Species differences in mGluR5 binding sites in mammalian central nervous system determined using in vitro binding with [18F]F-PEB

Nuclear Medicine and Biology

Volumn 34, Issue 8, 2007, Pages 1009-1017

  Patel, Shil ^a   Hamill, Terence G ^a   Connolly, Brett ^a   Jagoda, Elaine ^a   Li, Wenping ^a   Gibson, Raymond E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

CNS; mGluR5; Radioligand binding; Species differences

Indexed keywords

3 FLUORO 5 [(PYRIDIN 3 YL)ETHYNYL]BENZONITRILE F 18; METABOTROPIC RECEPTOR 5; RADIOPHARMACEUTICAL AGENT; TRACER; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BRAIN CORTEX; BRAIN MEMBRANE; CAUDATE NUCLEUS; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; MEMBRANE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; QUANTITATIVE ANALYSIS; RAT; RECEPTOR BINDING; RHESUS MONKEY; SIGNAL DETECTION; SPECIES DIFFERENCE; TISSUE DISTRIBUTION; TISSUE SECTION;

ANIMALS; BINDING SITES; BRAIN; HUMANS; MACACA MULATTA; METABOLIC CLEARANCE RATE; NITRILES; PROTEIN BINDING; PYRIDINES; RADIOPHARMACEUTICALS; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; SPECIES SPECIFICITY; TISSUE DISTRIBUTION;

EID: 35848943027     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2007.07.009     Document Type: Article

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