Understanding the role of cross-arm binding efficiency in the activity of monoclonal and multispecific therapeutic antibodies

Methods

Volumn 65, Issue 1, 2014, Pages 95-104

  Harms, Brian D ^a   Kearns, Jeffrey D ^a   Iadevaia, Sergio ^a   Lugovskoy, Alexey A ^a  

^a MERRIMACK PHARMACEUTICALS   (United States)

Author keywords

Avidity; Bispecific antibody; Computational modeling; Cross arm binding; Immunoglobulin; Multispecific antibodies

Indexed keywords

BISPECIFIC ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR 2; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; MULTISPECIFIC ANTIBODY; UNCLASSIFIED DRUG;

ANALYTICAL PARAMETERS; ANTIBODY ENGINEERING; ANTIGEN BINDING; ANTIGEN EXPRESSION; ARTICLE; CROSS ARM BINDING EFFICIENCY; GENE AMPLIFICATION; GENE OVEREXPRESSION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AVIDITY; BISPECIFIC ANTIBODY; COMPUTATIONAL MODELING; CROSS-ARM BINDING; DSIGG; DUAL-SPECIFIC IGG; HER2; HER3; HEREGULIN; HRG; HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2; HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 3; IGF-1; IGF-1R; IMMUNOGLOBULIN; INSULIN-LIKE GROWTH FACTOR-1; INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR; MULTISPECIFIC ANTIBODIES; PAKT; PHOSPHORYLATED AKT;

ANIMALS; ANTIBODIES, BISPECIFIC; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; CELL LINE; HUMANS; IMMUNOGLOBULIN G; INHIBITORY CONCENTRATION 50; PROTEIN BINDING; PROTEIN ENGINEERING; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, ERBB-2; RECEPTOR, ERBB-3; RECEPTOR, IGF TYPE 1;

EID: 84891629657     PISSN: 10462023     EISSN: 10959130     Source Type: Journal    
DOI: 10.1016/j.ymeth.2013.07.017     Document Type: Article

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