메뉴 건너뛰기




Volumn 4, Issue 2-3, 2007, Pages 236-253

Frontotemporal dementia with tau pathology

Author keywords

Frontotemporal dementia; FTDP 17; Neurodegeneration; Tau; Tau mutations

Indexed keywords

TAU PROTEIN;

EID: 34347220115     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000101848     Document Type: Review
Times cited : (62)

References (157)
  • 1
    • 0000244405 scopus 로고
    • Über die Beziehungen der senilen Hirnatrophie zur Aphasia
    • Pick A: Über die Beziehungen der senilen Hirnatrophie zur Aphasia. Prag Med Wochenschr 1892c17:165-167.
    • (1892) Prag Med Wochenschr , vol.c17 , pp. 165-167
    • Pick, A.1
  • 6
    • 1842483843 scopus 로고    scopus 로고
    • Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-contain protein
    • Watts GDJ, Wyner J, Kovach MJ, Metha SG, Mumm S, Darvish D, et al: Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-contain protein. Nat Genet 2004;36:377-381.
    • (2004) Nat Genet , vol.36 , pp. 377-381
    • Watts, G.D.J.1    Wyner, J.2    Kovach, M.J.3    Metha, S.G.4    Mumm, S.5    Darvish, D.6
  • 7
    • 0026488111 scopus 로고
    • Structure and novel exons of the human tau gene
    • Andreadis A, Brown WM, Kosik KS: Structure and novel exons of the human tau gene. Biochemistry 1992;31:10626-10633.
    • (1992) Biochemistry , vol.31 , pp. 10626-10633
    • Andreadis, A.1    Brown, W.M.2    Kosik, K.S.3
  • 8
    • 0024745894 scopus 로고    scopus 로고
    • Multiple isoforms of human microtubule-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease
    • Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA: Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron 1998;3:519-526.
    • (1998) Neuron , vol.3 , pp. 519-526
    • Goedert, M.1    Spillantini, M.G.2    Jakes, R.3    Rutherford, D.4    Crowther, R.A.5
  • 9
    • 0024387161 scopus 로고
    • Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: Differential expression of tau protein mRNAs in human brain
    • Goedert M, Spillantini MG, Potier MC, Ulrich J, Crowther RA: Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain. EMBO J 1989;8:393-399.
    • (1989) EMBO J , vol.8 , pp. 393-399
    • Goedert, M.1    Spillantini, M.G.2    Potier, M.C.3    Ulrich, J.4    Crowther, R.A.5
  • 10
    • 0028965635 scopus 로고
    • Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform
    • Gotz J, Probst A, Spillantini MG, Schafer T, Jakes R, Burki K, Goedert M: Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform. EMBO J 1995;14:1304-1313.
    • (1995) EMBO J , vol.14 , pp. 1304-1313
    • Gotz, J.1    Probst, A.2    Spillantini, M.G.3    Schafer, T.4    Jakes, R.5    Burki, K.6    Goedert, M.7
  • 12
    • 0028118917 scopus 로고
    • Microtubule organization and dynamics dependent on microtubule-associated proteins
    • Hirokawa N: Microtubule organization and dynamics dependent on microtubule-associated proteins. Curr Opin Cell Biol 1994;6:74-81.
    • (1994) Curr Opin Cell Biol , vol.6 , pp. 74-81
    • Hirokawa, N.1
  • 13
    • 0031035402 scopus 로고    scopus 로고
    • Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly
    • Goode BL, Denis PE, Panda D, Radeke MJ, Miller HP, Wilson L, Feinstein SC: Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly. Mol Biol Cell 1997;8:353-365.
    • (1997) Mol Biol Cell , vol.8 , pp. 353-365
    • Goode, B.L.1    Denis, P.E.2    Panda, D.3    Radeke, M.J.4    Miller, H.P.5    Wilson, L.6    Feinstein, S.C.7
  • 14
    • 0027058857 scopus 로고
    • Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau
    • Drechsel DN, Hyman AA, Cobb MH, Kirschner MW: Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau. Mol Biol Cell 1992;3:1141-1154.
