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Volumn 30, Issue 2, 2014, Pages 145-149

Melanocortin-4 receptor polymorphism rs17782313: Association with obesity and eating in the absence of hunger in Chilean children

Author keywords

Childhood obesity; Eating behavior; MCR4

Indexed keywords

GENOMIC DNA; MELANOCORTIN 4 RECEPTOR;

EID: 84891157332     PISSN: 08999007     EISSN: 18731244     Source Type: Journal    
DOI: 10.1016/j.nut.2013.05.030     Document Type: Article
Times cited : (27)

References (54)
  • 1
    • 84891160940 scopus 로고    scopus 로고
    • World Health Organization. Population-based prevention strategies for childhood obesity. Report of a WHO forum and technical meeting. Geneva, Switzerland, December 15-17
    • World Health Organization. Population-based prevention strategies for childhood obesity. Report of a WHO forum and technical meeting. Geneva, Switzerland, December 15-17,2009.
    • (2009)
  • 2
    • 84891160519 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention, National Center for Health Statistics. 2000 CDC growth charts: United States. Available at:
    • Centers for Disease Control and Prevention, National Center for Health Statistics. 2000 CDC growth charts: United States. Available at: .2008. http://www.cdc.gov/growthcharts.
    • (2008)
  • 3
    • 84891154671 scopus 로고    scopus 로고
    • Encuesta Nacional de Salud ENS 2009-2010. Ministerio de Salud de Chile.
    • Encuesta Nacional de Salud ENS 2009-2010. Ministerio de Salud de Chile. http://www.minsal.cl.
  • 4
    • 0036463512 scopus 로고    scopus 로고
    • Nutrition transition in Chile: determinants and consequences
    • Albala C., Vio F., Kain J., Uauy R. Nutrition transition in Chile: determinants and consequences. Public Health Nutr 2002, 5:123-128.
    • (2002) Public Health Nutr , vol.5 , pp. 123-128
    • Albala, C.1    Vio, F.2    Kain, J.3    Uauy, R.4
  • 5
    • 16244362019 scopus 로고    scopus 로고
    • Influence of heredity on dietary restraint, disinhibition, and perceived hunger in humans
    • De Castro J.M., Lilenfeld L.R. Influence of heredity on dietary restraint, disinhibition, and perceived hunger in humans. Nutrition 2005, 21:446-455.
    • (2005) Nutrition , vol.21 , pp. 446-455
    • De Castro, J.M.1    Lilenfeld, L.R.2
  • 6
    • 0036807407 scopus 로고    scopus 로고
    • Twins early development study (TEDS): a multivariate, longitudinal genetic investigation of language, cognition and behavior problems in childhood
    • Trouton A., Spinath F.M., Plomin R. Twins early development study (TEDS): a multivariate, longitudinal genetic investigation of language, cognition and behavior problems in childhood. Twin Res 2002, 5:444-448.
    • (2002) Twin Res , vol.5 , pp. 444-448
    • Trouton, A.1    Spinath, F.M.2    Plomin, R.3
  • 7
    • 84875480717 scopus 로고    scopus 로고
    • Genetic predictors of obesity
    • Oxford University Press, New York, F. Hu (Ed.)
    • Hu F. Genetic predictors of obesity. Obesity epidemiology 2008, 437-460. Oxford University Press, New York. F. Hu (Ed.).
    • (2008) Obesity epidemiology , pp. 437-460
    • Hu, F.1
  • 8
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
    • Fan W., Boston B., Kesterson R., Hurby V., Cone R. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 1997, 385:165-168.
    • (1997) Nature , vol.385 , pp. 165-168
    • Fan, W.1    Boston, B.2    Kesterson, R.3    Hurby, V.4    Cone, R.5
  • 9
    • 1842560331 scopus 로고    scopus 로고
    • Cholecystokinin-mediated suppression of feeding involves the brain stem melanocortin system
    • Fan W., Ellacott K.L., Halatchev I.G., Takahashi K., Yu P., Cone R.D. Cholecystokinin-mediated suppression of feeding involves the brain stem melanocortin system. Nat Neurosci 2004, 7:335-336.
