메뉴 건너뛰기




Volumn 3, Issue 1, 2013, Pages 26-33

CXCR4/CXCL12 axis in non small cell lung cancer (NSCLC) pathologic roles and therapeutic potential

Author keywords

Chemokines; Human; Lung; NSCLC

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; CHEMOKINE RECEPTOR CXCR7; CISPLATIN; PACLITAXEL; PLERIXAFOR; SMALL INTERFERING RNA; STROMAL CELL DERIVED FACTOR 1;

EID: 84883176178     PISSN: None     EISSN: 18387640     Source Type: Journal    
DOI: 10.7150/thno.4922     Document Type: Review
Times cited : (113)

References (81)
  • 4
    • 79251490374 scopus 로고    scopus 로고
    • New driver mutations in non-small-cell lung cancer
    • Feb
    • Pao W, Girard N. New driver mutations in non-small-cell lung cancer. Lancet Oncol 2011 Feb;12(2):175-80.
    • (2011) Lancet Oncol , vol.12 , Issue.2 , pp. 175-180
    • Pao, W.1    Girard, N.2
  • 5
    • 84857969863 scopus 로고    scopus 로고
    • Chipping away at the lung cancer genome
    • Mar
    • Pao W, Hutchinson KE. Chipping away at the lung cancer genome. Nat Med 2012 Mar;18(3):349-51.
    • (2012) Nat Med , vol.18 , Issue.3 , pp. 349-351
    • Pao, W.1    Hutchinson, K.E.2
  • 6
    • 34848837026 scopus 로고    scopus 로고
    • Epidemiology of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)
    • Sep
    • Alberg AJ, Ford JG, Samet JM. Epidemiology of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest 2007 Sep;132(3 Suppl):29S-55S.
    • (2007) Chest , vol.132 , Issue.3 SUPPL
    • Alberg, A.J.1    Ford, J.G.2    Samet, J.M.3
  • 10
    • 77957168962 scopus 로고    scopus 로고
    • Winning the battle, losing the war: the noncurative "curative" resection for stage I adenocarcinoma of the lung
    • Oct
    • Murthy SC, Reznik SI, Ogwudu UC, Farver CF, Arrossi A, Batizy LH, et al. Winning the battle, losing the war: the noncurative "curative" resection for stage I adenocarcinoma of the lung. Ann Thorac Surg 2010 Oct;90(4):1067-74.
    • (2010) Ann Thorac Surg , vol.90 , Issue.4 , pp. 1067-1074
    • Murthy, S.C.1    Reznik, S.I.2    Ogwudu, U.C.3    Farver, C.F.4    Arrossi, A.5    Batizy, L.H.6
  • 11
    • 84861199281 scopus 로고    scopus 로고
    • Five-year survival does not equal cure in non-small cell lung cancer: A Surveillance, Epidemiology, and End Results-based analysis of variables affecting 10- to 18-year survival
    • Hubbard MO, Fu P, Margevicius S, Dowlati A, Linden PA. Five-year survival does not equal cure in non-small cell lung cancer: A Surveillance, Epidemiology, and End Results-based analysis of variables affecting 10- to 18-year survival. J Thorac Cardiovasc Surg. 2012.
    • (2012) J Thorac Cardiovasc Surg.
    • Hubbard, M.O.1    Fu, P.2    Margevicius, S.3    Dowlati, A.4    Linden, P.A.5
  • 12
    • 84865417560 scopus 로고    scopus 로고
    • Recent advances in non-small cell lung cancer biology and clinical management
    • Apr
    • Saintigny P, Burger JA. Recent advances in non-small cell lung cancer biology and clinical management. Discov Med 2012 Apr;13(71):287-97.
    • (2012) Discov Med , vol.13 , Issue.71 , pp. 287-297
    • Saintigny, P.1    Burger, J.A.2
  • 13
    • 75749145931 scopus 로고    scopus 로고
    • Management of patients with advanced non-small cell lung cancer: current and emerging options
    • Triano LR, Deshpande H, Gettinger SN. Management of patients with advanced non-small cell lung cancer: current and emerging options. Drugs 2010;70(2):167-79.
    • (2010) Drugs , vol.70 , Issue.2 , pp. 167-179
    • Triano, L.R.1    Deshpande, H.2    Gettinger, S.N.3
  • 14
    • 64649092788 scopus 로고    scopus 로고
    • Evaluation of the new TNM staging system proposed by the International Association for the Study of Lung Cancer at a single institution
    • May
    • Kameyama K, Takahashi M, Ohata K, Igai H, Yamashina A, Matsuoka T, et al. Evaluation of the new TNM staging system proposed by the International Association for the Study of Lung Cancer at a single institution. J Thorac Cardiovasc Surg 2009 May;137(5):1180-4.
