Zinc-selective inhibition of the promiscuous bacterial amide-hydrolase DapE: Implications of metal heterogeneity for evolution and antibiotic drug design

Metallomics

Volumn 6, Issue 1, 2014, Pages 88-95

  Uda, Narasimha Rao ^a   Upert, Grégory ^a   Angelici, Gaetano ^a   Nicolet, Stefan ^a   Schmidt, Tobias ^b   Schwede, Torsten ^b   Creus, Marc ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBIOTICS; DRUG DELIVERY; ENZYMES; ZINC;

ANTIBIOTIC ACTIVITY; ANTIBIOTIC DRUGS; ANTIMICROBIAL COMPOUNDS; BUILDING BLOCKES; DIAMINOPIMELIC ACIDS; INHIBITORY ACTIVITY; NOVEL PROTEINS; PEPTIDOGLYCANS;

BACTERIA;

ANTIBIOTIC AGENT; BACTERIAL ENZYME; CAPTOPRIL; DIAMINOPIMELIC ACID; HYDROLASE; LEAD; MANGANESE; N SUCCINYL LEVO LEVO DIAMINOPIMELIC ACID DESUCCINYLASE; PEPTIDOGLYCAN; UNCLASSIFIED DRUG; ZINC;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL CELL WALL; BACTERIAL GROWTH; BACTERIUM CULTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME ACTIVITY; ENZYME INHIBITION; HAEMOPHILUS INFLUENZAE; HYDROLYSIS; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMIDOHYDROLASES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BINDING SITES; BIOCATALYSIS; CAPTOPRIL; DIAMINOPIMELIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; ISOENZYMES; KINETICS; MANGANESE; METALLOPROTEINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN STRUCTURE, TERTIARY; SALMONELLA ENTERICA; SULFHYDRYL COMPOUNDS; ZINC;

EID: 84890933773     PISSN: 17565901     EISSN: 1756591X     Source Type: Journal    
DOI: 10.1039/c3mt00125c     Document Type: Article

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