Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells

Diabetologia

Volumn 57, Issue 1, 2014, Pages 129-139

  Pearson, Gemma L ^a   Mellett, Natalie ^b   Chu, Kwan Yi ^a   Cantley, James ^a   Davenport, Aimee ^a   Bourbon, Pauline ^c   Cosner, Casey C ^c   Helquist, Paul ^c   Meikle, Peter J ^b   Biden, Trevor J ^a  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^c UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

Autophagy; Beta cell; Insulin secretion; Islet; Lipid metabolism; Lipophagy; Lysosomal acid lipase

Indexed keywords

ACID LIPASE; CERAMIDE; DIACYLGLYCEROL; FAT DROPLET; GLUCOSE; INSULIN; LYSOSOMAL ACID LIPASE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; PHOSPHOLIPID; SMALL INTERFERING RNA; SPHINGOLIPID; SPHINGOMYELIN; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FEEDBACK SYSTEM; HUMAN; HUMAN CELL; INSULIN RELEASE; LIPID STORAGE; LIPOPHAGOCYTOSIS; LYSOSOME; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANIMALS; CELL LINE, TUMOR; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; MICE; MICROSCOPY, CONFOCAL; STEROL ESTERASE;

EID: 84890971901     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-3083-x     Document Type: Article

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