메뉴 건너뛰기




Volumn 44, Issue 6, 2013, Pages 679-692

The density of macrophages in colorectal cancer is inversely correlated to TGF-β1 expression and patients' survival

Author keywords

CD68; Colorectal cancer; Prognosis; SMAD; TGF 1

Indexed keywords

ANTIBODY; CD68 ANTIGEN; CELL MARKER; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84890567508     PISSN: 15672379     EISSN: 15672387     Source Type: Journal    
DOI: 10.1007/s10735-013-9520-9     Document Type: Article
Times cited : (45)

References (66)
  • 1
    • 40049088602 scopus 로고    scopus 로고
    • The inflammatory micro-environment in tumor progression: The role o tumor-associated macrophages
    • 10.1016/j.critrevonc.2007.07.004 17913510
    • Allavena P, Sica A, Solinas G, Porta C, Mantovani A (2008) The inflammatory micro-environment in tumor progression: the role o tumor-associated macrophages. Crit Rev Oncol Hematol 66:1-9
    • (2008) Crit Rev Oncol Hematol , vol.66 , pp. 1-9
    • Allavena, P.1    Sica, A.2    Solinas, G.3    Porta, C.4    Mantovani, A.5
  • 2
    • 84855568783 scopus 로고    scopus 로고
    • Tumor cells and tumor-associated macrophages: Secreted proteins as potential targets for therapy
    • Article ID: 565187
    • Baay M, Brouwer A, Pauwels P, Peeters M, Lardon F (2011) Tumor cells and tumor-associated macrophages: secreted proteins as potential targets for therapy. Clin Dev Immunol 2011 (Article ID: 565187):1-12
    • (2011) Clin Dev Immunol 2011 , pp. 1-12
    • Baay, M.1    Brouwer, A.2    Pauwels, P.3    Peeters, M.4    Lardon, F.5
  • 3
    • 34748819999 scopus 로고    scopus 로고
    • TGF-beta receptor 2 downregulation in tumour-associated stroma worsens prognosis and high-grade tumours show more tumour-associated macrophages and lower TGF-beta1 expression in colon carcinoma: A retrospective study
    • 10.1186/1471-2407-7-156 17692120
    • Bacman D, Merkel S, Croner R, Papadopoulos T, Brueckl W, Dimmler A (2007) TGF-beta receptor 2 downregulation in tumour-associated stroma worsens prognosis and high-grade tumours show more tumour-associated macrophages and lower TGF-beta1 expression in colon carcinoma: a retrospective study. BMC Cancer 7:156
    • (2007) BMC Cancer , vol.7 , pp. 156
    • Bacman, D.1    Merkel, S.2    Croner, R.3    Papadopoulos, T.4    Brueckl, W.5    Dimmler, A.6
  • 4
    • 33748754842 scopus 로고    scopus 로고
    • Transforming growth factor-beta pathway disruption and infiltration of colorectal cancers by intraepithelial lymphocytes
    • 10.1111/j.1365-2559.2006.02520.x 1:STN:280:DC%2BD28rlsVSksA%3D%3D 16978200
    • Baker K, Chong G, Foulkes WD, Jass JR (2006) Transforming growth factor-beta pathway disruption and infiltration of colorectal cancers by intraepithelial lymphocytes. Histopathology 49(4):371-380
    • (2006) Histopathology , vol.49 , Issue.4 , pp. 371-380
    • Baker, K.1    Chong, G.2    Foulkes, W.D.3    Jass, J.R.4
  • 5
    • 30944432734 scopus 로고    scopus 로고
    • TGF-beta and cancer
    • 10.1016/j.cytogfr.2005.09.006 1:CAS:528:DC%2BD28Xos1CrsA%3D%3D 16289860
