The role of CXCL12-CXCR4 signaling pathway in pancreatic development

Theranostics

Volumn 3, Issue 1, 2013, Pages 11-17

  Katsumoto, Keiichi ^a,b   Kume, Shoen ^b  

^a University of Copenhagen   (Denmark)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

CXCL12; CXCR4; Signaling pathway

Indexed keywords

ACTIVIN; CD34 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; FIBROBLAST GROWTH FACTOR 2; LIM PROTEIN; PLERIXAFOR; SONIC HEDGEHOG PROTEIN; STREPTOZOCIN; STROMAL CELL DERIVED FACTOR 1; THAPSIGARGIN; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTION FACTOR TAL1; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

CELL DIFFERENTIATION; CXCL12 GENE; CXCR4 GENE; ENDODERM; ENZYME ACTIVITY; ENZYME INHIBITION; GENE; HEMANGIOBLAST; NONHUMAN; ORGANOGENESIS; PANCREAS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SHH GENE; SIGNAL TRANSDUCTION; STEM CELL;

CXCL12; CXCR4; SIGNALING PATHWAY;

ANIMALS; CHEMOKINE CXCL12; ENDODERM; HUMANS; ORGANOGENESIS; PANCREAS; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION;

EID: 84883152107     PISSN: None     EISSN: 18387640     Source Type: Journal    
DOI: 10.7150/thno.4806     Document Type: Review

References (44)

