Initiation of colorectal cancer: Where do the two hits hit?

Cell Cycle

Volumn 3, Issue 12, 2004, Pages 1558-1565

  Komarova, Natalia L ^a,b   Wang, Liming ^a  

^a RUTGERS UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

APC; Colon crypt; Differentiated cells; Mathematical modeling; Mutations; Stem cells

Indexed keywords

ADENOMATOUS POLYPOSIS COLI GENE; ARTICLE; CARCINOGENESIS; CELL IMMORTALIZATION; COLON POLYPOSIS; COLORECTAL CANCER; GENE; GENE MUTATION; MATHEMATICAL MODEL; STEM CELL;

EID: 17144366931     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.3.12.1186     Document Type: Article

References (42)

1. Kinzler KW, Vogelstein, B. The Genetic Basis of Human Cancer (McGraw-Hill, Toronto 1998).
2. The adenomatous polyposis coli (APC)tumor suppressor. Biochim Biophys Acta. 1997; 1332(3):F127-47.
3. Katoh M. WNT2 and human gastrointestinal cancer. Int J Mol Med. 2003; 12:811-6.
4. Polakis P. The oncogenic activation of beta-catenin. Curr Opin Genet Dev 1999; 9:15-21.
5. Behrens J, Jerchow BA, Wurtele M, Grimm J, Asbrand C, Wirtz R, Kuhl M, Wedlich D, Birchmeier W.Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science 1998; 280:596-9.
6. Potten CS, Loe_er M. Stem cells: attributes, cycles, spirals, pitfalls and uncertainties Lessons for and from the crypt. Development 1990; 110:1001-20.
7. Potten CS, Booth C, Hargreaves D. The small intestine as a model for evaluating adult tissue stem cell drug targets. Cell Prolif 2003; 36:115-29.
8. Vogelstein B, Kinzler, K W. Cancer genes and the pathways they control. Nat Med 2004; 10:789-99.
9. Wong WM, Wright NA. Cell proliferation in gastrointestinal mucosa. J Clin Pathol 1999; 52:321-33.
10. Bach SP, Renehan AG, Potten CS. Stem cells: the intestinal stem cell as a paradigm. Carcinogenesis 2000; 21:469-76.
11. Fuchs E, Segre JA. Stem cells: a new lease on life. Cell 2000; 100:143-55.
12. Winton, JD. Stem cells in the epithelium of the small intestine andcolon, in Stem Cell Biology, eds Marshak DR, Gardner RL, Gottlieb D (Spring Harbor Laboratory Press, Cold Spring Habor 2001); pp. 515-36.
13. Kim KM, Shibata D. Methylation reveals a niche: stem cell succession in human colon crypts. Oncogene 2002; 21:5441-9.
14. Cairns J Somatic stem cells and the kinetics of mutagenesis and carcinogenesis. Proc Natil Acad Sci USA 2002; 99:10567-70.
15. Wright NA, Poulsom R. Top down or bottom up? Competing management structures in the morphogenesis of colorectal neoplasms. Gut 2002; 51:306-8.
16. Preston SL, Wong WM, Chan AO, Poulsom R, Jeffery R, Goodkd RA, Mandir N, Elia G, Novelli M, Bodmer WF, etal. Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission. Cancer Res 2003; 63:3819-25.
17. Wong WM, Mandir N, Goodlad RA, Wong BC, Garcia SB, Lam SK Wright NA. Histogenesis of human colorectal adenomas and hyperplastic polyps: the role of cell proliferation and crypt fission. Gut 2002; 50:212-7.
18. Shih IM, Wang TL, Traverso G, Romans K, Hamilton SR, Ben-Sasson S, Kinzler KW, Vogelstein B. Top-down morphogenesis of colorectal tumors. Proc Natil Acad Sci USA 2001; 98:2640-5.
19. Fodde R, Smits R, Clevers H. APC, signal transduction and genetic instability in colorectal cancer. Nat Rev Cancer 2001; 1:55-67.
20. Lamprecht SA, Lipkin M. Migrating colonic crypt epithelial cells: primary targets for transformation. Carcinogenesis 2002; 23:1777-80.
