Virulence and pathogenicity of fungal pathogens with special reference to Candida albicans

Combating Fungal Infections: Problems and Remedy

Volumn , Issue , 2010, Pages 21-45

  Khan, Mohd Sajjad Ahmad ^a   Ahmad, Iqbal ^a   Aqil, Farrukh ^b   Owais, Mohd ^a   Shahid, Mohd ^c   Musarrat, Javed ^d  

^a ALIGARH MUSLIM UNIVERSITY   (India)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c ALIGARH MUSLIM UNIVERSITY   (India)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84890796594     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-12173-9_2     Document Type: Chapter

References (110)

1. Albrecht A, Felk A, Pichova I, Naglik JR, Schaller M, De Groot P, MacCallum D, Odds FC, Schafer W, Klis F, Monod M, Hube B (2006) Glycosylphosphatidylinositol anchored proteases of Candida albicans target proteins necessary for both cellular process and host pathogen interactions. J Biol Chem 281:668-694
2. Alem MAS, Oteef MDY, Flowers TH, Douglas LJ (2006) Production of tyrosol by Candida albicans biofilms and its role in quorum sensing and biofilm development. Eukaryotic Cell 5:1770-1779
3. Al-Fattani MA, Douglas LJ (2006) Biofilm matrix of Candida albicans and Candida tropicalis: chemical composition and role in drug resistance. J Med Microbiol 55:999-1008
4. Baille GS, Douglas LJ (1999) Role of dimorphism in the development of Candida albicans biofilm. J Med Microbiol 48:671-679
5. Berman J, Sudbery PE (2002) Candida albicans: a molecular revolution built on lessons from budding yeast. Nat Rev Genet 3:918-930
6. Blankenship JR, Mitchell AP (2006) How to build a biofilm: a fungal perspective. Curr Opin Microbiol 9:588-594
7. Braun BR, Johnson AD (1997) Control of filament formation in Candida albicans by the transcriptional repressor TUP1. Science 277:105-109
8. Braun BR, Johnson AD (2000) TUP1, CPH1 and EFG1 make independent contributions to filamentation in Candida albicans. Genetics 157:57-67
9. Brock M (2009) Fungal metabolism in host niches. Curr Opin Microbiol 12:371-376
10. Brown AJ, Gow NA (1999) Regulatory networks controlling Candida albicans morphogenesis. Trends Microbiol 7:333-338
11. Cao YY, Cao YB, Xu Z, Ying K, Li Y, Xie Y, Zhu ZY, Chen WS, Jiang YY (2005) cDNA microarray analysis of differential gene expression in Candida albicans biofilm exposed to farnesol. Antimicrob Agents Chemother 49:584-589
12. Casadevall A (2007) Determinants of virulence in the pathogenic fungi. Fungal Biol Rev 21:130-132
13. Casadevall A, Pirofski LA (2001) Host-pathogen interactions: the attributes of virulence. J Infect Dis 184:337-344
14. Celera JA, Claderone R (2001) Signalling and the biology of human fungal pathogens. In: Claderone R, Cihlar R (eds) Fungal pathogenesis: principles and clinical applications. Marcel Dekker, New York, pp 115-137
15. Chaffin WL, Lopez-Ribot Jl, Casanova M, Gozalbo D, Martinez JP (1998) Cell wall and secreted proteins of Candida albicans: identification, function and expression. Microbiol Mol Biol Rev 62:130-180
16. Chakrabarti A (2005) Microbiology of systemic fungal infection. J Postgrad Med 51(Suppl1):S16-S20
17. Chandra J, Kuhn DM, Mukherjee PK, Hoyer LL, McCormik T, Ghannoum MA (2001) Biofilm formation by the fungal pathogen Candida albicans: development, architecture and drug resistance. J Bacteriol 18:5385-5394
18. Chandra J, Patel JD, Li J, Zhou G, Mukherjee PK, McCormick TS et al (2005) Modification of surface properties of biomaterials influences the ability of Candida albicans to form biofilms. Appl Environ Microbiol 71:8795-8801
19. Claderone RA, Fonzi WA (2001) Virulence factors of Candida albicans. Trends Microbiol 9:327-336
