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Volumn 251, Issue , 2014, Pages 127-138

Fractalkine signaling and Tau hyper-phosphorylation are associated with autophagic alterations in lentiviral Tau and Aβ1-42 gene transfer models

Author keywords

Autophagosome; Autophagy; CX3CL1; Inflammation; Tau phosphorylation

Indexed keywords

ADAM10 ENDOPEPTIDASE; AMYLOID BETA PROTEIN[1-42]; CASPASE 3; CELL MARKER; FRACTALKINE; INTERLEUKIN 6; LENTIVIRUS VECTOR; MUTANT PROTEIN; TAU PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; VIRUS PROTEIN;

EID: 84890857919     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2013.01.009     Document Type: Article
Times cited : (14)

References (80)
  • 4
    • 27944504351 scopus 로고    scopus 로고
    • P62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    • Bjorkoy G., Lamark T., Brech A., Outzen H., Perander M., Overvatn A., Stenmark H., Johansen T. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J. Cell Biol. 2005, 171:603-614.
    • (2005) J. Cell Biol. , vol.171 , pp. 603-614
    • Bjorkoy, G.1    Lamark, T.2    Brech, A.3    Outzen, H.4    Perander, M.5    Overvatn, A.6    Stenmark, H.7    Johansen, T.8
  • 5
    • 49049096562 scopus 로고    scopus 로고
    • Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease
    • Boland B., Kumar A., Lee S., Platt F.M., Wegiel J., Yu W.H., Nixon R.A. Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J. Neurosci. 2008, 28:6926-6937.
    • (2008) J. Neurosci. , vol.28 , pp. 6926-6937
    • Boland, B.1    Kumar, A.2    Lee, S.3    Platt, F.M.4    Wegiel, J.5    Yu, W.H.6    Nixon, R.A.7
  • 6
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H., Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991, 82:239-259.
    • (1991) Acta Neuropathol. , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 8
    • 75949127362 scopus 로고    scopus 로고
    • Inflammation, microglia, and Alzheimer's disease
    • Cameron B., Landreth G.E. Inflammation, microglia, and Alzheimer's disease. Neurobiol. Dis. 2010, 37:503-509.
    • (2010) Neurobiol. Dis. , vol.37 , pp. 503-509
    • Cameron, B.1    Landreth, G.E.2
  • 10
    • 47649113481 scopus 로고    scopus 로고
    • Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues
    • Cardona A.E., Sasse M.E., Liu L., Cardona S.M., Mizutani M., Savarin C., Hu T., Ransohoff R.M. Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues. Blood 2008, 112:256-263.
    • (2008) Blood , vol.112 , pp. 256-263
    • Cardona, A.E.1    Sasse, M.E.2    Liu, L.3    Cardona, S.M.4    Mizutani, M.5    Savarin, C.6    Hu, T.7    Ransohoff, R.M.8
  • 11
    • 80052714655 scopus 로고    scopus 로고
    • CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease
    • Cho S.H., Sun B., Zhou Y., Kauppinen T.M., Halabisky B., Wes P., Ransohoff R.M., Gan L. CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease. J. Biol. Chem. 2011, 286:32713-32722.
    • (2011) J. Biol. Chem. , vol.286 , pp. 32713-32722
    • Cho, S.H.1    Sun, B.2    Zhou, Y.3    Kauppinen, T.M.4    Halabisky, B.5    Wes, P.6    Ransohoff, R.M.7    Gan, L.8
  • 12
    • 33745866310 scopus 로고    scopus 로고
    • Autophagic stress in neuronal injury and disease
    • Chu C.T. Autophagic stress in neuronal injury and disease. J. Neuropathol. Exp. Neurol. 2006, 65:423-432.
    • (2006) J. Neuropathol. Exp. Neurol. , vol.65 , pp. 423-432
    • Chu, C.T.1
  • 13
    • 66149186748 scopus 로고    scopus 로고
    • The liberation of fractalkine in the dorsal horn requires microglial cathepsin S
    • Clark A.K., Yip P.K., Malcangio M. The liberation of fractalkine in the dorsal horn requires microglial cathepsin S. J. Neurosci. 2009, 29:6945-6954.
    • (2009) J. Neurosci. , vol.29 , pp. 6945-6954
    • Clark, A.K.1    Yip, P.K.2    Malcangio, M.3
  • 15
    • 0035067021 scopus 로고    scopus 로고
    • Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice
    • Dawson H.N., Ferreira A., Eyster M.V., Ghoshal N., Binder L.I., Vitek M.P. Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. J. Cell Sci. 2001, 114:1179-1187.
