The 1.15 Å crystal structure of the Staphylococcus aureus methionyl-aminopeptidase and complexes with triazole based inhibitors

Journal of Molecular Biology

Volumn 332, Issue 1, 2003, Pages 13-21

  Oefner, Christian ^a   Douangamath, Alice ^a   D'Arcy, Allan ^a   Häfeli, Sascha ^a   Mareque, Daniel ^a   Sweeney, Aengus Mac ^a   Padilla, Juan ^a   Pierau, Sabine ^a   Schulz, Henk ^a   Thormann, Michael ^b   Wadman, Sjoerd ^a   Dale, Glenn E ^a  

^a Morphochem AG Basel   (Switzerland)

^b Morphochem AG   (Germany)

Author keywords

1,2,4 triazole; Inhibitor; MetAP; S. aureus; X ray structure

Indexed keywords

APOENZYME; DIVALENT CATION; METHIONYL AMINOPEPTIDASE; NITROGEN; PROTEIN; PROTEIN INHIBITOR; TRIAZOLE; TRIAZOLE DERIVATIVE; AMINOPEPTIDASE; ENZYME INHIBITOR;

ARTICLE; ATOMIC PARTICLE; BINDING SITE; CRYSTAL STRUCTURE; NONHUMAN; OBSERVATION; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENETICS; HUMAN; MACROMOLECULE; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT;

EUKARYOTA; PROKARYOTA; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

AMINO ACID SEQUENCE; AMINOPEPTIDASES; APOENZYMES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; STAPHYLOCOCCUS AUREUS; TRIAZOLES;

EID: 0041735178     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(03)00862-3     Document Type: Article

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