20. Corner BE, Magee PT (1997) Candida pathogenesis: unraveling the threads of infection. Curr Biol 2:R691-R694
21. de Bernardis F, Muhlschlegel FA, Cassone A, Fonzi WA (1998) The pH of the host niche controls the gene expression in and virulence of Candida albicans. Infect Immun 66:3317-3325
22. de Bernardis F, Arancia S, Morelli L, Hube B, Sanglard D, Schafer W, Cassone A (1999) Evidence that members of aspartyl proteinase gene family, in particular SAP 2, are virulence factors for Candida vaginitis. J Infect Dis 179:201-208
23. Dominic RM, Shenoy S, Baliga S (2007) Candida biofilms in medical devices: evolving trends. Kathmandu Univ Med J 5:431-436
24. Dos Santos AL, de Carvalno IM, daSilva BA, Portela MB, Alviano CS, de Aroujo Soares RM (2006) Secretion of serine peptidase by a clinical strain of Candida albicans: influence of growth condition and cleavage of human serum proteins and extracellular matrix components. FEMS Immunol Med Microbiol 46:209-220
25. Douglas LJ (2003) Candida biofilms and their role in infection. Trends Microbiol 11:30-36
26. Eckert SE, Sheth CC, Muhlschlegel FA (2007) Regulation of morphogenesis in Candia species. In: d'Enfert CH, Hube B (eds) Candida. Comparative and functional genomics. Caister Academic, Norfolk, pp 263-291
27. Fidel PL Jr, Vanquez JA, Sobel JD (1999) Candida glabrata: a review of epidemiology, pathogenesis and clinical disease with comparison to Candida albicans. Clin Microbiol Rev 12:80-96
28. Filler SG, Sheppard DC, Edwards JE Jr (2006) Molecular basis of fungal adherence to endothelial and epithelial cells. In: Heitman J, Filler SG, Edwards JE Jr, Mitchell AP (eds) Molecular principles of fungal pathogenesis. ASM, Washington, DC, pp 187-196
29. Fluckiger U, Marchetti O, Bille J, Eggiman P, Zimmerli S, Imhof A, Garbino J, Ruef C, Pittet D, Tauber M, Glauser M, Calandra T (2006) Treatment options of invasive fungal infections in adults. Swiss Med Wkly 136:447-463
30. Ghannoum MA (2000) Potential role of phospholipases in virulence and fungal pathogenesis. Clin Microbiol Rev 13:122-143
31. Gow NAR, Brown AJP, Odds FC (2002) Fungal morphogenesis and host invasion. Curr Opin Microbiol 5:366-371
32. Granger BL, Flenniken ML, Davis DA, Mitchell AP, Cutler JE (2005) Yeast wall protein 1 of Candida albicans. Microbiol 151:1631-1644
33. Green CB, Cheng G, Chandra J, Mukherjee P, Ghannoum MA, Hoyer LL (2004) RT-PCR detection of Candida albicans ALS gene expression in the reconstituted human epithelium (RHE) model of oral candidiasis and in model biofilms. Microbiol 150:267-275
34. Haas H, Eisendle M, Turgeon BG (2008) Siderophores in fungal physiology and virulence. Ann Rev Phytopathol 46:149-187
35. Hall-Stoodley L, Costerton JW, Stoodley P (2004) Bacterial biofilms: from the natural environment to infectious diseases. Nat Rev Microbiol 2:95-108
36. Hawser SP, Douglas LJ (1994) Biofilm formation by Candida species on the surface of catheter materials in vitro. Infect Immun 62:915-921
37. Hayens KA, Westerneng TJ (1996) Rapid identification of Candida albicans, C. glabrata, C. parapsilosis and C. krusei by species specific PCR of large subunit ribosomal DNA. J Med Microbiol 44:390-396
38. Haynes K (2001) Virulence in Candida species. Trends Microbiol 9:591-596
39. Hogan DA (2006) Talking to themselves: autoregulation and quorum sensing in fungi. Eukaryotic Cell 5:613-619
40. Hogan LH, Klein BS, Levitz SM (1996) Virulence factors of medically important fungi. Clin Microbiol Rev 9:469-488
41. Hoyer LL (2001) The ALS gene family of Candida albicans. Trends Microbiol 9:176-180
42. Hoyer LL, Payne TL, Bell M, Myers AM, Scherer S (1998) Candida albicans AL S3 and insights into the nature of the ALS gene family. Curr Genet 33:451-459