    • (2001) J. Cell Sci. , vol.114 , pp. 1179-1187
    • Dawson, H.N.1    Ferreira, A.2    Eyster, M.V.3    Ghoshal, N.4    Binder, L.I.5    Vitek, M.P.6
  • 17
    • 49549083278 scopus 로고    scopus 로고
    • Histone deacetylase 6 interacts with the microtubule-associated protein tau
    • Ding H., Dolan P.J., Johnson G.V. Histone deacetylase 6 interacts with the microtubule-associated protein tau. J. Neurochem. 2008, 106:2119-2130.
    • (2008) J. Neurochem. , vol.106 , pp. 2119-2130
    • Ding, H.1    Dolan, P.J.2    Johnson, G.V.3
  • 18
    • 77954571538 scopus 로고    scopus 로고
    • A caspase cleaved form of tau is preferentially degraded through the autophagy pathway
    • Dolan P.J., Johnson G.V. A caspase cleaved form of tau is preferentially degraded through the autophagy pathway. J. Biol. Chem. 2010, 285:21978-21987.
    • (2010) J. Biol. Chem. , vol.285 , pp. 21978-21987
    • Dolan, P.J.1    Johnson, G.V.2
  • 21
    • 0035851124 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1)
    • Garton K.J., Gough P.J., Blobel C.P., Murphy G., Greaves D.R., Dempsey P.J., Raines E.W. Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1). J. Biol. Chem. 2001, 276:37993-38001.
    • (2001) J. Biol. Chem. , vol.276 , pp. 37993-38001
    • Garton, K.J.1    Gough, P.J.2    Blobel, C.P.3    Murphy, G.4    Greaves, D.R.5    Dempsey, P.J.6    Raines, E.W.7
  • 23
    • 0035399785 scopus 로고    scopus 로고
    • Microglia in neurodegeneration: molecular aspects
    • Gebicke-Haerter P.J. Microglia in neurodegeneration: molecular aspects. Microsc. Res. Tech. 2001, 54:47-58.
    • (2001) Microsc. Res. Tech. , vol.54 , pp. 47-58
    • Gebicke-Haerter, P.J.1
  • 27
    • 79960951303 scopus 로고    scopus 로고
    • Proteasome inhibition drives HDAC6-dependent recruitment of tau to aggresomes
    • Guthrie C.R., Kraemer B.C. Proteasome inhibition drives HDAC6-dependent recruitment of tau to aggresomes. J. Mol. Neurosci. 2011, 45:32-41.
    • (2011) J. Mol. Neurosci. , vol.45 , pp. 32-41
    • Guthrie, C.R.1    Kraemer, B.C.2
  • 29
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • Hardy J., Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol. Sci. 1991, 12:383-388.
    • (1991) Trends Pharmacol. Sci. , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 30
    • 0026597063 scopus 로고
    • Alzheimer's disease: the amyloid cascade hypothesis
    • Hardy J.A., Higgins G.A. Alzheimer's disease: the amyloid cascade hypothesis. Science 1992, 256:184-185.
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 32
    • 0032561415 scopus 로고    scopus 로고
    • Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly
    • Hasegawa M., Smith M.J., Goedert M. Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly. FEBS Lett. 1998, 437:207-210.
    • (1998) FEBS Lett. , vol.437 , pp. 207-210
    • Hasegawa, M.1    Smith, M.J.2    Goedert, M.3
  • 33
    • 0036682239 scopus 로고    scopus 로고
    • Fractalkine and fractalkine receptors in human neurons and glial cells
    • Hatori K., Nagai A., Heisel R., Ryu J.K., Kim S.U. Fractalkine and fractalkine receptors in human neurons and glial cells. J. Neurosci. Res. 2002, 69:418-426.
    • (2002) J. Neurosci. Res. , vol.69 , pp. 418-426
    • Hatori, K.1    Nagai, A.2    Heisel, R.3    Ryu, J.K.4    Kim, S.U.5
  • 34
    • 72549095406 scopus 로고    scopus 로고
    • Regulation mechanisms and signaling pathways of autophagy
    • He C., Klionsky D.J. Regulation mechanisms and signaling pathways of autophagy. Annu. Rev. Genet. 2009, 43:67-93.
    • (2009) Annu. Rev. Genet. , vol.43 , pp. 67-93
    • He, C.1    Klionsky, D.J.2
  • 35
    • 0042206454 scopus 로고    scopus 로고
    • Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B
    • He H., Dang Y., Dai F., Guo Z., Wu J., She X., Pei Y., Chen Y., Ling W., Wu C., Zhao S., Liu J.O., Yu L. Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. J. Biol. Chem. 2003, 278:29278-29287.
