EGF signaling comes of age: Promotion of healthy aging in C. elegans

Experimental Gerontology

Volumn 46, Issue 2-3, 2011, Pages 129-134

  Yu, Simon ^a   Driscoll, Monica ^a  

^a The State University of New Jersey   (United States)

Author keywords

EGF binding proteins; EGF signaling; Healthspan; Insulin signaling; Longevity

Indexed keywords

ADVANCED GLYCATION END PRODUCT; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; INSULIN; INSULIN RECEPTOR; LIPOFUSCIN; PHOSPHOLIPASE C GAMMA; RYANODINE RECEPTOR; SOMATOMEDIN; SOMATOMEDIN RECEPTOR; TRANSCRIPTION FACTOR FOXO;

AGING; CAENORHABDITIS ELEGANS; GENE SILENCING; GENETIC CODE; GENETIC CONSERVATION; LIFESPAN; LOCOMOTION; LONGEVITY; MODULATION; MUSCLE ATROPHY; NONHUMAN; PRIORITY JOURNAL; PROGERIA; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN DEFICIENCY; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN SECRETION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY;

AGING; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; EPIDERMAL GROWTH FACTOR; GENE KNOCKDOWN TECHNIQUES; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; PHOSPHOLIPASE C GAMMA; RECEPTOR, INSULIN; SARCOPENIA; SIGNAL TRANSDUCTION;

ANIMALIA; CAENORHABDITIS ELEGANS;

EID: 78751705241     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2010.10.010     Document Type: Review

References (47)