43. Hube B (2004) From commensal to pathogen: stage and tissue specific gene expression of Candida albicans. Curr Opin Microbiol 7:336-341
44. Hube B, Naglik J (2001) Candida albicans proteinases resolving the mystery of a gene family. Microbiol 147:1997-2005
45. Hube B, Sanglard D, Odds FC, Hess D, Monod M, Schafer W, Brown AJ, Gow NA (1997) Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2 and SAP3 of Candida albicans attenuates virulence. Infect Immun 65:3529-3538
46. Hube B, Ruchel R, Monod M, Sanglard D, Odds FC (1998) Functional aspects of secreted Candida proteinases. Adv Exp Med Biol 436:339-344
47. Ibrahim AS, Mirbod F, Filler SG, Banno Y, Cole GT, Kitajima Y, Edwards JE Jr, Nozawa Y, Ghannoum MA (1995) Evidence implicating phospholipase as a virulence factor of Candida albicans. Infect Immun 63:1993-1998
48. Kelly MT, MacCallum DM, Clancy SD, Odds FC, Brown AJ, Butler G (2004) The Candida albicans CaACE 2 gene affects morphogenesis, adherence and virulence. Mol Microbiol 53:969-983
49. Khan ZK, Gyanchandani A (1998) Candidiasis: a review. PINSA 64:1-34
50. Klein BS, Tebbets B (2007) Dimorphism and virulence in fungi. Curr Opin Microbiol 10:314-319
51. Kruppa M, Krom BP, Chauhan N, Bambach AV, Cihlar RL, Calderone RA (2004) The twocomponent signal transduction protein Chk1p regulates quorum sensing in Candida albicans. Eukaryotic Cell 3:1062-1065
52. Kuleta JK, Kozik MR, Kozik A (2009) Fungi pathogenic to humans: molecular basis of virulence of Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. Acta Biochim Pol 56:211-224
53. Kvaal C, Lachke SA, Srikantha T, Daniels K, McCoy J, Soll DR (1999) Misexpression of the opaque phase specific gene PEP1 (SAP1) in the white phase of Candida albicans confers increased virulence in a mouse model of cutaneous infection. Infect Immun 67:6652-6662
54. Latge JP, Calderone R (2002) Host-microbe interactions: fungi Invasive human fungal opportunistic infections. Curr Opin Microbiol 5:355-358
55. Leberer E, Harcus D, Broadbent ID, Clark KL, Dignard D, Ziegelbauer K, Schmidt A, Gow NAR, Brown AJP, Thomas DY (1996) Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans. Proc Natl Acad Sci USA 93:13217-13222
56. Lewis RE, Lo HJ, Raad II, Kontoyiannis DP (2002) Lack of catheter infection by the efg1/efg1 cph1/cph1 double-null mutant, a Candida albicans strain that is defective in filamentous growth. Antimicrob Agents Chemother 46:1153-1155
57. Li F, Svarovsky MJ, Karlsson AJ, Wagner JP, Marchillo K, Oshel P, Andes D, Palecek SP (2007) Eap1p, a adhesin that mediates Candida albicans biofilm formation in vitro and in vivo. Eukaryotic Cell 6:931-939
58. Liu H (2001) Transcriptional control of dimorphism in Candida albicans. Curr Opin Microbiol 4:728-735
59. Lopez-Ribot JL (2005) Candida albicans biofilms: more than filamentation. Curr Biol 15:R453-R455
60. Martin GS, Mnnino DM, Eaton S, Moss M (2003) The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 348:546-1554
61. Martinez-Lopez R, Monteoliva L, Diez-Orejas R, Nombela C, Gil C (2004) The GPI-anchored protein CaEcm33p is required for cell wall integrity, morphogenesis and virulence in Candida albicans. Microbiol 150:3341-3354
62. Mendes-Giannini MJS, Da Silva JLM, Da Silva JF, Donofrio FC, Miranda ET, Andreotti PF, Soares CP (2008) Interactions of Paracoccidioides brasiliensis with host cells: recent advances. Mycopathologia 165:237-248
63. Miller MG, Johnson AD (2002) White opaque switching in Candida albicans is controlled by mating type locus homeodomain proteins and allows efficient mating. Cell 110:293-302
