Hydroxamic Acids as Potent Inhibitors of Fe II and Mn II E. coli Methionine Aminopeptidase: Biological Activities and X-ray Structures of Oxazole Hydroxamate-EcMetAP-Mn Complexes

ChemMedChem

Volumn 7, Issue 6, 2012, Pages 1020-1030

  Huguet, Florian ^a   Melet, Armelle ^a   Alves de Sousa, Rodolphe ^a   Lieutaud, Aurélie ^b   Chevalier, Jacqueline ^b   Maigre, Laure ^b   Deschamps, Patrick ^c   Tomas, Alain ^c   Leulliot, Nicolas ^c   Pages, Jean Marie ^b   Artaud, Isabelle ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b Aix Marseille University   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Antibacterial agents; Hydroxamic acids; Inhibitors; Methionine aminopeptidase; X ray structures

Indexed keywords

1,2,4 OXADIAZOLE DERIVATIVE; 1,3,4 OXADIAZOLE DERIVATIVE; 2 (2 CHLOROPHENYL)OXAZOLE 4 CARBOXYLIC ACID; 2 (2 TRIFLUOROMETHYLPHENYL)OXAZOLE 4 CARBOXYLIC ACID; 2 NAPHTHYLAMINE; 2 PHENYLOXAZOLE 4 CARBOXYLIC ACID; 5 (2 CHLOROPHENYL) 1,2,4 OXADIAZOLE 3 CARBOXYLIC ACID; 5 (2 CHLOROPHENYL) 1H IMIDAZOLE 2 CARBOXYLIC ACID; 5 (2 CHLOROPHENYL)FURAN 2 YL CARBOXYLIC ACID; 5 (2 CHLOROPHENYL)OXAZOLE 2 CARBOXYLIC ACID; 5 (2 TRIFLUOROMETHYLPHENYL)FURAN 2 YLCARBOXYLIC ACID; 5 [2 (TRIFLUOROMETHYL)PHENYL]FURAN 2 CARBOXYLIC ACID; 5 PHENYL 1,2,4 OXADIAZOL 3 YLCARBOXYLIC ACID METHYL ESTER; 5 PHENYL 1,2,4 OXADIAZOLE 3 CARBOXYLIC ACID; 5 PHENYLOXAZOLE 2 CARBOXYLIC ACID; ANTIBIOTIC AGENT; ARGININE; ESCHERICHIA COLI PROTEIN; HYDROXAMIC ACID; IMIDAZOLE; IRON; MANGANESE; METHIONYL AMINOPEPTIDASE; OXAZOLE DERIVATIVE; PEPTIDE DEFORMYLASE; PHENYLALANINE; POLYMYXIN B; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BACTERIAL STRAIN; BINDING SITE; BIOLOGICAL ACTIVITY; COMPETITIVE INHIBITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLIZATION; DRUG EFFICACY; DRUG SYNTHESIS; ESCHERICHIA COLI; HYDROGEN BOND; IC 50; ISOMER; LIGAND BINDING; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; WILD TYPE;

AMINOPEPTIDASES; ANTI-BACTERIAL AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FERROUS COMPOUNDS; HETEROCYCLIC COMPOUNDS; HYDROXAMIC ACIDS; MANGANESE; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84861569777     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200076     Document Type: Article

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