Imaging glutamate homeostasis in cocaine addiction with the metabotropic glutamate receptor 5 positron emission tomography radiotracer [ 11C]ABP688 and magnetic resonance spectroscopy

Biological Psychiatry

Volumn 75, Issue 2, 2014, Pages 165-171

  Martinez, Diana ^a   Slifstein, Mark ^a   Nabulsi, Nabeel ^b   Grassetti, Alexander ^a   Urban, Nina B L ^a   Perez, Audrey ^a   Liu, Fei ^a   Lin, Shu Fei ^b   Ropchan, Jim ^b   Mao, Xiangling ^c   Kegeles, Lawrence S ^a   Shungu, Dikoma C ^c   Carson, Richard E ^b   Huang, Yiyun ^b  

^a New York Presbyterian Columbia University Medical Center   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Addiction; cocaine; cocaine self administration; magnetic resonance spectroscopy; metabotropic glutamate receptor 5; positron emission tomography

Indexed keywords

4 AMINOBUTYRIC ACID; ABP 688 C 11; BRAIN PROTEIN; CHOLINE; COCAINE; CREATINE; GLUTAMIC ACID; GLUTAMINE; METABOTROPIC RECEPTOR 5; N ACETYLASPARTIC ACID; TRACER; UNCLASSIFIED DRUG;

4 AMINOBUTYRIC ACID BRAIN LEVEL; ADULT; AFRICAN AMERICAN; AMYGDALOID NUCLEUS; ANTERIOR CINGULATE; ARTICLE; CAUCASIAN; CAUDATE NUCLEUS; CEREBROSPINAL FLUID; CLINICAL ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; CORPUS STRIATUM; DRUG SEEKING BEHAVIOR; DSM-IV; ENTORHINAL CORTEX; FEMALE; GRAY MATTER; HIPPOCAMPUS; HOMEOSTASIS; HUMAN; HYPOTHESIS; MALE; MEDIAL PREFRONTAL CORTEX; MEDIAL TEMPORAL CORTEX; NUCLEAR MAGNETIC RESONANCE SCANNER; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OCCIPITAL CORTEX; ORBITAL CORTEX; PARAHIPPOCAMPAL GYRUS; PET SCANNER; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PRIORITY JOURNAL; PUTAMEN; SECONDARY ANALYSIS; SMOKING; TEMPORAL CORTEX; THALAMUS; UNCUS; WHITE MATTER;

ADDICTION; COCAINE; COCAINE SELF-ADMINISTRATION; MAGNETIC RESONANCE SPECTROSCOPY; METABOTROPIC GLUTAMATE RECEPTOR 5; POSITRON EMISSION TOMOGRAPHY;

ADULT; BRAIN; CARBON RADIOISOTOPES; CASE-CONTROL STUDIES; CHOICE BEHAVIOR; COCAINE; COCAINE-RELATED DISORDERS; CORPUS STRIATUM; FUNCTIONAL NEUROIMAGING; GLUTAMIC ACID; GLUTAMINE; HOMEOSTASIS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; OXIMES; POSITRON-EMISSION TOMOGRAPHY; PYRIDINES; RECEPTOR, METABOTROPIC GLUTAMATE 5; SELF ADMINISTRATION; YOUNG ADULT;

EID: 84890437650     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2013.06.026     Document Type: Article

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