21. van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A, van der Horn K, Batlle E, Coudreuse D, Haramis AP, et al. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 2002; 111:241-50.
22. Grimwade D, Enver T. Acute promyelocytic leukemia: where does it stem from? Leukemia 2004; 18:375-84.
23. Turhan AG, Lemoine FM, Debert C, Bonnet ML, Baillon C, Picard F, Macintyre EA, Varet B. Highly purified primitive hematopoietic stem cells are PML-RARA negative and generate nonclonal progenitors in acute promyelocytic leukemia. Blood 1995; 85:2154-2161.
24. Brown D, Kogan S, Lagasse E, Weissman I, Alcalay M, Pelicci PG, et al. Free in PMC A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. Proc Natl Acad Sci USA 1997; 94:2551-6.
25. Grisolano JL, Wesselschmidt RL, Pelicci PG Ley TJ. Altered myeloid development and acute leukemia in transgenic mice expressing PMLRAR alpha under control of cathepsin G regulatory sequences. Blood 1997; 89:376-87.
26. He LZ, Tribioli C, Rivi R, Peruzzi D, Pelicci PG, Soares V et al. Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice Proc Natl Acad Sci USA 1997; 94:5302-7.
27. Westervelt P, Lane AA, Pollock JL, Oldfather K, Holt MS, Zimonjic DB et al. A high penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RAR expression. Blood 2003; 102:1857-65.
28. Westervelt P, Ley TJ. Seed vs soil: The importance of the target cell for transgenic models of human leukemias. Blood 1999; 93:2143-8.
29. Perez-Losada J, Balmain A. Stem-cell chierarchy in skin cancer. Nature Reviews Cancer 2003; 3:434-43.
30. Kirchner T, Muller S, Hattori T, Mukaisyo K, Papadopoulos T, Brabletz T Jung A. Metaplasia, intraepithelial neoplasia and early cancer of the stomach are related to dedi_erentiated epithelial cells defined by cytokeratin-7 expression in gastritis. Virchows Arch 2001; 439:512-22.
31. Macleod K. Tumor suppressor genes. Curr Opin Genet Dev 2000; 10:81-93.
32. Knudson AG. Hereditary cancer: two hits revisited. J Cancer Res Clin Oncol 1996; 122:135-40.
33. Ro S, Rannal B. Methylation patterns and mathematical models reveal dynamics of stem cell turnover in the human colon. Proc Natil Acad Sci USA 2001; 98:10519-21.
34. Yatabe Y, Tavare S, Shibata D. Investigating stem cells in human colon by using methylation patterns. Proc Natil Acad Sci USA 2001; 98:10839-44.
35. Komarova NL, Sengupta A, Nowak MA. Mutation-selection networks of cancer initiation: tumor suppressor genes and chromosomal instability. J Theor Biol 2003; 223:433-50.
36. Albertini RJ, Nicklas JA, O'Neill JP, Robison SH. In vivo somatic mutations in humans: measurement and analysis. Annu Rev Genet 1990; 24:305-26.
37. Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature 1998; 396:643-9.
38. Shih IM, Zhou W, Goodman SN, Lengauer C, Kinzler KW, Vogelstein B. Evidence that genetic instability occurs atan early stage of colorectal tumorigenesis. Cancer Res 2001; 61:818-22.
39. Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in colorectal cancers. Nature 1997; 386:623-7.
40. Moolgavkar SH, Dewanji A, Venzon DJ. A stochastic two-stage model for cancer risk assessment. I. The hazard function and the probability of tumor. Risk Anal 1998; 8:383-92.
41. Nowak MA, Komarova NL, Sengupta A, Jallepalli PY Shih IM, Vogelstein B, Lengauer C. The role of chromosomal instability in tumor initiation. Proc Natil Acad Sci USA 2002; 99:16226-31.
42. Iwasa Y, Michor F, Nowak MA. Stochastic tunnels in evolutionary dynamics. Genetics 2003; 166:1571-9.