    • (2003) J. Biol. Chem. , vol.278 , pp. 29278-29287
    • He, H.1    Dang, Y.2    Dai, F.3    Guo, Z.4    Wu, J.5    She, X.6    Pei, Y.7    Chen, Y.8    Ling, W.9    Wu, C.10    Zhao, S.11    Liu, J.O.12    Yu, L.13
  • 38
    • 0034996076 scopus 로고    scopus 로고
    • Microglial activation parallels system degeneration in progressive supranuclear palsy and corticobasal degeneration
    • Ishizawa K., Dickson D.W. Microglial activation parallels system degeneration in progressive supranuclear palsy and corticobasal degeneration. J. Neuropathol. Exp. Neurol. 2001, 60:647-657.
    • (2001) J. Neuropathol. Exp. Neurol. , vol.60 , pp. 647-657
    • Ishizawa, K.1    Dickson, D.W.2
  • 39
    • 0038819945 scopus 로고    scopus 로고
    • Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta
    • Jiang Z., Tang H., Havlioglu N., Zhang X., Stamm S., Yan R., Wu J.Y. Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta. J. Biol. Chem. 2003, 278:18997-19007.
    • (2003) J. Biol. Chem. , vol.278 , pp. 18997-19007
    • Jiang, Z.1    Tang, H.2    Havlioglu, N.3    Zhang, X.4    Stamm, S.5    Yan, R.6    Wu, J.Y.7
  • 41
    • 0037379079 scopus 로고    scopus 로고
    • CSF and serum levels of soluble fractalkine (CX3CL1) in inflammatory diseases of the nervous system
    • Kastenbauer S., Koedel U., Wick M., Kieseier B.C., Hartung H.P., Pfister H.W. CSF and serum levels of soluble fractalkine (CX3CL1) in inflammatory diseases of the nervous system. J. Neuroimmunol. 2003, 137:210-217.
    • (2003) J. Neuroimmunol. , vol.137 , pp. 210-217
    • Kastenbauer, S.1    Koedel, U.2    Wick, M.3    Kieseier, B.C.4    Hartung, H.P.5    Pfister, H.W.6
  • 42
    • 0034307476 scopus 로고    scopus 로고
    • Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy
    • Kegel K.B., Kim M., Sapp E., McIntyre C., Castano J.G., Aronin N., DiFiglia M. Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy. J. Neurosci. 2000, 20:7268-7278.
    • (2000) J. Neurosci. , vol.20 , pp. 7268-7278
    • Kegel, K.B.1    Kim, M.2    Sapp, E.3    McIntyre, C.4    Castano, J.G.5    Aronin, N.6    DiFiglia, M.7
  • 43
    • 84155162961 scopus 로고    scopus 로고
    • Wild type and P301L mutant Tau promote neuro-inflammation and alpha-Synuclein accumulation in lentiviral gene delivery models
    • Khandelwal P.J., Dumanis S.B., Herman A.M., Rebeck G.W., Moussa C.E. Wild type and P301L mutant Tau promote neuro-inflammation and alpha-Synuclein accumulation in lentiviral gene delivery models. Mol. Cell. Neurosci. 2012, 49:44-53.
    • (2012) Mol. Cell. Neurosci. , vol.49 , pp. 44-53
    • Khandelwal, P.J.1    Dumanis, S.B.2    Herman, A.M.3    Rebeck, G.W.4    Moussa, C.E.5
  • 44
    • 41949125406 scopus 로고    scopus 로고
    • Changes in the levels of plasma soluble fractalkine in patients with mild cognitive impairment and Alzheimer's disease
    • Kim T.S., Lim H.K., Lee J.Y., Kim D.J., Park S., Lee C., Lee C.U. Changes in the levels of plasma soluble fractalkine in patients with mild cognitive impairment and Alzheimer's disease. Neurosci. Lett. 2008, 436:196-200.
    • (2008) Neurosci. Lett. , vol.436 , pp. 196-200
    • Kim, T.S.1    Lim, H.K.2    Lee, J.Y.3    Kim, D.J.4    Park, S.5    Lee, C.6    Lee, C.U.7
  • 45
    • 65549142204 scopus 로고    scopus 로고
    • A role for ubiquitin in selective autophagy
    • Kirkin V., McEwan D.G., Novak I., Dikic I. A role for ubiquitin in selective autophagy. Mol. Cell 2009, 34:259-269.