    • (1992) Mol Biol Cell , vol.3 , pp. 1141-1154
    • Drechsel, D.N.1    Hyman, A.A.2    Cobb, M.H.3    Kirschner, M.W.4
  • 15
    • 0033607298 scopus 로고    scopus 로고
    • Rapid tread-milling of brain microtubules free of microtubule-associated proteins in vitro and its suppression by tau
    • Panda D, Miller HP, Wilson L: Rapid tread-milling of brain microtubules free of microtubule-associated proteins in vitro and its suppression by tau. Proc Natl Acad Sci USA 1999;96:12459-12464.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12459-12464
    • Panda, D.1    Miller, H.P.2    Wilson, L.3
  • 16
    • 0042924434 scopus 로고    scopus 로고
    • Differential regulation of microtubule dynamics by three- and four-repeat tau: Implications for the onset of neurodegenerative disease
    • Panda D, Samuel JC, Massie M, Feinstein SC, Wilson L: Differential regulation of microtubule dynamics by three- and four-repeat tau: implications for the onset of neurodegenerative disease. Proc Natl Acad Sci USA 2003;100:9548-9553.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 9548-9553
    • Panda, D.1    Samuel, J.C.2    Massie, M.3    Feinstein, S.C.4    Wilson, L.5
  • 17
    • 0027237861 scopus 로고
    • Tau in paired helical filaments is functionally distinct from fetal tau: Assembly incompetence of paired helical filament-tau
    • Yoshida H, Ihara Y: Tau in paired helical filaments is functionally distinct from fetal tau: assembly incompetence of paired helical filament-tau. J Neurochem 1993;61:1183-1186.
    • (1993) J Neurochem , vol.61 , pp. 1183-1186
    • Yoshida, H.1    Ihara, Y.2
  • 19
    • 0002792366 scopus 로고
    • Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: Identification as the microtubule-associated protein tau
    • Goedert M, Wischik CM, Crowther RA, Walker JE, Klug A: Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau. Proc Natl Acad Sci USA 1988;85:4051-4055.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 4051-4055
    • Goedert, M.1    Wischik, C.M.2    Crowther, R.A.3    Walker, J.E.4    Klug, A.5
  • 22
    • 0002629086 scopus 로고
    • Re-examination of a family with Pick's disease
    • Schenk VW: Re-examination of a family with Pick's disease. Ann Hum Genet 1959;23:325-333.
    • (1959) Ann Hum Genet , vol.23 , pp. 325-333
    • Schenk, V.W.1
  • 23
    • 0019925346 scopus 로고
    • Hereditary Pick's disease: Second re-examination of the large family and discussion of other hereditary cases, with particular reference to electroencephalography, a computerized tomography
    • Groen JJ, Endtz LJ: Hereditary Pick's disease: second re-examination of the large family and discussion of other hereditary cases, with particular reference to electroencephalography, a computerized tomography. Brain 1982;105:443-459.
    • (1982) Brain , vol.105 , pp. 443-459
    • Groen, J.J.1    Endtz, L.J.2
  • 24
    • 0028073692 scopus 로고
    • Localization of disinhibition-dementia-parkinsonism-amyotrophy complex to 17q21-22
    • Wilhelmsen KC, Lynch T, Pavlou E, Higgins M, Nygaard TG: Localization of disinhibition-dementia-parkinsonism-amyotrophy complex to 17q21-22. Am J Hum Genet 1994;55:1159-1165.
    • (1994) Am J Hum Genet , vol.55 , pp. 1159-1165
    • Wilhelmsen, K.C.1    Lynch, T.2    Pavlou, E.3    Higgins, M.4    Nygaard, T.G.5
  • 26
    • 0030977392 scopus 로고    scopus 로고
    • Foster NL, Wilhelmsen K, Sima AA, Jones MZ, D'Amato CJ, Gilman S: Frontotemporal dementia and parkinsonism linked to chromosome 17: a consensus conference. Conference Participants. Ann Neurol 1997;41:706-715.
    • Foster NL, Wilhelmsen K, Sima AA, Jones MZ, D'Amato CJ, Gilman S: Frontotemporal dementia and parkinsonism linked to chromosome 17: a consensus conference. Conference Participants. Ann Neurol 1997;41:706-715.
  • 27
    • 0031949084 scopus 로고    scopus 로고
    • Frontotemporal dementia and Parkinsonism linked to chromosome 17: A new group of tauopathies
    • Spillantini MG, Bird TD, Ghetti B: Frontotemporal dementia and Parkinsonism linked to chromosome 17: a new group of tauopathies. Brain Pathol 1998;8:387-402.