64. Molero G, Dies-Oreja R, Navarro-Garcia F, Monteoliva L, Pla J, Gill C, Sanchez-Perez M, Nambela C (1998) Candida albicans: genetics, dimorphism and pathogenicity. Int J Microbiol 1:95-106
65. Monod M, Zepelin MB (2002) Secreted proteinases and other virulence mechanisms of Candida albicans. Chem Immunol 81:114-128
66. Moore RD, Chaisson RE (1996) Natural history of opportunistic disease in an HIV infected urban clinical cohort. Ann Intern Med 124:633-642
67. Muhlschlegel FA, Fonzi WA (1997) PHR2 of Candida albicans encodes a functional homolog of the pH regulated gene PHR1 with an inverted pattern of pH dependent expression. Mol Cell Biol 17:5960-5967
68. Mulhern SM, Logue ME, Butler G (2006) Candida albicans transcription factor Ace2 regulates metabolism and is required for filamentation in hypoxic conditions. Eukaryotic Cell 5:2001-2013
69. Murphy JW (1991) Mechanisms of natural resistance to human pathogenic fungi. Annu Rev Microbiol 45:509-538
70. Naglik JR, Challacombe SJ, Hube B (2003) Candia albicans secreted aspartyl proteinases in virulence and pathogenesis. Microbiol Mol Biol Rev 67:400-428
71. Naglik JR, Albercht A, Bader O, Hube B (2004) Candida albicans proteinases and host pathogen interactions. Cellular Microbiol 6:915-926
72. Naglik JR, Moyes D, Makwana J, Kanzaria P, Tsichlaki E, Weindl G, Tappuni AR, Rodgers CA, Woodman AJ, Challacombe SJ, Schaller M, Hube B (2008) Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis. Microbiol 154:3266-3280
73. Nobile CJ, Mitchell AP (2005) Regulation of cell surface genes and biofilm formation by the Candida albicans transcription factor Bcr1. Curr Biol 15:1150-1155
74. Nobile CJ, Andes DR, Nett JE, Smith FJ, Yue F, Phan QT, Edwards JE, Filler SG, Mitchell AP (2006a) Critical role of Bcr1-dependent adhesins in Candida albicans biofilms formation in vitro and in vivo. PLoS Pathog 2:636-649
75. Nobile CJ, Nett JE, Andes DR, Mitchell AP (2006b) Function of Candida albicans adhesin Hwp1 in biofilm formation. Eukaryotic Cell 5:1604-1610
76. Noffiz CS, Liedschulte V, Lengeler K, Ernst JF (2008) Functional mapping of the Candida albicans Efg1 regulator. Eukaryotic Cell 7:881-893
77. Norice CT, Smith FJ Jr, Solis N, Filler SG, Mitchell AP (2007) Requirement for Candida albicans Sun41 in biofilm formation and virulence. Eukaryot Cell 6:2046-2055
78. Odds FC (1988) Candida and Candidiasis: a review and bibliography. Bailliere Tindall, London, UK, p 67
79. Odds FC, Gow NAR, Brown AJP (2006) Toward a molecular understanding of Candida albicans virulence. In: Heitman J, Filler SG, Edwards JE Jr, Mitchell AP (eds) Molecular principles of fungal pathogenesis. ASM, Washington, DC, pp 305-319
80. Pfaller MA, Diekema DJ (2002) Role of sentinel surveillance of candidemia: trends in species distribution and antifungal susceptibility. J Clin Microbiol 40:3551-3557
81. Pommerville JC (2004) Alcamo's fundamentals of microbiology, 7th edn. Jones and Bartlett, Sudbury, MA
82. Ramage G, Saville SP, Wickes BL, Lopez-Ribot Jl (2002) Inhibition of Candida albicans biofilm formation by farnesol, a quorum sensing molecule. Appl Environ Microbiol 68:5459-5463
83. Ramage G, Saville SP, Thomas DP, Lopez-Ribot JL (2005) Candida biofilms: an update. Eukaryotic Cell 4:633-638
84. Ramage G, Ghannoum MA, Lopez-Ribot JL (2006) Fungal biofilms: agents of disease and drug resistance. In: Hetman J, Filler SG, Edwards JE Jr, Mitchell AP (eds) Molecular principles of fungal pathogenesis. ASM, Washington, DC, pp 177-185
85. Rappleye CA, Goldman WE (2006) Defining virulence genes in the dimorphic fungi. Annu Rev Microbiol 60:281-303
86. Reedy JL, Bastidas RJ, Heitman J (2007) The virulence of human pathogenic fungi: notes from the South of France. Cell Host Microbe 2:77-83