    • (2009) Mol. Cell , vol.34 , pp. 259-269
    • Kirkin, V.1    McEwan, D.G.2    Novak, I.3    Dikic, I.4
  • 48
    • 84863078686 scopus 로고    scopus 로고
    • Autophagy suppresses interleukin-1beta (IL-1beta) signaling by activation of p62 degradation via lysosomal and proteasomal pathways
    • Lee J., Kim H.R., Quinley C., Kim J., Gonzalez-Navajas J., Xavier R., Raz E. Autophagy suppresses interleukin-1beta (IL-1beta) signaling by activation of p62 degradation via lysosomal and proteasomal pathways. J. Biol. Chem. 2012, 287:4033-4040.
    • (2012) J. Biol. Chem. , vol.287 , pp. 4033-4040
    • Lee, J.1    Kim, H.R.2    Quinley, C.3    Kim, J.4    Gonzalez-Navajas, J.5    Xavier, R.6    Raz, E.7
  • 49
    • 78751672975 scopus 로고    scopus 로고
    • Autophagy in immunity and inflammation
    • Levine B., Mizushima N., Virgin H.W. Autophagy in immunity and inflammation. Nature 2011, 469:323-335.
    • (2011) Nature , vol.469 , pp. 323-335
    • Levine, B.1    Mizushima, N.2    Virgin, H.W.3
  • 51
    • 0021338217 scopus 로고
    • Phosphorylation affects the ability of tau protein to promote microtubule assembly
    • Lindwall G., Cole R.D. Phosphorylation affects the ability of tau protein to promote microtubule assembly. J. Biol. Chem. 1984, 259:5301-5305.
    • (1984) J. Biol. Chem. , vol.259 , pp. 5301-5305
    • Lindwall, G.1    Cole, R.D.2
  • 52
    • 78650338241 scopus 로고    scopus 로고
    • CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-beta phagocytosis
    • Liu Z., Condello C., Schain A., Harb R., Grutzendler J. CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-beta phagocytosis. J. Neurosci. 2010, 30:17091-17101.
    • (2010) J. Neurosci. , vol.30 , pp. 17091-17101
    • Liu, Z.1    Condello, C.2    Schain, A.3    Harb, R.4    Grutzendler, J.5
  • 53
    • 84872480032 scopus 로고    scopus 로고
    • Diminished parkin solubility and co-localization with intraneuronal amyloid-β are associated with autophagic defects in Alzheimer's disease
    • Lonskaya I., Shekoyan A.R., Hebron M.L., Desforges N., Algarzae N.K., Moussa C.E. Diminished parkin solubility and co-localization with intraneuronal amyloid-β are associated with autophagic defects in Alzheimer's disease. J. Alzheimers Dis. 2013, 33(1):231-247.
    • (2013) J. Alzheimers Dis. , vol.33 , Issue.1 , pp. 231-247
    • Lonskaya, I.1    Shekoyan, A.R.2    Hebron, M.L.3    Desforges, N.4    Algarzae, N.K.5    Moussa, C.E.6
  • 54
    • 84857858536 scopus 로고    scopus 로고
    • Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons
    • Maday S., Wallace K.E., Holzbaur E.L. Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons. J. Cell Biol. 2012, 196(4):407-417.
    • (2012) J. Cell Biol. , vol.196 , Issue.4 , pp. 407-417
    • Maday, S.1    Wallace, K.E.2    Holzbaur, E.L.3
  • 55
    • 0020085949 scopus 로고
    • Isolation of autophagic vacuoles from rat liver: morphological and biochemical characterization
    • Marzella L., Ahlberg J., Glaumann H. Isolation of autophagic vacuoles from rat liver: morphological and biochemical characterization. J. Cell Biol. 1982, 93:144-154.
    • (1982) J. Cell Biol. , vol.93 , pp. 144-154
    • Marzella, L.1    Ahlberg, J.2    Glaumann, H.3
  • 57
    • 0037821637 scopus 로고    scopus 로고
    • Production and neuroprotective functions of fractalkine in the central nervous system
    • Mizuno T., Kawanokuchi J., Numata K., Suzumura A. Production and neuroprotective functions of fractalkine in the central nervous system. Brain Res. 2003, 979:65-70.
    • (2003) Brain Res. , vol.979 , pp. 65-70
    • Mizuno, T.1    Kawanokuchi, J.2    Numata, K.3    Suzumura, A.4
  • 62
    • 67650966680 scopus 로고    scopus 로고
    • Microglial physiology: unique stimuli, specialized responses
    • Ransohoff R.M., Perry V.H. Microglial physiology: unique stimuli, specialized responses. Annu. Rev. Immunol. 2009, 27:119-145.
