Imaging changes in glutamate transmission in vivo with the metabotropic glutamate receptor 5 tracer [11C] ABP688 and N-acetylcysteine challenge

Biological Psychiatry

Volumn 69, Issue 9, 2011, Pages 822-824

  Miyake, Nobumi ^a,b   Skinbjerg, Mette ^a,b   Easwaramoorthy, Balu ^a,b   Kumar, Dileep ^a,b   Girgis, Ragy R ^a,b   Xu, Xiaoyan ^a,b   Slifstein, Mark ^a,b   Abi Dargham, Anissa ^a,b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

ABP688; allosteric modulator; glutamate transmission; mGluR5; N acetylcysteine; testretest

Indexed keywords

3 (6 METHYL PYRIDINE 2 YLETHYNYL) CYCLOHEX 2 ENONE O METHYLOXIME CARBON 11; ACETYLCYSTEINE; GLUTAMIC ACID; METABOTROPIC RECEPTOR 5; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CINGULATE GYRUS; CORPUS STRIATUM; FEASIBILITY STUDY; FRONTAL CORTEX; HIPPOCAMPUS; IN VIVO STUDY; MALE; NEUROTRANSMISSION; NONHUMAN; OCCIPITAL CORTEX; PARIETAL CORTEX; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; TEMPORAL CORTEX; TEST RETEST RELIABILITY; THALAMUS;

ACETYLCYSTEINE; ANIMALS; BRAIN; BRAIN MAPPING; CARBON RADIOISOTOPES; GLUTAMIC ACID; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; OXIMES; PAPIO; PYRIDINES; RECEPTORS, METABOTROPIC GLUTAMATE; SYNAPTIC TRANSMISSION; TISSUE DISTRIBUTION;

EID: 79954937158     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2010.12.023     Document Type: Article

References (18)

1. L.S. Kegeles, A. Abi-Dargham, W.G. Frankle, R. Gil, T.B. Cooper, and M. Slifstein Increased synaptic dopamine function in associative regions of the striatum in schizophrenia Arch Gen Psychiatry 67 2010 231 239
2. N.D. Volkow, J.S. Fowler, and G.J. Wang The addicted human brain: Insights from imaging studies J Clin Invest 111 2003 1444 1451 (Pubitemid 38063274)
3. M. Laruelle Imaging synaptic neurotransmission with in vivo binding competition techniques: A critical review J Cereb Blood Flow Metab 20 2000 423 451 (Pubitemid 30164887)
4. Y.H. Huang, and D.E. Bergles Glutamate transporters bring competition to the synapse Curr Opin Neurobiol 14 2004 346 352 (Pubitemid 38759865)
5. P.W. Kalivas The glutamate homeostasis hypothesis of addiction Nat Rev Neurosci 10 2009 561 572
6. G. Gegelashvili, and A. Schousboe Cellular distribution and kinetic properties of high-affinity glutamate transporters Brain Res Bull 45 1998 233 238 (Pubitemid 28113004)
7. N. Arnth-Jensen, D. Jabaudon, and M. Scanziani Cooperation between independent hippocampal synapses is controlled by glutamate uptake Nat Neurosci 5 2002 325 331 (Pubitemid 34279812)
8. K. Tanaka Functions of glutamate transporters in the brain Neurosci Res 37 2000 15 19 (Pubitemid 30236303)
9. Y.H. Huang, S.R. Sinha, K. Tanaka, J.D. Rothstein, and D.E. Bergles Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons J Neurosci 24 2004 4551 4559 (Pubitemid 38656611)
10. Y. Yang, O. Gozen, A. Watkins, I. Lorenzini, A. Lepore, and Y. Gao Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1 Neuron 61 2009 880 894
11. J. Burdo, R. Dargusch, and D. Schubert Distribution of the cystine/glutamate antiporter system xc-in the brain, kidney, and duodenum J Histochem Cytochem 54 2006 549 557
12. L.A. Knackstedt, S. LaRowe, P. Mardikian, R. Malcolm, H. Upadhyaya, and S. Hedden The role of cystine-glutamate exchange in nicotine dependence in rats and humans Biol Psychiatry 65 2009 841 845
13. M.L. Rathinam, L.T. Watts, A.A. Stark, L. Mahimainathan, J. Stewart, S. Schenker, and G.I. Henderson Astrocyte control of fetal cortical neuron glutathione homeostasis: Up-regulation by ethanol J Neurochem 96 2006 1289 1300
14. S.M. Ametamey, L.J. Kessler, M. Honer, M.T. Wyss, A. Buck, and S. Hintermann Radiosynthesis and preclinical evaluation of C-11-ABP688 as a probe for imaging the metabotropic glutamate receptor subtype 5 J Nucl Med 47 2006 698 705 (Pubitemid 46768472)
15. M. Slifstein, R.F. Suckow, J.A. Javitch, T. Cooper, J. Lieberman, and A. Abi-Dargham Characterization of in vivo pharmacokinetic properties of the dopamine D1 receptor agonist DAR-0100A in nonhuman primates using PET with [(11)C] NNC112 and [(11)C] raclopride J Cereb Blood Flow Metab 2011 2010 293 304
16. K.J. Friston, A.P. Holmes, K.J. Worsley, J.-P. Poline, C.D. Frith, and R.S.J. Frakowiak Statistical parametric maps in functional imaging: A general linear approach Hum Brain Mapp 2 1995 189 210 (Pubitemid 124008664)
17. R.B. Innis, V.J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, and R.N. Gunn Consensus nomenclature for in vivo imaging of reversibly binding radioligands J Cereb Blood Flow Metab 27 2007 1533 1539 (Pubitemid 47301451)
18. M. Laruelle, R.N. Iyer, M.S. al-Tikriti, Y. Zea-Ponce, R. Malison, and S.S. Zoghbi Microdialysis and SPECT measurements of amphetamine-induced dopamine release in nonhuman primates Synapse 25 1997 1 14 (Pubitemid 27014356)