1. Ganju RK, Brubaker SA, Meyer J, Dutt P, Yang Y, Qin S, et al. The alpha-chemokine, stromal cell-derived factor-1alpha, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways. J Biol Chem. 1998; 273: 23169-75.
2. Schober A, Karshovska E, Zernecke A, Weber C. SDF-1alpha-mediated tissue repair by stem cells: a promising tool in cardiovascular medicine. Trends Cardiovasc Med. 2006; 16: 103-8.
3. Zernecke A, Schober A, Bot I, von Hundelshausen P, Liehn EA, Mopps B, et al. SDF-1alpha/CXCR4 axis is instrumental in neointimal hyperplasia and recruitment of smooth muscle progenitor cells. Circ Res. 2005; 96: 784-91.
4. Yamaguchi J, Kusano KF, Masuo O, Kawamoto A, Silver M, Murasawa S, et al. Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation. 2003; 107: 1322-8.
5. Nelson TJ, Faustino RS, Chiriac A, Crespo-Diaz R, Behfar A, Terzic A. CXCR4+/FLK-1+ biomarkers select a cardiopoietic lineage from embryonic stem cells. Stem Cells. 2008; 26: 1464-73.
6. Moll NM, Ransohoff RM. CXCL12 and CXCR4 in bone marrow physiology. Expert Rev Hematol. 2010; 3: 315-22.
7. Kollet O, Spiegel A, Peled A, Petit I, Byk T, Hershkoviz R, et al. Rapid and efficient homing of human CD34(+)CD38(-/low)CXCR4(+) stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2m(null) mice. Blood. 2001; 97: 3283-91.
8. Gupta SK, Lysko PG, Pillarisetti K, Ohlstein E, Stadel JM. Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines. J Biol Chem. 1998; 273: 4282-7.
9. Broxmeyer HE. Chemokines in hematopoiesis. Curr Opin Hematol. 2008; 15: 49-58.
10. Cencioni C, Capogrossi MC, Napolitano M. The SDF-1/CXCR4 axis in stem cell preconditioning. Cardiovasc Res. 2012; 94: 400-7.
11. Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S, Kitamura Y, et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature. 1996; 382: 635-8.
12. Tachibana K, Hirota S, Iizasa H, Yoshida H, Kawabata K, Kataoka Y, et al. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature. 1998; 393: 591-4.
13. Zou YR, Kottmann AH, Kuroda M, Taniuchi I, Littman DR. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature. 1998; 393: 595-9.
14. Katsumoto K, Kume S. Endoderm and mesoderm reciprocal signaling mediated by CXCL12 and CXCR4 regulates the migration of angioblasts and establishes the pancreatic fate. Development. 2011; 138: 1947-55.
15. Yoshida T, Murata K, Shiraki N, Kume K, Kume S. Analysis of gene expressions of embryonic stem-derived Pdx1-expressing cells: implications of genes involved in pancreas differentiation. Dev Growth Differ. 2009; 51: 463-72.
16. Jonsson J, Carlsson L, Edlund T, Edlund H. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature. 1994; 371: 606-9.
17. Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, et al. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development. 1996; 122: 983-95.
18. Miki R, Yoshida T, Murata K, Oki S, Kume K, Kume S. Fate maps of ventral and dorsal pancreatic progenitor cells in early somite stage mouse embryos. Mech Dev. 2012; 128: 597-609.
19. Katsumoto K, Fukuda K, Kimura W, Shimamura K, Yasugi S, Kume S. Origin of pancreatic precursors in the chick embryo and the mechanism of endoderm regionalization. Mech Dev. 2009; 126: 539-51.
20. Matsuura K, Katsumoto K, Fukuda K, Kume K, Kume S. Conserved origin of the ventral pancreas in chicken. Mech Dev. 2009; 126: 817-27.
21. Kawaguchi Y, Cooper B, Gannon M, Ray M, MacDonald RJ, Wright CV. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet. 2002; 32: 128-34.
22. Seymour PA, Freude KK, Tran MN, Mayes EE, Jensen J, Kist R, et al. SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci U S A. 2007; 104: 1865-70.
23. Gu G, Dubauskaite J, Melton DA. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development. 2002; 129: 2447-57.
24. Grapin-Botton A, Majithia AR, Melton DA. Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes. Genes Dev. 2001; 15: 444-54.
25. Hebrok M, Kim SK, Melton DA. Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev. 1998; 12: 1705-13.
26. Kim SK, Hebrok M, Melton DA. Notochord to endoderm signaling is required for pancreas development. Development. 1997; 124: 4243-52.
27. Lammert E, Cleaver O, Melton D. Induction of pancreatic differentiation by signals from blood vessels. Science. 2001; 294: 564-7.
28. Tremblay KD, Zaret KS. Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues. Dev Biol. 2005; 280: 87-99.
29. Zaret KS. Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation. Nat Rev Genet. 2008; 9: 329-40.
30. Zaret KS, Grompe M. Generation and regeneration of cells of the liver and pancreas. Science. 2008; 322: 1490-4.
31. Deutsch G, Jung J, Zheng M, Lora J, Zaret KS. A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development. 2001; 128: 871-81.
32. Katsumoto K, Shiraki N, Miki R, Kume S. Embryonic and adult stem cell systems in mammals: ontology and regulation. Dev Growth Differ. 2010; 52: 115-29.
33. Nagasawa T, Tachibana K, Kishimoto T. A novel CXC chemokine PBSF/SDF-1 and its receptor CXCR4: their functions in development, hematopoiesis and HIV infection. Semin Immunol. 1998; 10: 179-85.
34. Kayali AG, Van Gunst K, Campbell IL, Stotland A, Kritzik M, Liu G, et al. The stromal cell-derived factor-1alpha/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas. J Cell Biol. 2003; 163: 859-69.
35. Yano T, Liu Z, Donovan J, Thomas MK, Habener JF. Stromal cell derived factor-1 (SDF-1)/CXCL12 attenuates diabetes in mice and promotes pancreatic beta-cell survival by activation of the prosurvival kinase Akt. Diabetes. 2007; 56: 2946-57.
36. Liu Z, Habener JF. Stromal cell-derived factor-1 promotes survival of pancreatic beta cells by the stabilisation of beta-catenin and activation of transcription factor 7-like 2 (TCF7L2). Diabetologia. 2009; 52: 1589-98.
37. Liu Z, Stanojevic V, Avadhani S, Yano T, Habener JF. Stromal cell-derived factor-1 (SDF-1)/chemokine (C-X-C motif) receptor 4 (CXCR4) axis activation induces intra-islet glucagon-like peptide-1 (GLP-1) production and enhances beta cell survival. Diabetologia. 2011; 54: 2067-76.
38. Kritzik MR, Lago CU, Kayali AG, Arnaud-Dabernat S, Liu G, Zhang YQ, et al. Epithelial progenitor 1, a novel factor associated with epithelial cell growth and differentiation. Endocrine. 2010; 37: 312-21.
39. Hick AC, van Eyll JM, Cordi S, Forez C, Passante L, Kohara H, et al. Mechanism of primitive duct formation in the pancreas and submandibular glands: a role for SDF-1. BMC Dev Biol. 2009; 9: 66.
40. Nair S, Schilling TF. Chemokine signaling controls endodermal migration during zebrafish gastrulation. Science. 2008; 322: 89-92.
41. Mizoguchi T, Verkade H, Heath JK, Kuroiwa A, Kikuchi Y. Sdf1/Cxcr4 signaling controls the dorsal migration of endodermal cells during zebrafish gastrulation. Development. 2008; 135: 2521-9.
42. Siekmann AF, Standley C, Fogarty KE, Wolfe SA, Lawson ND. Chemokine signaling guides regional patterning of the first embryonic artery. Genes Dev. 2009; 23: 2272-7.
43. Kume S. Stem-cell-based approaches for regenerative medicine. Dev Growth Differ. 2005; 47: 393-402.
44. Kume S. The molecular basis and prospects in pancreatic development. Dev Growth Differ. 2005; 47: 367-74.