메뉴 건너뛰기




Volumn 50, Issue 1, 2014, Pages 72-81

Dysfunctional survival-signaling and stress-intolerance in aged murine and human myocardium

Author keywords

Aging; Cardioprotection; Caveolae; G protein coupled receptors; Hormesis; Ischemia mitochondria; Protein kinase; Stress resistance

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ANISOMYCIN; CAVEOLIN 3; CHOLESTEROL; CYCLOSPORIN A; CYTOCHROME C; DIAZOXIDE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; GLYCOGEN SYNTHASE KINASE 3BETA; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MITOGEN ACTIVATED PROTEIN KINASE P38; OPIATE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; S6 KINASE;

EID: 84890592364     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2013.11.015     Document Type: Article
Times cited : (55)

References (70)
  • 1
    • 0032704549 scopus 로고    scopus 로고
    • Influence of age on hypoxia/reoxygenation-induced DNA fragmentation and bcl-2, bcl-xl, bax and fas in the rat heart and brain
    • Azhar G., Liu L., Zhang X., Wei J.Y. Influence of age on hypoxia/reoxygenation-induced DNA fragmentation and bcl-2, bcl-xl, bax and fas in the rat heart and brain. Mech. Ageing Dev. 1999, 112:5-25.
    • (1999) Mech. Ageing Dev. , vol.112 , pp. 5-25
    • Azhar, G.1    Liu, L.2    Zhang, X.3    Wei, J.Y.4
  • 2
    • 34147188924 scopus 로고    scopus 로고
    • Loss of ischemic preconditioning's cardioprotection in aged mouse hearts is associated with reduced gap junctional and mitochondrial levels of connexin 43
    • Boengler K., Konietzka I., Buechert A., Heinen Y., Garcia-Dorado D., Heusch G., Schulz R. Loss of ischemic preconditioning's cardioprotection in aged mouse hearts is associated with reduced gap junctional and mitochondrial levels of connexin 43. Am. J. Physiol. Heart Circ. Physiol. 2007, 292:H1764-H1769.
    • (2007) Am. J. Physiol. Heart Circ. Physiol. , vol.292
    • Boengler, K.1    Konietzka, I.2    Buechert, A.3    Heinen, Y.4    Garcia-Dorado, D.5    Heusch, G.6    Schulz, R.7
  • 5
    • 84865088842 scopus 로고    scopus 로고
    • Hormesis: why it is important to biogerontologists
    • Calabrese E.J., Iavicoli I., Calabrese V. Hormesis: why it is important to biogerontologists. Biogerontology 2012, 13:215-235.
    • (2012) Biogerontology , vol.13 , pp. 215-235
    • Calabrese, E.J.1    Iavicoli, I.2    Calabrese, V.3
  • 6
    • 84876413668 scopus 로고    scopus 로고
    • Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting
    • Chen M., Sato P.Y., Chuprun J.K., Peroutka R.J., Otis N.J., Ibetti J., Pan S., Sheu S.S., Gao E., Koch W.J. Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting. Circ. Res. 2013, 112:1121-1134.
    • (2013) Circ. Res. , vol.112 , pp. 1121-1134
    • Chen, M.1    Sato, P.Y.2    Chuprun, J.K.3    Peroutka, R.J.4    Otis, N.J.5    Ibetti, J.6    Pan, S.7    Sheu, S.S.8    Gao, E.9    Koch, W.J.10
  • 7
    • 10944220835 scopus 로고    scopus 로고
    • Caveolin-1 as a prime modulator of aging: a new modality for phenotypic restoration?
    • Cho K.A., Park S.C. Caveolin-1 as a prime modulator of aging: a new modality for phenotypic restoration?. Mech. Ageing Dev. 2005, 126:105-110.
    • (2005) Mech. Ageing Dev. , vol.126 , pp. 105-110
    • Cho, K.A.1    Park, S.C.2
  • 8
    • 84859896427 scopus 로고    scopus 로고
    • Contribution of impaired mitochondrial autophagy to cardiac aging: mechanisms and therapeutic opportunities
    • Dutta D., Calvani R., Bernabei R., Leeuwenburgh C., Marzetti E. Contribution of impaired mitochondrial autophagy to cardiac aging: mechanisms and therapeutic opportunities. Circ. Res. 2012, 110:1125-1138.