    • Bierie B, Moses HL (2006) TGF-beta and cancer. Cytokine Growth Factor Rev 17(1-2):29-40
    • (2006) Cytokine Growth Factor Rev , vol.17 , Issue.1-2 , pp. 29-40
    • Bierie, B.1    Moses, H.L.2
  • 6
    • 0036187615 scopus 로고    scopus 로고
    • The role of tumour-associated macrophages in tumour progression: Implications for new anticancer therapies
    • 10.1002/path.1027 1:STN:280:DC%2BD387it1eksQ%3D%3D 11857487
    • Bingle L, Brown NJ, Lewis CE (2002) The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J Pathol 196(3):254-265
    • (2002) J Pathol , vol.196 , Issue.3 , pp. 254-265
    • Bingle, L.1    Brown, N.J.2    Lewis, C.E.3
  • 8
    • 84862299043 scopus 로고    scopus 로고
    • Cell and molecular biology underpinning the effects of PEDF on cancers in general and osteosarcoma in particular
    • Article ID: 740295
    • Chandolu V, Dass CR (2012) Cell and molecular biology underpinning the effects of PEDF on cancers in general and osteosarcoma in particular. J Biomed Biotechnol 2012 (Article ID: 740295):1-9
    • (2012) J Biomed Biotechnol 2012 , pp. 1-9
    • Chandolu, V.1    Dass, C.R.2
  • 10
    • 81855166109 scopus 로고    scopus 로고
    • Tumor-associated macrophages (TAM) and inflammation in colorectal cancer
    • 10.1007/s12307-010-0052-5 1:CAS:528:DC%2BC38Xit1aktbg%3D 21909876
    • Erreni M, Mantovani A, Allavena P (2011) Tumor-associated macrophages (TAM) and inflammation in colorectal cancer. Cancer Microenviron 4(2):141-154
    • (2011) Cancer Microenviron , vol.4 , Issue.2 , pp. 141-154
    • Erreni, M.1    Mantovani, A.2    Allavena, P.3
  • 11
    • 33947432482 scopus 로고    scopus 로고
    • High macrophage infiltration along the tumor front correlates with improved survival in colon cancer
    • 10.1158/1078-0432.CCR-06-2073 1:CAS:528:DC%2BD2sXitlSjt70%3D 17332291
    • Forssell J, Oberg A, Henriksson ML, Stenling R, Jung A, Palmqvist R (2007) High macrophage infiltration along the tumor front correlates with improved survival in colon cancer. Clin Cancer Res 13(5):1472-1479
    • (2007) Clin Cancer Res , vol.13 , Issue.5 , pp. 1472-1479
    • Forssell, J.1    Oberg, A.2    Henriksson, M.L.3    Stenling, R.4    Jung, A.5    Palmqvist, R.6
  • 13
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • 10.1038/nri978 1:CAS:528:DC%2BD3sXovVw%3D 12511873
    • Gordon S (2003) Alternative activation of macrophages. Nat Rev Immunol 3(1):23-35
    • (2003) Nat Rev Immunol , vol.3 , Issue.1 , pp. 23-35
    • Gordon, S.1
  • 14
    • 77953268611 scopus 로고    scopus 로고
    • Alternative activation of macrophages: Mechanism and functions
    • 10.1016/j.immuni.2010.05.007 1:CAS:528:DC%2BC3cXnt1Kls78%3D 20510870
    • Gordon S, Martinez FO (2010) Alternative activation of macrophages: mechanism and functions. Immunity 32(5):593-604
    • (2010) Immunity , vol.32 , Issue.5 , pp. 593-604
    • Gordon, S.1    Martinez, F.O.2
  • 15
    • 68749085163 scopus 로고    scopus 로고
    • Prognostic significance of mast cell number and microvascular density for the survival of patients with primary colorectal cancer
    • 10.1111/j.1440-1746.2007.05009.x 17645466