    • (2009) J Thorac Cardiovasc Surg , vol.137 , Issue.5 , pp. 1180-1184
    • Kameyama, K.1    Takahashi, M.2    Ohata, K.3    Igai, H.4    Yamashina, A.5    Matsuoka, T.6
  • 15
    • 67650844443 scopus 로고    scopus 로고
    • The new lung cancer staging system
    • Jul
    • Detterbeck FC, Boffa DJ, Tanoue LT. The new lung cancer staging system. Chest 2009 Jul;136(1):260-71.
    • (2009) Chest , vol.136 , Issue.1 , pp. 260-271
    • Detterbeck, F.C.1    Boffa, D.J.2    Tanoue, L.T.3
  • 16
    • 34548457234 scopus 로고    scopus 로고
    • The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours
    • Aug
    • Goldstraw P, Crowley J, Chansky K, Giroux DJ, Groome PA, Rami-Porta R, et al. The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours. J Thorac Oncol 2007 Aug;2(8):706-14.
    • (2007) J Thorac Oncol , vol.2 , Issue.8 , pp. 706-714
    • Goldstraw, P.1    Crowley, J.2    Chansky, K.3    Giroux, D.J.4    Groome, P.A.5    Rami-Porta, R.6
  • 17
    • 34548462932 scopus 로고    scopus 로고
    • The IASLC Lung Cancer Staging Project: validation of the proposals for revision of the T, N, and M descriptors and consequent stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours
    • Aug
    • Groome PA, Bolejack V, Crowley JJ, Kennedy C, Krasnik M, Sobin LH, et al. The IASLC Lung Cancer Staging Project: validation of the proposals for revision of the T, N, and M descriptors and consequent stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours. J Thorac Oncol 2007 Aug;2(8):694-705.
    • (2007) J Thorac Oncol , vol.2 , Issue.8 , pp. 694-705
    • Groome, P.A.1    Bolejack, V.2    Crowley, J.J.3    Kennedy, C.4    Krasnik, M.5    Sobin, L.H.6
  • 18
    • 79551563284 scopus 로고    scopus 로고
    • International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma
    • Feb
    • Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, et al. International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 2011 Feb;6(2):244-85.
    • (2011) J Thorac Oncol , vol.6 , Issue.2 , pp. 244-285
    • Travis, W.D.1    Brambilla, E.2    Noguchi, M.3    Nicholson, A.G.4    Geisinger, K.R.5    Yatabe, Y.6
  • 19
    • 77956619564 scopus 로고    scopus 로고
    • Cell of origin of lung cancer
    • Oct
    • Sutherland KD, Berns A. Cell of origin of lung cancer. Mol Oncol 2010 Oct;4(5):397-403.
    • (2010) Mol Oncol , vol.4 , Issue.5 , pp. 397-403
    • Sutherland, K.D.1    Berns, A.2
  • 20
    • 80052094283 scopus 로고    scopus 로고
    • Homeostatic chemokine receptors and organ-specific metastasis
    • Sep
    • Zlotnik A, Burkhardt AM, Homey B. Homeostatic chemokine receptors and organ-specific metastasis. Nat Rev Immunol 2011 Sep;11(9):597-606. 21. Zlotnik A, Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity 2000 Feb;12(2):121-7.
    • (2011) Nat Rev Immunol , vol.11 , Issue.9 , pp. 597-606
    • Zlotnik, A.1    Burkhardt, A.M.2    Homey, B.3
  • 21
    • 0034144269 scopus 로고    scopus 로고
    • Chemokines: a new classification system and their role in immunity
    • Feb
    • Zlotnik A, Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity 2000 Feb;12(2):121-7.
    • (2000) Immunity , vol.12 , Issue.2 , pp. 121-127
    • Zlotnik, A.1    Yoshie, O.2
  • 22
    • 16544366844 scopus 로고    scopus 로고
    • Chemokines in neoplastic progression
    • Jun
    • Mantovani A. Chemokines in neoplastic progression. Semin Cancer Biol 2004 Jun;14(3):147-8.
    • (2004) Semin Cancer Biol , vol.14 , Issue.3 , pp. 147-148
    • Mantovani, A.1
  • 23
    • 2342565892 scopus 로고    scopus 로고
    • Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors
    • Jun
    • Mantovani A, Allavena P, Sozzani S, Vecchi A, Locati M, Sica A. Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors. Semin Cancer Biol 2004 Jun;14(3):155-60.
    • (2004) Semin Cancer Biol , vol.14 , Issue.3 , pp. 155-160
    • Mantovani, A.1    Allavena, P.2    Sozzani, S.3    Vecchi, A.4    Locati, M.5    Sica, A.6
  • 24
    • 0029775576 scopus 로고    scopus 로고
    • The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
    • Aug 29
    • Bleul CC, Farzan M, Choe H, Parolin C, Clark-Lewis I, Sodroski J, et al. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 1996 Aug 29;382(6594):829-33.