    • (2004) Nat Neurosci , vol.7 , pp. 335-336
    • Fan, W.1    Ellacott, K.L.2    Halatchev, I.G.3    Takahashi, K.4    Yu, P.5    Cone, R.D.6
  • 10
    • 70450183813 scopus 로고    scopus 로고
    • Sistema leptina-melanocortinas en la regulación de la ingesta y el peso corporal
    • Santos J.L. Sistema leptina-melanocortinas en la regulación de la ingesta y el peso corporal. Rev Med Chile 2009, 137:1225-1234.
    • (2009) Rev Med Chile , vol.137 , pp. 1225-1234
    • Santos, J.L.1
  • 13
    • 77955409173 scopus 로고    scopus 로고
    • The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology
    • Tao Y.X. The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology. Endocr Rev 2010, 31:506-543.
    • (2010) Endocr Rev , vol.31 , pp. 506-543
    • Tao, Y.X.1
  • 16
    • 14544272858 scopus 로고    scopus 로고
    • Monogenic obesity in humans
    • Farooqi I.S., O'Rahilly S. Monogenic obesity in humans. Annu Rev Med 2005, 56:443-458.
    • (2005) Annu Rev Med , vol.56 , pp. 443-458
    • Farooqi, I.S.1    O'Rahilly, S.2
  • 17
    • 31544447196 scopus 로고    scopus 로고
    • Obesity-associated mutations in the human melanocortin-4 receptor gene
    • MacKenzie R.G. Obesity-associated mutations in the human melanocortin-4 receptor gene. Peptides 2006, 27:395-403.
    • (2006) Peptides , vol.27 , pp. 395-403
    • MacKenzie, R.G.1
  • 18
    • 0033927916 scopus 로고    scopus 로고
    • Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
    • Vaisse C., Clement K., Durand E., Hercberg S., Guy-Grand B., Froguel P. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J Clin Invest 2000, 106:253-262.
    • (2000) J Clin Invest , vol.106 , pp. 253-262
    • Vaisse, C.1    Clement, K.2    Durand, E.3    Hercberg, S.4    Guy-Grand, B.5    Froguel, P.6
  • 19
    • 0037439274 scopus 로고    scopus 로고
    • Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations
    • Lubrano-Berthelier C., Durand E., Dubern B., Shapiro A., Dazin P., Weill J., et al. Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations. Hum Mol Genet 2003, 12:145-153.
    • (2003) Hum Mol Genet , vol.12 , pp. 145-153
    • Lubrano-Berthelier, C.1    Durand, E.2    Dubern, B.3    Shapiro, A.4    Dazin, P.5    Weill, J.6
  • 20
    • 0037927578 scopus 로고    scopus 로고
    • Poor cell surface expression of human melanocortin-4 receptor mutations associated with obesity
    • Nijenhuis W.A., Garner K.M., van Rozen R.J., Adan R.A. Poor cell surface expression of human melanocortin-4 receptor mutations associated with obesity. J Biol Chem 2003, 278:22939-22945.
    • (2003) J Biol Chem , vol.278 , pp. 22939-22945
    • Nijenhuis, W.A.1    Garner, K.M.2    van Rozen, R.J.3    Adan, R.A.4
  • 21
    • 0037341511 scopus 로고    scopus 로고
    • Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms
    • Yeo G.S., Lank E.J., Farooqi I.S., Keogh J., Challis B.G., O'Rahilly S. Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms. Hum Mol Genet 2003, 12:561-574.
    • (2003) Hum Mol Genet , vol.12 , pp. 561-574
    • Yeo, G.S.1    Lank, E.J.2    Farooqi, I.S.3    Keogh, J.4    Challis, B.G.5    O'Rahilly, S.6
  • 22
    • 54949113309 scopus 로고    scopus 로고
    • The common obesity variant nearMC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women
    • Qi L., Kraft P., Hunter D.J., Hu F.B., Randall J.C., Rayner N.W., et al. The common obesity variant nearMC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women. Hum Mol Genet 2008, 17:3502-3508.
    • (2008) Hum Mol Genet , vol.17 , pp. 3502-3508
    • Qi, L.1    Kraft, P.2    Hunter, D.J.3    Hu, F.B.4    Randall, J.C.5    Rayner, N.W.6
  • 23
    • 44349142294 scopus 로고    scopus 로고
    • Common variants near MC4R are associated with fat mass, weight and risk of obesity
    • Loos R.J., Lindgren C.M., Li S., Wheeler E., Zhao J.H., Bingham S.A., et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008, 40:768-775.
