Inhibitors of bacterial N-succinyl-l,l-diaminopimelic acid desuccinylase (DapE) and demonstration of in vitro antimicrobial activity

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 22, 2009, Pages 6350-6352

  Gillner, Danuta ^a,b   Armoush, Nicola ^a   Holz, Richard C ^a   Becker, Daniel P ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b SILESIAN UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

Antimicrobial; DapE; Enzyme inhibition; l Captopril; N Succinyl l,l diaminopimelic acid desuccinylase; ZBG (zinc binding group)

Indexed keywords

(2 CARBOXYETHYL)PHOSPHONIC ACID; (BENZYLOXYCARBONYL)HYDROXYLAMINE; 2 THIOPHENEBORONIC ACID; 3 CARBOXYPHENYLBORONIC; 3 MERCAPTOBENZOIC ACID; 4 CARBOXYPHENYLBORONIC ACID; ACETOHYDROXAMIC ACID; ANTIINFECTIVE AGENT; BACTERIAL ENZYME; BENZENEBORONIC ACID; BORONIC ACID DERIVATIVE; BUTYLBORONIC ACID; CAPTOPRIL; CARBOXYLIC ACID DERIVATIVE; DELTA MERCAPTOBUTYRIC ACID; ENALAPRIL; ENZYME INHIBITOR; HYDROXAMIC ACID DERIVATIVE; HYDROXYLAMINE; N SUCCINYLDIAMINOPIMELIC ACID DESUCCINYLASE; PENICILLAMINE; PHENYLTHIOUREA; PHOSPHONIC ACID DERIVATIVE; THIOL DERIVATIVE; UNCLASSIFIED DRUG; ZINC BINDING PROTEIN;

ANTIMICROBIAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; DRUG SCREENING; ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; IN VITRO STUDY; NONHUMAN;

AMIDOHYDROLASES; AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BINDING SITES; DIAMINOPIMELIC ACID; ENZYME INHIBITORS; ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; MICROBIAL SENSITIVITY TESTS; MUTAGENESIS, SITE-DIRECTED; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE;

EID: 71049142264     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.09.077     Document Type: Article

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