    • (2012) Circ. Res. , vol.110 , pp. 1125-1138
    • Dutta, D.1    Calvani, R.2    Bernabei, R.3    Leeuwenburgh, C.4    Marzetti, E.5
  • 9
  • 10
    • 26444551639 scopus 로고    scopus 로고
    • Inhibition of phosphatase activity enhances preconditioning and limits cell death in the ischemic/reperfused aged rat heart
    • Fenton R.A., Dickson E.W., Dobson J.G. Inhibition of phosphatase activity enhances preconditioning and limits cell death in the ischemic/reperfused aged rat heart. Life Sci. 2005, 77:3375-3388.
    • (2005) Life Sci. , vol.77 , pp. 3375-3388
    • Fenton, R.A.1    Dickson, E.W.2    Dobson, J.G.3
  • 12
    • 37549038706 scopus 로고    scopus 로고
    • Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning
    • Ferdinandy P., Schulz R., Baxter G.F. Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning. Pharmacol. Rev. 2007, 59:418-458.
    • (2007) Pharmacol. Rev. , vol.59 , pp. 418-458
    • Ferdinandy, P.1    Schulz, R.2    Baxter, G.F.3
  • 13
    • 33745234137 scopus 로고    scopus 로고
    • NECA at reperfusion limits infarction and inhibits formation of the mitochondrial permeability transition pore by activating p70S6 kinase
    • Förster K., Paul I., Solenkova N., Staudt A., Cohen M.V., Downey J.M., Felix S.B., Krieg T. NECA at reperfusion limits infarction and inhibits formation of the mitochondrial permeability transition pore by activating p70S6 kinase. Basic Res. Cardiol. 2006, 101:319-326.
    • (2006) Basic Res. Cardiol. , vol.101 , pp. 319-326
    • Förster, K.1    Paul, I.2    Solenkova, N.3    Staudt, A.4    Cohen, M.V.5    Downey, J.M.6    Felix, S.B.7    Krieg, T.8
  • 15
    • 84878970264 scopus 로고    scopus 로고
    • Caveolin and caveolae in age associated cardiovascular disease
    • Fridolfsson H.N., Patel H.H. Caveolin and caveolae in age associated cardiovascular disease. J Geriatr. Cardiol. 2013, 10:66-74.
    • (2013) J Geriatr. Cardiol. , vol.10 , pp. 66-74
    • Fridolfsson, H.N.1    Patel, H.H.2
  • 17
    • 79957865612 scopus 로고    scopus 로고
    • Institute of Medicine (US) Committee on Preventing the Global Epidemic of Cardiovascular Disease: Meeting the Challenges in Developing Countries. Promoting Cardiovascular Health in the Developing World: A Critical Challenge to Achieve Global Health
    • National Academies Press (US), Washington (DC), V. Fuster, B.B. Kelly (Eds.)
    • Institute of Medicine (US) Committee on Preventing the Global Epidemic of Cardiovascular Disease: Meeting the Challenges in Developing Countries. Promoting Cardiovascular Health in the Developing World: A Critical Challenge to Achieve Global Health. Epidemiology of Cardiovascular Disease 2010, 2. National Academies Press (US), Washington (DC). V. Fuster, B.B. Kelly (Eds.).
    • (2010) Epidemiology of Cardiovascular Disease , vol.2
  • 18
    • 12344309431 scopus 로고    scopus 로고
    • Broad spectrum detoxification: the major longevity assurance process regulated by insulin/IGF-1 signaling?
    • Gems D., McElwee J.J. Broad spectrum detoxification: the major longevity assurance process regulated by insulin/IGF-1 signaling?. Mech. Ageing Dev. 2005, 126:381-387.
    • (2005) Mech. Ageing Dev. , vol.126 , pp. 381-387
    • Gems, D.1    McElwee, J.J.2
  • 19
    • 1842841258 scopus 로고    scopus 로고
    • Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts
    • Gross E.R., Hsu A.K., Gross G.J. Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts. Circ. Res. 2004, 94:960-966.
    • (2004) Circ. Res. , vol.94 , pp. 960-966
    • Gross, E.R.1    Hsu, A.K.2    Gross, G.J.3
  • 20
    • 0020626413 scopus 로고
    • The isolated human pectinate muscle: a reliable preparation of human cardiac tissue
    • Guo Z., Levi R., Aaronson L. The isolated human pectinate muscle: a reliable preparation of human cardiac tissue. J. Pharmacol. Toxicol. Methods 1983, 9:127-135.