    • (1998) Brain Pathol , vol.8 , pp. 387-402
    • Spillantini, M.G.1    Bird, T.D.2    Ghetti, B.3
  • 33
    • 0036892302 scopus 로고    scopus 로고
    • Tau gene mutations: Dissecting the pathogenesis of FTDP-17
    • Ingram EM, Spillantini MG: Tau gene mutations: dissecting the pathogenesis of FTDP-17. Trends Mol Med 2002;8:555-562.
    • (2002) Trends Mol Med , vol.8 , pp. 555-562
    • Ingram, E.M.1    Spillantini, M.G.2
  • 40
    • 0029907548 scopus 로고    scopus 로고
    • Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans
    • Goedert M, Jakes R, Spillantini MG, Hasegawa M, Smith MJ, Crowther RA: Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans. Nature 1996;383:550-553.
    • (1996) Nature , vol.383 , pp. 550-553
    • Goedert, M.1    Jakes, R.2    Spillantini, M.G.3    Hasegawa, M.4    Smith, M.J.5    Crowther, R.A.6
  • 43
    • 0033545946 scopus 로고    scopus 로고
    • Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements
    • D'Souza I, Poorkaj P, Hong M, Nochlin D, Lee VM, Bird TD, Schellenberg GD: Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements. Proc Natl Acad Sci USA 1999;96:5598-5603.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5598-5603
    • D'Souza, I.1    Poorkaj, P.2    Hong, M.3    Nochlin, D.4    Lee, V.M.5    Bird, T.D.6    Schellenberg, G.D.7
  • 45
    • 0033529304 scopus 로고    scopus 로고
    • Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17
    • Varani L, Hasegawa M, Spillantini MG, Smith MJ, Murrell JR, Ghetti B, Klug A, Goedert M, Varani G: Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17. Proc Natl Acad Sci USA 1999;96:8229-8234.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 8229-8234
    • Varani, L.1    Hasegawa, M.2    Spillantini, M.G.3    Smith, M.J.4    Murrell, J.R.5    Ghetti, B.6    Klug, A.7    Goedert, M.8    Varani, G.9
  • 47
    • 0037135580 scopus 로고    scopus 로고
    • D'Souza I, Schellenberg GD: tau exon 10 expression involves a bipartite intron 10 regulatory sequence and weak 5′ and 3′ splice sites. J Biol Chem 2002;277:26587-26599.
    • D'Souza I, Schellenberg GD: tau exon 10 expression involves a bipartite intron 10 regulatory sequence and weak 5′ and 3′ splice sites. J Biol Chem 2002;277:26587-26599.
  • 49
    • 0037134098 scopus 로고    scopus 로고
    • Effects on splicing and protein function of three mutations in codon N296 of tau in vitro
    • Grover A, DeTure M, Yen SH, Hutton M: Effects on splicing and protein function of three mutations in codon N296 of tau in vitro. Neurosci Lett 2002;323:33-36.
    • (2002) Neurosci Lett , vol.323 , pp. 33-36
    • Grover, A.1    DeTure, M.2    Yen, S.H.3    Hutton, M.4
  • 50
    • 0034877085 scopus 로고    scopus 로고
    • Familial frontotemporal dementia and parkinsonism with a novel N296H mutation in exon 10 of the tau gene and a widespread tau accumulation in the glial cells
    • Iseki E, Matsumura T, Marui W, Hino H, Odawara T, Sugiyama N, Suzuki K, Sawada H, Arai T, Kosaka K: Familial frontotemporal dementia and parkinsonism with a novel N296H mutation in exon 10 of the tau gene and a widespread tau accumulation in the glial cells. Acta Neuropathol 2001;102:285-292.
    • (2001) Acta Neuropathol , vol.102 , pp. 285-292
    • Iseki, E.1    Matsumura, T.2    Marui, W.3    Hino, H.4    Odawara, T.5    Sugiyama, N.6    Suzuki, K.7    Sawada, H.8    Arai, T.9    Kosaka, K.10
  • 51
    • 0036488210 scopus 로고    scopus 로고
    • Functional effects of tau gene mutations delta N296 and N296H
    • Yoshida H, Crowther RA, Goedert M: Functional effects of tau gene mutations delta N296 and N296H. J Neurochem 2002;80:548-551.