    • (2008) Nat Genet , vol.40 , pp. 768-775
    • Loos, R.J.1    Lindgren, C.M.2    Li, S.3    Wheeler, E.4    Zhao, J.H.5    Bingham, S.A.6
  • 25
    • 62349130691 scopus 로고    scopus 로고
    • Common genetic variation near MC4R is associated with eating behaviour patterns in European populations
    • Stutzmann F., Cauchi S., Durand E., Calvacanti-Proença C., Pigeyre M., Hartikainen A.L., et al. Common genetic variation near MC4R is associated with eating behaviour patterns in European populations. Int J Obes 2009, 33:373-378.
    • (2009) Int J Obes , vol.33 , pp. 373-378
    • Stutzmann, F.1    Cauchi, S.2    Durand, E.3    Calvacanti-Proença, C.4    Pigeyre, M.5    Hartikainen, A.L.6
  • 29
    • 0036295270 scopus 로고    scopus 로고
    • Eating in the absence of hunger and overweight in girls from 5 to 7 y of age
    • Fisher J.O., Birch L.L. Eating in the absence of hunger and overweight in girls from 5 to 7 y of age. Am J Clin Nutr 2002, 76:226-231.
    • (2002) Am J Clin Nutr , vol.76 , pp. 226-231
    • Fisher, J.O.1    Birch, L.L.2
  • 30
    • 34547693311 scopus 로고    scopus 로고
    • Metabolic syndrome in childhood predicts adult cardiovascular disease 25 years later: the Princeton Lipid Research Clinics Follow-up Study
    • Morrison J.A., Friedman L.A., Gray-McGuire C. Metabolic syndrome in childhood predicts adult cardiovascular disease 25 years later: the Princeton Lipid Research Clinics Follow-up Study. Pediatrics 2007, 120:340-345.
    • (2007) Pediatrics , vol.120 , pp. 340-345
    • Morrison, J.A.1    Friedman, L.A.2    Gray-McGuire, C.3
  • 32
    • 4243119539 scopus 로고    scopus 로고
    • Binge-eating episodes are not characteristic of carriers ofmelanocortin-4 receptor gene mutations
    • Hebebrand J., Geller F., Dempfle A., Heinzel-Gutenbrunner M., Raab M., Gerber G., et al. Binge-eating episodes are not characteristic of carriers ofmelanocortin-4 receptor gene mutations. Mol Psychiatry 2004, 9:796-800.
    • (2004) Mol Psychiatry , vol.9 , pp. 796-800
    • Hebebrand, J.1    Geller, F.2    Dempfle, A.3    Heinzel-Gutenbrunner, M.4    Raab, M.5    Gerber, G.6
  • 33
    • 59849121365 scopus 로고    scopus 로고
    • Obesity and eating behaviour in a three-generation Chilean family with carriers of the Thr150Ile mutation in the melanocortin-4 receptor gene
    • Santos J.L., Amador P., Valladares M., Albala C., Martínez J.A., Martí A. Obesity and eating behaviour in a three-generation Chilean family with carriers of the Thr150Ile mutation in the melanocortin-4 receptor gene. J Physiol Biochem 2008, 64:205-210.
    • (2008) J Physiol Biochem , vol.64 , pp. 205-210
    • Santos, J.L.1    Amador, P.2    Valladares, M.3    Albala, C.4    Martínez, J.A.5    Martí, A.6
  • 34
    • 75649151727 scopus 로고    scopus 로고
    • Influence of common variants near INSIG2, in FTO, and near MC4R genes on overweight and the metabolic profile in adolescence: the TRAILS (Tracking Adolescents Individual Lives Survey) Study
    • Liem E., Vonk J., Sauer P., van der Steege G., Oosterom E., Stolk R.P., et al. Influence of common variants near INSIG2, in FTO, and near MC4R genes on overweight and the metabolic profile in adolescence: the TRAILS (Tracking Adolescents Individual Lives Survey) Study. Am J Clin Nutr 2010, 91:321-328.
