Dose-dependent neurorestorative effects of delayed treatment of traumatic brain injury with recombinant human erythropoietin in rats: Laboratory investigation

Journal of Neurosurgery

Volumn 115, Issue 3, 2011, Pages 550-560

  Meng, Yuling ^a   Xiong, Ye ^a   Mahmood, Asim ^a   Zhang, Yanlu ^a   Changsheng, Qu ^a   Chopp, Michael ^b,c  

^a HENRY FORD HEALTH SYSTEM   (United States)

^b HENRY FORD HOSPITAL   (United States)

^c OAKLAND UNIVERSITY   (United States)

Author keywords

Angiogenesis; Cell proliferation; Erythropoietin; Neurogenesis; Rat; Sensorimotor; Spatial learning; Traumatic brain injury

Indexed keywords

RECOMBINANT ERYTHROPOIETIN; SODIUM CHLORIDE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BRAIN CORTEX; CELL LOSS; CELL PROLIFERATION; COGNITION; CONTROLLED STUDY; CONVALESCENCE; DOSE RESPONSE; DRUG EFFICACY; EXPERIMENTAL TEST; FOOTFAULT TEST; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INJURY SCALE; LEARNING; MALE; MAZE TEST; MODIFIED NEUROLOGICAL SEVERITY SCORE TEST; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; OPTIMAL DRUG DOSE; PRIORITY JOURNAL; RAT; SENSORIMOTOR FUNCTION; SHAM PROCEDURE; THERAPY DELAY; TRAUMATIC BRAIN INJURY;

ANIMALS; BRAIN INJURIES; CELL COUNT; CELL PROLIFERATION; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROPOIETIN; HIPPOCAMPUS; MALE; MAZE LEARNING; NEUROGENESIS; NEURONS; PSYCHOMOTOR PERFORMANCE; RATS; RATS, WISTAR; RECOVERY OF FUNCTION;

EID: 80052342942     PISSN: 00223085     EISSN: 19330693     Source Type: Journal    
DOI: 10.3171/2011.3.JNS101721     Document Type: Article

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