    • Gulubova M, Vlaykova T (2009) Prognostic significance of mast cell number and microvascular density for the survival of patients with primary colorectal cancer. J Gastroenterol Hepatol 24(7):1265-1275
    • (2009) J Gastroenterol Hepatol , vol.24 , Issue.7 , pp. 1265-1275
    • Gulubova, M.1    Vlaykova, T.2
  • 16
    • 77953288010 scopus 로고    scopus 로고
    • Role of TGF-beta1, its receptor TGFbetaRII, and Smad proteins in the progression of colorectal cancer
    • 10.1007/s00384-010-0906-9 20165854
    • Gulubova M, Manolova I, Ananiev J, Julianov A, Yovchev Y, Peeva K (2010) Role of TGF-beta1, its receptor TGFbetaRII, and Smad proteins in the progression of colorectal cancer. Int J Colorectal Dis 25(5):591-599
    • (2010) Int J Colorectal Dis , vol.25 , Issue.5 , pp. 591-599
    • Gulubova, M.1    Manolova, I.2    Ananiev, J.3    Julianov, A.4    Yovchev, Y.5    Peeva, K.6
  • 18
    • 14844345809 scopus 로고    scopus 로고
    • Transforming growth factor beta can be a parameter of aggressiveness of pT1 colorectal cancer
    • 1:CAS:528:DC%2BD2MXjt1ygu7Y%3D 15754403
    • Guzinska-Ustymowicz K, Kemona A (2005) Transforming growth factor beta can be a parameter of aggressiveness of pT1 colorectal cancer. World J Gastroenterol 11(8):1193-1195
    • (2005) World J Gastroenterol , vol.11 , Issue.8 , pp. 1193-1195
    • Guzinska-Ustymowicz, K.1    Kemona, A.2
  • 19
    • 0031015530 scopus 로고    scopus 로고
    • Infiltration of mononuclear inflammatory cells into primary colorectal carcinomas: An immunohistological analysis
    • 10.1038/bjc.1997.61 1:STN:280:DyaK2s7nt1equg%3D%3D 9020482
    • Hakansson L, Adell G, Boeryd B, Sjogren F, Sjodahl R (1997) Infiltration of mononuclear inflammatory cells into primary colorectal carcinomas: an immunohistological analysis. Br J Cancer 75(3):374-380
    • (1997) Br J Cancer , vol.75 , Issue.3 , pp. 374-380
    • Hakansson, L.1    Adell, G.2    Boeryd, B.3    Sjogren, F.4    Sjodahl, R.5
  • 20
    • 80053901764 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor (PEDF) promotes tumor cell death by inducing macrophage membrane tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
    • 10.1074/jbc.M111.266064 1:CAS:528:DC%2BC3MXht1yhtrfM 21846721
    • Ho TC, Chen SL, Shih SC, Chang SJ, Yang SL, Hsieh JW, Cheng HC, Chen LJ, Tsao YP (2011) Pigment epithelium-derived factor (PEDF) promotes tumor cell death by inducing macrophage membrane tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Biol Chem 286(41):35943-35954
    • (2011) J Biol Chem , vol.286 , Issue.41 , pp. 35943-35954
    • Ho, T.C.1    Chen, S.L.2    Shih, S.C.3    Chang, S.J.4    Yang, S.L.5    Hsieh, J.W.6    Cheng, H.C.7    Chen, L.J.8    Tsao, Y.P.9
  • 21
    • 77952524907 scopus 로고    scopus 로고
    • Connection between inflammation and carcinogenesis in gastrointestinal tract: Focus on TGF-beta signaling
    • 10.3748/wjg.v16.i17.2080 1:CAS:528:DC%2BC3cXmtF2msr0%3D 20440848
    • Hong S, Lee HJ, Kim SJ, Hahm KB (2010) Connection between inflammation and carcinogenesis in gastrointestinal tract: focus on TGF-beta signaling. World J Gastroenterol 16(17):2080-2093