    • (2002) J Neurochem , vol.80 , pp. 548-551
    • Yoshida, H.1    Crowther, R.A.2    Goedert, M.3
  • 52
    • 0033060662 scopus 로고    scopus 로고
    • FTDP-17 mutations N279K and S305N in tau produce increased splicing of exon 10
    • Hasegawa M, Smith MJ, Iijima M, Tabira T, Goedert M: FTDP-17 mutations N279K and S305N in tau produce increased splicing of exon 10. FEBS Lett 1999;443:93-96.
    • (1999) FEBS Lett , vol.443 , pp. 93-96
    • Hasegawa, M.1    Smith, M.J.2    Iijima, M.3    Tabira, T.4    Goedert, M.5
  • 53
    • 0035930625 scopus 로고    scopus 로고
    • Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure
    • von Bergen M, Barghorn S, Li L, Marx A, Biernat J, Mandelkow EM, Mandelkow E: Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure. J Biol Chem 2001;276:48165-48174.
    • (2001) J Biol Chem , vol.276 , pp. 48165-48174
    • von Bergen, M.1    Barghorn, S.2    Li, L.3    Marx, A.4    Biernat, J.5    Mandelkow, E.M.6    Mandelkow, E.7
  • 54
    • 0032919462 scopus 로고    scopus 로고
    • Effects of frontotemporal dementia FTDP-17 mutations on heparin-induced assembly of tau filaments
    • Goedert M, Jakes R, Crowther RA: Effects of frontotemporal dementia FTDP-17 mutations on heparin-induced assembly of tau filaments. FEBS Lett 1999a;450:306-311.
    • (1999) FEBS Lett , vol.450 , pp. 306-311
    • Goedert, M.1    Jakes, R.2    Crowther, R.A.3
  • 55
    • 0032561415 scopus 로고    scopus 로고
    • Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly
    • Hasegawa M, Smith MJ, Goedert M: Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly. FEBS Lett 1998;437:207-210.
    • (1998) FEBS Lett , vol.437 , pp. 207-210
    • Hasegawa, M.1    Smith, M.J.2    Goedert, M.3
  • 57
    • 37049048544 scopus 로고
    • Paired helical filaments in electron microscopy of Alzheimer's disease
    • Kidd M: Paired helical filaments in electron microscopy of Alzheimer's disease. Nature 1963;197:192-193.
    • (1963) Nature , vol.197 , pp. 192-193
    • Kidd, M.1
  • 58
    • 78651158156 scopus 로고
    • Ultrastructural studies in Alzheimer's presenile dementia
    • Terry RD, Gonatas NK, Weiss M: Ultrastructural studies in Alzheimer's presenile dementia. Am J Pathol 1964;44:269-297.
    • (1964) Am J Pathol , vol.44 , pp. 269-297
    • Terry, R.D.1    Gonatas, N.K.2    Weiss, M.3
  • 59
    • 0026595846 scopus 로고
    • Tau proteins of Alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms
    • Goedert M, Spillantini MG, Cairns NJ, Crowther RA: Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms. Neuron 1992;8:159-168.
    • (1992) Neuron , vol.8 , pp. 159-168
    • Goedert, M.1    Spillantini, M.G.2    Cairns, N.J.3    Crowther, R.A.4
  • 60
    • 0025273951 scopus 로고
    • Immunocytochemical and ultrastructural studies of Pick's disease
    • Murayama S, Mori H, Ihara Y, Tomonaga M: Immunocytochemical and ultrastructural studies of Pick's disease. Ann Neurol 1990;27:394-405.
    • (1990) Ann Neurol , vol.27 , pp. 394-405
    • Murayama, S.1    Mori, H.2    Ihara, Y.3    Tomonaga, M.4
  • 62
    • 0029062956 scopus 로고
    • Widespread cytoskeletal pathology characterizes corticobasal degeneration
    • Feany MB, Dickson DW: Widespread cytoskeletal pathology characterizes corticobasal degeneration. Am J Pathol 1995;146:1388-1396.
    • (1995) Am J Pathol , vol.146 , pp. 1388-1396
    • Feany, M.B.1    Dickson, D.W.2
  • 63
    • 0028889282 scopus 로고
    • Thorn-shaped astrocytes: Possibly secondarily induced taupositive glial fibrillary tangles
    • Ikeda K, Akiyama H, Kondo H, Haga C, Tanno E, Tokuda T, Ikeda S: Thorn-shaped astrocytes: possibly secondarily induced taupositive glial fibrillary tangles. Acta Neuropathol 1995;90:620-625.
