CHO cell engineering to prevent polypeptide aggregation and improve therapeutic protein secretion

Metabolic Engineering

Volumn 21, Issue , 2014, Pages 91-102

  Le Fourn, Valérie ^a,b   Girod, Pierre Alain ^a   Buceta, Montse ^a   Regamey, Alexandre ^a   Mermod, Nicolas ^b  

^a Selexis   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

CHO cells; Immunoglobulins; Metabolic engineering; Protein secretion; Therapeutic proteins

Indexed keywords

CELL ENGINEERING; CELLS; CYTOLOGY; METABOLIC ENGINEERING; PHYSIOLOGY;

CHO CELL; IMMUNOGLOBULINS; POST-TRANSLATIONAL MODIFICATIONS; PROTEIN SECRETION; RECEPTOR PROTEINS; SECRETION EFFICIENCY; SECRETORY PATHWAYS; THERAPEUTIC PROTEIN;

PROTEINS;

IMMUNOGLOBULIN; POLYPEPTIDE; RECEPTOR PROTEIN; SRP 14 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ENGINEERING; CHO CELL; CONTROLLED STUDY; LIGHT CHAIN; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN SECRETION; SECRETORY PATHWAY;

MAMMALIA;

CHO CELLS; IMMUNOGLOBULINS; METABOLIC ENGINEERING; PROTEIN SECRETION; THERAPEUTIC PROTEINS;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; GENETIC ENGINEERING; HUMANS; RECOMBINANT PROTEINS; SECRETORY PATHWAY; SIGNAL RECOGNITION PARTICLE;

EID: 84891826628     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2012.12.003     Document Type: Article

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