    • (2010) World J Gastroenterol , vol.16 , Issue.17 , pp. 2080-2093
    • Hong, S.1    Lee, H.J.2    Kim, S.J.3    Hahm, K.B.4
  • 22
    • 33746510500 scopus 로고    scopus 로고
    • Pro-metastasis function of TGFbeta mediated by the Smad pathway
    • 10.1002/jcb.20928 1:CAS:528:DC%2BD28XnvFWktbY%3D 16598746
    • Kang Y (2006) Pro-metastasis function of TGFbeta mediated by the Smad pathway. J Cell Biochem 98(6):1380-1390
    • (2006) J Cell Biochem , vol.98 , Issue.6 , pp. 1380-1390
    • Kang, Y.1
  • 24
    • 0036846118 scopus 로고    scopus 로고
    • Tumor infiltrating lymphocytes and macrophages have a potential dual role in lung cancer by supporting both host-defense and tumor progression
    • 10.1067/mlc.2002.128317 12434133
    • Kataki A, Scheid P, Piet M, Marie B, Martinet N, Martinet Y, Vignaud JM (2002) Tumor infiltrating lymphocytes and macrophages have a potential dual role in lung cancer by supporting both host-defense and tumor progression. J Lab Clin Med 140(5):320-328
    • (2002) J Lab Clin Med , vol.140 , Issue.5 , pp. 320-328
    • Kataki, A.1    Scheid, P.2    Piet, M.3    Marie, B.4    Martinet, N.5    Martinet, Y.6    Vignaud, J.M.7
  • 25
    • 0037441914 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, CD68, and epidermal growth factor receptor expression and survival in patients with Stage II and Stage III colon carcinoma: A role for the host response in prognosis
    • 10.1002/cncr.11152 12569594
    • Khorana AA, Ryan CK, Cox C, Eberly S, Sahasrabudhe DM (2003) Vascular endothelial growth factor, CD68, and epidermal growth factor receptor expression and survival in patients with Stage II and Stage III colon carcinoma: a role for the host response in prognosis. Cancer 97(4):960-968
    • (2003) Cancer , vol.97 , Issue.4 , pp. 960-968
    • Khorana, A.A.1    Ryan, C.K.2    Cox, C.3    Eberly, S.4    Sahasrabudhe, D.M.5
  • 27
    • 50249144131 scopus 로고    scopus 로고
    • Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas
    • 10.1002/path.2370 1:CAS:528:DC%2BD1cXhtFSrtbbJ 18553315
    • Komohara Y, Ohnishi K, Kuratsu J, Takeya M (2008) Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas. J Pathol 216(1):15-24
    • (2008) J Pathol , vol.216 , Issue.1 , pp. 15-24
    • Komohara, Y.1    Ohnishi, K.2    Kuratsu, J.3    Takeya, M.4
  • 30
    • 4544292858 scopus 로고    scopus 로고
    • Prognostic relevance of tumour-associated macrophages and von Willebrand factor-positive microvessels in colorectal cancer
    • 10.1007/s00428-004-1051-z 1:CAS:528:DC%2BD2cXmsVKrsbY%3D 15232739
    • Lackner C, Jukic Z, Tsybrovskyy O, Jatzko G, Wette V, Hoefler G, Klimpfinger M, Denk H, Zatloukal K (2004) Prognostic relevance of tumour-associated macrophages and von Willebrand factor-positive microvessels in colorectal cancer. Virchows Arch 445(2):160-167
    • (2004) Virchows Arch , vol.445 , Issue.2 , pp. 160-167
    • Lackner, C.1    Jukic, Z.2    Tsybrovskyy, O.3    Jatzko, G.4    Wette, V.5    Hoefler, G.6    Klimpfinger, M.7    Denk, H.8    Zatloukal, K.9
  • 31
    • 79959742164 scopus 로고    scopus 로고
