-
1
-
-
55849106577
-
Role of body fat distribution and themetabolic complications of obesity
-
JensenMD.Role of body fat distribution and themetabolic complications of obesity. J Clin EndocrinolMetab 2008; 93: S57-S63.
-
(2008)
J Clin Endocrinol Metab
, vol.93
-
-
Jensen, M.D.1
-
2
-
-
33749017409
-
The human obesity gene map: The 2005 update
-
(Silver Spring)
-
Rankinen T, Zuberi A, Chagnon YC et al. The human obesity gene map: the 2005 update.Obesity (Silver Spring) 2006; 14: 529-644.
-
(2006)
Obesity
, vol.14
, pp. 529-644
-
-
Rankinen, T.1
Zuberi, A.2
Chagnon, Y.C.3
-
4
-
-
44249094622
-
Overview of human obesity and central mechanisms regulating energy homeostasis
-
Crowley VE. Overview of human obesity and central mechanisms regulating energy homeostasis. Ann Clin Biochem2008; 45: 245-255.
-
(2008)
Ann Clin Biochem
, vol.45
, pp. 245-255
-
-
Crowley, V.E.1
-
5
-
-
3142731898
-
The critical role of the melanocortin systemin the control of energy intake
-
Seeley RJ, Drazen DL, Clegg DJ. The critical role of the melanocortin systemin the control of energy intake. Annu RevNutr 2004; 24: 133-149.
-
(2004)
Annu Rev Nutr
, vol.24
, pp. 133-149
-
-
Seeley, R.J.1
Drazen, D.L.2
Clegg, D.J.3
-
6
-
-
0030889192
-
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
-
Huszar D, Lynch CA, Fairchild-Huntress V et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997; 88: 131-141.
-
(1997)
Cell
, vol.88
, pp. 131-141
-
-
Huszar, D.1
Lynch, C.A.2
Fairchild-Huntress, V.3
-
7
-
-
40949123295
-
Insights from the genetics of severe childhood obesity
-
Farooqi S. Insights from the genetics of severe childhood obesity. Horm Res 2007; 68: 5-7.
-
(2007)
Horm Res
, vol.68
, pp. 5-7
-
-
Farooqi, S.1
-
9
-
-
0034905674
-
Mutational analysis of melanocortin-4 receptor, Agouti-related protein, and alpha-melanocytestimulating hormone genes in severely obese children
-
Dubern B, Clément K, Pelloux V et al. Mutational analysis of melanocortin-4 receptor, Agouti-related protein, and alpha-melanocytestimulating hormone genes in severely obese children. J Pediatr 2001; 139: 204-209.
-
(2001)
J Pediatr
, vol.139
, pp. 204-209
-
-
Dubern, B.1
Clément, K.2
Pelloux, V.3
-
10
-
-
0033927916
-
Melanocortin-4 receptormutations are a frequent and heterogeneous cause of morbid obesity
-
Vaisse C, ClementK,Durand E et al.Melanocortin-4 receptormutations are a frequent and heterogeneous cause of morbid obesity. J Clin Invest 2000; 106: 253-262.
-
(2000)
J Clin Invest
, vol.106
, pp. 253-262
-
-
Vaisse, C.1
Clement, K.2
Durand, E.3
-
11
-
-
0037456768
-
Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene
-
Farooqi IS, Keogh JM, Yeo GS et al. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl JMed 2003; 348: 1085-1095.
-
(2003)
N Engl JMed
, vol.348
, pp. 1085-1095
-
-
Farooqi, I.S.1
Keogh, J.M.2
Yeo, G.S.3
-
13
-
-
58149508003
-
Eating behaviour and weight in children
-
Webber L,Hill C, Saxton J et al. Eating behaviour and weight in children. Int JObes (Lond) 2009; 33: 21-28.
-
(2009)
Int JObes (Lond)
, vol.33
, pp. 21-28
-
-
Webber Lhill, C.1
Saxton, J.2
-
14
-
-
44349142294
-
Common variants near MC4R are associated with fat mass, weight and risk of obesity
-
Loos RJ, Lindgren CM, Li S et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008; 40: 768-775.