    • (1996) Nature , vol.382 , Issue.6594 , pp. 829-833
    • Bleul, C.C.1    Farzan, M.2    Choe, H.3    Parolin, C.4    Clark-Lewis, I.5    Sodroski, J.6
  • 25
    • 79955101754 scopus 로고    scopus 로고
    • Potential of CXCR4 antagonists for the treatment of metastatic lung cancer
    • Apr
    • Burger JA, Stewart DJ, Wald O, Peled A. Potential of CXCR4 antagonists for the treatment of metastatic lung cancer. Expert Rev Anticancer Ther 2011 Apr;11(4):621-30.
    • (2011) Expert Rev Anticancer Ther , vol.11 , Issue.4 , pp. 621-630
    • Burger, J.A.1    Stewart, D.J.2    Wald, O.3    Peled, A.4
  • 26
    • 33748474838 scopus 로고    scopus 로고
    • A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development
    • Sep 4
    • Burns JM, Summers BC, Wang Y, Melikian A, Berahovich R, Miao Z, et al. A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J Exp Med 2006 Sep 4;203(9):2201-13.
    • (2006) J Exp Med , vol.203 , Issue.9 , pp. 2201-2213
    • Burns, J.M.1    Summers, B.C.2    Wang, Y.3    Melikian, A.4    Berahovich, R.5    Miao, Z.6
  • 27
    • 79958269508 scopus 로고    scopus 로고
    • The novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cells
    • Zabel BA, Lewen S, Berahovich RD, Jaen JC, Schall TJ. The novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cells. Mol Cancer 2011;10:73.
    • (2011) Mol Cancer , vol.10 , pp. 73
    • Zabel, B.A.1    Lewen, S.2    Berahovich, R.D.3    Jaen, J.C.4    Schall, T.J.5
  • 29
    • 0141828145 scopus 로고    scopus 로고
    • Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
    • Sep 18
    • Staller P, Sulitkova J, Lisztwan J, Moch H, Oakeley EJ, Krek W. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 2003 Sep 18;425(6955):307-11.
    • (2003) Nature , vol.425 , Issue.6955 , pp. 307-311
    • Staller, P.1    Sulitkova, J.2    Lisztwan, J.3    Moch, H.4    Oakeley, E.J.5    Krek, W.6
  • 30
    • 79958743310 scopus 로고    scopus 로고
    • Differential estrogen-regulation of CXCL12 chemokine receptors, CXCR4 and CXCR7, contributes to the growth effect of estrogens in breast cancer cells
    • Boudot A, Kerdivel G, Habauzit D, Eeckhoute J, Le Dily F, Flouriot G, et al. Differential estrogen-regulation of CXCL12 chemokine receptors, CXCR4 and CXCR7, contributes to the growth effect of estrogens in breast cancer cells. PLoS One 2011;6(6):e20898.
    • (2011) PLoS One , vol.6 , Issue.6
    • Boudot, A.1    Kerdivel, G.2    Habauzit, D.3    Eeckhoute, J.4    Le Dily, F.5    Flouriot, G.6
  • 33
    • 0035282432 scopus 로고    scopus 로고
    • Involvement of chemokine receptors in breast cancer metastasis
    • Mar 1
    • Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001 Mar 1;410(6824):50-6.
    • (2001) Nature , vol.410 , Issue.6824 , pp. 50-56
    • Muller, A.1    Homey, B.2    Soto, H.3    Ge, N.4    Catron, D.5    Buchanan, M.E.6
  • 35
    • 20144389833 scopus 로고    scopus 로고
    • Expression of CXCR4 predicts poor prognosis in patients with malignant melanoma
    • Mar 1
    • Scala S, Ottaiano A, Ascierto PA, Cavalli M, Simeone E, Giuliano P, et al. Expression of CXCR4 predicts poor prognosis in patients with malignant melanoma. Clin Cancer Res 2005 Mar 1;11(5):1835-41.
    • (2005) Clin Cancer Res , vol.11 , Issue.5 , pp. 1835-1841
    • Scala, S.1    Ottaiano, A.2    Ascierto, P.A.3    Cavalli, M.4    Simeone, E.5    Giuliano, P.6
  • 36
    • 4043161468 scopus 로고    scopus 로고
    • Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas
    • Aug 5
    • Castellone MD, Guarino V, De Falco V, Carlomagno F, Basolo F, Faviana P, et al. Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas. Oncogene 2004 Aug 5;23(35):5958-67.
    • (2004) Oncogene , vol.23 , Issue.35 , pp. 5958-5967
    • Castellone, M.D.1    Guarino, V.2    De Falco, V.3    Carlomagno, F.4    Basolo, F.5    Faviana, P.6
  • 37
    • 7944223780 scopus 로고    scopus 로고
    • Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis
    • Nov
    • Li YM, Pan Y, Wei Y, Cheng X, Zhou BP, Tan M, et al. Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell 2004 Nov;6(5):459-69.