    • Prognostic role of FOXP3+ regulatory T cells infiltrating human carcinomas: The paradox of colorectal cancer
    • 10.1007/s00262-011-1046-y 1:CAS:528:DC%2BC3MXnslOrsL4%3D 21644034
    • Ladoire S, Martin F, Ghiringhelli F (2011) Prognostic role of FOXP3+ regulatory T cells infiltrating human carcinomas: the paradox of colorectal cancer. Cancer Immunol Immunother 60(7):909-918
    • (2011) Cancer Immunol Immunother , vol.60 , Issue.7 , pp. 909-918
    • Ladoire, S.1    Martin, F.2    Ghiringhelli, F.3
  • 33
    • 56749160117 scopus 로고    scopus 로고
    • Tumor-host interactions: The role of inflammation
    • 10.1007/s00418-008-0527-3 1:CAS:528:DC%2BD1cXhsVSjsrzF 18953558
    • Le Bitoux MA, Stamenkovic I (2008) Tumor-host interactions: the role of inflammation. Histochem Cell Biol 130(6):1079-1090
    • (2008) Histochem Cell Biol , vol.130 , Issue.6 , pp. 1079-1090
    • Le Bitoux, M.A.1    Stamenkovic, I.2
  • 34
    • 0005339099 scopus 로고    scopus 로고
    • Tumor-associated macrophages in breast cancer
    • 10.1023/A:1020304003704 12463738
    • Leek RD, Harris AL (2002) Tumor-associated macrophages in breast cancer. J Mammary Gland Biol Neoplasia 7(2):177-189
    • (2002) J Mammary Gland Biol Neoplasia , vol.7 , Issue.2 , pp. 177-189
    • Leek, R.D.1    Harris, A.L.2
  • 35
    • 0029816609 scopus 로고    scopus 로고
    • Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma
    • 1:CAS:528:DyaK28XmsV2isbk%3D 8840975
    • Leek RD, Lewis CE, Whitehouse R, Greenall M, Clarke J, Harris AL (1996) Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res 56(20):4625-4629
    • (1996) Cancer Res , vol.56 , Issue.20 , pp. 4625-4629
    • Leek, R.D.1    Lewis, C.E.2    Whitehouse, R.3    Greenall, M.4    Clarke, J.5    Harris, A.L.6
  • 36
    • 31544441610 scopus 로고    scopus 로고
    • Distinct role of macrophages in different tumor microenvironments
    • 10.1158/0008-5472.CAN-05-4005 1:CAS:528:DC%2BD28XlsFOmtw%3D%3D 16423985
    • Lewis CE, Pollard JW (2006) Distinct role of macrophages in different tumor microenvironments. Cancer Res 66(2):605-612
    • (2006) Cancer Res , vol.66 , Issue.2 , pp. 605-612
    • Lewis, C.E.1    Pollard, J.W.2
  • 37
    • 0034266661 scopus 로고    scopus 로고
    • Tumor associated macrophages in human prostate cancer: Relation to clinicopathological variables and survival
    • 1:STN:280:DC%2BD3M%2FjtVKnsQ%3D%3D 10938382
    • Lissbrant IF, Stattin P, Wikstrom P, Damber JE, Egevad L, Bergh A (2000) Tumor associated macrophages in human prostate cancer: relation to clinicopathological variables and survival. Int J Oncol 17(3):445-451
    • (2000) Int J Oncol , vol.17 , Issue.3 , pp. 445-451
    • Lissbrant, I.F.1    Stattin, P.2    Wikstrom, P.3    Damber, J.E.4    Egevad, L.5    Bergh, A.6
  • 38
    • 84856104725 scopus 로고    scopus 로고
    • Tumour-infiltrating macrophages and clinical outcome in breast cancer
    • 10.1136/jclinpath-2011-200355 1:STN:280:DC%2BC387mtVynsA%3D%3D 22049225
    • Mahmoud SM, Lee AH, Paish EC, Macmillan RD, Ellis IO, Green AR (2012) Tumour-infiltrating macrophages and clinical outcome in breast cancer. J Clin Pathol 65(2):159-163