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 119-145
    • Ransohoff, R.M.1    Perry, V.H.2
  • 63
    • 0036566266 scopus 로고    scopus 로고
    • Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
    • Ravikumar B., Duden R., Rubinsztein D.C. Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum. Mol. Genet. 2002, 11:1107-1117.
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 1107-1117
    • Ravikumar, B.1    Duden, R.2    Rubinsztein, D.C.3
  • 64
    • 77951226607 scopus 로고    scopus 로고
    • Beta-amyloid1-42 gene transfer model exhibits intraneuronal amyloid, gliosis, tau phosphorylation, and neuronal loss
    • Rebeck G.W., Hoe H.S., Moussa C.E. Beta-amyloid1-42 gene transfer model exhibits intraneuronal amyloid, gliosis, tau phosphorylation, and neuronal loss. J. Biol. Chem. 2010, 285:7440-7446.
    • (2010) J. Biol. Chem. , vol.285 , pp. 7440-7446
    • Rebeck, G.W.1    Hoe, H.S.2    Moussa, C.E.3
  • 66
    • 33747819801 scopus 로고    scopus 로고
    • MTOR and cancer: insights into a complex relationship
    • Sabatini D.M. mTOR and cancer: insights into a complex relationship. Nat. Rev. Cancer 2006, 6:729-734.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 729-734
    • Sabatini, D.M.1
  • 67
    • 77953601881 scopus 로고    scopus 로고
    • Regulation of innate immune responses by autophagy-related proteins
    • Saitoh T., Akira S. Regulation of innate immune responses by autophagy-related proteins. J. Cell Biol. 2010, 189:925-935.
    • (2010) J. Cell Biol. , vol.189 , pp. 925-935
    • Saitoh, T.1    Akira, S.2
  • 68
    • 59649114573 scopus 로고    scopus 로고
    • Autophagic clearance of aggregate-prone proteins associated with neurodegeneration
    • Sarkar S., Ravikumar B., Rubinsztein D.C. Autophagic clearance of aggregate-prone proteins associated with neurodegeneration. Methods Enzymol. 2009, 453:83-110.
    • (2009) Methods Enzymol. , vol.453 , pp. 83-110
    • Sarkar, S.1    Ravikumar, B.2    Rubinsztein, D.C.3
  • 71
    • 0035894855 scopus 로고    scopus 로고
    • Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death
    • Stefanis L., Larsen K.E., Rideout H.J., Sulzer D., Greene L.A. Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death. J. Neurosci. 2001, 21:9549-9560.
    • (2001) J. Neurosci. , vol.21 , pp. 9549-9560
    • Stefanis, L.1    Larsen, K.E.2    Rideout, H.J.3    Sulzer, D.4    Greene, L.A.5
  • 72
    • 38949162988 scopus 로고    scopus 로고
    • Lysine 63-linked polyubiquitin potentially partners with p62 to promote the clearance of protein inclusions by autophagy
    • Tan J.M., Wong E.S., Dawson V.L., Dawson T.M., Lim K.L. Lysine 63-linked polyubiquitin potentially partners with p62 to promote the clearance of protein inclusions by autophagy. Autophagy 2007, 4.
    • (2007) Autophagy , vol.4
    • Tan, J.M.1    Wong, E.S.2    Dawson, V.L.3    Dawson, T.M.4    Lim, K.L.5
  • 75
    • 75149188760 scopus 로고    scopus 로고
    • Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation
    • Wang Y., Martinez-Vicente M., Kruger U., Kaushik S., Wong E., Mandelkow E.M., Cuervo A.M., Mandelkow E. Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation. Autophagy 2010, 6:182-183.
    • (2010) Autophagy , vol.6 , pp. 182-183
    • Wang, Y.1    Martinez-Vicente, M.2    Kruger, U.3    Kaushik, S.4    Wong, E.5    Mandelkow, E.M.6    Cuervo, A.M.7    Mandelkow, E.8
  • 78
    • 0036685522 scopus 로고    scopus 로고
    • Inflammation in neurodegenerative disease - a double-edged sword
    • Wyss-Coray T., Mucke L. Inflammation in neurodegenerative disease - a double-edged sword. Neuron 2002, 35:419-432.
    • (2002) Neuron , vol.35 , pp. 419-432
    • Wyss-Coray, T.1    Mucke, L.2
  • 80
    • 0034652697 scopus 로고    scopus 로고
    • Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activation
    • Zujovic V., Benavides J., Vige X., Carter C., Taupin V. Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activation. Glia 2000, 29:305-315.
    • (2000) Glia , vol.29 , pp. 305-315
    • Zujovic, V.1    Benavides, J.2    Vige, X.3    Carter, C.4    Taupin, V.5


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