X BOX BINDING PROTEIN 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL LEVEL; ENDOPLASMIC RETICULUM STRESS; ENZYME PHOSPHORYLATION; HOMEOSTASIS; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET DISEASE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

ACTIVATING TRANSCRIPTION FACTOR 6; ANIMALS; APOPTOSIS; CALPAIN; CELL LINE; DIABETES MELLITUS; EIF-2 KINASE; ENDOPLASMIC RETICULUM; EUKARYOTIC INITIATION FACTOR-2; GENE EXPRESSION REGULATION; GLUCOSE; HOMEODOMAIN PROTEINS; HOMEOSTASIS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MEMBRANE PROTEINS; MIFEPRISTONE; PHOSPHORYLATION; PREDNISOLONE; PROTEIN-SERINE-THREONINE KINASES; RATS; RECEPTORS, GLUCOCORTICOID; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; UNFOLDED PROTEIN RESPONSE;

EID: 80051468764     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2011.06.002     Document Type: Article

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