Lysine biosynthesis in bacteria: A metallodesuccinylase as a potential antimicrobial target

Journal of Biological Inorganic Chemistry

Volumn 18, Issue 2, 2013, Pages 155-163

  Gillner, Danuta M ^a,b   Becker, Daniel P ^a   Holz, Richard C ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b SILESIAN UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

Antibiotics; Catalytic mechanism; DapE; Inhibitor design; Metallohydrolase; X ray crystallography; Zinc

Indexed keywords

CAPTOPRIL; ENZYME INHIBITOR; HYDROLASE; LYSINE; METALLODESUCCINYLASE; N SUCCINYL LEVO LEVO DIAMINOPIMELIC ACID DESUCCINYLASE; N SUCCINYL LEVO LEVO DIAMINOPIMELIC ACID DESUCCINYLASE INHIBITOR; PENICILLAMINE; UNCLASSIFIED DRUG;

AMINO ACID SYNTHESIS; CATALYSIS; CRYSTALLOGRAPHY; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STRUCTURE; HUMAN; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

AMIDOHYDROLASES; ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL PROTEINS; CATALYTIC DOMAIN; DRUG RESISTANCE, BACTERIAL; ENZYME INHIBITORS; HUMANS; LYSINE; MODELS, MOLECULAR; PROTEIN BINDING;

EID: 84878875020     PISSN: 09498257     EISSN: 14321327     Source Type: Journal    
DOI: 10.1007/s00775-012-0965-1     Document Type: Review

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