-
(2008)
Nat Genet
, vol.40
, pp. 768-775
-
-
Loos, R.J.1
Lindgren, C.M.2
Li, S.3
-
15
-
-
54949113309
-
The common obesity variant nearMC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women
-
Qi L,Kraft P,HunterDJ et al. The common obesity variant nearMC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women. Hum Mol Genet 2008; 17: 3502-3508.
-
(2008)
Hum Mol Genet
, vol.17
, pp. 3502-3508
-
-
Qi, L.1
Kraft, P.2
Hunter, D.J.3
-
16
-
-
58149163141
-
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
-
Thorleifsson G, Walters GB, Gudbjartsson DF et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.Nat Genet 2009; 41: 18-24.
-
(2009)
Nat Genet
, vol.41
, pp. 18-24
-
-
Thorleifsson, G.1
Walters, G.B.2
Gudbjartsson, D.F.3
-
17
-
-
62349130691
-
Common genetic variation near MC4R is associated with eating behaviour patterns in European populations
-
Stutzmann F, Cauchi S, Durand E et al. Common genetic variation near MC4R is associated with eating behaviour patterns in European populations. Int JObes 2009; 33: 373-378.
-
(2009)
Int JObes
, vol.33
, pp. 373-378
-
-
Stutzmann, F.1
Cauchi, S.2
Durand, E.3
-
18
-
-
59849121365
-
Eating behaviour and obesity in a three-generation Chilean family with carriers of the Thr150Ilemutation in themelanocortin-4 receptor gene
-
Santos JL,Amador P,ValladaresMet al. Eating behaviour and obesity in a three-generation Chilean family with carriers of the Thr150Ilemutation in themelanocortin-4 receptor gene. J Physiol Biochem2008; 64: 205-210.
-
(2008)
J Physiol Biochem
, vol.64
, pp. 205-210
-
-
Santos, J.L.1
Amador, P.2
Valladares, M.3
-
19
-
-
34247338093
-
Waist-to-height ratio is an accurate and easier index for evaluating obesity in children and adolescents
-
Weili Y, He B, Yao H et al.Waist-to-height ratio is an accurate and easier index for evaluating obesity in children and adolescents. Obesity 2007; 15: 748-752.
-
(2007)
Obesity
, vol.15
, pp. 748-752
-
-
Weili, Y.1
He, B.2
Yao, H.3
-
20
-
-
0033343736
-
Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans
-
Hinney A, Schmidt A, Nottebom K et al. Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans. J Clin EndocrinolMetab 1999; 84: 1483-1486.
-
(1999)
J Clin Endocrinol Metab
, vol.84
, pp. 1483-1486
-
-
Hinney, A.1
Schmidt, A.2
Nottebom, K.3
-
22
-
-
58149508003
-
Eating behaviour and weight in children
-
Webber L,Hill C, Saxton J et al. Eating behaviour and weight in children. Int JObes (Lond) 2009; 33: 21-28.
-
(2009)
Int JObes (Lond)
, vol.33
, pp. 21-28
-
-
Webber Lhill, C.1
Saxton, J.2
-
23
-
-
4444238569
-
The Three-Factor Eating Questionnaire-R18 is able to distinguish among different eating patterns in a general population
-
De Lauzon B, Romon M, Deschamps V et al. The Three-Factor Eating Questionnaire-R18 is able to distinguish among different eating patterns in a general population. JNutr 2004; 134: 2372-2380.
-
(2004)
JNutr
, vol.134
, pp. 2372-2380
-
-
De Lauzon, B.1
Romon, M.2
Deschamps, V.3
-
25
-
-
0035871320
-
Association between HLA-DQB1 alleles and type 1 diabetes in a case-parents study conducted in Santiago Chile
-
Santos JL, Pérez-Bravo F, Carrasco E. Association between HLA-DQB1 alleles and type 1 diabetes in a case-parents study conducted in Santiago, Chile. Am J Epidemiol 2001; 153: 794-798.