    • (1983) J. Pharmacol. Toxicol. Methods , vol.9 , pp. 127-135
    • Guo, Z.1    Levi, R.2    Aaronson, L.3
  • 21
    • 0030826778 scopus 로고    scopus 로고
    • Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury
    • Halestrap A.P., Connern C.P., Griffiths E.J., Kerr P.M. Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury. Mol. Cell. Biochem. 1997, 174:167-172.
    • (1997) Mol. Cell. Biochem. , vol.174 , pp. 167-172
    • Halestrap, A.P.1    Connern, C.P.2    Griffiths, E.J.3    Kerr, P.M.4
  • 23
    • 30744432149 scopus 로고    scopus 로고
    • Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium
    • Hassouna A., Loubani M., Matata B.M., Fowler A., Standen N.B., Galinanes M. Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium. Cardiovasc. Res. 2006, 69:450-458.
    • (2006) Cardiovasc. Res. , vol.69 , pp. 450-458
    • Hassouna, A.1    Loubani, M.2    Matata, B.M.3    Fowler, A.4    Standen, N.B.5    Galinanes, M.6
  • 24
    • 24144462378 scopus 로고    scopus 로고
    • G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes
    • Head B.P., Patel H.H., Roth D.M., Lai N.C., Niesman I.R., Farquhar M.G., Insel P.A. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. J. Biol. Chem. 2005, 280:31036-31044.
    • (2005) J. Biol. Chem. , vol.280 , pp. 31036-31044
    • Head, B.P.1    Patel, H.H.2    Roth, D.M.3    Lai, N.C.4    Niesman, I.R.5    Farquhar, M.G.6    Insel, P.A.7
  • 26
    • 0032128428 scopus 로고    scopus 로고
    • Aging impairs functional, metabolic and ionic recovery from ischemia-reperfusion and hypoxia-reoxygenation
    • Headrick J.P. Aging impairs functional, metabolic and ionic recovery from ischemia-reperfusion and hypoxia-reoxygenation. J. Mol. Cell. Cardiol. 1998, 30:1415-1430.
    • (1998) J. Mol. Cell. Cardiol. , vol.30 , pp. 1415-1430
    • Headrick, J.P.1
  • 30
    • 78649751904 scopus 로고    scopus 로고
    • Cyclosporine A administered during reperfusion fails to restore cardioprotection in prediabetic Zucker obese rats in vivo
    • Huhn R., Heinen A., Hollmann M.W., Schlack W., Preckel B., Weber N.C. Cyclosporine A administered during reperfusion fails to restore cardioprotection in prediabetic Zucker obese rats in vivo. Nutr. Metab. Cardiovasc. Dis. 2010, 20:706-712.
    • (2010) Nutr. Metab. Cardiovasc. Dis. , vol.20 , pp. 706-712
    • Huhn, R.1    Heinen, A.2    Hollmann, M.W.3    Schlack, W.4    Preckel, B.5    Weber, N.C.6
  • 36
    • 33646034941 scopus 로고    scopus 로고
    • Acute PKCδ inhibition limits ischaemia-reperfusion injury in the aged rat heart: role of GSK-3β
    • Kostyak J.C., Hunter J.C., Korzick D.H. Acute PKCδ inhibition limits ischaemia-reperfusion injury in the aged rat heart: role of GSK-3β. Cardiovasc. Res. 2006, 70:325-334.
    • (2006) Cardiovasc. Res. , vol.70 , pp. 325-334
    • Kostyak, J.C.1    Hunter, J.C.2    Korzick, D.H.3
  • 37
    • 0026052721 scopus 로고
    • Validation of human trabecular preparation for evaluation of inotropic substances
    • Labow R., Desjardins S., Keon W. Validation of human trabecular preparation for evaluation of inotropic substances. J. Pharmacol. Toxicol. Methods. 1991, 26:257-268.
    • (1991) J. Pharmacol. Toxicol. Methods. , vol.26 , pp. 257-268
    • Labow, R.1    Desjardins, S.2    Keon, W.3
  • 38
    • 33845664452 scopus 로고    scopus 로고
    • Reversal of mitochondrial defects before ischemia protects the aged heart
    • Lesnefsky E.J., He D., Moghaddas S., Hoppel C.L. Reversal of mitochondrial defects before ischemia protects the aged heart. FASEB J. 2006, 20:1543-1545.
