Designing allosteric control into enzymes by chemical rescue of structure

Journal of the American Chemical Society

Volumn 134, Issue 24, 2012, Pages 10055-10060

  Deckert, Katelyn ^a   Budiardjo, S Jimmy ^a   Brunner, Luke C ^a   Lovell, Scott ^a   Karanicolas, John ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACTIVE SITE ARCHITECTURE; ALLOSTERIC CONTROL; ALLOSTERIC EFFECTORS; CATALYTIC DOMAINS; CELL MORPHOLOGY; CELLULAR SIGNALING; CHEMICAL RESCUE; ENZYME INACTIVATION; GLUCURONIDASE; GLYCOSIDASES; LIVING CELL; PROTEIN STRUCTURES; STRUCTURAL BASIS; TRYPTOPHAN SIDE CHAIN; WILD-TYPE ENZYMES;

AMINO ACIDS; RESTORATION;

ENZYMES;

BETA GLUCURONIDASE; GLYCOSIDASE;

ALLOSTERISM; ARTICLE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME KINETICS; ENZYME STRUCTURE; NONHUMAN; SIGNAL TRANSDUCTION;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; BETA-GLUCOSIDASE; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; GLUCURONIDASE; INDOLES; MODELS, MOLECULAR; POINT MUTATION; PROTEIN CONFORMATION; SULFOLOBUS SOLFATARICUS;

EID: 84862529699     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja301409g     Document Type: Article

References (29)

1. Karginov, A. V.; Ding, F.; Kota, P.; Dokholyan, N. V.; Hahn, K. M. Nat. Biotechnol. 2010, 28, 743
2. Yeh, B. J.; Rutigliano, R. J.; Deb, A.; Bar-Sagi, D.; Lim, W. A. Nature 2007, 447, 596
3. Tucker, C. L.; Fields, S. Nat. Biotechnol. 2001, 19, 1042
4. Guntas, G.; Mansell, T. J.; Kim, J. R.; Ostermeier, M. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 11224
5. Ostermeier, M. Curr. Opin. Struct. Biol. 2009, 19, 442
6. Lee, J.; Natarajan, M.; Nashine, V. C.; Socolich, M.; Vo, T.; Russ, W. P.; Benkovic, S. J.; Ranganathan, R. Science 2008, 322, 438
7. Nomura, A. M.; Marnett, A. B.; Shimba, N.; Dotsch, V.; Craik, C. S. Nat. Struct. Mol. Biol. 2005, 12, 1019
8. Korendovych, I. V.; Kulp, D. W.; Wu, Y.; Cheng, H.; Roder, H.; Degrado, W. F. Proc. Natl. Acad. Sci.U.S.A. 2011, 108, 6823
9. Baker, D. Protein Sci. 2010, 19, 1817
10. Eriksson, A. E.; Baase, W. A.; Wozniak, J. A.; Matthews, B. W. Nature 1992, 355, 371
11. Das, A.; Wei, Y.; Pelczer, I.; Hecht, M. H. Protein Sci. 2011, 20, 702
12. Lin, Q.; Barbas, C. F., III; Schultz, P. G. J. Am. Chem. Soc. 2003, 125, 612
13. Guo, Z.; Zhou, D.; Schultz, P. G. Science 2000, 288, 2042
14. Lockless, S. W.; Ranganathan, R. Science 1999, 286, 295
15. Gloster, T. M.; Roberts, S.; Perugino, G.; Rossi, M.; Moracci, M.; Panday, N.; Terinek, M.; Vasella, A.; Davies, G. J. Biochemistry 2006, 45, 11879
16. Gloster, T. M.; Roberts, S.; Ducros, V. M.; Perugino, G.; Rossi, M.; Hoos, R.; Moracci, M.; Vasella, A.; Davies, G. J. Biochemistry 2004, 43, 6101
17. Wallace, B. D.; Wang, H.; Lane, K. T.; Scott, J. E.; Orans, J.; Koo, J. S.; Venkatesh, M.; Jobin, C.; Yeh, L. A.; Mani, S.; Redinbo, M. R. Science 2010, 330, 831
18. Sheffler, W.; Baker, D. Protein Sci. 2009, 18, 229
19. Bernstein, F. C.; Koetzle, T. F.; Williams, G. J.; Meyer, E. F., Jr.; Brice, M. D.; Rodgers, J. R.; Kennard, O.; Shimanouchi, T.; Tasumi, M. J. Mol. Biol. 1977, 112, 535
20. Reinhart, G. D. Arch. Biochem. Biophys. 1983, 224, 389
21. Namchuk, M. N.; Withers, S. G. Biochemistry 1995, 34, 16194
22. Reynolds, K. A.; McLaughlin, R. N.; Ranganathan, R. Cell 2011, 147, 1564
23. Machicado, C.; Bueno, M.; Sancho, J. Protein Eng. 2002, 15, 669
24. Demerdash, O. N.; Daily, M. D.; Mitchell, J. C. PLoS Comput. Biol. 2009, 5, e1000531
25. Dixit, A.; Verkhivker, G. M. PLoS Comput. Biol. 2011, 7, e1002179
26. Kidd, B. A.; Baker, D.; Thomas, W. E. PLoS Comput. Biol. 2009, 5, e1000484
27. Laine, E.; Goncalves, C.; Karst, J. C.; Lesnard, A.; Rault, S.; Tang, W. J.; Malliavin, T. E.; Ladant, D.; Blondel, A. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 11277
28. Hardy, J. A.; Wells, J. A. Curr. Opin. Struct. Biol. 2004, 14, 706
29. Wright, C. M.; Heins, R. A.; Ostermeier, M. Curr. Opin. Chem. Biol. 2007, 11, 342