Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by piperine via the inhibition of PKCα/ERK1/2-dependent matrix metalloproteinase-9 expression

Toxicology Letters

Volumn 203, Issue 1, 2011, Pages 9-19

  Hwang, Yong Pil ^a   Yun, Hyo Jeong ^a   Kim, Hyung Gyun ^a   Han, Eun Hee ^a   Choi, Jae Ho ^a   Chung, Young Chul ^b   Jeong, Hye Gwang ^a  

^a Chungnam National University   (South Korea)

^b Korea International University   (South Korea)

Author keywords

Antitumor activity; Invasion; MMP 9; Piperine; PKC

Indexed keywords

GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHORBOL 13 ACETATE 12 MYRISTATE; PIPERINE; PROTEIN KINASE C ALPHA; STRESS ACTIVATED PROTEIN KINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSCRIPTION FACTOR AP 1;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL INVASION; CELL MIGRATION; DOWN REGULATION; DRUG MECHANISM; DRUG POTENCY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; METASTASIS INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOMA CELL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR CELL;

ALKALOIDS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BENZODIOXOLES; CELL LINE, TUMOR; CELL MOVEMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FIBROSARCOMA; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MATRIX METALLOPROTEINASE 9; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOPLASM INVASIVENESS; NF-KAPPA B; PHOSPHORYLATION; PIPERIDINES; POLYUNSATURATED ALKAMIDES; PROTEIN KINASE C-ALPHA; PROTO-ONCOGENE PROTEINS C-JUN; RNA, MESSENGER; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; TIME FACTORS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; TRANSFECTION;

PIPER NIGRUM;

EID: 79954645941     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.02.013     Document Type: Article

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