    • (2004) Cancer Cell , vol.6 , Issue.5 , pp. 459-469
    • Li, Y.M.1    Pan, Y.2    Wei, Y.3    Cheng, X.4    Zhou, B.P.5    Tan, M.6
  • 38
    • 33751071832 scopus 로고    scopus 로고
    • Regulation of the chemokine receptor CXCR4 and metastasis by hypoxia-inducible factor in non small cell lung cancer cell lines
    • Oct
    • Liu YL, Yu JM, Song XR, Wang XW, Xing LG, Gao BB. Regulation of the chemokine receptor CXCR4 and metastasis by hypoxia-inducible factor in non small cell lung cancer cell lines. Cancer Biol Ther 2006 Oct;5(10):1320-6.
    • (2006) Cancer Biol Ther , vol.5 , Issue.10 , pp. 1320-1326
    • Liu, Y.L.1    Yu, J.M.2    Song, X.R.3    Wang, X.W.4    Xing, L.G.5    Gao, B.B.6
  • 39
    • 33751256842 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion
    • Dec
    • Zagzag D, Lukyanov Y, Lan L, Ali MA, Esencay M, Mendez O, et al. Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion. Lab Invest 2006 Dec;86(12):1221-32.
    • (2006) Lab Invest , vol.86 , Issue.12 , pp. 1221-1232
    • Zagzag, D.1    Lukyanov, Y.2    Lan, L.3    Ali, M.A.4    Esencay, M.5    Mendez, O.6
  • 40
    • 9444239192 scopus 로고    scopus 로고
    • Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis
    • Aug
    • Darash-Yahana M, Pikarsky E, Abramovitch R, Zeira E, Pal B, Karplus R, et al. Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis. FASEB J 2004 Aug;18(11):1240-2.
    • (2004) FASEB J , vol.18 , Issue.11 , pp. 1240-1242
    • Darash-Yahana, M.1    Pikarsky, E.2    Abramovitch, R.3    Zeira, E.4    Pal, B.5    Karplus, R.6
  • 42
    • 2342432307 scopus 로고    scopus 로고
    • Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome
    • Apr
    • Spano JP, Andre F, Morat L, Sabatier L, Besse B, Combadiere C, et al. Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome. Ann Oncol 2004 Apr;15(4):613-7.
    • (2004) Ann Oncol , vol.15 , Issue.4 , pp. 613-617
    • Spano, J.P.1    Andre, F.2    Morat, L.3    Sabatier, L.4    Besse, B.5    Combadiere, C.6
  • 43
    • 28544440733 scopus 로고    scopus 로고
    • Differential expression of CXCR4 is associated with the metastatic potential of human non-small cell lung cancer cells
    • Dec 1
    • Su L, Zhang J, Xu H, Wang Y, Chu Y, Liu R, et al. Differential expression of CXCR4 is associated with the metastatic potential of human non-small cell lung cancer cells. Clin Cancer Res 2005 Dec 1;11(23):8273-80.
    • (2005) Clin Cancer Res , vol.11 , Issue.23 , pp. 8273-8280
    • Su, L.1    Zhang, J.2    Xu, H.3    Wang, Y.4    Chu, Y.5    Liu, R.6
  • 45
    • 78651304334 scopus 로고    scopus 로고
    • High-level CXCR4 expression correlates with brain-specific metastasis of non-small cell lung cancer
    • Jan
    • Chen G, Wang Z, Liu XY, Liu FY. High-level CXCR4 expression correlates with brain-specific metastasis of non-small cell lung cancer. World J Surg 2011 Jan;35(1):56-61.
    • (2011) World J Surg , vol.35 , Issue.1 , pp. 56-61
    • Chen, G.1    Wang, Z.2    Liu, X.Y.3    Liu, F.Y.4
  • 46
    • 84860321876 scopus 로고    scopus 로고
    • CXCL12-binding receptors expression in non-small cell lung cancer relates to tumoral microvascular density and CXCR4 positive circulating tumoral cells in lung draining venous blood
    • Feb
    • Franco R, Pirozzi G, Scala S, Cantile M, Scognamiglio G, Camerlingo R, et al. CXCL12-binding receptors expression in non-small cell lung cancer relates to tumoral microvascular density and CXCR4 positive circulating tumoral cells in lung draining venous blood. Eur J Cardiothorac Surg 2011 Feb;41(2):368-75.
