Behavioral and functional evidence of metabotropic glutamate receptor 2/3 and metabotropic glutamate receptor 5 dysregulation in cocaine-escalated rats: Factor in the transition to dependence

Biological Psychiatry

Volumn 68, Issue 3, 2010, Pages 240-248

  Hao, Yue ^a   Martin Fardon, Rmi ^a   Weiss, Friedbert ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Cocaine; compulsive drug taking; metabotropic glutamate receptor; neuroadaptation; self administration

Indexed keywords

3 [(2 METHYL 4 THIAZOLYL)ETHYNYL]PYRIDINE; 4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; COCAINE; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR 5;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR CHANGE; COCAINE DEPENDENCE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE ESCALATION; DRUG EXPOSURE; HIPPOCAMPUS; IMMUNOBLOTTING; MALADJUSTMENT; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PHASE TRANSITION; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; REINFORCEMENT;

AMINO ACIDS; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ADDICTIVE; BICYCLO COMPOUNDS, HETEROCYCLIC; CENTRAL NERVOUS SYSTEM DEPRESSANTS; COCAINE; COCAINE-RELATED DISORDERS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; MALE; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; REINFORCEMENT SCHEDULE; SELF ADMINISTRATION; THIAZOLES;

EID: 77955688416     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2010.02.011     Document Type: Article

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