    • (2010) Am J Clin Nutr , vol.91 , pp. 321-328
    • Liem, E.1    Vonk, J.2    Sauer, P.3    van der Steege, G.4    Oosterom, E.5    Stolk, R.P.6
  • 35
    • 78049337953 scopus 로고    scopus 로고
    • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    • Speliotes E.K., Willer C.J., Berndt S.I., Monda K.L., Thorleifsson G., Jackson A.U., et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010, 42:937-950.
    • (2010) Nat Genet , vol.42 , pp. 937-950
    • Speliotes, E.K.1    Willer, C.J.2    Berndt, S.I.3    Monda, K.L.4    Thorleifsson, G.5    Jackson, A.U.6
  • 37
    • 77951110421 scopus 로고    scopus 로고
    • Melanocortin-4 receptor gene variants in Chilean families: association with childhood obesity and eating behavior
    • Valladares M., Domínguez-Vásquez P., Obregón A.M., Weisstaub G., Burrows R., Maiz A., et al. Melanocortin-4 receptor gene variants in Chilean families: association with childhood obesity and eating behavior. Nutr Neurosci 2010, 13:71-78.
    • (2010) Nutr Neurosci , vol.13 , pp. 71-78
    • Valladares, M.1    Domínguez-Vásquez, P.2    Obregón, A.M.3    Weisstaub, G.4    Burrows, R.5    Maiz, A.6
  • 38
    • 67649744249 scopus 로고    scopus 로고
    • Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestry
    • Grant S.F.A., Bradfield J.P., Zhang H., Wang K., Kim C.E., Annaiah K., et al. Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestry. Obesity Res 2009, 17:1461-1465.
    • (2009) Obesity Res , vol.17 , pp. 1461-1465
    • Grant, S.F.A.1    Bradfield, J.P.2    Zhang, H.3    Wang, K.4    Kim, C.E.5    Annaiah, K.6
  • 39
    • 0035871320 scopus 로고    scopus 로고
    • Association between HLA-DQB1 alleles and type 1 diabetes in a case-parents study conducted in Santiago, Chile
    • Santos J.L., Pérez-Bravo F., Carrasco E., Calvillán M., Albala C. Association between HLA-DQB1 alleles and type 1 diabetes in a case-parents study conducted in Santiago, Chile. Am J Epidemiol 2001, 153:794-798.
    • (2001) Am J Epidemiol , vol.153 , pp. 794-798
    • Santos, J.L.1    Pérez-Bravo, F.2    Carrasco, E.3    Calvillán, M.4    Albala, C.5
  • 41
    • 78650037262 scopus 로고    scopus 로고
    • Associations of six single nucleotide polymorphisms in obesity-related genes with body mass index and risk of obesity in the Chinese children
    • Wu L., Xi B., Zhang M., Shen Y., Zhao X., Cheng H., et al. Associations of six single nucleotide polymorphisms in obesity-related genes with body mass index and risk of obesity in the Chinese children. Diabetes 2010, 59:3085-3089.
    • (2010) Diabetes , vol.59 , pp. 3085-3089
    • Wu, L.1    Xi, B.2    Zhang, M.3    Shen, Y.4    Zhao, X.5    Cheng, H.6
  • 42
    • 77952746932 scopus 로고    scopus 로고
    • Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese
    • Ng M.C.Y., Tam C.H.T., So W.Y., Ho J.S.K., Chan A.W., Lee H.M., et al. Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. J Clin Endocrinol Metab 2010, 95:2418-2425.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2418-2425
    • Ng, M.C.Y.1    Tam, C.H.T.2    So, W.Y.3    Ho, J.S.K.4    Chan, A.W.5    Lee, H.M.6
  • 43
    • 67349188883 scopus 로고    scopus 로고
    • A large-scale genome wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits
    • Cho Y.S., Go M.J., Kim Y.J., Heo J.Y., Oh J.H., Ban H.J., et al. A large-scale genome wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet 2009, 41:527-534.
    • (2009) Nat Genet , vol.41 , pp. 527-534
    • Cho, Y.S.1    Go, M.J.2    Kim, Y.J.3    Heo, J.Y.4    Oh, J.H.5    Ban, H.J.6
  • 44
    • 77955165654 scopus 로고    scopus 로고
    • Evaluation of genetic susceptibility loci for obesity in Chinese women
    • Shi J., Long J., Gao Y.T., Lu W., Cai Q., Wen W., et al. Evaluation of genetic susceptibility loci for obesity in Chinese women. Am J Epidemiol 2010, 172:244-254.
