Small molecule inhibitors of anthrax lethal factor toxin

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 1, 2014, Pages 419-434

  Williams, John D ^a   Khan, Atiyya R ^a   Cardinale, Steven C ^a   Butler, Michelle M ^a   Bowlin, Terry L ^a   Peet, Norton P ^a  

^a MICROBIOTIX INC   (United States)

Author keywords

Anthrax; Bacillus anthracis; Botulinum neurotoxin A; Desymmetrized; Hybrid compound; Lethal factor; Light chain; Matrix metalloprotease; Quinoline; Zinc metalloprotease

Indexed keywords

ANTHRAX TOXIN; BACILLUS ANTHRACIS LETHAL FACTOR; BOTULINUM TOXIN A; GELATINASE B; INTERSTITIAL COLLAGENASE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 2 (BENZO[D][1,3]DIOXOL 5 YL)ACETAMIDE TRIFLUOROACETATE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 2 [(4 BENZYLOXY)PHENOXY]ACETAMIDE TRIFLUOROACETATE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 2 PHENYLACETAMIDE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 3 (2 METHOXYPHENYL)PROPIONAMIDE TRIFLUOROACETATE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 3 (2,5 DIMETHOXYPHENYL)PROPIONAMIDE 4 TOLUENESULFONATE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 3 (3 METHOXYPHENYL)PROPIONAMIDE TRIFLUOROACETATE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 3 (4 DIMETHYLAMINOPHENYL)BENZAMIDE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 3 (4 METHOXYPHENYL)PROPIONAMIDE 4 TOLUENESULFONATE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 3 (DIMETHYLAMINO)BENZAMIDE TRIFLUOROACETATE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 3 BENZOYLBENZAMIDE TRIFLUOROACETATE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 3 PHENYLPROPIONAMIDE TRIFLUOROACETATE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 4 (1 MORPHOLINO)BENZAMIDE TRIFLUOROACETATE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 4 (PYRIDIN 3 YL)BENZAMIDE TRIFLUOROACETATE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 4 (QUINOLINE 6 YL)BENZAMIDE TRIFLUOROACETATE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 4 METHOXYCINAMAMIDE TRIFLUOROACETATE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 4 PHENOXYBENZAMIDE TRIFLUOROACETATE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 5 METHOXYINDOLE 2 CARBOXAMIDE TRIFLUOROACETATE; N (4 AMINO 2 METHYLQUINOLIN 6 YL)BENZOFURAN 2 CARBOXAMIDE TRIFLUOROACETATE; N (4 AMINO 2 METHYLQUINOLIN 6 YL)BIPHENYL 4 CARBOXAMIDE TRIFLUOROACETATE; N (4 AMINO 2 METHYLQUINOLIN 6 YL)FURAN 2 CARBOXAMIDE TRIFLUOROACETATE; N (4 AMINO 2 METHYLQUINOLIN 6 YL)ISOQUINOLINE 3 CARBOXAMIDE TRIFLUOROACETATE; N (4 AMINO 2 METHYLQUINOLIN 6 YL)QUINOLINE 2 CARBOXAMIDE TRIFLUOROACETATE; N (4 AMINO 6 METHYLQUINOLIN 6 YL)NICOTINAMIDE TRIFLUOROACETATE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BACILLUS ANTHRACIS; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

BACILLUS ANTHRACIS;

ANTHRAX; BACILLUS ANTHRACIS; BOTULINUM NEUROTOXIN A; DESYMMETRIZED; HYBRID COMPOUND; LETHAL FACTOR; LIGHT CHAIN; MATRIX METALLOPROTEASE; QUINOLINE; ZINC METALLOPROTEASE;

ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACTERIAL TOXINS; HUMANS; MODELS, MOLECULAR;

EID: 84891496899     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.11.009     Document Type: Article

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