87. Ribaud P, Chastang C, Latge JP, BAffroy-Lafitte C, Parquet N, Devergie A, Esperou H, Selini F, Rocha V, Derouin F, Socie G, Gluckman E (1999) Outcome and prognostic factors of invasive aspergillosis after allogenic bone marrow transplantation. Clin Infect Dis 28:322-330
88. Richard ML, Nobile CJ, Bruno VM, Mitchell AP (2005) Candida albicans biofilm-defective mutants. Eukaryote Cell 4:1493-1502
89. Richardson MD (2005) Changing pattern and trends in systemic fungal infections. J Antimicrob Chemother 56:5-11
90. Ruiz-Herrera J, Elorza MV, Valentin E, Sentandreu R (2006) Molecular organization of the cell wall of Candida albicans and its relation to pathogenicity. FEMS Yeast Res 6:14-29
91. Rupp S (2007) Interactions of the fungal pathogen Candida albicans with the host. Future Microbiol 2:141-151
92. Saporito-Irwin SM, Birse CE, Sypherd PS, Fonzi WA (1995) PHR1, a pH regulated gene of Candida albicans, is required for morphogenesis. Mol Cell Biol 15:601-613
93. Schaller M, Hube B, Ollert MW, Schafer W, Borg-Von ZM, Thoma-Greber E, Korting HC (1999) In vivo expression and localization of Candida albicans secreted aspartyl proteinases during oral candidiasis in HIV infected patients. J Invest Dermatol 112:383-386
94. Senet JM (1998) Candida adherence pheneomenon, from commensalisms to pathogenicity. Int Microbiol 1:117-122
95. Seneviratne CJ, Jin L, Samaranayke LP (2007) Biofilm lifestyle of Candida: a mini review. Oral Dis 14:582-590
96. Soll DR (1992) High frequency switching in Candida albicans. Clin Microbiol Rev 5:183-203
97. Soll DR (1997) Gene regulation during high frequency switching in Candida albicans. Microbiol 143:279-288
98. Soll DR (2002a) Phenotypic switching. In: Claderone R (ed) Candida and candidiasis. ASM, Washington, DC, pp 123-142
99. Soll DR (2002b) Candida commensalism and virulence: the evolution of phenotypic plasticity. Acta Trop 81:101-110
100. Staab JF, Bradway SD, Fidel PL, Sundstrom P (1999) Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1. Science 283:1535-1538
101. Staib P, Kretschmar M, Nichterlein T, Hof H, Morschhauser J (2002) Transcriptional regulators cph1p and Efg1p mediate activation of the Candida albicans virulence gene SAP5 during infection. Infect Immun 70:921-927
102. Sullivan D, Moran G, Coleman D (2005) Fungal diseases of humans. In: Kavanagh K (ed) Fungi: biology and applications. Wiley, Chichester, UK, pp 171-190
103. Theiss S, Ishdorj G, Brenot A, Kretschmar M, Lan CY, Nichterlein T, Hacker J, Nigam S, Agabian N, Kohler GA (2006) Inactivation of the phospholipase B gene PLB5 in wild type Candida albicans reduces cell associated phospholiupase A2 activity and attenuates virulence. Int J Med Microbiol 296:405-420
104. Tomee JFCH, Kauffman HF (2000) Putative virulence factors of Aspergillus fumigatus. Clin Exp Allergy 30:476-484
105. Wanner A, Salathe M, O'Riordan TG (1996) Mucociliary clearance in the airways. Am J Respir Crit Care Med 154:1868-1902
106. Watamoto T, Samaranayake LP, Jayatilake JAMS, Egusa H, Yatani H, Seneviratne CJ (2009) Effect of filamentation and mode of growth on antifungal susceptibility of Candida albicans. Int J Antimicrob Agents 34:333-339
107. Weitzman I, Summerbell RC (1995) The dermatophytes. Clin Microbiol Rev 8:240-259
108. Willey JM, Sherwood LM, Woolverton CJ (2008) Prescott, Harley and Klein's microbiology, 7th edn. McGraw Hill, Singapore
109. Yang YL (2003) Virulence factors of Candida species. J Microbiol Immunol Infect 36:223-228
110. Zhao X, Daniels KJ, Oh SH, Green CB, Veater KM, Soll DR, Hoyer LL (2006) Candida albicans Als3p is required for wild type biofilm formation on silicone elastomer surface. Microbiology 152:2287-2299