Optimized signal peptides for the development of high expressing CHO cell lines

Biotechnology and Bioengineering

Volumn 110, Issue 4, 2013, Pages 1164-1173

  Kober, Lars ^a   Zehe, Christoph ^a   Bode, Juergen ^b  

^a Cellca GmbH   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Cell specific productivity; Chinese hamster ovary (CHO); Fed batch; High productive; Recombinant antibody; Signal peptide

Indexed keywords

CHINESE HAMSTER OVARY; FED BATCHES; HIGH PRODUCTIVE; RECOMBINANT ANTIBODY; SIGNAL PEPTIDE;

CELL CULTURE; CELLS; EFFICIENCY; EXPERIMENTS; MONOCLONAL ANTIBODIES; OPTIMIZATION; PHOSPHATASES; PHYSIOLOGY; PRODUCTIVITY; RECOMBINANT PROTEINS;

GENE ENCODING;

ALBUMIN; AZUROCIDIN; IMMUNOGLOBULIN G; RENILLA LUCIFERIN 2 MONOOXYGENASE; SIGNAL PEPTIDE;

ANIMAL CELL; ARTICLE; CHO CELL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPRESSION VECTOR; FED BATCH FERMENTATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION;

AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETINAE; CRICETULUS; GENETIC VECTORS; MOLECULAR SEQUENCE DATA; PROTEIN SORTING SIGNALS; TRANSFECTION;

CRICETULUS GRISEUS; VARGULA;

EID: 84874195223     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.24776     Document Type: Article

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