    • (2012) J Clin Pathol , vol.65 , Issue.2 , pp. 159-163
    • Mahmoud, S.M.1    Lee, A.H.2    Paish, E.C.3    Macmillan, R.D.4    Ellis, I.O.5    Green, A.R.6
  • 39
    • 0034994770 scopus 로고    scopus 로고
    • Tumor-infiltrating macrophages (CD68(+) cells) and prognosis in malignant uveal melanoma
    • 1:STN:280:DC%2BD3M3pvVOktg%3D%3D 11381040
    • Makitie T, Summanen P, Tarkkanen A, Kivela T (2001) Tumor-infiltrating macrophages (CD68(+) cells) and prognosis in malignant uveal melanoma. Invest Ophthalmol Vis Sci 42(7):1414-1421
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , Issue.7 , pp. 1414-1421
    • Makitie, T.1    Summanen, P.2    Tarkkanen, A.3    Kivela, T.4
  • 40
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • 10.1016/S1471-4906(02)02302-5 1:CAS:528:DC%2BD38XotVKktrc%3D 12401408
    • Mantovani A, Sozzani S, Locati M, Allavena P, Sica A (2002) Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 23(11):549-555
    • (2002) Trends Immunol , vol.23 , Issue.11 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 41
    • 26644452073 scopus 로고    scopus 로고
    • Macrophage polarization comes of age
    • 10.1016/j.immuni.2005.10.001 1:CAS:528:DC%2BD2MXht1Shs77O 16226499
    • Mantovani A, Sica A, Locati M (2005) Macrophage polarization comes of age. Immunity 23(4):344-346
    • (2005) Immunity , vol.23 , Issue.4 , pp. 344-346
    • Mantovani, A.1    Sica, A.2    Locati, M.3
  • 42
    • 33845524204 scopus 로고    scopus 로고
    • Role of tumor-associated macrophages in tumor progression and invasion
    • 10.1007/s10555-006-9001-7 16967326
    • Mantovani A, Schioppa T, Porta C, Allavena P, Sica A (2006) Role of tumor-associated macrophages in tumor progression and invasion. Cancer Metastasis Rev 25(3):315-322
    • (2006) Cancer Metastasis Rev , vol.25 , Issue.3 , pp. 315-322
    • Mantovani, A.1    Schioppa, T.2    Porta, C.3    Allavena, P.4    Sica, A.5
  • 44
    • 34347331057 scopus 로고    scopus 로고
    • Roles of Smad3 in TGF-beta signaling during carcinogenesis
    • 10.1615/CritRevEukarGeneExpr.v17.i4.30 1:CAS:528:DC%2BD2sXhtVWgtLjF 17725494
    • Millet C, Zhang YE (2007) Roles of Smad3 in TGF-beta signaling during carcinogenesis. Crit Rev Eukaryot Gene Expr 17(4):281-293
    • (2007) Crit Rev Eukaryot Gene Expr , vol.17 , Issue.4 , pp. 281-293
    • Millet, C.1    Zhang, Y.E.2
  • 47
    • 38649136919 scopus 로고    scopus 로고
    • Tumor-infiltrating macrophages and dendritic cells in human colorectal cancer: Relation to local regulatory T cells, systemic T-cell response against tumor-associated antigens and survival
    • 10.1186/1479-5876-5-62 18047662
    • Nagorsen D, Voigt S, Berg E, Stein H, Thiel E, Loddenkemper C (2007) Tumor-infiltrating macrophages and dendritic cells in human colorectal cancer: relation to local regulatory T cells, systemic T-cell response against tumor-associated antigens and survival. J Transl Med 5:62
    • (2007) J Transl Med , vol.5 , pp. 62
    • Nagorsen, D.1    Voigt, S.2    Berg, E.3    Stein, H.4    Thiel, E.5    Loddenkemper, C.6
