In vivo expression and localization of Candida albicans secreted aspartyl proteinases during oral candidiasis in HIV-infected patients

Journal of Investigative Dermatology

Volumn 112, Issue 3, 1999, Pages 383-386

  Schaller, Martin ^a   Hube, Bernhard ^b   Ollert, Markus W ^c   Schäfer, Wilhelm ^b   Borg Von Zepelin, Margarete ^d   Thoma Greber, Eva ^a   Korting, Hans C ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF HAMBURG   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

HIV infected patients; Immunoelectron microscopy; SAP; Silver enhancement

Indexed keywords

ASPARTIC PROTEINASE;

ADULT; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; CASE REPORT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOELECTRON MICROSCOPY; MALE; MYCOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; THRUSH; VIRUS INFECTION;

EID: 0033018944     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.1999.00525.x     Document Type: Article

References (29)

1. Abad-Zapatero C, Goldman R, Muchmore SW, et al: Structure of secreted aspartic protease from C. albicans complexed with a potent inhibitor: implication for the design of antifungal agents. Protein Science 5:640-652, 1996
2. Borg-von Zepelin M, Grüness V: Characterization of two monoclonal antibodies against secretory proteinase against Candida tropicalis DSM 4328. J Med Vet Mycol 31:1-15, 1993
3. Borg-von Zepelin M, Rüchel R: Expression of extracellular acid proteinase by proteolytic Candida spp during experimental infection of oral mucosa. Infect Immun 56:626-631, 1988
4. Borg-von Zepelin M, Beggah S, Boggian K, Sanglard D, Monod M: The expression of the secreted aspartyl proteinases Sap4 to Sap6 from Candida albicans in murine macrophages. Mol Microbiol 28:543-554, 1998
5. Colina AR, Aumont F, Deslauriers N, Belhumeur P, De Repenigny L: Evidence for degradation of gastrointestinal mucin by Candida albicans secretory aspartyl proteinase. Infect Immun 64:4514-4519, 1996
6. De Bernardis F, Boccanera M, Rainaldi L, Guerra CE, Quinti I, Cassone A: The secretion of aspartyl proteinase, a virulence enzyme, by isolates of Candida albicans from the oral cavity of HIV-infected subjects. Eur J Epidemiol 8:362-367, 1992
7. De Bernardis F, Cassone A, Sturvetant J, Calderone R: Expression of Candida albicans SAP1 and SAP2 in experimental vagimtis. Infect Immun 63:1887-1892, 1995
8. Fallon K, Bausch K, Noonan J, Huguenel E, Tamburini P: Role of aspartic proteases in disseminated Candida albicans infection in mice. Infect Immun 65:551-556, 1997
9. Ghannoum M, Abu Elteen K: Correlative relationship between proteinase production, adherence and pathogenicity of various strains of Candida albicans. J Med Vet Mycol 24:407-413, 1986
10. Hoegl L, Ollert MW, Korting HC: The role of Candida albicans secreted aspartic proteinase in the development of candidoses. J Mol Med 74:135-142, 1996
11. Homma M, Kanabe T, Hiroji C, Tanak K: Detection of intracellular forms of secretory aspartic proteinase in Candida albicans. J Gen Microbiol 138:627-633, 1992
12. Homma M, Chibana H, Tanaka K: Induction of extracellular proteinase in Candida albicans. J Gen Microbiol 139:1187-1193, 1993
13. Hube B: Candida albicans secreted aspartyl proteinases. Curr Top Med Mycol 7:55-69, 1996
14. Hube B, Monod M, Schofield DA, Brown AJP, Gow NAR: Expression of seven members of the gene family encoding secretory aspartyl proteinase in Candida albicans. Mol Microbiol 14:87-99, 1994
15. Hube B, Sanglard D, Odds FC, Hess D, Monod M, Schäfer W, Brown AJP, Gow NAR: Gene disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2 and SAP3 in Candida albicans attenuates virulence. Infect Immun 65:3529-3538, 1997
16. Kwon-Chung KJ, Lehman D, Good C, Magee PT: Genetic evidence for role of extracellular proteinase in virulence of Candida albicans. Infect Immun 49:571-575, 1985
17. MacDonald F, Odds FC: Virulence for mice of a proteinase-secreting strain of Candida albicans and a proteinase-deficient mutant. J Gen Microbiol 129:431-438, 1983
18. Monod M, Togni G, Hube B, Heß D, Sanglard D: Cloning, sequencing and expression of two new members of the secreted aspartyl proteinase family of Candida albicans. Microbiology 144:2731-2737, 1998
19. Negi M, Tsuboi R, Matsui T, Ogawa H: Isolation and characterization of proteinase from Candida albicans: substrate specificity. J Invest Dermatol 83:32-36, 1984
20. Ollert MW, Söhnchen R, Korting HC, Ollert U, Bräutigam S, Bräutigam W: Mechanisms of adherence of Candida albicans to cultured human epidermal keratinocytes. Infect Immun 61:4560-4568, 1993
21. Ollert MW, Wende C, Görlich M, McMullan-Vogel MG, Borg-von Zepelin M, Vogel C-W, Korting HC: Increased expression of Candida albicans secretory proteinase, a virulence factor, in isolates from human immunodeficiency virus-positive patients. J Clin Microbiol 33:2543-2549, 1995
22. Pugh D, Cawson RA: The cytochemical localization of phospholipase A in Candida albicans. Sabouraudia 13:110-115, 1975
23. Ray TL, Payne CD: Scanning electron microscopy of epidermal adherence and cavitation in murine candidiasis: a role for Candida acid proteinase. Infect Immun 56:1942-1949, 1988
24. Reid GA: Protein targeting in yeasts. J Gen Microbiol 137:1765-1772, 1991
25. Rüchel R: On the role of proteinases from Candida albicans in the pathogenesis of acronecrosis. Zbl Bakt Hyg Orig a 255:524-536, 1983
26. Rüchel R, Zimmermann F, Böning-Stutzer B, Helmchen U: Candidiasis visualized by proteinase-directed immunofluorescence. Virchows Arch a Pathol Anat 419:199-202, 1991
27. Sanglard D, Hube B, Monod M, Odds FC, Gow NAR: A triple deletion in SAP4, SAP5 and SAP6 secretory aspartyl proteinase genes of Candida albicans causes attenuated virulence. Infect Immun 65:3539-3546, 1997
28. Schaller M, Schäfer W, Korting HC, Hube B: Differential expression of secreted aspartyl proteinases in a model of human oral candidosis and in patient samples from the oral cavity. Mol Microbiol 29:605-615, 1998
29. White TC, Agabian N: Candida albicans secreted aspartyl proteinases: isoenzyme pattern is determined by cell type, levels are determined by environmental factors. J Bacteriol 177:5215-5221, 1995