    • (2011) Eur J Cardiothorac Surg , vol.41 , Issue.2 , pp. 368-375
    • Franco, R.1    Pirozzi, G.2    Scala, S.3    Cantile, M.4    Scognamiglio, G.5    Camerlingo, R.6
  • 47
    • 2342451359 scopus 로고    scopus 로고
    • Stromal-derived factor-1alpha/CXCL12-CXCR 4 axis is involved in the dissemination of NSCLC cells into pleural space
    • May
    • Oonakahara K, Matsuyama W, Higashimoto I, Kawabata M, Arimura K, Osame M. Stromal-derived factor-1alpha/CXCL12-CXCR 4 axis is involved in the dissemination of NSCLC cells into pleural space. Am J Respir Cell Mol Biol 2004 May;30(5):671-7.
    • (2004) Am J Respir Cell Mol Biol , vol.30 , Issue.5 , pp. 671-677
    • Oonakahara, K.1    Matsuyama, W.2    Higashimoto, I.3    Kawabata, M.4    Arimura, K.5    Osame, M.6
  • 48
    • 79959906050 scopus 로고    scopus 로고
    • CXCR4 overexpression is associated with poor outcome in females diagnosed with stage IV non-small cell lung cancer
    • Jul
    • Otsuka S, Klimowicz AC, Kopciuk K, Petrillo SK, Konno M, Hao D, et al. CXCR4 overexpression is associated with poor outcome in females diagnosed with stage IV non-small cell lung cancer. J Thorac Oncol 2011 Jul;6(7):1169-78.
    • (2011) J Thorac Oncol , vol.6 , Issue.7 , pp. 1169-1178
    • Otsuka, S.1    Klimowicz, A.C.2    Kopciuk, K.3    Petrillo, S.K.4    Konno, M.5    Hao, D.6
  • 49
    • 33750795581 scopus 로고    scopus 로고
    • CD4+CXCR4highCD69+ T cells accumulate in lung adenocarcinoma
    • Nov 15
    • Wald O, Izhar U, Amir G, Avniel S, Bar-Shavit Y, Wald H, et al. CD4+CXCR4highCD69+ T cells accumulate in lung adenocarcinoma. J Immunol 2006 Nov 15;177(10):6983-90.
    • (2006) J Immunol , vol.177 , Issue.10 , pp. 6983-6990
    • Wald, O.1    Izhar, U.2    Amir, G.3    Avniel, S.4    Bar-Shavit, Y.5    Wald, H.6
  • 50
    • 79956093785 scopus 로고    scopus 로고
    • Interaction between neoplastic cells and cancer-associated fibroblasts through the CXCL12/CXCR4 axis: role in non-small cell lung cancer tumor proliferation
    • Jun
    • Wald O, Izhar U, Amir G, Kirshberg S, Shlomai Z, Zamir G, et al. Interaction between neoplastic cells and cancer-associated fibroblasts through the CXCL12/CXCR4 axis: role in non-small cell lung cancer tumor proliferation. J Thorac Cardiovasc Surg 2011 Jun;141(6):1503-12.
    • (2011) J Thorac Cardiovasc Surg , vol.141 , Issue.6 , pp. 1503-1512
    • Wald, O.1    Izhar, U.2    Amir, G.3    Kirshberg, S.4    Shlomai, Z.5    Zamir, G.6
  • 51
    • 34548824078 scopus 로고    scopus 로고
    • CXCL12 G801A polymorphism is a risk factor for sporadic prostate cancer susceptibility
    • Sep 1
    • Hirata H, Hinoda Y, Kikuno N, Kawamoto K, Dahiya AV, Suehiro Y, et al. CXCL12 G801A polymorphism is a risk factor for sporadic prostate cancer susceptibility. Clin Cancer Res 2007 Sep 1;13(17):5056-62.
    • (2007) Clin Cancer Res , vol.13 , Issue.17 , pp. 5056-5062
    • Hirata, H.1    Hinoda, Y.2    Kikuno, N.3    Kawamoto, K.4    Dahiya, A.V.5    Suehiro, Y.6
  • 52
    • 79960032599 scopus 로고    scopus 로고
    • Association of genetic polymorphisms of CXCL12/SDF1 gene and its receptor, CXCR4, to the susceptibility and prognosis of non-small cell lung cancer
    • Aug
    • Lee YL, Kuo WH, Lin CW, Chen W, Cheng WE, Chen SC, et al. Association of genetic polymorphisms of CXCL12/SDF1 gene and its receptor, CXCR4, to the susceptibility and prognosis of non-small cell lung cancer. Lung Cancer 2011 Aug;73(2):147-52.
