Erythropoietin improves motor and cognitive deficit, axonal pathology, and neuroinflammation in a combined model of diffuse traumatic brain injury and hypoxia, in association with upregulation of the erythropoietin receptor

Journal of Neuroinflammation

Volumn 10, Issue , 2013, Pages

  Hellewell, Sarah C ^a,b   Yan, Edwin B ^c   Alwis, Dasuni S ^a,c   Bye, Nicole ^a,b   Morganti Kossmann, M C ^b,d,e  

^a ALFRED HOSPITAL   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d Australian New Zealand Intensive Care Research Centre   (Australia)

^e UNIVERSITY OF ARIZONA   (United States)

Author keywords

EPO; Erythropoietin; Hypoxia; Neuroprotection; Traumatic axonal injury; Traumatic brain injury (TBI)

Indexed keywords

CD68 ANTIGEN; ERYTHROPOIETIN RECEPTOR; INTERLEUKIN 1BETA; MICROTUBULE ASSOCIATED PROTEIN 2; RECOMBINANT ERYTHROPOIETIN; SODIUM CHLORIDE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; CELL INFILTRATION; COGNITIVE DEFECT; CONTROLLED STUDY; CORPUS CALLOSUM; CYTOKINE PRODUCTION; DIFFUSE AXONAL INJURY; DRUG EFFECT; MACROPHAGE ACTIVATION; MALE; MICROGLIA; MOTOR DYSFUNCTION; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; OPEN FIELD TEST; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RECEPTOR UPREGULATION; ROTAROD TEST; SEPTUM NUCLEUS; SINGLE DRUG DOSE; TRAUMATIC BRAIN INJURY; WHITE MATTER INJURY;

ANIMALS; AXONS; BEHAVIOR, ANIMAL; BRAIN INJURIES; ERYTHROPOIETIN; HYPOXIA, BRAIN; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ERYTHROPOIETIN; RECOVERY OF FUNCTION; UP-REGULATION;

EID: 84890408530     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-10-156     Document Type: Article

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