-
(2001)
Am J Epidemiol
, vol.153
, pp. 794-798
-
-
Santos, J.L.1
Pérez-Bravo, F.2
Carrasco, E.3
-
26
-
-
0034255484
-
Choosing a retrospective design to assess joint genetic and environmental contributions to risk
-
Weinberg CR, Umbach DM. Choosing a retrospective design to assess joint genetic and environmental contributions to risk. Am J Epidemiol 2000; 152: 197-203.
-
(2000)
Am J Epidemiol
, vol.152
, pp. 197-203
-
-
Weinberg, C.R.1
Umbach, D.M.2
-
27
-
-
0030740803
-
Molecular screening of the human melanocortin-4 receptor gene: Identification of a missense variant showing no association with obesity, plasma glucose, or insulin
-
Gotoda T, Scott J, Aitman TJ. Molecular screening of the human melanocortin-4 receptor gene: identification of a missense variant showing no association with obesity, plasma glucose, or insulin. Diabetologia 1997; 40: 976-979.
-
(1997)
Diabetologia
, vol.40
, pp. 976-979
-
-
Gotoda, T.1
Scott, J.2
Aitman, T.J.3
-
28
-
-
33646404622
-
Melanocortin 4 receptor mutations in a large cohort of severely obese adults: Prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating
-
Lubrano-Berthelier C, Dubern B, Lacorte JM et al. Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating. J Clin Endocrinol Metab 2006; 91: 1811-1818.
-
(2006)
J Clin Endocrinol Metab
, vol.91
, pp. 1811-1818
-
-
Lubrano-Berthelier, C.1
Dubern, B.2
Lacorte, J.M.3
-
29
-
-
0037456733
-
Binge eating as amajor phenotype of melanocortin 4 receptor gene mutations
-
BransonR, PotocznaN,Kral JGet al. Binge eating as amajor phenotype of melanocortin 4 receptor gene mutations. N Engl J Med 2003; 348: 1096-1103.
-
(2003)
N Engl J Med
, vol.348
, pp. 1096-1103
-
-
Branson, R.1
Potoczna, N.2
Kral, J.G.3
-
30
-
-
34247855844
-
AnovelmutationThr162Arg of the melanocortin 4 receptor gene in a Spanish children and adolescent population
-
(Oxf)
-
OchoaMC,AzconaC,BiebermannHet al.AnovelmutationThr162Arg of the melanocortin 4 receptor gene in a Spanish children and adolescent population. Clin Endocrinol (Oxf) 2007; 66: 652-658.
-
(2007)
Clin Endocrinol
, vol.66
, pp. 652-658
-
-
Ochoa, M.C.1
Azcona, C.2
Biebermann, H.3
-
31
-
-
0036257961
-
Low frequency of melanocortin-4 receptor (MC4R) mutations in a Mediterranean population with early-onset obesity
-
Miraglia Del Giudice E, Cirillo G, Nigro V et al. Low frequency of melanocortin-4 receptor (MC4R) mutations in a Mediterranean population with early-onset obesity. Int JObes 2002; 26: 647-651.
-
(2002)
Int JObes
, vol.26
, pp. 647-651
-
-
Miraglia Del Giudice, E.1
Cirillo, G.2
Nigro, V.3
-
32
-
-
32544455518
-
Screening for melanocortin-4 receptor mutations in a cohort of Belgian morbidly obese adults and children
-
Beckers S, Mertens I, Peeters A et al. Screening for melanocortin-4 receptor mutations in a cohort of Belgian morbidly obese adults and children. Int JObes (Lond) 2006; 30: 221-225.
-
(2006)
Int JObes (Lond)
, vol.30
, pp. 221-225
-
-
Beckers, S.1
Mertens, I.2
Peeters, A.3
-
33
-
-
51749121252
-
Association of the melanocortin-4 receptor V103I polymorphism with dietary intake in severely obese persons
-
PichlerM, Kollerits B, Heid IMet al. Association of the melanocortin-4 receptor V103I polymorphism with dietary intake in severely obese persons. AmJ ClinNutr 2008; 88: 797-800.
