Comparison of 18F-labeled CXCR4 antagonist peptides for PET imaging of CXCR4 expression

Molecular Imaging and Biology

Volumn 15, Issue 6, 2013, Pages 758-767

  Zhang, Xiao Xiang ^a   Sun, Zhongchan ^b   Guo, Jinxia ^a,c   Wang, Zhe ^a,c   Wu, Chenxi ^a   Niu, Gang ^a   Ma, Ying ^a   Kiesewetter, Dale O ^a   Chen, Xiaoyuan ^a  

^a NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c XIAMEN UNIVERSITY   (China)

Author keywords

18F labeling; CXCR4; CXCR4 antagonist peptides; PET imaging

Indexed keywords

2 FLUOROPROPIONATE AC TC14012 F 18; 4 FLUOROBENZOATE AC TC14012 F 18; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; TRACER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG PROTEIN BINDING; DRUG RETENTION; DRUG UPTAKE; FEMALE; IMAGE QUALITY; IN VITRO STUDY; KIDNEY; LIVER; MOUSE; NONHUMAN; PET SCANNER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR XENOGRAFT;

CRICETULUS GRISEUS; MUS;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; FLUORINE RADIOISOTOPES; MICE; MICE, NUDE; MOLECULAR IMAGING; NEOPLASMS; OLIGOPEPTIDES; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, CXCR4; TISSUE DISTRIBUTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84890553284     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-013-0640-0     Document Type: Article

References (41)