    • (2011) Lung Cancer , vol.73 , Issue.2 , pp. 147-152
    • Lee, Y.L.1    Kuo, W.H.2    Lin, C.W.3    Chen, W.4    Cheng, W.E.5    Chen, S.C.6
  • 53
    • 70349317159 scopus 로고    scopus 로고
    • Contribution of genetic polymorphisms of stromal cell-derived factor-1 and its receptor, CXCR4, to the susceptibility and clinicopathologic development of oral cancer
    • Oct
    • Teng YH, Liu TH, Tseng HC, Chung TT, Yeh CM, Li YC, et al. Contribution of genetic polymorphisms of stromal cell-derived factor-1 and its receptor, CXCR4, to the susceptibility and clinicopathologic development of oral cancer. Head Neck 2009 Oct;31(10):1282-8.
    • (2009) Head Neck , vol.31 , Issue.10 , pp. 1282-1288
    • Teng, Y.H.1    Liu, T.H.2    Tseng, H.C.3    Chung, T.T.4    Yeh, C.M.5    Li, Y.C.6
  • 54
    • 0038206771 scopus 로고    scopus 로고
    • The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases
    • Jun 15
    • Phillips RJ, Burdick MD, Lutz M, Belperio JA, Keane MP, Strieter RM. The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases. Am J Respir Crit Care Med 2003 Jun 15;167(12):1676-86.
    • (2003) Am J Respir Crit Care Med , vol.167 , Issue.12 , pp. 1676-1686
    • Phillips, R.J.1    Burdick, M.D.2    Lutz, M.3    Belperio, J.A.4    Keane, M.P.5    Strieter, R.M.6
  • 55
    • 20444445920 scopus 로고    scopus 로고
    • Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha
    • Jun 10
    • Phillips RJ, Mestas J, Gharaee-Kermani M, Burdick MD, Sica A, Belperio JA, et al. Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha. J Biol Chem 2005 Jun 10;280(23):22473-81.
    • (2005) J Biol Chem , vol.280 , Issue.23 , pp. 22473-81
    • Phillips, R.J.1    Mestas, J.2    Gharaee-Kermani, M.3    Burdick, M.D.4    Sica, A.5    Belperio, J.A.6
  • 56
    • 0037319360 scopus 로고    scopus 로고
    • The therapeutic potential of CXCR4 antagonists in the treatment of HIV
    • Feb
    • Fujii N, Nakashima H, Tamamura H. The therapeutic potential of CXCR4 antagonists in the treatment of HIV. Expert Opin Investig Drugs 2003 Feb;12(2):185-95.
    • (2003) Expert Opin Investig Drugs , vol.12 , Issue.2 , pp. 185-195
    • Fujii, N.1    Nakashima, H.2    Tamamura, H.3
  • 57
    • 0032583575 scopus 로고    scopus 로고
    • A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140
    • Dec 30
    • Tamamura H, Xu Y, Hattori T, Zhang X, Arakaki R, Kanbara K, et al. A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140. Biochem Biophys Res Commun 1998 Dec 30;253(3):877-82.
    • (1998) Biochem Biophys Res Commun , vol.253 , Issue.3 , pp. 877-882
    • Tamamura, H.1    Xu, Y.2    Hattori, T.3    Zhang, X.4    Arakaki, R.5    Kanbara, K.6
  • 58
    • 85027918527 scopus 로고    scopus 로고
    • In vitro and in vivo therapeutic efficacy of CXCR4 antagonist BKT140 against human non-small cell lung cancer
    • Fahham D, Weiss ID, Abraham M, Beider K, Hanna W, Shlomai Z, et al. In vitro and in vivo therapeutic efficacy of CXCR4 antagonist BKT140 against human non-small cell lung cancer. J Thorac Cardiovasc Surg; 2012.
    • (2012) J Thorac Cardiovasc Surg
    • Fahham, D.1    Weiss, I.D.2    Abraham, M.3    Beider, K.4    Hanna, W.5    Shlomai, Z.6
  • 59
    • 80052855773 scopus 로고    scopus 로고
    • Involvement of CCR6/CCL20/IL-17 axis in NSCLC disease progression
    • Kirshberg S, Izhar U, Amir G, Demma J, Vernea F, Beider K, et al. Involvement of CCR6/CCL20/IL-17 axis in NSCLC disease progression. PLoS One 2011;6(9):e24856.
    • (2011) PLoS One , vol.6 , Issue.9
    • Kirshberg, S.1    Izhar, U.2    Amir, G.3    Demma, J.4    Vernea, F.5    Beider, K.6
  • 60
    • 39449088496 scopus 로고    scopus 로고
    • Identification and expansion of the tumorigenic lung cancer stem cell population
    • Mar
    • Eramo A, Lotti F, Sette G, Pilozzi E, Biffoni M, Di Virgilio A, et al. Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ 2008 Mar;15(3):504-14.
    • (2008) Cell Death Differ , vol.15 , Issue.3 , pp. 504-514
    • Eramo, A.1    Lotti, F.2    Sette, G.3    Pilozzi, E.4    Biffoni, M.5    Di Virgilio, A.6
  • 61
    • 77950832189 scopus 로고    scopus 로고
    • Lung cancer stem cells as a target for therapy
    • Feb
    • Gorelik E, Lokshin A, Levina V. Lung cancer stem cells as a target for therapy. Anticancer Agents Med Chem 2010 Feb;10(2):164-71.