  • 50
    • 79957822818 scopus 로고    scopus 로고
    • Infiltration of tumour-associated macrophages in prostate biopsy specimens is predictive of disease progression after hormonal therapy for prostate cancer
    • 10.1111/j.1464-410X.2010.09804.x 21044246
    • Nonomura N, Takayama H, Nakayama M, Nakai Y, Kawashima A, Mukai M, Nagahara A, Aozasa K, Tsujimura A (2011) Infiltration of tumour-associated macrophages in prostate biopsy specimens is predictive of disease progression after hormonal therapy for prostate cancer. BJU Int 107(12):1918-1922
    • (2011) BJU Int , vol.107 , Issue.12 , pp. 1918-1922
    • Nonomura, N.1    Takayama, H.2    Nakayama, M.3    Nakai, Y.4    Kawashima, A.5    Mukai, M.6    Nagahara, A.7    Aozasa, K.8    Tsujimura, A.9
  • 51
    • 0036355045 scopus 로고    scopus 로고
    • Different occurrence of CD8+, CD45R0+, and CD68+ immune cells in regional lymph node metastases from colorectal cancer as potential prognostic predictors
    • 10.1007/s003840100337 1:STN:280:DC%2BD383nslGmug%3D%3D 12018450
    • Oberg A, Samii S, Stenling R, Lindmark G (2002) Different occurrence of CD8+, CD45R0+, and CD68+ immune cells in regional lymph node metastases from colorectal cancer as potential prognostic predictors. Int J Colorectal Dis 17(1):25-29
    • (2002) Int J Colorectal Dis , vol.17 , Issue.1 , pp. 25-29
    • Oberg, A.1    Samii, S.2    Stenling, R.3    Lindmark, G.4
  • 52
    • 10744224063 scopus 로고    scopus 로고
    • The degree of macrophage infiltration into the cancer cell nest is a significant predictor of survival in gastric cancer patients
    • 14981961
    • Ohno S, Inagawa H, Dhar DK, Fujii T, Ueda S, Tachibana M, Suzuki N, Inoue M, Soma G, Nagasue N (2003) The degree of macrophage infiltration into the cancer cell nest is a significant predictor of survival in gastric cancer patients. Anticancer Res 23 (6D):5015-5022
    • (2003) Anticancer Res , vol.23 , Issue.6 D , pp. 5015-5022
    • Ohno, S.1    Inagawa, H.2    Dhar, D.K.3    Fujii, T.4    Ueda, S.5    Tachibana, M.6    Suzuki, N.7    Inoue, M.8    Soma, G.9    Nagasue, N.10
  • 55
    • 33845334175 scopus 로고    scopus 로고
    • Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer
    • Pardali K, Moustakas A (2007) Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer. Biochim Biophys Acta 1:21-62
    • (2007) Biochim Biophys Acta , vol.1 , pp. 21-62
    • Pardali, K.1    Moustakas, A.2
  • 56
    • 0347123433 scopus 로고    scopus 로고
    • Tumour-educated macrophages promote tumour progression and metastasis
    • 10.1038/nrc1256 1:CAS:528:DC%2BD2cXos12qtA%3D%3D 14708027
    • Pollard JW (2004) Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 4(1):71-78
    • (2004) Nat Rev Cancer , vol.4 , Issue.1 , pp. 71-78
    • Pollard, J.W.1
  • 57
    • 84862128998 scopus 로고    scopus 로고
    • Differentiation and gene expression profile of tumor-associated macrophages
    • 10.1016/j.semcancer.2012.02.002 1:CAS:528:DC%2BC38XosVKjtb0%3D 22349514
    • Schmieder A, Michel J, Schonhaar K, Goerdt S, Schledzewski K (2012) Differentiation and gene expression profile of tumor-associated macrophages. Semin Cancer Biol 22(4):289-297