    • (2006) FASEB J. , vol.20 , pp. 1543-1545
    • Lesnefsky, E.J.1    He, D.2    Moghaddas, S.3    Hoppel, C.L.4
  • 39
    • 9344264666 scopus 로고    scopus 로고
    • Attenuation of antioxidative capacity enhances reperfusion injury in aged rat myocardium after MI/R
    • Liu P., Xu B., Cavalieri T.A., Hock C.E. Attenuation of antioxidative capacity enhances reperfusion injury in aged rat myocardium after MI/R. Am. J. Physiol. Heart Circ. Physiol. 2004, 287:H2719-H2727.
    • (2004) Am. J. Physiol. Heart Circ. Physiol. , vol.287
    • Liu, P.1    Xu, B.2    Cavalieri, T.A.3    Hock, C.E.4
  • 40
    • 79954509823 scopus 로고    scopus 로고
    • Age-associated differences in the inhibition of mitochondrial permeability transition pore opening by cyclosporine A
    • Liu L., Zhu J., Brink P.R., Glass P.S., Rebecchi M.J. Age-associated differences in the inhibition of mitochondrial permeability transition pore opening by cyclosporine A. Acta Anaesthesiol. Scand. 2011, 55:622-630.
    • (2011) Acta Anaesthesiol. Scand. , vol.55 , pp. 622-630
    • Liu, L.1    Zhu, J.2    Brink, P.R.3    Glass, P.S.4    Rebecchi, M.J.5
  • 41
    • 77649194644 scopus 로고    scopus 로고
    • Cardiac preconditioning for ischaemia: lost in translation
    • Ludman A.J., Yellon D.M., Hausenloy D.J. Cardiac preconditioning for ischaemia: lost in translation. Dis. Model. Mech. 2010, 3:35-38.
    • (2010) Dis. Model. Mech. , vol.3 , pp. 35-38
    • Ludman, A.J.1    Yellon, D.M.2    Hausenloy, D.J.3
  • 44
    • 33745234267 scopus 로고    scopus 로고
    • NADPH oxidases are in part responsible for increased cardiovascular superoxide production during aging
    • Oudot A., Martin C., Busseuil D., Vergely C., Demaison L., Rochette L. NADPH oxidases are in part responsible for increased cardiovascular superoxide production during aging. Free Radic. Biol. Med. 2006, 40:2214-2222.
    • (2006) Free Radic. Biol. Med. , vol.40 , pp. 2214-2222
    • Oudot, A.1    Martin, C.2    Busseuil, D.3    Vergely, C.4    Demaison, L.5    Rochette, L.6
  • 46
    • 0038545554 scopus 로고    scopus 로고
    • Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects
    • Peart J., Headrick J.P. Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects. Cardiovasc. Res. 2003, 58:589-601.
    • (2003) Cardiovasc. Res. , vol.58 , pp. 589-601
    • Peart, J.1    Headrick, J.P.2
  • 47
    • 66949145127 scopus 로고    scopus 로고
    • Clinical cardioprotection and the value of conditioning responses
    • Peart J.N., Headrick J.P. Clinical cardioprotection and the value of conditioning responses. Am. J. Physiol. Heart Circ. Physiol. 2009, 296:H1705-H1720.
    • (2009) Am. J. Physiol. Heart Circ. Physiol. , vol.296
    • Peart, J.N.1    Headrick, J.P.2
  • 48
    • 33749349574 scopus 로고    scopus 로고
    • Cardioprotective effects of acute and chronic opioid treatment are mediated via different signaling pathways
    • Peart J.N., Gross G.J. Cardioprotective effects of acute and chronic opioid treatment are mediated via different signaling pathways. Am. J. Physiol. Heart Circ. Physiol. 2006, 291:H1746-H1753.
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.291
    • Peart, J.N.1    Gross, G.J.2
  • 49
    • 34247619761 scopus 로고    scopus 로고
    • Impaired p38-MAPK/HSP27 signaling underlies aging-related failure in opioid-mediated cardioprotection
    • Peart J.N., Gross E.R., Headrick J.P., Gross G.J. Impaired p38-MAPK/HSP27 signaling underlies aging-related failure in opioid-mediated cardioprotection. J. Mol. Cell. Cardiol. 2007, 42:972-980.
