Dynamics of mutant cells in hierarchical organized tissues

PLoS Computational Biology

Volumn 7, Issue 12, 2011, Pages

  Werner, Benjamin ^a   Dingli, David ^b   Lenaerts, Tom ^c,d   Pacheco, Jorge M ^e,f   Traulsen, Arne ^a  

^a MAX PLANCK INSTITUTE FOR EVOLUTIONARY BIOLOGY   (Germany)

^b MAYO CLINIC   (United States)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^d VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^e UNIVERSITY OF MINHO   (Portugal)

^f Universidade de Lisboa   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROLIFERATION; DYNAMICS; HISTOLOGY; ORDINARY DIFFERENTIAL EQUATIONS; STOCHASTIC MODELS; STOCHASTIC SYSTEMS; TISSUE;

CELL DIFFERENTIATION; CELL DIVISIONS; CELL DRIVEN; CELL/B.E; ERROR PRONES; MULTICELLULAR ORGANISMS; MUTANT CELLS; RENEWAL PROCESS; STEM-CELL; TISSUE STRUCTURE;

STEM CELLS;

ARTICLE; CELL COUNT; CELL DEATH; CELL DIFFERENTIATION; CELL MUTANT; CELL PROLIFERATION; COMPARTMENT MODEL; CONTROLLED STUDY; CRYPT CELL; EPIDERMIS; HEMATOPOIESIS; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; POPULATION STRUCTURE; STEM CELL; STOCHASTIC MODEL; TISSUE STRUCTURE; BIOLOGICAL MODEL; CELL GROWTH; COLON; COMPUTER SIMULATION; CYTOLOGY; HUMAN; MUTATION; PHYSIOLOGY; STATISTICS;

CELL DIFFERENTIATION; CELL GROWTH PROCESSES; COLON; COMPUTER SIMULATION; EPIDERMIS; HEMATOPOIESIS; HUMANS; MODELS, BIOLOGICAL; MUTATION; STEM CELLS; STOCHASTIC PROCESSES;

EID: 84055179139     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002290     Document Type: Article

References (45)