    • (2010) Anticancer Agents Med Chem , vol.10 , Issue.2 , pp. 164-171
    • Gorelik, E.1    Lokshin, A.2    Levina, V.3
  • 62
    • 79957622341 scopus 로고    scopus 로고
    • Concise review: Emerging concepts in clinical targeting of cancer stem cells
    • Jun
    • Rasheed ZA, Kowalski J, Smith BD, Matsui W. Concise review: Emerging concepts in clinical targeting of cancer stem cells. Stem Cells 2011 Jun;29(6):883-7.
    • (2011) Stem Cells , vol.29 , Issue.6 , pp. 883-887
    • Rasheed, Z.A.1    Kowalski, J.2    Smith, B.D.3    Matsui, W.4
  • 63
    • 79251641963 scopus 로고    scopus 로고
    • Lung cancer stem cell: new insights on experimental models and preclinical data
    • Rivera C, Rivera S, Loriot Y, Vozenin MC, Deutsch E. Lung cancer stem cell: new insights on experimental models and preclinical data. J Oncol 2011;2011:549181.
    • (2011) J Oncol , vol.2011 , pp. 549181
    • Rivera, C.1    Rivera, S.2    Loriot, Y.3    Vozenin, M.C.4    Deutsch, E.5
  • 64
    • 77955756250 scopus 로고    scopus 로고
    • Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer
    • Aug 15
    • Ooi AT, Mah V, Nickerson DW, Gilbert JL, Ha VL, Hegab AE, et al. Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer. Cancer Res 2010 Aug 15;70(16):6639-48.
    • (2010) Cancer Res , vol.70 , Issue.16 , pp. 6639-6648
    • Ooi, A.T.1    Mah, V.2    Nickerson, D.W.3    Gilbert, J.L.4    Ha, V.L.5    Hegab, A.E.6
  • 65
    • 84872191453 scopus 로고    scopus 로고
    • Upregulation of CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cells
    • Jung MJ, Rho JK, Kim YM, Jung JE, Jin YB, Ko YG, et al. Upregulation of CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cells. Oncogene 2012.
    • (2012) Oncogene
    • Jung, M.J.1    Rho, J.K.2    Kim, Y.M.3    Jung, J.E.4    Jin, Y.B.5    Ko, Y.G.6
  • 66
    • 75149117750 scopus 로고    scopus 로고
    • Elimination of human lung cancer stem cells through targeting of the stem cell factor-c-kit autocrine signaling loop
    • Jan 1
    • Levina V, Marrangoni A, Wang T, Parikh S, Su Y, Herberman R, et al. Elimination of human lung cancer stem cells through targeting of the stem cell factor-c-kit autocrine signaling loop. Cancer Res 2010 Jan 1;70(1):338-46.
    • (2010) Cancer Res , vol.70 , Issue.1 , pp. 338-346
    • Levina, V.1    Marrangoni, A.2    Wang, T.3    Parikh, S.4    Su, Y.5    Herberman, R.6
  • 67
    • 70349479538 scopus 로고    scopus 로고
    • Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment
    • Sep 22
    • Bertolini G, Roz L, Perego P, Tortoreto M, Fontanella E, Gatti L, et al. Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment. Proc Natl Acad Sci U S A 2009 Sep 22;106(38):16281-6.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.38 , pp. 16281-6
    • Bertolini, G.1    Roz, L.2    Perego, P.3    Tortoreto, M.4    Fontanella, E.5    Gatti, L.6
  • 68
    • 79958819359 scopus 로고    scopus 로고
    • Delineation of a cellular hierarchy in lung cancer reveals an oncofetal antigen expressed on tumor-initiating cells
    • Jun 15
    • Damelin M, Geles KG, Follettie MT, Yuan P, Baxter M, Golas J, et al. Delineation of a cellular hierarchy in lung cancer reveals an oncofetal antigen expressed on tumor-initiating cells. Cancer Res 2011 Jun 15;71(12):4236-46.
    • (2011) Cancer Res , vol.71 , Issue.12 , pp. 4236-4246
    • Damelin, M.1    Geles, K.G.2    Follettie, M.T.3    Yuan, P.4    Baxter, M.5    Golas, J.6
  • 69
    • 78650236850 scopus 로고    scopus 로고
    • Chemotherapy, chemoresistance and the changing treatment landscape for NSCLC
    • Chang A. Chemotherapy, chemoresistance and the changing treatment landscape for NSCLC. Lung Cancer 2011.