    • (2007) J. Mol. Cell. Cardiol. , vol.42 , pp. 972-980
    • Peart, J.N.1    Gross, E.R.2    Headrick, J.P.3    Gross, G.J.4
  • 50
    • 84857244369 scopus 로고    scopus 로고
    • Opposing effects of age and calorie restriction on molecular determinants of myocardial ischemic tolerance
    • Peart J.N., See Hoe L., Pepe S., Johnson P., Headrick J.P. Opposing effects of age and calorie restriction on molecular determinants of myocardial ischemic tolerance. Rejuvenation Res. 2012, 15:59-70.
    • (2012) Rejuvenation Res. , vol.15 , pp. 59-70
    • Peart, J.N.1    See Hoe, L.2    Pepe, S.3    Johnson, P.4    Headrick, J.P.5
  • 53
    • 0344413625 scopus 로고    scopus 로고
    • Mechanisms of myocardial ischemic preconditioning are age related: PKC-epsilon does not play a requisite role in old rabbits
    • Przyklenk K., Li G., Simkhovich B.Z., Kloner R.A. Mechanisms of myocardial ischemic preconditioning are age related: PKC-epsilon does not play a requisite role in old rabbits. J. Appl. Physiol. 2003, 95:2563-2569.
    • (2003) J. Appl. Physiol. , vol.95 , pp. 2563-2569
    • Przyklenk, K.1    Li, G.2    Simkhovich, B.Z.3    Kloner, R.A.4
  • 54
    • 41149127345 scopus 로고    scopus 로고
    • Aging mouse hearts are refractory to infarct size reduction with post-conditioning
    • Przyklenk K., Maynard M., Darling C.E., Whittaker P. Aging mouse hearts are refractory to infarct size reduction with post-conditioning. J. Am. Coll. Cardiol. 2008, 51:1393-1398.
    • (2008) J. Am. Coll. Cardiol. , vol.51 , pp. 1393-1398
    • Przyklenk, K.1    Maynard, M.2    Darling, C.E.3    Whittaker, P.4
  • 55
    • 0032588766 scopus 로고    scopus 로고
    • Coenzyme Q10 improves the tolerance of the senescent myocardium to aerobic and ischemic stress: studies in rats and in human atrial tissue
    • Rosenfeldt F.L., Pepe S., Ou R., Mariani J.A., Rowland M.A., Nagley P., Linnane A.W. Coenzyme Q10 improves the tolerance of the senescent myocardium to aerobic and ischemic stress: studies in rats and in human atrial tissue. Biofactors 1999, 9:291-299.
    • (1999) Biofactors , vol.9 , pp. 291-299
    • Rosenfeldt, F.L.1    Pepe, S.2    Ou, R.3    Mariani, J.A.4    Rowland, M.A.5    Nagley, P.6    Linnane, A.W.7
  • 56
    • 0141674628 scopus 로고    scopus 로고
    • Protection of myocardium by cyclosporin A and insulin: in vitro simulated ischemia study in human myocardium
    • Schneider A., Ad N., Izhar U., Khaliulin I., Borman J.B., Schwalb H. Protection of myocardium by cyclosporin A and insulin: in vitro simulated ischemia study in human myocardium. Ann. Thorac. Surg. 2003, 76:1240-1245.
    • (2003) Ann. Thorac. Surg. , vol.76 , pp. 1240-1245
    • Schneider, A.1    Ad, N.2    Izhar, U.3    Khaliulin, I.4    Borman, J.B.5    Schwalb, H.6
  • 57
    • 0034795316 scopus 로고    scopus 로고
    • Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury
    • Schulman D., Latchman D.S., Yellon D.M. Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury. Am. J. Physiol. Heart Circ. Physiol. 2001, 281:H1630-H1636.
    • (2001) Am. J. Physiol. Heart Circ. Physiol. , vol.281
    • Schulman, D.1    Latchman, D.S.2    Yellon, D.M.3
  • 58
    • 84864622015 scopus 로고    scopus 로고
    • Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways
    • Shore D.E., Carr C.E., Ruvkun G. Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. PLoS Genet. 2012, 8:e1002792.
    • (2012) PLoS Genet. , vol.8
    • Shore, D.E.1    Carr, C.E.2    Ruvkun, G.3
  • 60
    • 0027515127 scopus 로고
    • Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling
    • Sutherland C., Leighton I.A., Cohen P. Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling. Biochem. J. 1993, 296:15-19.