1. Antebi A. Genetics of aging in Caenorhabditis elegans. PLoS Genet. 2007, 3:1565-1571.
2. Aroian R.V., Koga M., Mendel J.E., Ohshima Y., Sternberg P.W. The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily. Nature 1990, 348:693-699.
3. Bolanowski M.A., Russell R.L., Jacobson L.A. Quantitative measures of aging in the nematode Caenorhabditis elegans. I. Popul. longitudinal studies two behavioral parameters. Mech Ageing Dev. 1981, 15:279-295.
4. Chow D.K., Glenn C.F., Johnston J.L., Goldberg I.G., Wolkow C.A. Sarcopenia in the Caenorhabditis elegans pharynx correlates with muscle contraction rate over lifespan. Exp. Gerontol. 2006, 41:252-260.
5. Citri A., Yarden Y. EGF-ERBB signalling: towards the systems level. Nat. Rev. Mol. Cell Biol. 2006, 7:505-516.
6. Clandinin T.R., DeModena J.A., Sternberg P.W. Inositol trisphosphate mediates a RAS independent response to LET-23 receptor tyrosine kinase activation in C. elegans. Cell 1998, 92:523-533.
7. Clokey G.V., Jacobson L.A. The autofluorescent "lipofuscin granules" in the intestinal cells of Caenorhabditis elegans are secondary lysosomes. Mech. Ageing Dev. 1986, 35:79-94.
8. Collins J.J., Huang C., Hughes S., Kornfeld K. The measurement and analysis of age-related changes in Caenorhabditis elegans, WormBook, ed. The C. elegans Research Community, WormBook 2008, http://www.wormbook.org. 10.1895/wormbook.1.137.1.
9. Dillin A., Hsu A.L., Arantes-Oliveira N., Lehrer-Graiwer J., Hsin H., Fraser A.G., Kamath R.S., Ahringer J., Kenyon C. Rates of behavior and aging specified by mitochondrial function during development. Science 2002, 298:2398-2401.
10. Dlakić M. A new family of putative insulin receptor-like proteins. Curr Biol. 2002, 2:R155-157. C. elegans. (Ed.).
11. Emmons S.W. Male development. WormBook, ed. The C. elegans Research Community, WormBook 2005, http://www.wormbook.org. 10.1895/wormbook.1.33.1.
12. Garigan D., Hsu A.L., Fraser A.G., Kamath R.S., Ahringer J., Kenyon C. Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 2002, 161:1101-1112.
13. Gerstbrein B., Stamatas G., Kollias N., Driscoll M. In vivo spectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction in Caenorhabditis elegans. Aging Cell 2005, 4:127-137.
14. Glenn C.F., Chow D.K., David L., Cooke C.A., Gami M.S., Iser W.B., Hanselman K.B., Goldberg I.G., Wolkow C.A. Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory deficits possibly linked to muscle frailty. J. Gerontol. A Biol. Sci. Med. Sci. 2004, 59:1251-1256.
15. Herbst R.S. Review of epidermal growth factor receptor biology. Int. J. Radiat. Oncol. Biol. Phys. 2004, 59:21-26.
16. Herndon L.A., Schmeissner P.J., Dudaronek J.M., Brown P.A., Listner K.M., Sakano Y., Paupard M.C., Hall D.H., Driscoll M. Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 2002, 419:808-814.
17. Hill R.J., Sternberg P.W. The gene lin-3 encodes an inductive signal for vulval development in C. elegans. Nature 1992, 358:470-476.
18. Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 2004, 101:8084-8089.
19. Huang K.M., Cosman P., Schafer W.R. Machine vision based detection of omega bends and reversals in C. elegans. J. Neurosci. Meth. 2006, 158:323-336.
20. Iwasa H., Yu S., Xue J., Driscoll M. Novel EGF pathway regulators modulate C. elegans healthspan and lifespan via EGF receptor, PLC-gamma, and IP3R activation. Aging Cell 2010, 9:490-505.
21. Johnson T.E. Aging can be genetically dissected into component processes using longlived lines of Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 1987, 84:3777-3781.
22. Kenyon C.J. The genetics of ageing. Nature 2010, 464:504-512.
23. Kimura K.D., Tissenbaum H.A., Liu Y., Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 1997, 277:942-946.
24. Klein D.E., Nappi V.M., Reeves G.T., Shvartsman S.Y., Lemmon M.A. Argos inhibits epidermal growth factor receptor signalling by ligand sequestration. Nature 2004, 430:1040-1044.
25. Klein D.E., Stayrook S.E., Shi F., Narayan K., Lemmon M.A. Structural basis for EGFR ligand sequestration by Argos. Nature 2008, 453:1271-1275.
26. Li W., Kennedy S.G., Ruvkun G. daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes Dev. 2003, 17:844-858.
27. Luetteke N.C., Qiu T.H., Fenton S.E., Troyer K.L., Riedel R.F., Chang A., Lee D.C. Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. Development 1999, 126:2739-2750.
28. Mango S.E. The C. elegans pharynx: a model for organogenesis, WormBook, ed. The C. elegans Research Community WormBook 2007, http://www.wormbook.org. 10.1895/wormbook.1.129.1.
29. Marciniak D.J., Rishi A.K., Sarkar F.H., Majumdar A.P. Epidermal growth factor receptor related peptide inhibits growth of PC-3 prostate cancer cells. Mol. Cancer Ther. 2004, 3:1615-1621.
30. Moghal N., Sternberg P.W. The epidermal growth factor system in Caenorhabditis elegans. Exp. Cell Res. 2003, 284:150-159.
31. Murakami H., Bessinger K., Hellmann J., Murakami S. Manipulation of serotonin signal suppresses early phase of behavioral aging in Caenorhabditis elegans. Neurobiol. Aging 2008, 29:1093-1100.
32. Nilson L.A., Schüpbach T. EGF receptor signaling in Drosophila oogenesis. Curr. Top. Dev. Biol. 1999, 44:203-243.
33. Pierce S.B., Costa M., Wisotzkey R., Devadhar S., Homburger S.A., Buchman A.R., Ferguson K.C., Heller J., Platt D.M., Pasquinelli A.A., Liu L.X., Doberstein S.K., Ruvkun G. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev. 2001, 15:672-686.
34. Reich A., Shilo B.Z., Keren A new ligand of the Drosophila epidermal growth factor receptor, undergoes two modes of cleavage. EMBO J. 2002, 21:4287-4296.
35. Reiter J.L., Maihle N.J., Clinton G.M. Therapeutic potential of epidermal growth factor receptor-related protein. Mol. Cancer Ther. 2006, 5:2954.
36. Schmelz E.M., Xu H., Sengupta R., Du J., Banerjee S., Sarkar F.H., Rishi A.K., Majumdar A.P. Regression of early and intermediate stages of colon cancer by targeting multiple members of the EGFR family with EGFR-related protein. Cancer Res. 2007, 67:5389-5396.
37. Schnepp B., Grumbling G., Donaldson T., Simcox A. Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins. Genes Dev. 1996, 10:2302-2313.
38. Schreiber M.A., Pierce-Shimomura J.T., Chan S., Parry D., McIntire S.L. Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1. PLoS Genet. 2010, 6:e1000972.
39. Schweitzer R., Shaharabany M., Seger R., Shilo B.Z. Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination. Genes Dev. 1995, 9:1518-1529.
40. Shilo B.Z. Signaling by the Drosophila epidermal growth factor receptor pathway during development. Exp. Cell Res. 2003, 284:140-149.
41. Shurin G.V., Yurkovetsky Z.R., Chatta G.S., Tourkova I.L., Shurin M.R., Lokshin A.E. Dynamic alteration of soluble serum biomarkers in healthy aging. Cytokine 2007, 39:123-129.
42. Sternberg P.W. Vulval development. WormBook, ed. The C. elegans Research Community, WormBook 2005, http://www.wormbook.org. 10.1895/wormbook.1.129.1.
43. Sundaram M.V. RTK/Ras/MAPK signaling. WormBook, ed. The C. elegans Research Community, WormBook 2006, http://www.wormbook.org. 10.1895/wormbook.1.80.1.
44. Tsechpenakis G., Bianchi L., Metaxas D., Driscoll M. A novel computational approach for simultaneous tracking and feature extraction of C. elegans populations in fluid environments. IEEE Trans. Biomed. Eng. 2008, 55:1539-1549.
45. Van Buskirk C., Sternberg P.W. Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans. Nat. Neurosci. 2007, 10:1300-1307.
46. Yin X., Gower N.J., Baylis H.A., Strange K. Inositol 1,4,5-trisphosphate signaling regulates rhythmic contractile activity of myoepithelial sheath cells in Caenorhabditis elegans. Mol. Biol. Cell 2004, 15:3938-3949.
47. Yu Y., Rishi A.K., Turner J.R., Liu D., Black E.D., Moshier J.A., Majumdar A.P. Cloning of a novel EGFR-related peptide: a putative negative regulator of EGFR. Am. J. Physiol. Cell Physiol. 2001, 280:C1083-C1089.