    • (1995) Acta Neuropathol , vol.90 , pp. 620-625
    • Ikeda, K.1    Akiyama, H.2    Kondo, H.3    Haga, C.4    Tanno, E.5    Tokuda, T.6    Ikeda, S.7
  • 65
    • 0030000867 scopus 로고    scopus 로고
    • Comparison of the neurofibrillary pathology in Alzheimer's disease and familial presenile dementia with tangles
    • Spillantini MG, Crowther RA, Goedert M: Comparison of the neurofibrillary pathology in Alzheimer's disease and familial presenile dementia with tangles. Acta Neuropathol 1996;92:42-48.
    • (1996) Acta Neuropathol , vol.92 , pp. 42-48
    • Spillantini, M.G.1    Crowther, R.A.2    Goedert, M.3
  • 75
    • 0029796168 scopus 로고    scopus 로고
    • Polymerization of tau into filaments in the presence of heparin: The minimal sequence required for tau-tau interaction
    • Perez M, Valpuesta JM, Medina M, Montejo DG, Avila J: Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction. J Neurochem 1996;67:1183-1190.
    • (1996) J Neurochem , vol.67 , pp. 1183-1190
    • Perez, M.1    Valpuesta, J.M.2    Medina, M.3    Montejo, D.G.4    Avila, J.5
  • 77
    • 0035811050 scopus 로고    scopus 로고
    • Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments
    • Epub May 29
    • Alonso A, Zaidi T, Novak M, Grundke-Iqbal I, Iqbal K: Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments. Proc Natl Acad Sci USA 2001;98:6923-6928. Epub 2001 May 29.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 6923-6928
    • Alonso, A.1    Zaidi, T.2    Novak, M.3    Grundke-Iqbal, I.4    Iqbal, K.5
  • 78
    • 0035800219 scopus 로고    scopus 로고
    • Compartmentalized tau hyperphosphorylation and increased levels of kinases in transgenic mice
    • Gotz J, Nitsch RM: Compartmentalized tau hyperphosphorylation and increased levels of kinases in transgenic mice. Neuroreport 2001;12:2007-2016.
    • (2001) Neuroreport , vol.12 , pp. 2007-2016
    • Gotz, J.1    Nitsch, R.M.2
  • 80
    • 11144249896 scopus 로고    scopus 로고
    • Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: Evidence for distinct molecular processes underlying tau abnormalities
    • Lambourne SL, Sellers LA, Bush TG, Choudhury SK, Emson PC, Suh YH, Wilkinson LS: Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities. Mol Cell Biol 2005;25:278-293.
    • (2005) Mol Cell Biol , vol.25 , pp. 278-293
    • Lambourne, S.L.1    Sellers, L.A.2    Bush, T.G.3    Choudhury, S.K.4    Emson, P.C.5    Suh, Y.H.6    Wilkinson, L.S.7
  • 81
    • 4844219627 scopus 로고    scopus 로고
    • Promotion of hyperphosphorylation by frontotemporal dementia tau mutations
    • Alonso AC, Mederlyova A, Novak M, Grundke-Iqbal I, Iqbal K: Promotion of hyperphosphorylation by frontotemporal dementia tau mutations. J Biol Chem 2004;279:34873-34881.
    • (2004) J Biol Chem , vol.279 , pp. 34873-34881
    • Alonso, A.C.1    Mederlyova, A.2    Novak, M.3    Grundke-Iqbal, I.4    Iqbal, K.5
  • 83
    • 0033055359 scopus 로고    scopus 로고
    • Stable expression in Chinese hamster ovary cells of mutated tau genes causing frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)
    • Matsumura N, Yamazaki T, Ihara Y: Stable expression in Chinese hamster ovary cells of mutated tau genes causing frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Am J Pathol 1999;154:1649-1656.