    • (1993) Biochem. J. , vol.296 , pp. 15-19
    • Sutherland, C.1    Leighton, I.A.2    Cohen, P.3
  • 61
    • 0035208471 scopus 로고    scopus 로고
    • Differences in the expression of protein kinase C isoforms and its translocation after stimulation with phorbol ester between young-adult and middle-aged ventricular cardiomyocytes isolated from Fischer 344 rats
    • Takayama M., Ebihara Y., Tani M. Differences in the expression of protein kinase C isoforms and its translocation after stimulation with phorbol ester between young-adult and middle-aged ventricular cardiomyocytes isolated from Fischer 344 rats. Jpn. Circ. J. 2001, 65:1071-1076.
    • (2001) Jpn. Circ. J. , vol.65 , pp. 1071-1076
    • Takayama, M.1    Ebihara, Y.2    Tani, M.3
  • 62
    • 0034749272 scopus 로고    scopus 로고
    • ATP channels mimics preconditioning but protein kinase C activation is less effective in middle-aged rat hearts
    • ATP channels mimics preconditioning but protein kinase C activation is less effective in middle-aged rat hearts. Cardiovasc. Res. 2001, 49:56-68.
    • (2001) Cardiovasc. Res. , vol.49 , pp. 56-68
    • Tani, M.1    Honma, Y.2    Hasegawa, H.3    Tamaki, K.4
  • 63
    • 4043060632 scopus 로고    scopus 로고
    • Postconditioning: a form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway
    • Tsang A., Hausenloy D.J., Mocanu M.M., Yellon D.M. Postconditioning: a form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway. Circ. Res. 2004, 95:230-232.
    • (2004) Circ. Res. , vol.95 , pp. 230-232
    • Tsang, A.1    Hausenloy, D.J.2    Mocanu, M.M.3    Yellon, D.M.4
  • 67
    • 78751705241 scopus 로고    scopus 로고
    • EGF signaling comes of age: promotion of healthy aging in C. elegans
    • Yu S., Driscoll M. EGF signaling comes of age: promotion of healthy aging in C. elegans. Exp. Gerontol. 2011, 46:129-134.
    • (2011) Exp. Gerontol. , vol.46 , pp. 129-134
    • Yu, S.1    Driscoll, M.2
  • 68
    • 33748177384 scopus 로고    scopus 로고
    • Ischemic postconditioning protects remodeled myocardium via the PI3K-PKB/Akt reperfusion injury salvage kinase pathway
    • Zhu M., Feng J., Lucchinetti E., Fischer G., Xu L., Pedrazzini T., Schaub M.C., Zaugg M. Ischemic postconditioning protects remodeled myocardium via the PI3K-PKB/Akt reperfusion injury salvage kinase pathway. Cardiovasc. Res. 2006, 72:152-162.
    • (2006) Cardiovasc. Res. , vol.72 , pp. 152-162
    • Zhu, M.1    Feng, J.2    Lucchinetti, E.3    Fischer, G.4    Xu, L.5    Pedrazzini, T.6    Schaub, M.C.7    Zaugg, M.8
  • 69
    • 77953001152 scopus 로고    scopus 로고
    • Age-associated differences in activation of Akt/GSK-3β signaling pathways and inhibition of mitochondrial permeability transition pore opening in the rat heart
    • Zhu J., Rebecchi M.J., Tan M., Glass P.S., Brink P.R., Liu L. Age-associated differences in activation of Akt/GSK-3β signaling pathways and inhibition of mitochondrial permeability transition pore opening in the rat heart. J. Gerontol. A Biol. Sci. Med. Sci. 2010, 65:611-619.
    • (2010) J. Gerontol. A Biol. Sci. Med. Sci. , vol.65 , pp. 611-619
    • Zhu, J.1    Rebecchi, M.J.2    Tan, M.3    Glass, P.S.4    Brink, P.R.5    Liu, L.6
  • 70
    • 84875164497 scopus 로고    scopus 로고
    • Interactions of GSK-3β with mitochondrial permeability transition pore modulators during preconditioning: age-associated differences
    • Zhu J., Rebecchi M.J., Glass P.S., Brink P.R., Liu L. Interactions of GSK-3β with mitochondrial permeability transition pore modulators during preconditioning: age-associated differences. J. Gerontol. A Biol. Sci. Med. Sci. 2013, 68:395-403.
    • (2013) J. Gerontol. A Biol. Sci. Med. Sci. , vol.68 , pp. 395-403
    • Zhu, J.1    Rebecchi, M.J.2    Glass, P.S.3    Brink, P.R.4    Liu, L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.