1. Dingli D, Traulsen A, Pacheco JM, (2007) Compartmental architecture and dynamics of hematopoiesis. PLoS One 4: e345.
2. Nowak MA, (2006) Evolutionary Dynamics Cambridge, MA Harvard University Press.
3. Fuchs E, (2008) Skin stem cells: rising to the surface. J Cell Biol 180: 273-284.
4. Tumbar T, Guasch G, Greco V, Blanpain C, Lowry WE, et al. (2004) Defining the epithelial stem cell niche in skin. Science 303: 359-363.
5. Potten CS, Gandara R, Mahida YR, Loeffler M, Wright NA, (2009) The stem cells of small intestinal crypts: where are they? Cell Prolif 42: 731-750.
6. McCulloch JE, Till JE, (2005) Perspectives on the properties of stem cells. Nature Medicine 11: 1026-1028.
7. Michor F, Nowak MA, Frank SA, Iwasa Y, (2003) Stochastic elimination of cancer cells. Proc Biol Sci 270: 2017-2024.
8. Komarova N, Cheng P, (2006) Epithelial tissue architecture protects against cancer. Math Biosci 200: 90-117.
9. Johnston MD, Edwards CM, Bodmer WF, Maini PK, Chapman SJ, (2007) Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer. Proc Natl Acad Sci U S A 104: 4008-4013.
10. Michor F, Hughes TP, Iwasa Y, Branford S, Shah NP, et al. (2005) Dynamics of chronic myeloid leukaemia. Nature 435: 1267-1270.
11. Wodarz D, Komarova N, (2005) Computational Biology of Cancer: Lecture notes and mathematical modeling World Scientific Publishing.
12. Abkowitz J, Catlin S, McCallie M, Guttorp P, (2002) Evidence that the number of hematopoietic stem cells per animal is conserved in mammals. Blood 100: 2665-2667.
13. Dingli D, Traulsen A, Michor F, (2007) (a)symmetric stem cell replication and cancer. PLoS Comput Biol 3: e53.
14. Lenaerts T, Pacheco JM, Traulsen A, Dingli D, (2010) Tyrosine kinase inhibitor therapy can cure chronic myeloid leukemia without hitting leukemic stem cells. Haematologica 95: 900-907.
15. Jackson TL, (2003) Intracellular accumulation and mechanism of action of doxorubicin in a spatiotemporal tumor model. J Theor Biol 220: 201-213.
16. Nowak MA, Michor F, Komarova NL, Iwasa Y, (2004) Evolutionary dynamics of tumor suppressor gene inactivation. Proc Natl Acad Sci U S A 101: 10635-10638.
17. Johnston MD, Edwards CM, Bodmer WF, Maini PK, Chapman SJ, (2007) Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer. Proc Natl Acad Sci U S A 104: 4008-4013.
18. Marciniak-Czochra A, Stiehl T, Ho AD, Jäger W, Wagner W, (2009) Modeling of asymmetric cell division in hematopoietic stem cells-regulation of self-renewal is essential for efficient repopulation. Stem Cells Dev 18: 377-385.
19. Gerlee P, Anderson ARA, (2010) Diffusion-limited tumour growth: simulations and analysis. Math Biosci Eng 7: 385-400.
20. Kampen NGv, (1997) Stochastic Processes in Physics and Chemistry. 2nd edition Amsterdam Elsevier.
21. Abkowitz JL, Catlin SN, Guttorp P, (1996) Evidence that hematopoiesis may be a stochastic process in vivo. Nat Med 2: 190-197.
22. Gillespie D, (1976) A general method for numerically simulating the stochastic time evolution of coupled chemical reactions. J Comput Phys 22: 403-434.
23. Dingli D, Pacheco JM, Traulsen A, (2008) Multiple mutant clones in blood rarely coexist. Phys Rev E 77: 021915.
24. Brummendorf TH, Dragowska W, Zijlmans J, Thornbury G, Lansdorp PM, (1998) Asymmetric cell divisions sustain long-term hematopoiesis from single-sorted human fetal liver cells. J Exp Med 188: 1117-1124.
25. Traulsen A, Pacheco JM, Luzzatto L, Dingli D, (2010) Somatic mutations and the hierarchy of hematopoiesis. Bioessays 32: 1003-1008.
26. Dingli D, Traulsen A, Pacheco JM, (2007) Stochastic dynamics of hematopoietic tumor stem cells. Cell Cycle 6: e2-e6.
27. Araten DJ, Nafa K, Pakdeesuwan K, Luzzatto L, (1999) Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals. Proc Nat Acad Sci U S A 96: 5209-5214.
28. Hillmen P, Bessler M, Mason PJ, Watkins WM, Luzzatto L, (1993) Specific defect in nacetylglucosamine incorporation in the biosynthesis of the glycosylphosphatidylinositol anchor in cloned cell lines from patients with paroxysmal nocturnal hemoglobinuria. Proc Natl Acad Sci U S A 90: 5272-5276.
29. Longo L, Bessler M, Beris P, Swirsky D, Luzzatto L, (1994) Myelodysplasia in a patient with preexisting paroxysmal nocturnal haemoglobinuria: a clonal disease originating from within a clonal disease. Br J Haematol 87: 401-403.
30. Luzzatto L, Bessler M, Rotoli B, (1997) Somatic mutations in paroxysmal nocturnal hemoglobinuria: a blessing in disguise? Cell 88: 1-4.
31. Dingli D, Luzzatto L, Pacheco JM, (2008) Neutral evolution in paroxysmal nocturnal hemoglobinuria. Proc Natl Acad Sci U S A 104: 18496-18500.
32. England SJ, McGrath KE, Frame JM, Palis J, (2011) Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus. Blood 117: 2708-2717.
33. Vaziri H, Dragowska W, Allsopp RC, Thomas TE, Harley CB, et al. (1994) Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci U S A 91: 9857-9860.
34. Dingli D, Traulsen A, Pacheco JM, (2008) Dynamics of haemopoiesis across mammals. Proc Biol Sci 275: 2389-2392.
35. Araten DJ, Bessler M, McKenzie S, Castro-Malaspina H, Childs BH, et al. (2002) Dynamics of hematopoiesis in paroxysmal nocturnal hemoglobinuria (pnh): no evidence for intrinsic growth advantage of pnh clones. Leukemia 16: 2243-2248.
36. Maciejewski JP, Sloand EM, Sato T, Anderson S, Young NS, (1997) Impaired hematopoiesis in paroxysmal nocturnal hemoglobinuria/aplastic anemia is not associated with a selective proliferative defect in the glycosylphosphatidylinositol-anchored protein-deficient clone. Blood 89: 1173-1181.
37. Dunn DE, Yu J, Nagarajan S, Devetten M, Weichold FF, et al. (1996) A knock-out model of paroxysmal nocturnal hemoglobinuria: Pig-a(-) hematopoiesis is reconstituted following intercellular transfer of gpi-anchored proteins. Proc Natl Acad Sci U S A 93: 7938-7943.
38. Traulsen A, Pacheco JM, Dingli D, (2007) On the origin of multiple mutant clones in paroxysmal nocturnal globinuria. Stem Cells 25: 3081-3084.
39. Nielsen C, Birgens HS, Nordestgaard BG, Kjær L, Bojesen SE, (2011) The jak2 v617f somatic mutation, mortality and cancer risk in the general population. Haematologica 96: 450-453.
40. Xue H, Yan J, Ildstad S, (2007) Xenotransplantation: a step closer to reality? Blood 110: 3815-3815.
41. Daley GQ, Van Etten RA, Baltimore D, (1990) Induction of chronic myelogenous leukemia in mice by the p210bcr/abl gene of the philadelphia chromosome. Science 247: 824-830.
42. Bose S, Deininger M, Gora-Tybor J, Goldman JM, Melo JV, (1998) The presence of typical and atypical bcr-abl fusion genes in leukocytes of normal individuals: biologic signifiance and implications for the assessment of minimal residual disease. Blood 92: 3362-3367.
43. Krivtsov AV, Twomey D, Feng Z, Stubbs MC, Wang Y, et al. (2006) Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature 442: 818-822.
44. Huntly BJ, Shigematsu H, Deguchi K, Lee BH, Mizuno S, et al. (2004) Moz-tif2, but not bcr-abl, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. Cancer Cell 6: 587-596.
45. Guibal FC, Alberich-Jorda M, Hirai H, Ebralidze A, Levantini E, et al. (2009) Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia. Blood 114: 5415-5425.