    • (1999) Am J Pathol , vol.154 , pp. 1649-1656
    • Matsumura, N.1    Yamazaki, T.2    Ihara, Y.3
  • 84
    • 0031012497 scopus 로고    scopus 로고
    • Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau
    • Alonso AD, Grundke-Iqbal I, Barra HS, Iqbal K: Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau. Proc Natl Acad Sci USA 1997;94:298-303.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 298-303
    • Alonso, A.D.1    Grundke-Iqbal, I.2    Barra, H.S.3    Iqbal, K.4
  • 85
    • 0029999787 scopus 로고    scopus 로고
    • Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules
    • Alonso AC, Grundke-Iqbal I, Iqbal K: Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat Med 1996;2:783-787.
    • (1996) Nat Med , vol.2 , pp. 783-787
    • Alonso, A.C.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 86
    • 0028227962 scopus 로고
    • Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease
    • Alonso AC, Zaidi T, Grundke-Iqbal I, Iqbal K: Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease. Proc Natl Acad Sci USA 1994;91:5562-5566.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5562-5566
    • Alonso, A.C.1    Zaidi, T.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 89
    • 33744952341 scopus 로고    scopus 로고
    • FTDP-17 Mutations Compromise the ability of Tau to Regulate Microtubule Dynamics in Cells
    • Bunker JM, Kamath K, Wilson L, Jordan MA, Feinstein SC: FTDP-17 Mutations Compromise the ability of Tau to Regulate Microtubule Dynamics in Cells. J Biol Chem 2006;281:11856-11863.
    • (2006) J Biol Chem , vol.281 , pp. 11856-11863
    • Bunker, J.M.1    Kamath, K.2    Wilson, L.3    Jordan, M.A.4    Feinstein, S.C.5
  • 90
    • 10944256690 scopus 로고    scopus 로고
    • Inability of tau to properly regulate neuronal microtubule dynamics: A loss-of-function mechanism by which tau might mediate neuronal cell death
    • Feinstein SC, Wilson L: Inability of tau to properly regulate neuronal microtubule dynamics: a loss-of-function mechanism by which tau might mediate neuronal cell death. Biochim Biophys Acta 2005;1739:268-279.
    • (2005) Biochim Biophys Acta , vol.1739 , pp. 268-279
    • Feinstein, S.C.1    Wilson, L.2
  • 92
  • 93
    • 2542464892 scopus 로고    scopus 로고
    • Modulation of microtubule dynamics by tau in living cells: Implications for development and neurodegeneration
    • Bunker JM, Wilson L, Jordan MA, Feinstein SC: Modulation of microtubule dynamics by tau in living cells: implications for development and neurodegeneration. Mol Biol Cell 2004;15:2720-2728.
    • (2004) Mol Biol Cell , vol.15 , pp. 2720-2728
    • Bunker, J.M.1    Wilson, L.2    Jordan, M.A.3    Feinstein, S.C.4
  • 94
    • 0037128935 scopus 로고    scopus 로고
    • Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
    • Stamer K, Vogel R, Thies E, Mandelkow E, Mandelkow EM: Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. J Cell Biol 2002;156:1051-1063.
    • (2002) J Cell Biol , vol.156 , pp. 1051-1063
    • Stamer, K.1    Vogel, R.2    Thies, E.3    Mandelkow, E.4    Mandelkow, E.M.5
  • 95
    • 0033230886 scopus 로고    scopus 로고
    • Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform
    • Ishihara T, Hong M, Zhang B, Nakagawa Y, Lee MK, Trojanowski JQ, Lee VM: Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. Neuron 1999;24:751-762.
    • (1999) Neuron , vol.24 , pp. 751-762
    • Ishihara, T.1    Hong, M.2    Zhang, B.3    Nakagawa, Y.4    Lee, M.K.5    Trojanowski, J.Q.6    Lee, V.M.7
  • 99
    • 0036042633 scopus 로고    scopus 로고
    • Polymorphisms in the tau gene in sporadic frontotemporal dementia and other neurodegenerative disorders
    • Panegyres PK, Zafiris-Toufexis K: Polymorphisms in the tau gene in sporadic frontotemporal dementia and other neurodegenerative disorders. Eur J Neurol 2002;9:485-489.
    • (2002) Eur J Neurol , vol.9 , pp. 485-489
    • Panegyres, P.K.1    Zafiris-Toufexis, K.2
  • 102
    • 0031883252 scopus 로고    scopus 로고
    • Progressive supranuclear gaze palsy is in linkage disequilibrium with the tau and not the alpha-synuclein gene
    • Higgins JJ, Litvan I, Pho LT, Li W, Nee LE: Progressive supranuclear gaze palsy is in linkage disequilibrium with the tau and not the alpha-synuclein gene. Neurology 1998;50:270-273.
