Metal ions as cofactors for the binding of inhibitors to methionine aminopeptidase: A critical view of the relevance of in vitro metalloenzyme assays

Angewandte Chemie - International Edition

Volumn 44, Issue 23, 2005, Pages 3620-3623

  Schiffmann, Rolf ^a   Heine, Andreas ^b   Klebe, Gerhard ^b   Klein, Christian D P ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Drug design; Inhibitors; Metalloenzymes; Methionine aminopeptidase; X ray diffraction

Indexed keywords

CRYSTAL STRUCTURE; ENZYME INHIBITION; ENZYME KINETICS; ESCHERICHIA COLI; IONS; METALS;

COFACTOR; METAL IONS; METAL-DEPENDENT ENZYMES; METHIONINE AMINOPEPTIDASE;

ENZYMES;

AMINOPEPTIDASE; COBALT; DIVALENT CATION; ESCHERICHIA COLI PROTEIN; METALLOPROTEINASE; METHIONYL AMINOPEPTIDASE; PROTEINASE INHIBITOR; PYRIDONE DERIVATIVE; TIABENDAZOLE;

ARTICLE; BINDING SITE; CHEMISTRY; COENZYME; DRUG ANTAGONISM;

AMINOPEPTIDASES; BINDING SITES; CATIONS, DIVALENT; COBALT; COENZYMES; ESCHERICHIA COLI PROTEINS; METALLOENDOPEPTIDASES; PROTEASE INHIBITORS; PYRIDONES; THIABENDAZOLE;

EID: 20644434591     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200500592     Document Type: Article

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