1. Balkwill F (2004) The significance of cancer cell expression of the chemokine receptor CXCR4. Semin Cancer Biol 14:171-179
2. Zhou Y, Larsen PH, Hao C, Yong VW (2002) CXCR4 is a major chemokine receptor on glioma cells and mediates their survival. J Biol Chem 277:49481-49487
3. Corcione A, Ottonello L, Tortolina G et al (2000) Stromal cell-derived factor-1 as a chemoattractant for follicular center lymphoma B cells. J Natl Cancer Inst 92:628-635
4. Koshiba T, Hosotani R, Miyamoto Y et al (2000) Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression. Clin Cancer Res 6:3530-3535
5. Scotton CJ, Wilson JL, Scott K et al (2002) Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res 62:5930-5938
6. Hwang JH, Hwang JH, Chung HK et al (2003) CXC chemokine receptor 4 expression and function in human anaplastic thyroid cancer cells. J Clin Endocrinol Metab 88:408-416
7. Muller A, Homey B, Soto H et al (2001) Involvement of chemokine receptors in breast cancer metastasis. Nature 410:50-56
8. Geminder H, Sagi-Assif O, Goldberg L et al (2001) A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastoma. J Immunol 167:4747-4757
9. Wald O, Shapira OM, Izhar U (2013) CXCR4/CXCL12 axis in non-small cell lung cancer (NSCLC) pathologic roles and therapeutic potential. Theranostics 3:26-33
10. Werner L, Guzner-Gur H, Dotan I (2013) Involvement of CXCR4/CXCR7/CXCL12 interactions in inflammatory bowel disease. Theranostics 3:40-46
11. Ratajczak MZ, Serwin K, Schneider G (2013) Innate immunity derived factors as external modulators of the CXCL12-CXCR4 axis and their role in stem cell homing and mobilization. Theranostics 3:3-10
12. Katsumoto K, Kume S (2013) The role of CXCL12-CXCR4 signaling pathway in pancreatic development. Theranostics 3:11-17
13. Staller P, Sulitkova J, Lisztwan J, Moch H, Oakeley EJ, Krek W (2003) Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 425:307-311
14. Helbig G, Christopherson KW, Bhat-Nakshatri P et al (2003) NF-κ B promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4. J Biol Chem 278:21631-21638
15. Azab AK, Runnels JM, Pitsillides C et al (2009) CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy. Blood 113:4341-4351
16. Kurtova AV, Tamayo AT, Ford RJ, Burger JA (2009) Mantle cell lymphoma cells express high levels of CXCR4, CXCR5, and VLA-4 (CD49d): importance for interactions with the stromal microenvironment and specific targeting. Blood 113:4604-4613
17. Peled A, Tavor S (2013) Role of CXCR4 in the pathogenesis of acute myeloid leukemia. Theranostics 3:34-39
18. Zhang S, Qi L, Li M et al (2008) Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancer. J Exp Clin Cancer Res 27:62
19. Yoon Y, Liang Z, Zhang X et al (2007) CXC chemokine receptor-4 antagonist blocks both growth of primary tumor and metastasis of head and neck cancer in xenograft mouse models. Cancer Res 67:7518-7524
20. 64Cu-AMD3100. Mol Imaging Biol 14:106-114
21. 64Cu-AMD3465. J Nucl Med 52:986-993
22. 64Cu-AMD3100 - a novel imaging agent for targeting chemokine receptor CXCR4. Biorg Med Chem 17:1486-1493
23. 64Cu]AMD3100 positron emission tomography. Cancer Res 70:3935-3944
24. 68Ga-DOTA-4-FBn-TN14003, a novel tracer for the imaging of CXCR4 expression. Bioorg Med Chem 20:1502-1510
25. 18F-T140. J Nucl Med 51:1796-1804
26. Jacobson OWI, Szajek LP, Niu G, Ma Y, Kiesewetter DO, Farber JM, Chen X (2011) PET imaging of CXCR4 using copper-64 labeled peptide antagonist. Theranostics 1:251-262
27. Jacobson O, Weiss ID, Szajek LP et al (2012) Improvement of CXCR4 tracer specificity for PET imaging. J Control Release 157:216-223
28. Demmer O, Gourni E, Schumacher U, Kessler H, Wester H-J (2011) PET Imaging of CXCR4 receptors in cancer by a new optimized ligand. ChemMedChem 6:1789-1791
29. Demmer O, Dijkgraaf I, Schumacher U et al (2011) Design, synthesis, and functionalization of dimeric peptides targeting chemokine receptor CXCR4. J Med Chem 54:7648-7662
30. Tamamura H, Omagari A, Oishi S et al (2000) Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes. Bioorg Med Chem Lett 10:2633-2637
31. Tamamura H, Omagari A, Hiramatsu K et al (2001) Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140. Bioorg Med Chem Lett 11:1897-1902
32. Tamamura H, Hiramatsu K, Mizumoto M et al (2003) Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists. Org Biomol Chem 1:3663-3669
33. Tamamura H, Hiramatsu K, Kusano S et al (2003) Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives. Org Biomol Chem 1:3656-3662
34. 68Ga]Ga-NOTA-PRGD2 for PET imaging of U87MG tumors in mice. Bioconjug Chem 22:2415-2422
35. 18F]FBEM: a thiol reactive synthon for radiofluorination of peptides and proteins. Appl Radiat Isot 69:410-414
36. Wong ML, Xin WW, Duman RS (1996) Rat LCR1: cloning and cellular distribution of a putative chemokine receptor in brain. Mol Psychiatr 1:133-140
37. Lazarini F, Casanova P, Tham TN et al (2000) Differential signalling of the chemokine receptor CXCR4 by stromal cell-derived factor 1 and the HIV glycoprotein in rat neurons and astrocytes. Eur J Neurosci 12:117-125
38. Lavi E, Strizki JM, Ulrich AM et al (1997) CXCR-4 (fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons. Am J Pathol 151:1035-1042
39. Kuil J, Buckle T, Yuan H et al (2011) Synthesis and evaluation of a bimodal CXCR4 antagonistic peptide. Bioconjug Chem 22:859-864
40. Moepps B, Frodl R, Rodewald H-R, Baggiolini M, Gierschik P (1997) Two murine homologues of the human chemokine receptor CXCR4 mediating stromal cell-derived factor 1α activation of Gi2 are differentially expressed in vivo. Eur J Immunol 27:2102-2112
41. 111In-labeled peptide derivative targeting a chemokine receptor, CXCR4, for imaging tumors. Nucl Med Biol 33:489-494