Growth inhibition of Escherichia coli and methicillin-resistant Staphylococcus aureus by targeting cellular methionine aminopeptidase

European Journal of Medicinal Chemistry

Volumn 46, Issue 8, 2011, Pages 3537-3540

  Chai, Sergio C ^a,b   Wang, Wen Long ^a   Ding, De Rong ^a   Ye, Qi Zhuang ^a  

^a INDIANA UNIVERSITY   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Antibiotic; Drug discovery; Drug resistance; Enzyme inhibition; Hydrolase; Metalloenzyme

Indexed keywords

ANTIINFECTIVE AGENT; METHIONYL AMINOPEPTIDASE; METHIONYL AMINOPEPTIDASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GROWTH; ENZYME ACTIVITY; ESCHERICHIA COLI; GROWTH INHIBITION; IC 50; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN;

AMINOPEPTIDASES; ANIMALS; ANTI-BACTERIAL AGENTS; CELL PROLIFERATION; CHICKENS; COUMARINS; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; FLUORESCENT DYES; HUMANS; INHIBITORY CONCENTRATION 50; MASS SPECTROMETRY; METHICILLIN RESISTANCE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; PLASMIDS; PROTEASE INHIBITORS; RECOMBINANT PROTEINS; SMALL MOLECULE LIBRARIES; STAPHYLOCOCCAL INFECTIONS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 79958249114     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.04.056     Document Type: Article

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