A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues

Journal of the Royal Society Interface

Volumn 10, Issue 85, 2013, Pages

  Werner, Benjamin ^a   Dingli, David ^b   Traulsen, Arne ^a  

^a MAX PLANCK INSTITUTE FOR EVOLUTIONARY BIOLOGY   (Germany)

^b MAYO CLINIC   (United States)

Author keywords

Cancer; Clonal extinction and diversity; Mathematical modelling

Indexed keywords

CELL PROLIFERATION; CLONE CELLS; CYTOLOGY; DISEASES; DYNAMICS; HISTOLOGY; MATHEMATICAL MODELS;

ACUTE LYMPHOBLASTIC LEUKAEMIAS; BIOLOGICAL CONSTRAINTS; CANCER; CLONAL EXTINCTION AND DIVERSITY; DETERMINISTIC MODELS; MULTIPLE MUTATIONS; REPRODUCTIVE CAPACITY; WHOLE GENOME SEQUENCING;

TISSUE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CANCER GENETICS; CELL CLONE; CELL PROLIFERATION; CELL SIZE; CHILDHOOD LEUKEMIA; MULTIPLE MUTATION; MUTATION; SIMULATION; BIOLOGICAL MODEL; CELL AGING; GENETIC ASSOCIATION; GENETICS; HUMAN; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; PATHOPHYSIOLOGY; TELOMERE SHORTENING; CLONAL EXTINCTION AND DIVERSITY; MATHEMATICAL MODELLING; NEOPLASM;

CELL AGING; CELL PROLIFERATION; DNA MUTATIONAL ANALYSIS; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MODELS, BIOLOGICAL; MUTATION; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; TELOMERE SHORTENING;

CANCER; CLONAL EXTINCTION AND DIVERSITY; MATHEMATICAL MODELLING;

EID: 84891379120     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2013.0349     Document Type: Article

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