-
(2008)
AmJ ClinNutr
, vol.88
, pp. 797-800
-
-
Pichler, M.1
Kollerits, B.2
Heid, I.M.3
-
34
-
-
34547831224
-
The V103I polymorphism of theMC4R gene and obesity: Population based studies and meta-analysis of 29 563 individuals
-
Young EH, Wareham NJ, Farooqi S et al. The V103I polymorphism of theMC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals. Int JObes 2007; 31: 1437-1441.
-
(2007)
Int JObes
, vol.31
, pp. 1437-1441
-
-
Young, E.H.1
Wareham, N.J.2
Farooqi, S.3
-
35
-
-
12144289073
-
Melanocortin-4 receptor gene variant 103 is negatively associated with obesity
-
Geller F, Reichwald K, Dempfle A et al. Melanocortin-4 receptor gene variant 103 is negatively associated with obesity. Am J Hum Genet 2004; 74: 572-581.
-
(2004)
Am J Hum Genet
, vol.74
, pp. 572-581
-
-
Geller, F.1
Reichwald, K.2
Dempfle, A.3
-
36
-
-
0037350649
-
A novel nonsense mutation in the melanocortin-4 receptor associated with obesity in a Spanish population
-
Marti A, CorbalánMS, Forga L et al. A novel nonsense mutation in the melanocortin-4 receptor associated with obesity in a Spanish population. Int JObes 2003; 27: 385-388.
-
(2003)
Int JObes
, vol.27
, pp. 385-388
-
-
Marti, A.1
Corbalánms Forga, L.2
-
37
-
-
33745036725
-
Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist
-
Xiang Z, Litherland SA, Sorensen NB et al. Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist. Biochemistry 2006; 45: 7277-7288.
-
(2006)
Biochemistry
, vol.45
, pp. 7277-7288
-
-
Xiang, Z.1
Litherland, S.A.2
Sorensen, N.B.3
-
38
-
-
67649744249
-
Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestry
-
(Silver Spring)
-
Grant SF, Bradfield JP, Zhang H et al. Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestry.Obesity (Silver Spring) 2009; 17: 1461-1465.
-
(2009)
Obesity
, vol.17
, pp. 1461-1465
-
-
Grant, S.F.1
Bradfield, J.P.2
Zhang, H.3
-
39
-
-
52749092130
-
Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees
-
Stutzmann F, TanK,VatinVet al. Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees.Diabetes 2008; 57: 2511-2518.
-
(2008)
Diabetes
, vol.57
, pp. 2511-2518
-
-
Stutzmann, F.1
Tan, K.2
-
40
-
-
34548675339
-
Leptin regulates striatal regions and human eating behavior
-
Farooqi IS, Bullmore E, Keogh J et al. Leptin regulates striatal regions and human eating behavior. Science 2007; 317: 1355.
-
(2007)
Science
, vol.317
, pp. 1355
-
-
Farooqi, I.S.1
Bullmore, E.2
Keogh, J.3
-
41
-
-
36448969695
-
Imaging obesity: FMRI, food reward, and feeding
-
Grill HJ, Skibicka KP, HayesMR. Imaging obesity: fMRI, food reward, and feeding. CellMetab 2007; 6: 423-425.
-
(2007)
Cell Metab
, vol.6
, pp. 423-425
-
-
Grill, H.J.1
Skibicka, K.P.2
Hayes, M.R.3
-
42
-
-
0023316229
-
A socio-genetic cline in Chilean population
-
Valenzuela C, Acuna M, Harb Z. A socio-genetic cline in Chilean population. RevMed Chile 1987; 115: 295-299.
-
(1987)
RevMed Chile
, vol.115
, pp. 295-299
-
-
Valenzuela, C.1
Acuna, M.2
Harb, Z.3
|