    • (2010) Am J Epidemiol , vol.172 , pp. 244-254
    • Shi, J.1    Long, J.2    Gao, Y.T.3    Lu, W.4    Cai, Q.5    Wen, W.6
  • 45
    • 77749233777 scopus 로고    scopus 로고
    • Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a Chinese population
    • Cheung C., Tso A., Cheung B.M., Xu A., Ong K.L., Fong C.H., et al. Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a Chinese population. J Clin Endocrinol Metab 2010, 95:1395-1403.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 1395-1403
    • Cheung, C.1    Tso, A.2    Cheung, B.M.3    Xu, A.4    Ong, K.L.5    Fong, C.H.6
  • 46
    • 79951727548 scopus 로고    scopus 로고
    • Combined effects of FTO rs9939609 and MC4R rs17782313 on obesity and BMI in Chinese Han populations
    • Huang W., Sun Y., Sun J. Combined effects of FTO rs9939609 and MC4R rs17782313 on obesity and BMI in Chinese Han populations. Endocr 2011, 39:69-74.
    • (2011) Endocr , vol.39 , pp. 69-74
    • Huang, W.1    Sun, Y.2    Sun, J.3
  • 47
    • 74449091029 scopus 로고    scopus 로고
    • Do maternal ratings of appetite in infants predict later Child Eating Behaviour Questionnaire scores and body mass indexα
    • Parkinson K.N., Drewett R.F., Le Couteur A.S., Hyland R.M., Pearce M.S., Adamson A.J., et al. Do maternal ratings of appetite in infants predict later Child Eating Behaviour Questionnaire scores and body mass indexα. Appetite 2010, 54:186-190.
    • (2010) Appetite , vol.54 , pp. 186-190
    • Parkinson, K.N.1    Drewett, R.F.2    Le Couteur, A.S.3    Hyland, R.M.4    Pearce, M.S.5    Adamson, A.J.6
  • 48
    • 52949136316 scopus 로고    scopus 로고
    • Children's Eating Behaviour Questionnaire: associations with BMI in Portuguese children
    • Viana V., Sinde S., Saxton J.C. Children's Eating Behaviour Questionnaire: associations with BMI in Portuguese children. Br J Nutr 2008, 100:445-450.
    • (2008) Br J Nutr , vol.100 , pp. 445-450
    • Viana, V.1    Sinde, S.2    Saxton, J.C.3
  • 49
    • 77949267632 scopus 로고    scopus 로고
    • Associations between child weight and maternal feeding styles are mediated by maternal perceptions and concerns
    • Webber L., Hill C., Cooke L., Carnell S., Wardle J. Associations between child weight and maternal feeding styles are mediated by maternal perceptions and concerns. Eur J Clin Nutr 2010, 64:259-265.
    • (2010) Eur J Clin Nutr , vol.64 , pp. 259-265
    • Webber, L.1    Hill, C.2    Cooke, L.3    Carnell, S.4    Wardle, J.5
  • 53
    • 84857689197 scopus 로고    scopus 로고
    • Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat
    • Mul J.D., van Boxtel R., Bergen D.J.M., Brans M.A.D., Brakkee J.H., Toonen P.W., et al. Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat. Obesity 2012, 2:612-621.
    • (2012) Obesity , vol.2 , pp. 612-621
    • Mul, J.D.1    van Boxtel, R.2    Bergen, D.J.M.3    Brans, M.A.D.4    Brakkee, J.H.5    Toonen, P.W.6
  • 54
    • 78651311701 scopus 로고    scopus 로고
    • Influence of parents and friends on children's and adolescents' food intake and food selection
    • Salvy S.J., Elmo A., Nitecki L.A., Kluczynski M.A., Roemmich J.N. Influence of parents and friends on children's and adolescents' food intake and food selection. Am J Clin Nutr 2011, 93:87-92.
    • (2011) Am J Clin Nutr , vol.93 , pp. 87-92
    • Salvy, S.J.1    Elmo, A.2    Nitecki, L.A.3    Kluczynski, M.A.4    Roemmich, J.N.5


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