The metalloproteolytic activity of the anthrax lethal factor is substrate-inhibited

Journal of Biological Chemistry

Volumn 278, Issue 41, 2003, Pages 40075-40078

  Tonello, Fiorella ^a   Ascenzi, Paolo ^b   Montecucco, Cesare ^a,c  

^a CNR   (Italy)

^b ROMA TRE UNIVERSITY   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHROMOGENICS; PH EFFECTS; PROTEINS; REACTION KINETICS;

PROTEOLYTIC ACTIVITIES;

BIOCHEMISTRY;

METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEINASE; ZINC;

AMINO TERMINAL SEQUENCE; ANTHRAX; ARTICLE; CYTOSOL; ENZYME BINDING; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; GENE ACTIVITY; LETHAL GENE; NONHUMAN; PH; PRIORITY JOURNAL; TEMPERATURE DEPENDENCE;

AMINO ACID SEQUENCE; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACTERIAL TOXINS; BINDING SITES; CHROMOGENIC COMPOUNDS; HYDROLYSIS; KINETICS; METALLOPROTEASES; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEASE INHIBITORS; SUBSTRATE SPECIFICITY;

ANTHRAX; POSIBACTERIA;

EID: 0141994729     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M306466200     Document Type: Article

References (34)

1. Mock, M., and Mignot, T. (2003) Cell. Microbiol. 5, 15-23
2. Ascenzi, P., Visca, P., Ippolito, G., Spallarossa, A., Bolognesi, M., and Montecucco, C. (2002) FEBS Lett. 531, 384-388
3. Lacy, D. B., and Collier, R. J. (2002) Curr. Top. Microbiol. Immunol. 271, 61-85
4. Gladston, G. P. (1946) Br. J. Exp. Pathol. 27, 349-418
5. Friedlander, A. M., Welkos, S. M., and Ivins, B. E. (2002) Curr. Top. Microbiol. Immunol. 271, 33-60
6. Bradley, K. A., Mogridge, J., Mourez, M., Collier, R. J., and Young, J. A. (2001) Nature 414, 225-229
7. Liu, S., and Leppla, S. H. (2003) J. Biol. Chem. 278, 5227-5234
8. Scobie, H. M., Rainey, G. J., Bradley, K. A., and Young, J. A. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 5170-5174
9. Abrami, L., Liu, S., Cosson, P., Leppla, S. H., and van der Goot, F. G. (2003) J. Cell Biol. 160, 321-328
10. Miller, C. J., Elliott, J. L., and Collier, R. J. (1999) Biochemistry 38, 10432-10441
11. Menard, A., Papini, E., Mock, M., and Montecucco, C. (1996) Biochem. J. 320, 687-691
12. Leppla, S. H., Arora, N., and Varughese, M. (1999) J. Appl. Microbiol. 87, 284
13. Duesbery, N. S., Webb, C. P., Leppla, S. H., Gordon, V. M., Klimpel, K. R., Copeland, T. D., Ahn, N. G., Oskarsson, M. K., Fukasawa, K., Paull, K. D., and Vande Woude, G. F. (1998) Science 280, 734-737
14. Vitale, G., Pellizzari, R., Recchi, C., Napolitani, G., Mock, M., and Montecucco, C. (1998) Biochem. Biophys. Res. Commun. 248, 706-711
15. Vitale, G., Bernardi, L., Napolitani, G., Mock, M., and Montecucco, C. (2000) Biochem. J. 352, 739-745
16. Chopra, A. P., Boone, S. A., Liang, X., and Duesbery, N. S. (2003) J. Biol. Chem. 278, 9402-9406
17. Pannifer, A. D., Wong, T. Y., Schwarzenbacher, R., Renatus, M., Petosa, C., Bienkowska, J., Lacy, D. B., Collier, R. J., Park, S., Leppla, S. H., Hanna, P., and Liddington, R. C. (2001) Nature 414, 229-233
18. Tonello, F., Seveso, M., Marin, O., Mock, M., and Montecucco, C. (2002) Nature 418, 386
19. Friedlander, A. M. (1986) J. Biol. Chem. 261, 7123-7126
20. Dixon, T. C., Meselson, M., Guillemin, J., and Hanna, P. C. (1999) N. Engl. J. Med. 341, 815-826
21. Klimpel, K. R., Arora, N., and Leppla, S. H. (1994) Mol. Microbiol. 6, 1093-1100
22. Fields, G. B, and Noble, R. L. (1990) Int. J. Pept. Protein Res. 35, 161-214
23. Johansson, A., Akerblom, E., Ersmark, K., Lindeberg, G., and Hallberg, A. (2000) J. Comb. Chem. 2, 496-507
24. DiBella, E. E., and Scheraga, H. A. (1996) Biochemistry 35, 4427-4433
25. Zimmerman M., and Patel, G. (1976) Anal. Biochem. 70, 258-262
26. Cleland, W. W. (1979) Methods Enzymol. 63, 500-513
27. Salvati, L., Mattu, M., Polticelli, F., Tiberi, F., Gradoni, L., Venturini, G., Bolognesi, M., and Ascenzi, P. (2001) Eur. J. Biochem. 268, 3253-3258
28. Morgan, G., and Fruton, J. S. (1978) Biochemistry 17, 3562-3568
29. Johnson, G. L., and Lapadat, R. (2002) Science 298, 1911-1912
30. Gallo, K. A., and Johnson, G. L. (2002) Nat. Rev. Mol. Cell Biol. 3, 663-672
31. Hanna, P. C., Kruskal, B. A., Ezekowitz, R. A., Bloom, B. R., and Collier, R. J. (1994) Mol. Med. (Camb.) 1, 7-18
32. Park, J. M., Greten, F. R., Li, Z. W., and Karin, M. (2002) Science 297, 2048-2051
33. Kim, S. O., Jing, Q., Hoebe, K., Beutler, B., Duesbery, N. S., and Han, J. (2003) J. Biol. Chem. 278, 7413-7421
34. Pellizzari, R., Guidi-Rontani, C., Vitale, G., Mock M., and Montecucco, C. (1999) FEBS Lett. 462, 199-204