Overexpression of recombinant human antithrombin III in Chinese hamster ovary cells results in malformation and decreased secretion of recombinant protein

Biotechnology and Bioengineering

Volumn 53, Issue 6, 1997, Pages 547-559

  Schröder, Martin ^a   Friedl, Peter ^a  

^a DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Chinese hamster ovary cells; human antithrombin III; protein folding; protein secretion; recombinant protein production; serum free culture

Indexed keywords

AMPLIFICATION; ANTIGENS; CELL CULTURE; CELLS; DNA; GENES;

CHINESE HAMSTER OVARY CELLS; GENE AMPLIFICATION; HUMAN ANTITHROMBIN; PROTEIN SECRETION; RECOMBINANT PROTEINS;

PROTEINS;

ANTITHROMBIN III; DIHYDROFOLATE REDUCTASE; LACTATE DEHYDROGENASE; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; CULTURE MEDIUM; GENE AMPLIFICATION; GENE OVEREXPRESSION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN MODIFICATION; PROTEIN SECRETION;

EID: 0345960852     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19970320)53:6<547::AID-BIT2>3.0.CO;2-M     Document Type: Article

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