Automated radiochemical synthesis of [18F]FBEM: A thiol reactive synthon for radiofluorination of peptides and proteins

Applied Radiation and Isotopes

Volumn 69, Issue 2, 2011, Pages 410-414

  Kiesewetter, Dale O ^a   Jacobson, Orit ^a   Lang, Lixin ^a   Chen, Xiaoyuan ^a  

^a NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

Author keywords

18F FBEM; Fluorine 18; PET; Thiol reactive synthon

Indexed keywords

[18F]FBEM; ACIDIC CONDITIONS; FLUORINE-18; FLUOROBENZOIC ACIDS; MALEIMIDES; NUCLEOPHILIC DISPLACEMENT; PET; PROSTHETIC GROUPS; RADIOCHEMICAL SYNTHESIS; RADIOFLUORINATION; RADIOLABELING; SPECIFIC ACTIVITY; SULFHYDRYL GROUPS; SYNTHONS;

ESTERIFICATION; ESTERS; FLUORINE; PEPTIDES;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

4 FLUOROBENZOIC ACID F 18; FLUORINE 18; N MALEOYLETHYL 4 FLUOROBENZAMIDE F 18; RADIOPHARMACEUTICAL AGENT; THIOL; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

ARTICLE; AUTOANALYSIS; CONTROLLED STUDY; DEPROTECTION REACTION; DRUG SYNTHESIS; EVAPORATION; FLUORINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; MOLECULAR STABILITY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PURIFICATION; RADIOACTIVITY; REPRODUCIBILITY;

AUTOMATION, LABORATORY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUORINE RADIOISOTOPES; ISOTOPE LABELING; MALEIMIDES; PEPTIDES; PROTEINS; RADIOPHARMACEUTICALS;

EID: 78650304774     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apradiso.2010.09.023     Document Type: Article

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