    • (1998) Neurology , vol.50 , pp. 270-273
    • Higgins, J.J.1    Litvan, I.2    Pho, L.T.3    Li, W.4    Nee, L.E.5
  • 109
    • 0033553641 scopus 로고    scopus 로고
    • No genetic association between polymorphisms in the Tau gene and Alzheimer's disease in clinic or population based samples
    • Crawford F, Freeman M, Town T, Fallin D, Gold M, Duara R, Mullan M: No genetic association between polymorphisms in the Tau gene and Alzheimer's disease in clinic or population based samples. Neurosci Lett 1999;266:193-196.
    • (1999) Neurosci Lett , vol.266 , pp. 193-196
    • Crawford, F.1    Freeman, M.2    Town, T.3    Fallin, D.4    Gold, M.5    Duara, R.6    Mullan, M.7
  • 112
    • 0036219387 scopus 로고    scopus 로고
    • Differences in tau and apolipoprotein E polymorphism frequencies in sporadic frontotemporal lobar degeneration syndromes
    • Short RA, Graff-Radford NR, Adamson J, Baker M, Hutton M: Differences in tau and apolipoprotein E polymorphism frequencies in sporadic frontotemporal lobar degeneration syndromes. Arch Neurol 2002;59:611-615.
    • (2002) Arch Neurol , vol.59 , pp. 611-615
    • Short, R.A.1    Graff-Radford, N.R.2    Adamson, J.3    Baker, M.4    Hutton, M.5
  • 113
    • 0037403561 scopus 로고    scopus 로고
    • Tau haplotype frequency in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    • Hughes A, Mann D, Pickering-Brown S: Tau haplotype frequency in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Exp Neurol 2003;181:12-16.
    • (2003) Exp Neurol , vol.181 , pp. 12-16
    • Hughes, A.1    Mann, D.2    Pickering-Brown, S.3
  • 119
    • 0032747502 scopus 로고    scopus 로고
    • Identification of a novel polymorphism in the promoter region of the tau gene highly associated to progressive supranuclear palsy in humans
    • Ezquerra M, Pastor P, Valldeoriola F, Molinuevo JL, Blesa R, Tolosa E, Oliva R: Identification of a novel polymorphism in the promoter region of the tau gene highly associated to progressive supranuclear palsy in humans. Neurosci Lett 1999;275:183-186.
    • (1999) Neurosci Lett , vol.275 , pp. 183-186
    • Ezquerra, M.1    Pastor, P.2    Valldeoriola, F.3    Molinuevo, J.L.4    Blesa, R.5    Tolosa, E.6    Oliva, R.7
  • 120
    • 0035812874 scopus 로고    scopus 로고
    • Strong association of a novel Tau promoter haplotype in progressive supranuclear palsy
    • de Silva R, Weiler M, Morris HR, Martin ER, Wood NW, Lees AJ: Strong association of a novel Tau promoter haplotype in progressive supranuclear palsy. Neurosci Lett 2001;311:145-148.
    • (2001) Neurosci Lett , vol.311 , pp. 145-148
    • de Silva, R.1    Weiler, M.2    Morris, H.R.3    Martin, E.R.4    Wood, N.W.5    Lees, A.J.6
  • 131
    • 0034093228 scopus 로고    scopus 로고
    • Progressive supranuclear palsy pathology caused by a novel silent mutation in exon 10 of the tau gene: Expansion of the disease phenotype caused by tau gene mutations
    • Stanford PM, Halliday GM, Brooks WS, Kwok JB, Storey CE, Creasey H, Morris JG, Fulham MJ, Schofield PR: Progressive supranuclear palsy pathology caused by a novel silent mutation in exon 10 of the tau gene: expansion of the disease phenotype caused by tau gene mutations. Brain 2000;123:880-893.
    • (2000) Brain , vol.123 , pp. 880-893
    • Stanford, P.M.1    Halliday, G.M.2    Brooks, W.S.3    Kwok, J.B.4    Storey, C.E.5    Creasey, H.6    Morris, J.G.7    Fulham, M.J.8    Schofield, P.R.9
  • 140
    • 0034950555 scopus 로고    scopus 로고
    • Familial frontotemporal dementia and parkinsonism with a novel mutation at an intron 10 + 11-splice site in the tau gene
    • Miyamoto K, Kowalska A, Hasegawa M, Tabira T, Takahashi K, Araki W, Akiguchi I, Ikemoto A: Familial frontotemporal dementia and parkinsonism with a novel mutation at an intron 10 + 11-splice site in the tau gene. Ann Neurol 2001;50:117-120.