    • (2011) Lung Cancer
    • Chang, A.1
  • 70
    • 84856868390 scopus 로고    scopus 로고
    • Development of novel CXCR4-based therapeutics
    • Mar
    • Peled A, Wald O, Burger J. Development of novel CXCR4-based therapeutics. Expert Opin Investig Drugs 2012 Mar;21(3):341-53.
    • (2012) Expert Opin Investig Drugs , vol.21 , Issue.3 , pp. 341-353
    • Peled, A.1    Wald, O.2    Burger, J.3
  • 71
    • 82755194789 scopus 로고    scopus 로고
    • The chemokine system and cancer
    • Jan
    • Balkwill FR. The chemokine system and cancer. J Pathol 2012 Jan;226(2):148-57.
    • (2012) J Pathol , vol.226 , Issue.2 , pp. 148-157
    • Balkwill, F.R.1
  • 72
    • 33344464945 scopus 로고    scopus 로고
    • CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment
    • Mar 1
    • Burger JA, Kipps TJ. CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood 2006 Mar 1;107(5):1761-7.
    • (2006) Blood , vol.107 , Issue.5 , pp. 1761-1767
    • Burger, J.A.1    Kipps, T.J.2
  • 73
    • 58249100053 scopus 로고    scopus 로고
    • CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers
    • Jan
    • Burger JA, Peled A. CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers. Leukemia 2009 Jan;23(1):43-52.
    • (2009) Leukemia , vol.23 , Issue.1 , pp. 43-52
    • Burger, J.A.1    Peled, A.2
  • 74
    • 61449451621 scopus 로고    scopus 로고
    • The CXCR4/SDF-1 chemokine receptor axis: a new target therapeutic for non-small cell lung cancer
    • Dec
    • Otsuka S, Bebb G. The CXCR4/SDF-1 chemokine receptor axis: a new target therapeutic for non-small cell lung cancer. J Thorac Oncol 2008 Dec;3(12):1379-83.
    • (2008) J Thorac Oncol , vol.3 , Issue.12 , pp. 1379-1383
    • Otsuka, S.1    Bebb, G.2
  • 75
    • 64249173226 scopus 로고    scopus 로고
    • The AMD3100 story: the path to the discovery of a stem cell mobilizer (Mozobil)
    • Jun 1
    • De Clercq E. The AMD3100 story: the path to the discovery of a stem cell mobilizer (Mozobil). Biochem Pharmacol 2009 Jun 1;77(11):1655-64.
    • (2009) Biochem Pharmacol , vol.77 , Issue.11 , pp. 1655-1664
    • De Clercq, E.1
  • 76
    • 67651089936 scopus 로고    scopus 로고
    • Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma
    • Jun 4
    • DiPersio JF, Stadtmauer EA, Nademanee A, Micallef IN, Stiff PJ, Kaufman JL, et al. Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma. Blood 2009 Jun 4;113(23):5720-6.
    • (2009) Blood , vol.113 , Issue.23 , pp. 5720-5726
    • DiPersio, J.F.1    Stadtmauer, E.A.2    Nademanee, A.3    Micallef, I.N.4    Stiff, P.J.5    Kaufman, J.L.6
  • 78
    • 52049104887 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors in stem cell circulation
    • Beider K, Abraham M, Peled A. Chemokines and chemokine receptors in stem cell circulation. Front Biosci 2008;13:6820-33.
    • (2008) Front Biosci , vol.13 , pp. 6820-6833
    • Beider, K.1    Abraham, M.2    Peled, A.3
  • 79
    • 23244435467 scopus 로고    scopus 로고
    • How do stem cells find their way home?
    • Sep 15
    • Lapidot T, Dar A, Kollet O. How do stem cells find their way home? Blood 2005 Sep 15;106:6:1901-10
    • (2005) Blood , vol.106 , Issue.6 , pp. 1901-1910
    • Lapidot, T.1    Dar, A.2    Kollet, O.3
  • 80
    • 0033524834 scopus 로고    scopus 로고
    • Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4
    • Feb 5
    • Peled A, Petit I, Kollet O, Magid M, Ponomaryov T, Byk T, et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 1999 Feb 5;283(5403):845-8.
    • (1999) Science , vol.283 , Issue.5403 , pp. 845-848
    • Peled, A.1    Petit, I.2    Kollet, O.3    Magid, M.4    Ponomaryov, T.5    Byk, T.6
  • 81
    • 84859227686 scopus 로고    scopus 로고
    • Development of a unique small molecule modulator of CXCR4
    • Liang Z, Zhan W, Zhu A, Yoon Y, Lin S, Sasaki M, et al. Development of a unique small molecule modulator of CXCR4. PLoS One 2012;7(4):e34038.
    • (2012) PLoS One , vol.7 , Issue.4
    • Liang, Z.1    Zhan, W.2    Zhu, A.3    Yoon, Y.4    Lin, S.5    Sasaki, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.