The designability of protein switches by chemical rescue of structure: Mechanisms of inactivation and reactivation

Journal of the American Chemical Society

Volumn 135, Issue 50, 2013, Pages 18840-18849

  Xia, Yan ^a   Diprimio, Nina ^b   Keppel, Theodore R ^a   Vo, Binh ^a   Fraser, Keith ^c   Battaile, Kevin P ^d   Egan, Chet ^a   Bystroff, Christopher ^c   Lovell, Scott ^a   Weis, David D ^a   Anderson, J Christopher ^b   Karanicolas, John ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b University of California at Berkeley   (United States)

^c RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^d HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC CONTROL; ALLOSTERIC EFFECTORS; COMPUTATIONAL STRUCTURE; CONFORMATIONAL CHANGE; ENERGETIC ANALYSIS; FLUORESCENCE STUDIES; PHARMACOLOGICAL AGENTS; RECOGNITION PROPERTIES;

AMINO ACIDS; BINDING SITES; CONFORMATIONS; ENZYMES; MASS SPECTROMETRY; POLYCYCLIC AROMATIC HYDROCARBONS; PROTEINS; SENSORS; STABILITY; X RAY CRYSTALLOGRAPHY;

CHEMICAL STABILITY;

DEUTERIUM; GLYCINE; HYDROGEN; INDOLE; TRYPTOPHAN;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYMOLOGY; FLUORESCENCE ANALYSIS; MASS SPECTROMETRY; MUTATION; NONHUMAN; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; REPORTER GENE; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; INDOLES; MUTATION; PROTEIN CONFORMATION; PROTEINS;

EID: 84890694600     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja407644b     Document Type: Article

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