    • (2001) Ann Neurol , vol.50 , pp. 117-120
    • Miyamoto, K.1    Kowalska, A.2    Hasegawa, M.3    Tabira, T.4    Takahashi, K.5    Araki, W.6    Akiguchi, I.7    Ikemoto, A.8
  • 145
    • 0030048833 scopus 로고    scopus 로고
    • Familial dementia with swollen achromatic neurons and corticobasal inclusion bodies: A clinical and pathological study
    • Brown J, Lantos PL, Roques P, Fidani L, Rossor MN: Familial dementia with swollen achromatic neurons and corticobasal inclusion bodies: a clinical and pathological study. J Neurol Sci 1996;135:21-30.
    • (1996) J Neurol Sci , vol.135 , pp. 21-30
    • Brown, J.1    Lantos, P.L.2    Roques, P.3    Fidani, L.4    Rossor, M.N.5
  • 146
    • 0031738468 scopus 로고    scopus 로고
    • Tau pathology in two Dutch families with mutations in the microtubule-binding region of tau
    • Spillantini MG, Crowther RA, Kamphorst W, Heutink P, van Swieten JC: Tau pathology in two Dutch families with mutations in the microtubule-binding region of tau. Am J Pathol 1998;153:1359-1363.
    • (1998) Am J Pathol , vol.153 , pp. 1359-1363
    • Spillantini, M.G.1    Crowther, R.A.2    Kamphorst, W.3    Heutink, P.4    van Swieten, J.C.5
  • 148
    • 29144449788 scopus 로고    scopus 로고
    • Familial autosomal dominant cortico-basal degeneration with the P301S mutation in the tau gene: An example of phenotype variability
    • Casseron W, Azulay JP, Guedj E, Gastaut JL, Pouget J: Familial autosomal dominant cortico-basal degeneration with the P301S mutation in the tau gene: an example of phenotype variability. J Neurol 2005;252:1546-1548.
    • (2005) J Neurol , vol.252 , pp. 1546-1548
    • Casseron, W.1    Azulay, J.P.2    Guedj, E.3    Gastaut, J.L.4    Pouget, J.5
  • 150
    • 0026567475 scopus 로고
    • Familial presenile dementia with psychosis associated with cortical neurofibrillary tangles and degeneration of the amygdala
    • Sumi SM, Bird TD, Nochlin D, Raskind MA: Familial presenile dementia with psychosis associated with cortical neurofibrillary tangles and degeneration of the amygdala. Neurology 1992;42:120-127.
    • (1992) Neurology , vol.42 , pp. 120-127
    • Sumi, S.M.1    Bird, T.D.2    Nochlin, D.3    Raskind, M.A.4
  • 151
    • 0030887854 scopus 로고    scopus 로고
    • Familial multiple system tauopathy with presenile dementia: A disease with abundant neuronal and glial tau filaments
    • Spillantini MG, Goedert M, Crowther RA, Murrell JR, Farlow MR, Ghetti B: Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments. Proc Natl Acad Sci USA 1997;94:4113-4118.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4113-4118
    • Spillantini, M.G.1    Goedert, M.2    Crowther, R.A.3    Murrell, J.R.4    Farlow, M.R.5    Ghetti, B.6
  • 152
    • 0033866455 scopus 로고    scopus 로고
    • A new case of frontotemporal dementia and parkinsonism resulting from an intron 10 +3-splice site mutation in the tau gene: Clinical and pathological features
    • Tolnay M, Grazia SM, Rizzini C, Eccles D, Lowe J, Ellison D: A new case of frontotemporal dementia and parkinsonism resulting from an intron 10 +3-splice site mutation in the tau gene: clinical and pathological features. Neuropathol Appl Neurobiol 1999;26:368-378.
    • (1999) Neuropathol Appl Neurobiol , vol.26 , pp. 368-378
    • Tolnay, M.1    Grazia, S.M.2    Rizzini, C.3    Eccles, D.4    Lowe, J.5    Ellison, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.