    • (2012) Semin Cancer Biol , vol.22 , Issue.4 , pp. 289-297
    • Schmieder, A.1    Michel, J.2    Schonhaar, K.3    Goerdt, S.4    Schledzewski, K.5
  • 58
    • 33645991795 scopus 로고    scopus 로고
    • Tumour-associated macrophages are distinct M2 polarised population promoting tumour progression: Potential targets of anti-cancer therapy
    • 10.1016/j.ejca.2006.01.003 1:CAS:528:DC%2BD28Xjs1Grt78%3D 16520032
    • Sica A, Schioppa T, Mantovani A, Allavena P (2006) Tumour-associated macrophages are distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur J Cancer 42(6):717-727
    • (2006) Eur J Cancer , vol.42 , Issue.6 , pp. 717-727
    • Sica, A.1    Schioppa, T.2    Mantovani, A.3    Allavena, P.4
  • 59
    • 47749155653 scopus 로고    scopus 로고
    • Cancer related inflammation: The macrophage connection
    • 10.1016/j.canlet.2008.03.028 1:CAS:528:DC%2BD1cXovF2hsLk%3D 18448242
    • Sica A, Allavena P, Mantovani A (2008) Cancer related inflammation: the macrophage connection. Cancer Lett 267(2):204-215
    • (2008) Cancer Lett , vol.267 , Issue.2 , pp. 204-215
    • Sica, A.1    Allavena, P.2    Mantovani, A.3
  • 60
    • 18244375863 scopus 로고    scopus 로고
    • Characterization of macrophage subpopulations in colon cancer using tissue microarrays
    • 10.1111/j.1365-2559.2005.02129.x 1:STN:280:DC%2BD2M3gvVylsQ%3D%3D 15842633
    • Sickert D, Aust DE, Langer S, Haupt I, Baretton GB, Dieter P (2005) Characterization of macrophage subpopulations in colon cancer using tissue microarrays. Histopathology 46(5):515-521
    • (2005) Histopathology , vol.46 , Issue.5 , pp. 515-521
    • Sickert, D.1    Aust, D.E.2    Langer, S.3    Haupt, I.4    Baretton, G.B.5    Dieter, P.6
  • 61
    • 77951635438 scopus 로고    scopus 로고
    • Inflammation and colon cancer
    • 10.1053/j.gastro.2010.01.058 1:CAS:528:DC%2BC3cXms1yitbg%3D 20420949
    • Terzic J, Grivennikov S, Karin E, Karin M (2010) Inflammation and colon cancer. Gastroenterology 138(6):2101-2114
    • (2010) Gastroenterology , vol.138 , Issue.6 , pp. 2101-2114
    • Terzic, J.1    Grivennikov, S.2    Karin, E.3    Karin, M.4
  • 63
    • 34547789841 scopus 로고    scopus 로고
    • TGF-beta signaling alterations and susceptibility to colorectal cancer
    • 10.1093/hmg/ddl486
    • Xu Y, Pasche B (2007) TGF-beta signaling alterations and susceptibility to colorectal cancer. Hum Mol Genet 15(16):R14-R20
    • (2007) Hum Mol Genet , vol.15 , Issue.16
    • Xu, Y.1    Pasche, B.2
  • 64
    • 61849183646 scopus 로고    scopus 로고
    • Targeting transforming growth factor-beta signaling in liver metastasis of colon cancer
    • 10.1016/j.canlet.2008.11.035 1:CAS:528:DC%2BD1MXjtFOhs7w%3D 19147275
    • Zhang B, Halder SK, Zhang S, Datta PK (2009) Targeting transforming growth factor-beta signaling in liver metastasis of colon cancer. Cancer Lett 277(1):114-120
    • (2009) Cancer Lett , vol.277 , Issue.1 , pp. 114-120
    • Zhang, B.1    Halder, S.K.2    Zhang, S.3    Datta, P.K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.